7 research outputs found
Erratum to: Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species
Upon publication of the original article [1], it was noticed that Dr Papanicolaou’s surname was spelt incorrectly. The correct spelling is “Papanicolaou”, as shown in the author list of this erratum.Additional co-authors: A. Anderson, S. Asgari, P. G. Board, A. Bretschneider, P. M. Campbell, T. Chertemps, J. T. Christeller, C. W. Coppin, S. J. Downes, G. Duan, C. A. Farnsworth, R. T. Good, L. B. Han, Y. C. Han, K. Hatje, I. Horne, Y. P. Huang, D. S. T. Hughes, E. Jacquin-Joly, W. James, S. Jhangiani, M. Kollmar, S. S. Kuwar, S. Li, N-Y. Liu, M. T. Maibeche, J. R. Miller, N. Montagne, T. Perry, J. Qu, S. V. Song, G. G. Sutton, H. Vogel, B. P. Walenz, W. Xu, H-J. Zhang, Z. Zou, P. Batterham, O. R. Edwards, R. Feyereisen, R. A. Gibbs, D. G. Heckel, A. McGrath, C. Robin, S. E. Scherer, K. C. Worley, Y. D. W
Mitochondrial superclusters influence age of onset of Parkinsonâs disease in a gender specific manner in the Cypriot population: A case-control study
Despite evidence supporting an involvement of mitochondrial dysfunction in the pathogenesis of some neurodegenerative disorders, there are inconsistent findings concerning mitochondrial haplogroups and their association to neurodegenerative disorders, including idiopathic Parkinson's disease (PD).To test this hypothesis for the Greek-Cypriot population, a cohort of 230 PD patients and 457 healthy matched controls were recruited. Mitochondrial haplogroup distributions for cases and controls were determined. Association tests were carried out between mitochondrial haplogroups and PD.Mitochondrial haplogroup U was associated with a reduced PD risk in the Cypriot population. After pooling mitochondrial haplogroups together into haplogroup clusters and superclusters, association tests demonstrated a significantly protective effect of mitochondrial haplogroup cluster N (xR) and supercluster LMN for PD risk only in females. In addition, for female PD cases belonging to UKJT and R (xH, xUKJT) haplogroup, the odds of having a later age of onset of PD were 13 and 15 times respectively higher than the odds for female cases with an H haplogroup.Statistically significant associations regarding PD risk and PD age of onset were mostly detected for females thus suggesting that gender is a risk modifier between mitochondrial haplogroups and PD status / PD age of onset. The biological mechanisms behind this gender specificity remain to be determined
Computational Modeling of a Small-Scale, Solar Concentrating Device Based on a Fresnel-Lens Collector and a Flat Plate Receiver with Cylindrical Channels
The energy efficiency of a small-scale solar concentrating thermal device is investigated, based on Monte-Carlo Ray-Tracing (MCRT) and Computational Fluid Dynamics (CFD) modeling. The device consists of a Fresnel lens collectorâengraved on a 1 m rectangular plateâand a 10 cm sized plate receiver, with drilled cylindrical channels with a diameter of 10 mm. Inlet velocities and heat transfer fluid (HTF) temperatures lie within the range of 0.25â1 m/s and 100â200 °C, respectively. The configurations examined involve the utilization of a selective coating on the absorbing surface of the receiver, increasing the channel diameter to 15 mm and the receiver size to 20 cm, and insertion of a glass envelope in front of the absorbing surface. Energy efficiency increases with increasing fluid velocity up to 80%, a level beyond which no further improvement is observed. The coating contributes to a reduction in heat losses; it brings substantial benefits for the lower velocities examined. The increase in channels diameter also contributes to an increase in the energy efficiency, while the increase in receiver dimensions leads to the opposite effect. The glass cover does not improve the performance of the collector, due to substantial optical losses
Odds Ratios (95% Confidence Intervals) showing associations between mitochondrial haplogroup clusters and superclusters and PD.
<p>Odds Ratios (95% Confidence Intervals) showing associations between mitochondrial haplogroup clusters and superclusters and PD.</p
Distribution of mtDNA haplogroups between Cypriot PD patients and controls and Odds Ratios (95% Confidence Intervals) showing their association with PD.
<p>Distribution of mtDNA haplogroups between Cypriot PD patients and controls and Odds Ratios (95% Confidence Intervals) showing their association with PD.</p