A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems

Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products. HL7 (Health level 7) International, an international non-profit organization, defines and maintains standards related to health information systems. However, the modelling languages proposed by HL7 are far removed from standard languages and widely known by software engineers. In these lines, NDT is a software development methodology that has a support tool called NDT-Suite and is based, on the one hand, on the paradigm of model-driven engineering and, on the other hand, in UML that is a widely recognized standard language. This paper proposes an extension of the NDT methodology called MoDHE (Model Driven Health Engineering) to offer software engineers a methodology capable of modelling health information systems conforming to HL7 using UML domain models

Wave attenuation and dispersion due to floating ice covers

Experiments investigating the attenuation and dispersion of surface waves in a variety of ice covers are performed using a refrigerated wave flume. The ice conditions tested in the experiments cover naturally occurring combinations of continuous, fragmented, pancake and grease ice. Attenuation rates are shown to be a function of ice thickness, wave frequency, and the general rigidity of the ice cover. Dispersion changes were minor except for large wavelength increases when continuous covers were tested. Results are verified and compared with existing literature to show the extended range of investigation in terms of incident wave frequency and ice conditions

Positivity and conservation of superenergy tensors

Two essential properties of energy-momentum tensors T_{\mu\nu} are their positivity and conservation. This is mathematically formalized by, respectively, an energy condition, as the dominant energy condition, and the vanishing of their divergence \nabla^\mu T_{\mu\nu}=0. The classical Bel and Bel-Robinson superenergy tensors, generated from the Riemann and Weyl tensors, respectively, are rank-4 tensors. But they share these two properties with energy momentum tensors: the Dominant Property (DP) and the divergence-free property in the absence of sources (vacuum). Senovilla defined a universal algebraic construction which generates a basic superenergy tensor T{A} from any arbitrary tensor A. In this construction the seed tensor A is structured as an r-fold multivector, which can always be done. The most important feature of the basic superenergy tensors is that they satisfy automatically the DP, independently of the generating tensor A. In a previous paper we presented a more compact definition of T{A} using the r-fold Clifford algebra. This form for the superenergy tensors allowed to obtain an easy proof of the DP valid for any dimension. In this paper we include this proof. We explain which new elements appear when we consider the tensor T{A} generated by a non-degree-defined r-fold multivector A and how orthogonal Lorentz transformations and bilinear observables of spinor fields are included as particular cases of superenergy tensors. We find some sufficient conditions for the seed tensor A, which guarantee that the generated tensor T{A} is divergence-free. These sufficient conditions are satisfied by some physical fields, which are presented as examples.Comment: 19 pages, no figures. Language and minor changes. Published versio

Host plant effects on the development, survival, and reproduction of dysmicoccus brevipes (Hemiptera: Pseudococcidae) on grapevines.

Dysmicoccus brevipes (Cockerell, 1893) (Hemiptera: Pseudococcidae) is one of the most frequent and abundant mealybugs in Brazilian vineyards, where it causes direct and indirect damage to the vines. In this study, we investigated the effect of plant structures, cultivars, and vine rootstocks on the development, survival, and reproduction of D. brevipes under laboratory conditions. Leaves of the tablegrape cultivar ÔIta´liaÕ (Vitis vinifera) and ÔNia´gara RosadaÕ (Vitis labrusca) and the vine roots of the rootstocks Paulsen 1103 (Vitis berlandieriV. rupestris) and IAC 572 (Vitis caribaea101-14 Mgt) were used as host plants. D. brevipes developed on different vegetative structures, cultivars, and vine rootstocks. D. brevipes showed the shortest developmental period and highest survival and fecundity rates on leaves of cultivar Ita´lia. Survival on leaves was signiÞcantly higher than on roots. Roots of IAC 572 were unsuitable for D. brevipes development, resulting in nonreproductive females.ThemealybugsÕ longevityonleaves and vine roots was similar. Higher intrinsic and Þnite rates of increase and net reproductive rate were observed whenmealybugs developed on Ita´lia leaves.Weconcluded that the host plant affects the development and survival of D. brevipes and that the choice of the most appropriate cultivar or vine rootstock can help to reduce pest infestation, and is therefore an additional component to be included in the integrated pest management of grapes

Differences in the fly-load of Haematobia irritans (Diptera: Muscidae) on cattle is modified by endophyte infection of pastures

Background: The horn fly, Haematobia irritans, is an obligate bloodsucking ectoparasite of pastured cattle and is a major pest of livestock production in North and South America and Europe. In this study, we investigated the potential to use cattle pastures, infected with non-toxic, "friendly" fungal-endophyte-infected (E+) tall fescue, Festuca arundinacea Schreb., as a strategy for reducing horn fly loads in cattle, and to evaluate the possible bioinsecticide effect on horn fly larvae. Results: When cattle grazed in E+ tall fescue, a decrease in fly-load was observed, compared with other pastures (endophyte-free (E-) pastures). The infestation of horn fly load decreased according to an increase in the percentage of endophyte present in the different pastures (0 to 100%). Moreover, two groups of animals with significant differences in the fly-load (high and low fly-load) in the same herd were observed (P < 0.05). Additionally, it was possible to determine a bioinsecticide effect of cattle dung, upon horn fly larvae (80%), from animals fed E+ tall fescue. Conclusions: These results constitute the first report on the potential for exploiting pasture management for controlling 1) horn fly-loads on cattle and 2) the normal development of horn fly larvae. In conclusion, this information provides preliminary understanding of the role of cattle pasture diet management for controlling horn fliesas part of an integrated pest management strategy for this major pest of farmed livestock

Effects of inhomogeneities and drift on the dynamics of temporal solitons in fiber cavities and microresonators

In Ref. [Parra-Rivas at al., 2013], using the Swift-Hohenberg equation, we introduced a mechanism that allows to generate oscillatory and excitable soliton dynamics. This mechanism was based on a competition between a pinning force at inhomogeneities and a pulling force due to drift. Here, we study the effect of such inhomogeneities and drift on temporal solitons and Kerr frequency combs in fiber cavities and microresonators, described by the Lugiato-Lefever equation with periodic boundary conditions. We demonstrate that for low values of the frequency detuning the competition between inhomogeneities and drift leads to similar dynamics at the defect location, confirming the generality of the mechanism. The intrinsic periodic nature of ring cavities and microresonators introduces, however, some interesting differences in the final global states. For higher values of the detuning we observe that the dynamics is no longer described by the same mechanism and it is considerably more complex.Comment: 11 pages, 9 figure

Perpendicular momentum injection by lower hybrid wave in a tokamak

The injection of lower hybrid waves for current drive into a tokamak affects the profile of intrinsic rotation. In this article, the momentum deposition by the lower hybrid wave on the electrons is studied. Due to the increase in the poloidal momentum of the wave as it propagates into the tokamak, the parallel momentum of the wave increases considerably. The change of the perpendicular momentum of the wave is such that the toroidal angular momentum of the wave is conserved. If the perpendicular momentum transfer via electron Landau damping is ignored, the transfer of the toroidal angular momentum to the plasma will be larger than the injected toroidal angular momentum. A proper quasilinear treatment proves that both perpendicular and parallel momentum are transferred to the electrons. The toroidal angular momentum of the electrons is then transferred to the ions via different mechanisms for the parallel and perpendicular momentum. The perpendicular momentum is transferred to ions through an outward radial electron pinch, while the parallel momentum is transferred through collisions.Comment: 22 pages, 4 figure

Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients

Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis and haemodiafiltration of tryptophan and tryptophan-derived uremic toxins, indoxyl sulfate (IS) and indole acetic acid (IAA), in ESKD patients in different dialysis treatment settings. This prospective multicentre study in four European dialysis centres enrolled 78 patients with ESKD. Blood and spent dialysate samples obtained during dialysis were analysed with high-performance liquid chromatography to assess uremic solutes, their reduction ratio (RR) and total removed solute (TRS). Mean free serum tryptophan and IS concentrations increased, and concentration of IAA decreased over pre-dialysis levels (67%, 49%, -0.8%, respectively) during the first hour of dialysis. While mean serum total urea, IS and IAA concentrations decreased during dialysis (-72%, -39%, -43%, respectively), serum tryptophan levels increased, resulting in negative RR (-8%) towards the end of the dialysis session (p < 0.001), despite remarkable Trp losses in dialysate. RR and TRS values based on serum (total, free) and dialysate solute concentrations were lower for conventional low-flux dialysis (p < 0.001). High-efficiency haemodiafiltration resulted in 80% higher Trp losses than conventional low-flux dialysis, despite similar neutral Trp RR values. In conclusion, serum Trp concentrations and RR behave differently from uremic solutes IS, IAA and urea and Trp RR did not reflect dialysis Trp losses. Conventional low-flux dialysis may not adequately clear Trp-related uremic toxins while high efficiency haemodiafiltration increased Trp losses