A solution to a slightly subcritical elliptic problem with non-power nonlinearity

We consider a slightly subcritical Dirichlet problem with a non-power nonlinearity in a bounded smooth domain. For this problem, standard compact embeddings cannot be used to guarantee the existence of solutions as in the case of power-type nonlinearities. Instead, we use a Ljapunov-Schmidt reduction method to show that there is a positive solution which concentrates at a non-degenerate critical point of the Robin function. This is the first existence result for this type of generalized slightly subcritical problems.Comment: 25 page

Red de caminos integrador de la cultura Kogui desplazada por la violencia

"El proyecto consiste en lograr un mayor reconocimiento a la población indígena de esta zona, en este caso la comunidad KOGUI, la cual por situaciones de conflicto armado ha sido aislada y desplazada a las partes altas de La Sierra. Una de las opciones del gobierno para atender a estas poblaciones es entregarles un espacio. Este espacio es llamado ""Casa Indígena"". Sin embargo, las condiciones habitacionales de estos espacios se caracterizan por el deterioro. Son espacios en los que estas comunidades no se sienten bien ya que sus características espaciales son totalmente diferentes a sus hábitos, y están hechos con materiales inadecuados al entorno, al clima y al ambiente. Por todo esto, es pertinente hacer una propuesta arquitectónica de una Casa Indígena adaptada a las costumbres de la población KOGUI, que permita un reconocimiento de estas comunidades en las principales ciudades de DIBULLA.""The project pretends to support the indigenous population of the north of Colombia, the KOGUIS, a community isolated and displaced to the higher parts of the La Sierra Nevada de Santa Marta partly because of the armed conflict that has taken place in the country for about 50 years. The government has given these populations a space, which it called ""Indian House"". "Arquitecto (a)Pregrad

Review of Applications of Microneedling in Dermatology.

Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. MN has become increasingly utilized over the last several years as it is a relatively simple procedure that is cost-effective, well tolerated, and offers both cosmetic and therapeutic benefits. The ability to treat localized areas of disease has led to numerous studies gauging its potential in focal diseases of inflammation, dyschromia, and photodamage. This review discusses the principles and evidence behind the expanding applications of MN. It has shown promising results as an adjuvant therapy for enhanced drug delivery in the treatment of atrophic scars, alopecia, actinic keratoses, and disorders of pigmentation such as melasma. The efficacy in treatment of vitiligo remains limited. Overall, the procedure has few adverse sequelae compared to other therapies, is highly efficacious, and is a viable resurfacing option for skin of color. Future research is needed to determine the frequency, interval, and specific device settings that foster optimal results. Additionally, large controlled trials are needed to shed light on the utility of MN as an evidence-based regimen for the treatment of various dermatologic conditions

Perceptual maps to aggregate information from decision makers

Understanding different perceptions of human being when using linguistic terms is a crucial issue in human-machine interaction. In this paper, we propose the concept of perceptual maps to model human opinions in a group decision-making context. The proposed approach considers a multi-granular structure using unbalanced hesitant linguistic term sets. An illustrative case is presented in the location decisions made by multinationals enterprises of the energy sector within the European smart city context.This research was supported partly by the INVITE research project (TIN2016- 80049-C2-1-R and TIN2016-80049-C2-2-R), funded by the Spanish Ministry of Science and Information Technology and the European Union Horizon 2020 Research and Innovation Programme, under the grant agreement No 731297.Postprint (published version

Profile of dupilumab and its potential in the treatment of inadequately controlled moderate-to-severe atopic dermatitis.

Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma. Historically, moderate-to-severe disease has been managed with systemic immunosuppression, such as oral corticosteroids, which result in relapse and limiting side effects. Due to recent advancements in the identification of interleukin (IL)-4 and IL-13 as key mediators in AD, new biological agents have been developed for treatment. Dupilumab is a recently approved monoclonal antibody that targets the alpha subunit of the IL-4 receptor and, thus, downregulates activity of IL-4 and IL-13. This review discusses the profile of dupilumab and its potential for efficacy and safety in treating moderate-to-severe AD by reviewing data from Phase I-III clinical trials. Results suggest that dupilumab shows great therapeutic promise for AD. Further studies investigating extended use of dupilumab and dupilumab in comparison to other agents are needed to establish long-term efficacy and safety

Combinatorial Patterns of D-Optimal Weighing Designs Using a Spring Balance

Given a spring balance that reports the true total weight of items plus a white noise of an unknown variance, which n subsets of n items will you weigh in order to estimate the true weights of each item with the highest possible precision? For n ≤ 6, we classify all D-optimal weighing designs according to the combinatorial patterns they exhibit (modulo permutation), we count the D-optimal designs exhibiting each pattern, and we explain how a D-optimal design for n items may arise out of a D-optimal design for (n − 1) items. For n = 7, 11 we exhibit D-optimal designs obtained from balanced incomplete block designs (BIBDs). We discuss some strategies to construct D-optimal designs of larger sizes, and pose some unsolved problems

Which stem in total hip arthroplasty for developmental hip dysplasia? A comparative study using a 3D CT-based software for pre-operative surgical planning

Background Stem choice in total hip arthroplasty (THA) for hip dysplasia is still controversial. The aims of the study were to evaluate (1) which stem design provided the highest percentage of adequate reconstructions in THA for dysplasia and (2) any correlation between the reconstructions provided by the stems and the native femoral morphology. Materials and methods 150 CT scans including 200 adult dysplastic hips were randomly selected. Using the 3D CT-based software Hip-Op for surgical planning, the native hip anatomy was studied. Then, a single wedge tapered stem, an anatomical stem and a conical tapered stem were simulated in every hip. An adequate reconstruction of hip biomechanics was obtained when combined anteversion, offset restoration, coronal and sagittal tilt, canal filling and leg lengthening were inside the normal ranges. Results Conical stems achieved the highest percentage of adequate reconstructions (87%, p < 0.0001). The anatomical stem was the worst performer. Single wedge and anatomical stem acceptability was mainly influenced by the combined anteversion. Stem anteversion was correlated with the femoral anteversion (fair correlation), the calcar femorale (fair) and the mediolateral femoral diameter at isthmus (poor). When the femoral anteversion was >= 25 degrees, combined anteversion was very acceptable for the conical stem (99.2%), whereas the rate of acceptable combined anteversion for the single wedge tapered stem was 71.4%, and that for the anatomical stem was 51.6% (p < 0.0001). Conclusions Stem choice in developmental hip dysplasia is mainly driven by appropriate combined anteversion, which is dependent on the coronal and axial femoral morphologies. As a rule of thumb, tapered stems are adequate when femoral anteversion is < 25 degrees; conical stems should be adopted for higher anteversions

Understanding location decisions of energy multinational enterprises within the European smart cities’ context: An integrated AHP and extended fuzzy linguistic TOPSIS method

Becoming a smart city is one of the top priorities in the urban agenda of many European cities. Among the various strategies in the transition path, local governments seek to bring innovation to their cities by encouraging multinational enterprises to deploy their green energy services and products in their municipalities. Knowing how to attract these enterprises implies that political leaders understand the multi-criteria decision problem that the energy sector enterprises face when deciding whether to expand to one city or another. To this end, the purpose of this study is to design a new manageable and controllable framework oriented to European cities’ public managers, based on the assessment of criteria and sub-criteria governing the strategic location decision made by these enterprises. A decision support framework is developed based on the AHP technique combined with an extended version of the hesitant fuzzy linguistic TOPSIS method. The main results indicate the higher relative importance of government policies, such as degree of transparency or bureaucracy level, as compared to market conditions or economic aspects of the city’s host country. These results can be great assets to current European leaders, they show the feasibility of the method and open up the possibility to replicate the proposed framework to other sectors or geographical areas.The authors acknowledge the support from the European Union “Horizon 2020 Research and Innovation Programme” under the grant agreements No 731297. Also, this research has been partially supported by the INVITE Research Project (TIN2016-80049-C2-1-R and TIN2016-80049-C2-2-R (AEI/FEDER, UE)), funded by the Spanish Ministry of Science and Information Technology.Peer ReviewedPostprint (published version

Absence of anisakis nematodes in smoked farmed Atlantic salmon (Salmo salar) products on sale in European countries

The increase of global demand of aquaculture products as compensation for the lowering of fishery sustainability has shown a parallel awareness by the consumers on the importance of the safety and quality of fish products. Among these, salmon industry has reached a leading position demonstrating the negligible risk of presence of zoonotic helminths such as anisakis nematodes in farmed salmon. Despite the massive production of data in literature on parasitological surveys carried out on fresh salmon, no data are published on processed farmed salmon such as smoked products. In 2016, 270 slices of smoked farmed Atlantic salmon (Salmo salar) and 13 smoked slices from wild sockeye salmon (Oncorhynchus nerka) have been analyzed by visual inspection and UV-press method searching for the presence of anisakid nematodes. No parasites were detected in samples from farmed Atlantic salmon, while 10 out of 13 from wild salmon were positive for Anisakis simplex s.s. larvae. This first survey on the possible presence of anisakid nematodes in processed smoked salmon confirms that this risk in farmed Atlantic salmon products has to be considered negligible

Arbuscular mycorrhizae and Rhizobium: A dual symbiosis of interest

Los microorganismos benéfi cos juegan un rol fundamental en los agroecosistemas naturalmente sustentables. Algunos de ellos pueden ser utilizados como inoculantes para bene- fi ciar a las plantas, ya que desarrollan actividades que involucran una promoción de su crecimiento y su protección. Las asociaciones de Rhizobium-micorrizas arbusculares (MA) actúan sinérgicamente en los niveles de infección, nutrición mineral y crecimiento de las plantas.Fil: Spagnoletti, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; ArgentinaFil: Fernández Di Pardo, Agustina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tobar Gomez, Natalia Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; ArgentinaFil: Chiocchio, Viviana Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; Argentin