Aseptic meningoencephalitis mimicking transient ischaemic attacks

Purpose: To highlight meningoencephalitis as a transient ischaemic attack (TIA) mimic and suggest clinical clues for differential diagnosis. Methods: This was an observational study of consecutively admitted patients over a 9.75-year period presenting as TIAs at a stroke unit. Results: A total of 790 patients with TIAs and seven with TIA-like symptoms but a final diagnosis of viral meningoencephalitis were recognised. The most frequent presentations of meningoencephalitis patients were acute sensory hemisyndrome (6) and cognitive deficits (5). Signs of meningeal irritation were minor or absent on presentation. Predominantly lymphocytic pleocytosis, hyperproteinorachia and a normal cerebrospinal fluid (CSF)/serum glucose index (in 5 out of 6 documented patients) were present. Meningeal thickening on a brain magnetic resonance imaging (MRI) scan was the only abnormal imaging finding. Six patients received initial vascular treatment; one thrombolysed. Finally, six patients were treated with antivirals and/or antibiotics. Although neither bacterial nor viral agents were identified on extensive testing, viral meningoencephalitis was the best explanation for all clinical and laboratory findings. Conclusions: Aseptic meningoencephalitis should be part of the differential diagnosis in patients presenting as TIA. The threshold for a lumbar puncture in such patients should be set individually and take into account the presence of mild meningeal symptoms, age and other risk factors for vascular disease, the results of brain imaging and the basic diagnostic work-up for a stroke sourc

Transport Properties of Shale Gas in Relation to Kerogen Porosity

Kerogen is a micro-porous amorphous solid, which consist the major component of the organic matter scattered in the potentially lucrative shale formations hosting shale gas. Deeper understanding of the way kerogen porosity characteristics affect the transport properties of hosted gas is important for the optimal design of the extraction process. In this work, we employ molecular simulation techniques in order to investigate the role of porosity on the adsorption and transport behavior of shale gas in overmature type II kerogen found at many currently productive shales. To account for the wide range of porosity characteristics present in the real system, a large set of 60 kerogen structures that exhibit a diverse set of void space attributes was used. Grand Canonical Monte Carlo (GCMC) simulations were performed for the study of the adsorption of CH4, C2H6, n-C4H10 and CO2 at 298.15 K and 398.15 K and a variety of 2 pressures. The amount adsorbed is found to correlate linearly with the porosity of the kerogen. Furthermore, the adsorption of a quaternary mixture of CH4, C2H6, CO2 and N2 was investigated in the same conditions, indicating that the composition resembling that of the shale gas is achieved under higher temperature and pressure values, i.e. conditions closer to these prevailing in the hosting shale field. The diffusion of CH4, C2H6 and CO2, both as pure components and as components of the quaternary mixture, was investigated using equilibrium Molecular Dynamics (MD) simulations at temperatures of 298.15 and 398.15 K and pressures of 1 and 250 atm. In addition to the effect of temperature and pressure, the importance of limiting pore diameter (LPD), maximum pore diameter (MPD), accessible volume (Vacc) and accessible surface (Sacc) on the observed adsorbed amount and diffusion coefficient was revealed by qualitative relationships. The diffusion across the models was found to be anisotropic and the maximum component of the diffusion coefficient to correlate linearly with LPD, indicating that the controlling step of the transport process is the crossing of the limiting pore region. Finally, the transport behavior of the pure compounds was compared with their transport properties when in mixture and it was found that the diffusion coefficient of each compound in the mixture is similar to the corresponding one in pure. This observation agrees with earlier studies in different kerogen models comprising wider pores that have revealed negligible cross-correlation Onsager coefficients

Analytical Stress-Strain Model for FRP-Confined Rectangular RC Columns

One of the major applications of Fiber Reinforced Polymers (FRPs) in construction is in the confinement of reinforced concrete (RC) columns. The performance of FRP-confined concrete in circular columns has been extensively investigated in literature and the efficiency of the available models is nowadays considered to be satisfactory. However, the case of confinement of rectangular RC sections with FRPs is a more complex problem, the mechanism of which has not yet been adequately described. The aim of this work is to simplify the problem by proposing an iterative procedure based on the results of a three-dimensional finite element (3D FEM) analysis. An interesting finding is that the arching effect is not observed: indeed, the unconfined regions are partially confined and contribute a certain amount to the overall strength of the rectangular RC sections. Based on (a) a system of “generalized” springs, (b) well-known stress-strain laws, and (c) a failure criterion, a simplified mechanical model which gives the stress-strain behavior of a rectangular RC section confined by FRPs under concentric load is proposed. The algorithm takes into account all parameters available to designers, such as corner rounding radius, stiffness of the FRP, and concrete strength, while it can be easily understood and implemented. Its results are found to correlate adequately to recent experimental data yielded by large-scale tests on FRP-confined rectangular RC columns. Finally, in order to further evaluate the performance of this material model, it was implemented in the simulation of a series of experimental tests of FRP-retrofitted square RC columns under cyclic lateral loading simulating earthquake loads and simultaneous constant axial compression. In particular, all specimens were simulated using non-linear fiber elements, in which the FRP-confined concrete was modeled using the aforementioned material model. Comparison between the numerical and experimental hysteresis of the column is indicative of the effectiveness of the implemented modeling

Seismic collapse of self-centering steel MRFs with different column base structural properties

The effect of the strength and stiffness characteristics of a previously proposed novel column base on the seismic performance and collapse capacity of steel self-centering moment-resisting frames is evaluated in this paper. This is done through three normalised parameters that represent the initial stiffness, post-yield stiffness, and strength of the column base, which can be independently adjusted. For these evaluations, a prototype steel building, which serves as a case study, is designed with sixteen different cases of a self-centering moment-resisting frame with different column base stiffness and strength characteristics (SC-MRF-CBs). A self-centering moment-resisting frame with conventional column bases and the same members and beam-column connections as those of the SC-MRF-CBs, named SC-MRF, serves as a benchmark frame. A set of 44 ground motions was used to conduct non-linear dynamic analyses and evaluate the seismic performance of the frames. Incremental dynamic analyses were also performed with the same ground motions set to evaluate the collapse capacity of the frames. Collapse capacity fragility curves and adjusted collapse margin ratios of the frames were derived and used for the comparison of the seismic risk of the frames. The results show that the new self-centering column base significantly improves the seismic performance of the SC-MRF, demonstrating the potential of the SC-MRF-CBs to be redesigned with smaller member sections. Moreover, the SC-MRF-CBs achieve significant reduction in collapse risk compared to the SC-MRF. Finally, the results show that increasing the base strength and stiffness improves the seismic performance and collapse capacity of the SC-MRF-CBs. © 2020 Elsevier Lt

Fragility curves for mixed concrete/steel frames subjected to seismic excitation

Use of appropriate fragility curves for structures is an essential and basic tool for earthquake loss estimation. Fragility curves for frames made only of concrete or only of steel members are already available in the literature. In this paper, fragility curves for plane mixed concrete/steel moment resisting framed structures are developed. Parametric numerical results for these mixed structures are presented and discussed

Residual drift risk of self-centering steel MRFs with novel steel column bases in near-fault regions

This paper evaluates the potential of novel steel column bases to reduce the residual drift risk of steel buildings located at near-fault regions when installed to post-tensioned self-centering moment-resisting frames (SC-MRFs). To this end, a prototype steel building is designed that consists of either conventional moment-resisting frames (MRFs) or SC-MRFs or SC-MRFs equipped with the novel steel column base (SC-MRF-CBs). The MRFs and SC-MRFs are used as benchmark frames. The frames are modelled in OpenSees where material and geometrical non-linearities are considered along with stiffness and strength degradation. A set of 91 near-fault ground motions with different pulse periods is used to perform incremental dynamic analysis (IDA), in which each ground motion is scaled appropriately until different residual storey drift limits are exceeded. The probability of exceedance of these limits is then computed as a function of the ground motion intensity and the period of the velocity pulse. Finally, the results of IDA are combined with probabilistic seismic hazard analysis models that account for near-fault directivity to evaluate and compare the residual drift risk of the frames used in this study. Results show that the predicted residual drift performance of the frames is influenced by the pulse period of the near-fault ground motions. The use of the novel steel column base significantly reduces the residual drift risk of the frames and the SC-MRF-CB exhibits the best residual drift performance. Finally, the paper highlights the effectiveness of combining post-tensioned beam-column connections with the novel steel column base, by showing that the SC-MRF-CB improves the residual drift performance of the MRF and SC-MRF by 80% and 50%, respectively

Small-vessel occlusion versus large-artery atherosclerotic strokes in diabetics: Patient characteristics, outcomes, and predictors of stroke mechanism

Peer reviewe

Modeling of bulk kerogen porosity: Methods for control and characterization

Shale gas is an unconventional source of energy, which has attracted a lot of attention during the last years. Kerogen is a prime constituent of shale formations and plays a crucial role in shale gas technology. Significant experimental effort in the study of shales and kerogen has produced a broad diversity of experimentally determined structural and thermodynamic properties even for samples of the same well. Moreover, proposed methods reported in the literature for constructing realistic bulk kerogen configurations have not been thoroughly investigated. One of the most important characteristics of kerogens is their porosity, due to its direct connection with their transport properties and its potential as discriminating and classifying metric between samples. In this study, molecular dynamics (MD) simulations are used to study the porosity of model kerogens. The porosity is controlled effectively with systematic variations of the number and the size of dummy LJ particles that are used during the construction of system’s configuration. The porosity of each sample is characterized with a newly proposed algorithm for analyzing the free space of amorphous materials. It is found that, with moderately sized configurations, it is possible to construct percolated pores of interest in the shale gas industry

Transport Properties of Shale Gas in Relation to Kerogen Porosity

Kerogen is a micro-porous amorphous solid, which consist the major component of the organic matter scattered in the potentially lucrative shale formations hosting shale gas. Deeper understanding of the way kerogen porosity characteristics affect the transport properties of hosted gas is important for the optimal design of the extraction process. In this work, we employ molecular simulation techniques in order to investigate the role of porosity on the adsorption and transport behavior of shale gas in overmature type II kerogen found at many currently productive shales. To account for the wide range of porosity characteristics present in the real system, a large set of 60 kerogen structures that exhibit a diverse set of void space attributes was used. Grand Canonical Monte Carlo (GCMC) simulations were performed for the study of the adsorption of CH4, C2H6, n-C4H10 and CO2 at 298.15 K and 398.15 K and a variety of 2 pressures. The amount adsorbed is found to correlate linearly with the porosity of the kerogen. Furthermore, the adsorption of a quaternary mixture of CH4, C2H6, CO2 and N2 was investigated in the same conditions, indicating that the composition resembling that of the shale gas is achieved under higher temperature and pressure values, i.e. conditions closer to these prevailing in the hosting shale field. The diffusion of CH4, C2H6 and CO2, both as pure components and as components of the quaternary mixture, was investigated using equilibrium Molecular Dynamics (MD) simulations at temperatures of 298.15 and 398.15 K and pressures of 1 and 250 atm. In addition to the effect of temperature and pressure, the importance of limiting pore diameter (LPD), maximum pore diameter (MPD), accessible volume (Vacc) and accessible surface (Sacc) on the observed adsorbed amount and diffusion coefficient was revealed by qualitative relationships. The diffusion across the models was found to be anisotropic and the maximum component of the diffusion coefficient to correlate linearly with LPD, indicating that the controlling step of the transport process is the crossing of the limiting pore region. Finally, the transport behavior of the pure compounds was compared with their transport properties when in mixture and it was found that the diffusion coefficient of each compound in the mixture is similar to the corresponding one in pure. This observation agrees with earlier studies in different kerogen models comprising wider pores that have revealed negligible cross-correlation Onsager coefficients