Time perspective, depression, and substance misuse among the homeless

Using the Zimbardo Time Perspective Inventory (ZTPI; P. G. Zimbardo & J. N. Boyd, 1999), the authors found that homeless people, in comparison with a control group, had a significantly more negative outlook concerning their past and present as evinced by high Past-Negative and Present-Fatalistic scores and low Past-Positive scores on the ZTPI. However, the homeless individuals were almost indistinguishable from control participants on measures of Present-Hedonism and Future thinking. The homeless individuals had significantly higher levels of depression, with 31 out of 50 (62%) reaching criteria for probable depression. However, this finding was unrelated to their atypical time perspective. There was no significant relation between substance misuse and time perspective. Despite their current difficulties, including depression and drug abuse, the homeless individuals maintained a propensity toward future thinking characterized by striving to achieve their goals.

Active-site protonation states in an Acyl-Enzyme intermediate of a Class A β-Lactamase with a Monobactam Substrate

The monobactam antibiotic aztreonam is used to treat cystic fibrosis patients with chronic pulmonary infections colonized by Pseudomonas aeruginosa strains expressing CTX-M extended-spectrum β-lactamases. The protonation states of active-site residues that are responsible for hydrolysis have been determined previously for the apo form of a CTX-M β-lactamase but not for a monobactam acyl-enzyme intermediate. Here we used neutron and high-resolution X-ray crystallography to probe the mechanism by which CTX-M extended-spectrum β-lactamases hydrolyze monobactam antibiotics. In these first reported structures of a class A β-lactamase in an acyl-enzyme complex with aztreonam, we directly observed most of the hydrogen atoms (as deuterium) within the active site. Although Lys 234 is fully protonated in the acyl intermediate, we found that Lys 73 is neutral. These findings are consistent with Lys 73 being able to serve as a general base during the acylation part of the catalytic mechanism, as previously proposed

Geodiversity Supports Cultural Ecosystem Services: an Assessment Using Social Media

Geodiversity is under threat from both anthropogenic activities and environmental change which therefore requires active management in the form of geoconservation to minimise future damage. As research on the role of geodiversity on ecosystem service (ES) provision has been limited, there is a need to improve our understanding of which aspects are most important to providing ES to better inform approaches to its conservation. Here, we focus on the cultural ES of hiking in Wales, UK. Harnessing big data from the social media website Flickr, we used the locations of geotagged images of hiking and a range of spatial layers representing geodiversity, biodiversity and anthropogenic predictor variables in habitat suitability models. To gain a deeper understanding of the role of geodiversity in driving the distribution of this cultural service, we estimated the strength and nature of the relationship of each geodiversity, biodiversity and anthropogenic indicator with hiking. Our models show that three geodiversity (distance from coast, range in slope and range in elevation) and two anthropogenic (distance from greenspace access point and distance from road) variables were the most important drivers of hiking. Furthermore, we assessed the content of the images to understand which features of geodiversity people interact with while hiking. We found that people generally take images of geomorphological and hydrological features, such as mountains and lakes. Through understanding the geodiversity, biodiversity and anthropogenic drivers of hiking in Wales, as well as identifying the geodiversity features people interact with while hiking, this analysis can help to inform future geoconservation methods by focusing efforts on these important features

Quantum-classical transition of the escape rate of uniaxial antiferromagnetic particles in an arbitrarily directed field

Quantum-classical escape rate transition has been studied for uniaxial antiferromagnetic particles with an arbitrarily directed magnetic field. In the case that the transverse and longitudinal fileds coexist, we calculate the phase boundary line between first- and second-order transitions, from which phase diagrams can be obtained. It is shown that the effects of the applied longitudinal magnetic field on quantum-classical transition vary greatly for different relative magnitudes of the non-compensation.Comment: to be appeared in Phys. Rev.

Quantum dynamics of crystals of molecular nanomagnets inside a resonant cavity

It is shown that crystals of molecular nanomagnets exhibit enhanced magnetic relaxation when placed inside a resonant cavity. Strong dependence of the magnetization curve on the geometry of the cavity has been observed, providing evidence of the coherent microwave radiation by the crystals. A similar dependence has been found for a crystal placed between Fabry-Perot superconducting mirrors. These observations open the possibility of building a nanomagnetic microwave laser pumped by the magnetic field

Free flux flow resistivity in strongly overdoped high-T_c cuprate; purely viscous motion of the vortices in semiclassical d-wave superconductor

We report the free flux flow (FFF) resistivity associated with a purely viscous motion of the vortices in moderately clean d-wave superconductor Bi:2201 in the strongly overdoped regime (T_c=16K) for a wide range of the magnetic field in the vortex state. The FFF resistivity is obtained by measuring the microwave surface impedance at different microwave frequencies. It is found that the FFF resistivity is remarkably different from that of conventional s-wave superconductors. At low fields (H<0.2H_c2) the FFF resistivity increases linearly with H with a coefficient which is far larger than that found in conventional s-wave superconductors. At higher fields, the FFF resistivity increases in proportion to \sqrt H up to H_c2. Based on these results, the energy dissipation mechanism associated with the viscous vortex motion in "semiclassical" d-wave superconductors with gap nodes is discussed. Two possible scenarios are put forth for these field dependence; the enhancement of the quasiparticle relaxation rate and the reduction of the number of the quasiparticles participating the energy dissipation in d-wave vortex state.Comment: 9 pages 7 figures, to appear in Phys. Rev.

Quantum transport through STM-lifted single PTCDA molecules

Using a scanning tunneling microscope we have measured the quantum conductance through a PTCDA molecule for different configurations of the tip-molecule-surface junction. A peculiar conductance resonance arises at the Fermi level for certain tip to surface distances. We have relaxed the molecular junction coordinates and calculated transport by means of the Landauer/Keldysh approach. The zero bias transmission calculated for fixed tip positions in lateral dimensions but different tip substrate distances show a clear shift and sharpening of the molecular chemisorption level on increasing the STM-surface distance, in agreement with experiment.Comment: accepted for publication in Applied Physics

Electric current circuits in astrophysics

Cosmic magnetic structures have in common that they are anchored in a dynamo, that an external driver converts kinetic energy into internal magnetic energy, that this magnetic energy is transported as Poynting fl ux across the magnetically dominated structure, and that the magnetic energy is released in the form of particle acceleration, heating, bulk motion, MHD waves, and radiation. The investigation of the electric current system is particularly illuminating as to the course of events and the physics involved. We demonstrate this for the radio pulsar wind, the solar flare, and terrestrial magnetic storms

Recent Advances in Understanding Particle Acceleration Processes in Solar Flares

We review basic theoretical concepts in particle acceleration, with particular emphasis on processes likely to occur in regions of magnetic reconnection. Several new developments are discussed, including detailed studies of reconnection in three-dimensional magnetic field configurations (e.g., current sheets, collapsing traps, separatrix regions) and stochastic acceleration in a turbulent environment. Fluid, test-particle, and particle-in-cell approaches are used and results compared. While these studies show considerable promise in accounting for the various observational manifestations of solar flares, they are limited by a number of factors, mostly relating to available computational power. Not the least of these issues is the need to explicitly incorporate the electrodynamic feedback of the accelerated particles themselves on the environment in which they are accelerated. A brief prognosis for future advancement is offered.Comment: This is a chapter in a monograph on the physics of solar flares, inspired by RHESSI observations. The individual articles are to appear in Space Science Reviews (2011

Functional Anatomy of the Female Pelvic Floor

The anatomic structures in the female that prevent incontinence and genital organ prolapse on increases in abdominal pressure during daily activities include sphincteric and supportive systems. In the urethra, the action of the vesical neck and urethral sphincteric mechanisms maintains urethral closure pressure above bladder pressure. Decreases in the number of striated muscle fibers of the sphincter occur with age and parity. A supportive hammock under the urethra and vesical neck provides a firm backstop against which the urethra is compressed during increases in abdominal pressure to maintain urethral closure pressures above the rapidly increasing bladder pressure. This supporting layer consists of the anterior vaginal wall and the connective tissue that attaches it to the pelvic bones through the pubovaginal portion of the levator ani muscle, and the uterosacral and cardinal ligaments comprising the tendinous arch of the pelvic fascia. At rest the levator ani maintains closure of the urogenital hiatus. They are additionally recruited to maintain hiatal closure in the face of inertial loads related to visceral accelerations as well as abdominal pressurization in daily activities involving recruitment of the abdominal wall musculature and diaphragm. Vaginal birth is associated with an increased risk of levator ani defects, as well as genital organ prolapse and urinary incontinence. Computer models indicate that vaginal birth places the levator ani under tissue stretch ratios of up to 3.3 and the pudendal nerve under strains of up to 33%, respectively. Research is needed to better identify the pathomechanics of these conditions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72597/1/annals.1389.034.pd