La metacognición y el mejoramiento de la enseñanza de química universitaria

En este trabajo, que es parte de una investigación más extensa, sobre mejoramiento de la enseñanza de química universitaria, se presentan algunos resultados obtenidos luego de aplicar una nueva propuesta de enseñanza, destinada a la comprensión y resolución de problemas sobre el tema «Soluciones». Con el objeto de facilitar el aprendizaje significativo, la propuesta de trabajo incluye el uso de las denominadas herramientas metacognitivas que permitan aplicar metodologías conducentes al logro de dichos aprendizajes por parte de los estudiantes. Luego de aplicar las mencionadas herramientas, se procedió a realizar la evaluación de los estudiantes participantes para obtener datos sobre los logros alcanzados y sus aprendizajes. El análisis de los resultados muestra que el uso del nuevo enfoque instruccional ayuda a los estudiantes en sus procesos de aprendizaje, en la medida que se vayan haciendo conscientes de los mecanismos que se utilizan para obtener aprendizaje significativo.This work, which is part of a more extensive research project on the improvement of Chemistry teaching at university level, presents the results obtained by applying an innovative teaching methodology. This methodology was designed with the objective of helping students to better understand and solve problems regarding the topic "Solutions". In order to facilitate learning, the proposed methodology includes the use of metacognitive tools (concept maps, Gowin's Vee and clinical interviews), which allows the students to apply significant learning methodologies. After applying these tools, we evaluated the students in order to measure their achievements and their learning. The analysis of the results shows that the use of this new instructional approach helps the students in their learning process because they become aware of the mechanism they use to achieve significant learning

Paper-based electroanalytical devices with an integrated, stable reference electrode

This paper describes the development of a referenced Electrochemical Paper-based Analytical Device (rEPAD) comprising a sample zone, a reference zone, and a connecting microfluidic channel that includes a central contact zone. We demonstrated that the rEPADs provide a simple system for direct and accurate voltammetric measurements that are referenced by an electrode with a constant, well-defined potential. The performance of the rEPADs is comparable to commercial electrochemical cells, and the layout can be easily integrated into systems that permit multiplexed analysis and pipette-free sampling. The cost of this portable device is sufficiently low that it could be for single-use, disposable applications, and its method of fabrication is compatible with that used for other paper-based systems.Chemistry and Chemical Biolog

Compuestos y reacciones quimicas naturales como motivadores del aprendizaje

Uno de los componentes importantes en el proceso de aprendizaje, se relaciona con la fuerte motivación intrínseca que el estudiante muestra hacia los contenidos que debe incorporar. Mas allá de los intereses propios de los alumnos es posible aportar, desde los materiales didácticos con los cuales se trabaja en el aula, información, imágenes, e inquietudes que, al relacionarse con temas aplicados de su entorno natural conduzcan a un aumento en la atención, como modo de mejorar la comprensión, retención y posterior uso activo de los conocimientos adquiridos (Teoría Uno, Perkins, 1995). En esta propuesta el aprendizaje de la escritura de fórmulas y ecuaciones químicas, con todos sus componentes asociados se presenta como material didáctico que describe compuestos y reacciones químicas observables en el entorno natural circundante del alumno

Compuestos y reacciones quimicas naturales como motivadores del aprendizaje

Uno de los componentes importantes en el proceso de aprendizaje, se relaciona con la fuerte motivación intrínseca que el estudiante muestra hacia los contenidos que debe incorporar. Mas allá de los intereses propios de los alumnos es posible aportar, desde los materiales didácticos con los cuales se trabaja en el aula, información, imágenes, e inquietudes que, al relacionarse con temas aplicados de su entorno natural conduzcan a un aumento en la atención, como modo de mejorar la comprensión, retención y posterior uso activo de los conocimientos adquiridos (Teoría Uno, Perkins, 1995). En esta propuesta el aprendizaje de la escritura de fórmulas y ecuaciones químicas, con todos sus componentes asociados se presenta como material didáctico que describe compuestos y reacciones químicas observables en el entorno natural circundante del alumno

Spatio-Temporal Characteristics of Global Warming in the Tibetan Plateau during the Last 50 Years Based on a Generalised Temperature Zone - Elevation Model

Temperature is one of the primary factors influencing the climate and ecosystem, and examining its change and fluctuation could elucidate the formation of novel climate patterns and trends. In this study, we constructed a generalised temperature zone elevation model (GTEM) to assess the trends of climate change and temporal-spatial differences in the Tibetan Plateau (TP) using the annual and monthly mean temperatures from 1961-2010 at 144 meteorological stations in and near the TP. The results showed the following: (1) The TP has undergone robust warming over the study period, and the warming rate was 0.318°C/decade. The warming has accelerated during recent decades, especially in the last 20 years, and the warming has been most significant in the winter months, followed by the spring, autumn and summer seasons. (2) Spatially, the zones that became significantly smaller were the temperature zones of -6°C and -4°C, and these have decreased 499.44 and 454.26 thousand sq km from 1961 to 2010 at average rates of 25.1% and 11.7%, respectively, over every 5-year interval. These quickly shrinking zones were located in the northwestern and central TP. (3) The elevation dependency of climate warming existed in the TP during 1961-2010, but this tendency has gradually been weakening due to more rapid warming at lower elevations than in the middle and upper elevations of the TP during 1991-2010. The higher regions and some low altitude valleys of the TP were the most significantly warming regions under the same categorizing criteria. Experimental evidence shows that the GTEM is an effective method to analyse climate changes in high altitude mountainous regions

Nanodiagnostics to Face SARS-CoV-2 and Future Pandemics: From an Idea to the Market and beyond

The COVID-19 pandemic made clear how our society requires quickly available tools to address emerging healthcare issues. Diagnostic assays and devices are used every day to screen for COVID-19 positive patients, with the aim to decide the appropriate treatment and containment measures. In this context, we would have expected to see the use of the most recent diagnostic technologies worldwide, including the advanced ones such as nano-biosensors capable to provide faster, more sensitive, cheaper, and high-throughput results than the standard polymerase chain reaction and lateral flow assays. Here we discuss why that has not been the case and why all the exciting diagnostic strategies published on a daily basis in peer-reviewed journals are not yet successful in reaching the market and being implemented in the clinical practice.We acknowledge funding from the European Union Horizon2020 Programme under Grant No. 881603 (Graphene Flagship Core 3). We acknowledge Consejo Superior de Investigaciones Científicas (CSIC) for the project “COVID19-122” granted in the call “Nuevas ayudas extraordinarias a proyectos de investigación en el marco de las medidas urgentes extraordinarias para hacer frente al impacto económico y social del COVID-19 (Ayudas CSIC–COVID-19)”. We acknowledge the MICROB-PREDICT Project for partially supporting the work. The MICROB-PREDICT project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant No. 825694. This reflects only the author’s view, and the European Commission is not responsible for any use that may be made of the information it contains. We also acknowledge Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) for the project MAT2017-87202-P. A.I. was supported by a PROBIST postdoctoral fellowship funded by European Research Council (Marie Skłodowska-Curie Grant No. 754510). C.C.C.S. acknowledges funding through CAPES–PRINT (Programa Institucional de Internacionalização; Grant Nos. 88887.310281/2018-00 and 88887.467442/2019-00) and Mackpesquisa-UPM. L.H. acknowledges funding through the China Scholarship Council. ICN2 is funded by the CERCA Programme/Generalitat de Catalunya and supported by the Severo Ochoa programme (MINECO Grant No. SEV-2017-0706)

Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians

Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct population

Genome-wide risk prediction of common diseases across ancestries in one million people

Peer reviewe

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen study with 8401 breast cancer cases, the PRS modifies the breast cancer risk of two high-impact frameshift risk variants. Similarly, we show that after the breast cancer diagnosis, individuals with elevated PRS have an elevated risk of developing contralateral breast cancer, and that the PRS can considerably improve risk assessment among their female first-degree relatives. In more detail, women with the c.1592delT variant in PALB2 (242-fold enrichment in Finland, 336 carriers) and an average PRS (10-90(th) percentile) have a lifetime risk of breast cancer at 55% (95% CI 49-61%), which increases to 84% (71-97%) with a high PRS (>90(th) percentile), and decreases to 49% (30-68%) with a low PRS (<10(th) percentile). Similarly, for c.1100delC in CHEK2 (3.7-fold enrichment; 1648 carriers), the respective lifetime risks are 29% (27-32%), 59% (52-66%), and 9% (5-14%). The PRS also refines the risk assessment of women with first-degree relatives diagnosed with breast cancer, particularly among women with positive family history of early-onset breast cancer. Here we demonstrate the opportunities for a comprehensive way of assessing genetic risk in the general population, in breast cancer patients, and in unaffected family members. Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease