Witte-broot voor de Predicanten tot Campen, om het Camper-Steurtjen bequamelicken op te eeten.

Verpakt met de steun van Fonds Inbev-Latour (2010-2012)Europeana-GoogleBook

Den ouden Leytschen patroon ofte Derden Octobers bancket : Waer in kortelijck en waerachtelijck wort voorgeset de stercke belegeringe der Stad, de groote benautheyt der borgeren, ende de wonderbare wercken Godes betoont in 't ontsetten van de Stad Leyden: geschiet [...] 1574, op den 3. October [...].

D4 blanco ontbreektVingerafdruk: 163004 - b1 A2 en : b2 D2 $deVingerafdruk: 163004 - b1 A3 en : b2 D2$deVerpakt met de steun van Fonds Inbev-Latour (2010-2012)Tiele, P. A. Bibliotheek van Nederlandsche pamfletten. Verzameling Frederik Muller ; 242

Tacrolimus population pharmacokinetics in adult heart transplant patients

International audienceAbstract Introduction Tacrolimus is an immunosuppressant largely used in heart transplantation. However, the calculation of its exposure based on the area under the curve (AUC) requires the use of a population pharmacokinetic (PK) model. The aims of this work were (i) to develop a population PK model for tacrolimus in heart transplant patients, (ii) to derive a maximum a posteriori Bayesian estimator (MAP‐BE) based on a limited sampling strategy (LSS) and (iii) to estimate probabilities of target attainment (PTAs) for AUC and trough concentration (C0). Material and Methods Forty‐seven PK profiles (546 concentrations) of 18 heart transplant patients of the Pharmacocinétique des Immunosuppresseurs chez les patients GREffés Cardiaques study receiving tacrolimus (Prograf®) were included. The database was split into a development (80%) and a validation (20%) set. PK parameters were estimated in MONOLIX® and based on this model a Bayesian estimator using an LSS was built. Simulations were performed to calculate the PTA for AUC and C0. Results The best model to describe the tacrolimus PK was a two‐compartment model with a transit absorption and a linear elimination. Only the CYP3A5 covariate was kept in the final model. The derived MAP‐BE based on the LSS (0‐1‐2 h postdose) yielded an AUC bias ± SD = 2.7 ± 10.2% and an imprecision of 9.9% in comparison to the reference AUC calculated using the trapezoidal rule. PTAs based on AUC or C0 allowed new recommendations to be proposed for starting doses (0.11 mg·kg −1 ·12 h −1 for the CYP3A5 nonexpressor and 0.22 mg·kg 1 ·12 h −1 for the CYP3A5 expressor). Conclusion The MAP‐BE developed should facilitate estimation of tacrolimus AUC in heart transplant patients