The Meaning of Zenocrate in Tamburlaine, Parts I and II

Christopher Marlowe\u27s Tamburlaine the Great, Parts I and II are built around a single towering superman, Tamburlaine, just as three of his other plays are built around strong protagonists: Barabas, Guise, and Faustus. Most critics have acknowledged that the protagonist, Tamburlaine, is the only unifying factor, or the be-all and end-all of the action. From the beginning to the end, both plays unfold while centering exclusively on the protagonist, and the protagonist powerfully dominates both plays. The other characters of the play are often referred to merely as Tamburlaine\u27s “puppets and serve as his foils. Furthermore, the subsidiary figures, whether miserable or not, are enormously influenced and wholly swayed by Tamburlaine\u27s movements. In turn, Tamburlaine is generous and fair to his loyal friends, while savagely bloody and cruel to his disobedient enemies. Throughout both plays, with the exception of the Soldan and Zenocrate, the other characters never change their attitudes toward Tamburlaine, and Tamburlaine also never changes his attitude toward them. Therefore, Irving Ribner has criticized that all the characters of the Tamburlaine plays are fixed and changeless, and there is no development, and when the play ends, they are no more or no less than they had been at the beginning. C. B. Kuriyama has similarly remarked that Tamburlaine may be fairly described as a play of extremes that tends to represent experience as a continuous oscillation between opposites, \u27 and that no character in these plays possesses strengths and weaknesses in roughly equal proportions. In view of these remarks, there is no middle ground \u27 in Tamburlaine\u27s world. But it is my opinion that there is one exceptional character in Tamburlaine\u27s world--the fair and divine Zenocrate. On the whole, then, Zenocrate seems to be timid and elusive, but her presence in both plays is crucial to understanding Tamburlaine and his world. Apparently, because of Zenocrate\u27s absence, Part· II seems to lose its balance as the play goes on, while Part I remains balanced because of her presence. My aim in this thesis is to study the meaning of Zenocrate in both Tambu rlaine plays. The main focus of this work will be on the relationship of Tamburlaine and Zenocrate: Zenocrate\u27s meaning as conceived by Tamburlaine, her influence (particularly her moderating influence) over Tamburlaine and his reaction to her influence, the meaning of Zenocrate\u27s death and its impact on Tamburlaine, and the outcome of the reciprocal conflicts of both figures

Multi-jet electrospinning of polystyrene/polyamide 6 blend: thermal and mechanical properties

Citation: Yoon, J. W., Park, Y., Kim, J., & Park, C. H. (2017). Multi-jet electrospinning of polystyrene/polyamide 6 blend: thermal and mechanical properties. Fashion and Textiles, 4, 12. doi:10.1186/s40691-017-0090-4Polystyrene (PS) has high thermal resistance thus can be applied as thermally comfortable textile. However, the application is limited due its low mechanical strength. In this study, polyamide 6 (PA6) was blended with PS to improve the mechanical strength of PS, by means of a multi-jet electrospinning. Content ratio of the blend web was measured by chemical immersion test and confocal microscopy analysis. Fiber content was in accordance with the number of syringes used for PS and PA6 respectively. The effects of content ratio on the web morphology, thermal resistance, tensile behavior, air and water vapor permeability, and surface hydrophilicity were investigated. The influence of environmental humidity during electrospinning process on three dimensional (3D) web structure was also reported. PS web produced from higher humidity had more pores and corrugations at the surface. The increased surface roughness and porosity led to the increased hydrophobicity and thermal resistance. Though the blending of PA6 with PS enhanced the mechanical strength, the added PA6 decreased air/water vapor permeability and thermal resistance. The lowered thermal resistance by the addition of PA6 was mainly attributed to higher thermal conductivity of PA6 material and lowered air content with PA6 fibers

THE EFFECT OF SHOULDER MOBILITY ON AGONIST AND SYNERGIST DURING SHOULDER PRESS

The purpose of this study was to investigate the effect of shoulder mobility score on agonist and synergist muscle activation during shoulder press and to provide an underpinning fundamental to optimize the training effect while reducing the risk of injuries when instructing training in the field. The participants were divided to two different groups according to individual shoulder mobility score which is part of the Functional Movement Screen (FMS). There were five participants in the score of 3 group (upper group) and six included in the group with the score of less than 3 (lower group). The results of this study revealed that the shoulder mobility score showed a negative correlation with the ratio of the left and right latissimus dorsi/anterior deltoid muscle activation in the concentric contraction phase (

Topological Structure of Dense Hadronic Matter

We present a summary of work done on dense hadronic matter, based on the Skyrme model, which provides a unified approach to high density, valid in the large $N_c$ limit. In our picture, dense hadronic matter is described by the {\em classical} soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons.Comment: 13 pages, 8 figures, Talk given at the KIAS-APCTP Symposium in Astro-Hadron Physics "Compact Stars: Quest for New States of Dense Matter", November 10-14, 2003, Seoul, Korea, published by World Scientific. Based on talk by B.-Y. Par

Skyrmions at finite density and temperature: The Chiral phase transition

The Skyrme model, an effective low energy theory rooted in large Nc QCD, has been applied to the study of dense matter. Matter is described by various crystal structures of skyrmions. When this system is heated, the dominating thermal degrees of freedom are the fluctuating pions. Taking these mechanisms jointly produces a description of the chiral phase transition leading to the conventional phase diagram with critical temperatures and densities in agreement with expected values

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment. Several drugs have targeted HSPs, since cancer cells are known to hijack these helper proteins to shield themselves from destruction by the body. However, the drugs have had limited success. Hye-Kyung Park and Byoung Heon Kang at Ulsan National Institutes of Science and Technology in South Korea and coworkers noticed that the drugs were not absorbed into mitochondria, a key cellular compartment, and HSPs in this compartment were therefore not being blocked. They identified a new HSP inhibitor that can reach every cellular compartment and inhibit all HSPs. Testing in mice showed that this inhibitor effectively triggered death of tumor cells, and therefore shows promise for anti-cancer therapy. The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reasonable strategy for cancer therapy. However, since the existing pan-Hsp90 inhibitor does not accumulate in mitochondria, the potential anticancer activity of pan-Hsp90 inhibition has not yet been fully examined in vivo. Analysis of The Cancer Genome Atlas database revealed that all Hsp90 paralogs were upregulated in prostate cancer. Inactivation of all Hsp90 paralogs induced mitochondrial dysfunction, increased cytosolic calcium, and activated calcineurin. Active calcineurin blocked prosurvival heat shock responses upon Hsp90 inhibition by preventing nuclear translocation of HSF1. The purine scaffold derivative DN401 inhibited all Hsp90 paralogs simultaneously and showed stronger anticancer activity than other Hsp90 inhibitors. Pan-Hsp90 inhibition increased cytotoxicity and suppressed mechanisms that protect cancer cells, suggesting that it is a feasible strategy for the development of potent anticancer drugs. The mitochondria-permeable drug DN401 is a newly identified in vivo pan-Hsp90 inhibitor with potent anticancer activity

The pion velocity in dense skyrmion matter

We have developed a field theory formalism to calculate in-medium properties of hadrons within a unified approach that exploits a single Lagrangian to describe simultaneously both matter background and meson fluctuations. In this paper we discuss the consequences on physical observables of a possible phase transition of hadronic matter taking place in the chiral limit. We pay special attention to the pion velocity vπ, which controls, through a dispersion relation, the pion propagation in the hadronic medium. The vπ is defined in terms of parameters related to the matrix element in matter of the axial-vector current, namely, the in-medium pion decay constants, ft and fs. Both of the pion decay constants change dramatically with density and even vanish in the chiral limit when chiral symmetry is restored, but the pion velocity does not go to zero, decreasing at most 10% over the whole density range studied. A possible pseudogap structure is indicated

A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC

Rationale: Unlike traditional biopsy, liquid biopsy, which is a largely non-invasive diagnostic and monitoring tool, can be performed more frequently to better track tumors and mutations over time and to validate the efficiency of a cancer treatment. Circulating tumor cells (CTCs) are considered promising liquid biopsy biomarkers; however, their use in clinical settings is limited by high costs and a low throughput of standard platforms for CTC enumeration and analysis. In this study, we used a label-free, high-throughput method for CTC isolation directly from whole blood of patients using a standalone, clinical setting-friendly platform. Methods: A CTC-based liquid biopsy approach was used to examine the efficacy of therapy and emergent drug resistance via longitudinal monitoring of CTC counts, DNA mutations, and single-cell-level gene expression in a prospective cohort of 40 patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer. Results: The change ratio of the CTC counts was associated with tumor response, detected by CT scan, while the baseline CTC counts did not show association with progression-free survival or overall survival. We achieved a 100% concordance rate for the detection of EGFR mutation, including emergence of T790M, between tumor tissue and CTCs. More importantly, our data revealed the importance of the analysis of the epithelial/mesenchymal signature of individual pretreatment CTCs to predict drug responsiveness in patients. Conclusion: The fluid-assisted separation technology disc platform enables serial monitoring of CTC counts, DNA mutations, as well as unbiased molecular characterization of individual CTCs associated with tumor progression during targeted therapy