Применение интерферометрического метода исследования в изучении кинетики реакций бромидов бария и рубидия с хлористым водородом

The two-layer shallow water system looses hyperbolicity if the mag- nitude of the shear velocity is above a certain threshold, which is es- sentially determined by the density difference between the two layers. The focus of the paper is to explore a technique to possibly recover hyperbolicity by adapting the model in regions of strong shear. The approach is to introduce an additional, third layer in such regions. We demonstrate that this adaptive two/three-layer approach can cure some of the shortcomings of the two-layer model but needs further improvement with respect to the model

In-cell discontinuous reconstruction path-conservative methods for non conservative hyperbolic systems - Second-order extension

We are interested in the numerical approximation of discontinuous solutions in non conservative hyperbolic systems. An extension to second-order of a new strategy based on in-cell discontinuous reconstructions to deal with this challenging topic is presented. This extension is based on the combination of the first-order in-cell reconstruction with the standard MUSCL-Hancock reconstruction. The first-order strategy allowed in particular to capture exactly the isolated shocks and this new second-order extension keep this property. Moreover, the well-balanced property of the method is also studied. Several numerical tests are proposed to validate the methods for the Coupled-Burgers system, Gas dynamics equations in Lagrangian coordinates and the modified shallow water system.The research of CP, MC and EPG was partially supported by the Spanish Government (SG), the European Regional Development Fund (ERDF), the Regional Government of Andalusia (RGA), and the University of Málaga (UMA) through the projects of reference RTI2018-096064-B-C21 (SG-ERDF), UMA18-Federja-161 (RGA-ERDF-UMA), and P18-RT-3163 (RGA-ERDF). EPG was also financed by the Junior Scientific Visibility Program from the Foundation Mathématiques Jacques Hadamard for a stay of three month in the Laboratoire de Mathématiques de Versailles (LMV) with reference ANR-11-LABX-0056-LMH, LabEx LMH. TML was supported by the Spanish Government (SG) through the projects of reference RTI2018-096064-B-C22. The authors thank the anonymous reviewer whose comments helped to improve the paper. Funding for open access charge: Universidad de Málaga / CBU

Telemedicina i VIH

L'atenció de malalties cròniques complexes (diabetis, MPOC, VIH/Sida...) necessita cada vegada més recursos sanitaris. En el cas del VIH/Sida, els problemes a què s'enfronta una persona infectada han canviat força darrerament. Abans els principals esforços se centraven a augmentar el temps de vida dels pacients i ara es vol millorar la seva qualitat de vida, que és afectada per múltiples factors (mèdics, psicològics i socials). L'Hospital VIHrtual és un sistema de telemedicina que millora el seguiment i l'atenció a domicili de pacients VIH/Sida. Els principals serveis que el sistema ofereix tant als pacients com al personal sanitari per Internet són les consultes (per videoconferència, per xat i per missatges), la visualització de les dades del pacient, la gestió de cites, la telefarmàcia, les comunitats virtuals i la biblioteca. La principal innovació del sistema és que inclou tot el procés d'atenció del pacient de forma global per Internet (consultes, seguiment mèdic, psicològic i social, medicació, qualitat de vida, coordinació de l'equip d'atenció, etc.) sense pretendre grans innovacions tecnològiques sinó de serveis, ja que s'empren tecnologies provades i de baix cost. Durant dos anys es duu a terme una experiència pilot a l'Hospital Clínic de Barcelona amb un total de cent pacients (cinquanta en el grup experimental i cinquanta en el grup control, intercanviant-se al cap de l'any) i vint professionals sanitaris (metges, infermers, psicòlegs, psiquiatres, treballadors socials, farmacèutics, etc.). Amb aquest experiment es vol observar en quins casos el sistema de telemedicina és viable i millora l'atenció del pacient i en quins casos no, ja sigui per l'estat de salut del pacient, per la seva situació o pels seus coneixements, o ja sigui per limitacions en la coordinació dels professionals sanitaris

Catch-up growth in juvenile rats, fat expansion, and dysregulation of visceral adipose tissue

BACKGROUND: Accelerated catch-up growth following intrauterine restriction increases the risk of developing visceral adiposity and metabolic abnormalities. However, the underlying molecular mechanisms of such metabolic programming are still poorly understood. METHODS: A Wistar rat model of catch-up growth following intrauterine restriction was used. A gene expression array was performed in the retroperitoneal adipose tissue sampled at postnatal day (PD) 42. RESULTS: Five hundred and forty-six differentially expressed genes (DEGs) were identified (adjusted p value < 0.05). Gene ontology enrichment analysis identified pathways related to immune and lipid metabolic processes, brown fat cell differentiation, and regulation of PI3K. Ccl21, Npr3, Serpina3n, Pnpla3, Slc2a4, and Serpina12 were validated to be upregulated in catch-up pups (all p < 0.01) and related to several fat expansion and metabolic parameters, including body weight at PD42, postnatal body weight gain, white and brown adipose tissue mass, plasma triglycerides, and insulin resistance index (all p < 0.05). CONCLUSIONS: Genes related to immune and metabolic processes were upregulated in retroperitoneal adipose tissue following catch-up growth in juvenile rats and were found to be associated with fat expansion and metabolic parameters. Our results provide evidence for several dysregulated genes in white adipose tissue that could help develop novel strategies to prevent the metabolic abnormalities associated with catch-up growth

Caracterização de paisagens e solos representativos do Estado do Rio de Janeiro para fins de estimativa de estoques de carbono no solo.

Oito áreas representativas do Estado do Rio de Janeiro foram selecionadas para caracterização e amostragem por classe de solo e uso atual, para fins de estudo de estimativa da magnitude do estoque de carbono orgânico sequestrado pelos solos, bem como a sua distribuição vertical nos perfis de solos e a distribuição espacial na paisagem. Dezesseis (16) perfis de solo foram caracterizados, amostrados e analisados quanto à composição química e condições físicas, compreendendo análises completas, granulométrica, densidade do solo e de partículas, e distribuição vertical do carbono orgânico nos perfis, às profundidades de 0-10, 10-20, 20-40, 40-60, 60-80 e 80-100 cm.bitstream/CNPS-2010/14904/1/bpd66-2005-caract-paisagens.pd

The correlation of RNase A enzymatic activity with the changes in the distance between Nepsilon2-His12 and N delta1-His119 upon addition of stabilizing and destabilizing salts.

The effect of stabilizing and destabilizing salts on the catalytic behavior of ribonuclease A (RNase A) was investigated at pH 7.5 and 25 degrees C, using spectrophotometric, viscometric and molecular dynamic methods. The changes in the distance between N(epsilon2) of His(12) and N(delta1) of His(119) at the catalytic center of RNase A upon the addition of sodium sulfate, sodium hydrogen sulfate and sodium thiocyanate were evaluated by molecular dynamic methods. The compactness and expansion in terms of Stokes radius of RNase A upon the addition of sulfate ions as kosmotropic salts, and thiocyanate ion as a chaotropic salt, were estimated by viscometric measurements. Enzyme activity was measured using cytidine 2', 3'-cyclic monophosphate as a substrate. The results from the measurements of distances between N(epsilon2) of His(12) and N(delta1) of His(119) and Stokes radius suggest (i) that the presence of sulfate ions decreases the distance between the catalytic His residues and increases the globular compactness, and (ii) that there is an expansion of the enzyme surface as well as elongation of the catalytic center in the presence of thiocyanate ion. These findings are in agreement with activity measurements

High‐resolution rock magnetic cyclostratigraphy in an Eocene flysch, Spanish Pyrenees

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95346/1/ggge1746.pd