Many-to-Many Digital Wireless Music Distribution System

The goal of this project was the development of a many-to-many digital wireless music distribution system. While other wireless audio technologies exist, none offer the unique combination of many-to-many scalability, lossless digital transmission, source control, and universal connectivity to home audio equipment. As our primary deliverable, we developed a two-by-two proof of concept of this system on x86-based single board computers with 802.11a/g capability. We developed software enabling source units to distribute audio data to receiver units over an ad hoc network using multicast. We also designed hardware for wireless RF transmission of infrared remote control commands back to the audio source. Testing was performed to verify the range and scalability of the wireless link

Human Papillomavirus Type 16 E1(∧)E4-Induced G(2) Arrest Is Associated with Cytoplasmic Retention of Active Cdk1/Cyclin B1 Complexes

Human papillomavirus type 16 (HPV16) can cause cervical cancer. Expression of the viral E1(∧)E4 protein is lost during malignant progression, but in premalignant lesions, E1(∧)E4 is abundant in cells supporting viral DNA amplification. Expression of 16E1(∧)E4 in cell culture causes G(2) cell cycle arrest. Here we show that unlike many other G(2) arrest mechanisms, 16E1(∧)E4 does not inhibit the kinase activity of the Cdk1/cyclin B1 complex. Instead, 16E1(∧)E4 uses a novel mechanism in which it sequesters Cdk1/cyclin B1 onto the cytokeratin network. This prevents the accumulation of active Cdk1/cyclin B1 complexes in the nucleus and hence prevents mitosis. A mutant 16E1(∧)E4 (T22A, T23A) which does not bind cyclin B1 or alter its intracellular location fails to induce G(2) arrest. The significance of these results is highlighted by the observation that in lesions induced by HPV16, there is evidence for Cdk1/cyclin B1 activity on the keratins of 16E1(∧)E4-expressing cells. We hypothesize that E1(∧)E4-induced G(2) arrest may play a role in creating an environment optimal for viral DNA replication and that loss of E1(∧)E4 expression may contribute to malignant progression

The DUNE Far Detector Vertical Drift Technology, Technical Design Report

International audienceDUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals