Wide-Field Hubble Space Telescope Observations of the Globular Cluster System in NGC1399

We present a comprehensive high spatial-resolution imaging study of globular clusters (GCs) in NGC1399, the central giant elliptical cD galaxy in the Fornax galaxy cluster, conducted with HST/ACS. Using a novel technique to construct drizzled PSF libraries for HST/ACS data, we accurately determine the fidelity of GC structural parameter measurements from detailed artificial star cluster experiments. The measurement of rh for the major fraction of the NGC1399 GC system reveals a trend of increasing rh versus galactocentric distance, Rgal, out to about 10 kpc and a flat relation beyond. This trend is very similar for blue and red GCs which are found to have a mean size ratio of rh(red)/rh(blue)=0.82+/-0.11 at all galactocentric radii from the core regions of the galaxy out to ~40 kpc. This suggests that the size difference between blue and red GCs is due to internal mechanisms related to the evolution of their constituent stellar populations. Modeling the mass density profile of NGC1399 shows that additional external dynamical mechanisms are required to limit the GC size in the galaxy halo regions to rh~2 pc. We suggest that this may be realized by an exotic GC orbit distribution function, an extended dark matter halo, and/or tidal stress induced by the increased stochasticity in the dwarf halo substructure at larger Rgal. We match our GC rh measurements with radial velocity data from the literature and find that compact GCs show a significantly smaller line-of-sight velocity dispersion, =225+/-25 km/s, than their extended counterparts, =317+/-21 km/s. Considering the weaker statistical correlation in the GC rh-color and the GC rh-Rgal relations, the more significant GC size-dynamics relation appears to be astrophysically more relevant and hints at the dominant influence of the GC orbit distribution function on the evolution of GC structural parameters.Comment: 22 pages, 17 figures, accepted for publication in The Astrophysical Journal, a high-quality PDF version is available at http://www.astro.puc.cl/~tpuzia/PUC/Home.htm

Probing the Low Mass X-ray Binaries/Globular Cluster connection in NGC1399

We present a wide field study of the Globular Clusters/Low Mass X-ray Binaries connection in the cD elliptical NGC1399, combining HST/ACS and Chandra high resolution data. We find evidence that LMXB formation likelihood is influenced by GCs structural parameters, in addition to the well known effects of mass and metallicity, independently from galactocentric distance.Comment: in press in the Proceedings of the X-ray 2009 Conference, 7-11 September 2009, Bologna, Ital

The Luminosity Function of Low Mass X-Ray Binaries in the Globular Cluster System of NGC 1399

We present a study of the faint-end of the X-ray Luminosity Function of Low Mass X-ray binaries in the Globular Cluster system of the cD galaxy NGC 1399 by performing a stacking experiment on 618 X-ray undetected GCs, in order to verify the presence of faint LMXBs and to constrain the faint-end slope of the GC-LMXBs XLF below the individual detection threshold of $8\times10^{37}$ erg s$^{-1}$ in the $0.5-8$ keV band. We obtain a significant X-ray detection for the whole GC sample, as well as for the red and blue GC subpopulations, corresponding to an average luminosity per GC $_{GC}$ of $(3.6\pm1.0)\times10^{36}\ erg\ s^{-1}$, $(6.9\pm2.1)\times10^{36}\ erg\ s^{-1}$and$(1.7\pm0.9)\times10^{36}\ erg\ s^{-1}$, respectively for all, red and blue GCs. If LMXBs in red and blue GCs have the same average intrinsic luminosity, we derive a red/blu ratio$\simeq 3$of GCs hosting LMXBs ($2.5\pm1.0$or$4.1\pm2.5$depending on the surveyed region); alternatively, assuming the fractions observed for brighter sources, we measure an average X-ray luminosity of$L_{X}=(4.3\pm1.3)\times10^{37}\ erg\ s^{-1}$and$L_{X}=(3.4\pm1.7)\times10^{37}\ erg\ s^{-1}$per red and blue GC-LMXBs respectively. In the assumption that the XLF follows a power-law distribution, we find that a low-luminosity break is required at$L_{X}\leq 8\times10^{37}$erg s$^{-1}$both in the whole, as well as in the color-selected (red and blue) subsamples. Given the bright-end slopes measured above the X-ray completeness limit, this result is significant at$>3\sigma$level. Our best estimates for the faint end slope are$\beta_{L}=-1.39/-1.38/-1.36$for all/red/blue GC-LMXBs. We also find evidence that the luminosity function becomes steeper at luminosities$L_X\gtrsim 3\times 10^{39}$erg s$^{-1}$, as observed in old ellipticals.Comment: In press on A&

Globular Cluster Scale Sizes in Giant Galaxies: Orbital Anisotropy and Tidally Under-filling Clusters in M87, NGC 1399, and NGC 5128

We investigate the shallow increase in globular cluster half-light radii with projected galactocentric distance $R_{gc}$ observed in the giant galaxies M87, NGC 1399, and NGC 5128. To model the trend in each galaxy, we explore the effects of orbital anisotropy and tidally under-filling clusters. While a strong degeneracy exists between the two parameters, we use kinematic studies to help constrain the distance $R_\beta$ beyond which cluster orbits become anisotropic, as well as the distance $R_{f\alpha}$ beyond which clusters are tidally under-filling. For M87 we find $R_\beta > 27$ kpc and $20 < R_{f\alpha} 13$ kpc and $10 < R_{f\alpha} < 30$ kpc. The connection of $R_{f\alpha}$ with each galaxy's mass profile indicates the relationship between size and $R_{gc}$ may be imposed at formation, with only inner clusters being tidally affected. The best fitted models suggest the dynamical histories of brightest cluster galaxies yield similar present-day distributions of cluster properties. For NGC 5128, the central giant in a small galaxy group, we find $R_\beta > 5$ kpc and $R_{f\alpha} > 30$ kpc. While we cannot rule out a dependence on $R_{gc}$, NGC 5128 is well fitted by a tidally filling cluster population with an isotropic distribution of orbits, suggesting it may have formed via an initial fast accretion phase. Perturbations from the surrounding environment may also affect a galaxy's orbital anisotropy profile, as outer clusters in M87 and NGC 1399 have primarily radial orbits while outer NGC 5128 clusters remain isotropic.Comment: 16 pages, 7 figures, 4 tables, Accepted for publication in MNRA

C IV BAL disappearance in a large SDSS QSO sample

Broad absorption lines (BALs) in the spectra of quasi-stellar objects (QSOs) originate from outflowing winds along our line of sight; winds are thought to originate from the inner regions of the QSO accretion disk, close to the central supermassive black hole (SMBH). Winds likely play a role in galaxy evolution and aid the accretion mechanism onto the SMBH. BAL equivalent widths can change on typical timescales from months to years; such variability is generally attributed to changes in the covering factor and/or in the ionization level of the gas. We investigate BAL variability, focusing on BAL disappearance. We analyze multi-epoch spectra of more than 1500 QSOs -the largest sample ever used for such a study- observed by different programs from the Sloan Digital Sky Survey-I/II/III (SDSS), and search for disappearing C IV BALs. The spectra rest-frame time baseline ranges from 0.28 to 4.9 yr; the source redshifts range from 1.68 to 4.27. We detect 73 disappearing BALs in the spectra of 67 sources. This corresponds to 3.9% of disappearing BALs, and 5.1% of our BAL QSOs exhibit at least one disappearing BAL. We estimate the average lifetime of a BAL along our line of sight (~ 80-100 yr), which appears consistent with the accretion disk orbital time at distances where winds are thought to originate. We inspect properties of the disappearing BALs and compare them to the properties of our main sample. We also investigate the existence of a correlation in the variability of multiple troughs in the same spectrum, and find it persistent at large velocity offsets between BAL pairs, suggesting that a mechanism extending on a global scale is necessary to explain the phenomenon. We select a more reliable sample of disappearing BALs following Filiz Ak et al. (2012), where a subset of our sample was analyzed, and compare the findings from the two works, obtaining generally consistent results.Comment: 22 pages, 9 figures. Accepted for publication in A&

The XMM deep survey in the CDF-S. X. X-ray variability of bright sources

We aim to study the variability properties of bright hard X-ray selected Active Galactic Nuclei (AGN) with redshift between 0.3 and 1.6 detected in the Chandra Deep Field South (XMM-CDFS) by a long XMM observation. Taking advantage of the good count statistics in the XMM CDFS we search for flux and spectral variability using the hardness ratio techniques. We also investigated spectral variability of different spectral components. The spectra were merged in six epochs (defined as adjacent observations) and in high and low flux states to understand whether the flux transitions are accompanied by spectral changes. The flux variability is significant in all the sources investigated. The hardness ratios in general are not as variable as the fluxes. Only one source displays a variable HR, anti-correlated with the flux (source 337). The spectral analysis in the available epochs confirms the steeper when brighter trend consistent with Comptonisation models only in this source. Finding this trend in one out of seven unabsorbed sources is consistent, within the statistical limits, with the 15 % of unabsorbed AGN in previous deep surveys. No significant variability in the column densities, nor in the Compton reflection component, has been detected across the epochs considered. The high and low states display in general different normalisations but consistent spectral properties. X-ray flux fluctuations are ubiquitous in AGN. In general, the significant flux variations are not associated with a spectral variability: photon index and column densities are not significantly variable in nine out of the ten AGN over long timescales (from 3 to 6.5 years). The photon index variability is found only in one source (which is steeper when brighter) out of seven unabsorbed AGN. These results are consistent with previous deep samples.Comment: 14 pages, 11 figures. Accepted in A&

Prevalence of X-ray variability in the Chandra Deep Field South

We studied the X-ray variability of sources detected in the Chandra Deep Field South (Giacconi et al. 2002), nearly all of which are low to moderate z AGN (Tozzi et al. 2001). We find that 45% of the sources with >100 counts exhibit significant variability on timescales ranging from a day up to a year. The fraction of sources found to be variable increases with observed flux, suggesting that >90% of all AGNs possess intrinsic variability. We also find that the fraction of variable sources appears to decrease with increasing intrinsic absorption; a lack of variability in hard, absorbed AGNs could be due to an increased contribution of reflected X-rays to the total flux. We do not detect significant spectral variability in the majority (~70%) of our sources. In half of the remaining 30%, the hardness ratio is anti-correlated with flux, mimicking the high/soft-low/hard states of galactic sources. The X-ray variability appears anti-correlated with the luminosity of the sources, in agreement with previous studies. High redshift sources, however, have larger variability amplitudes than expected from extrapolations of their low-z counterparts, suggesting a possible evolution in the accretion rate and/or size of the X-ray emitting region. Finally, we discuss some effects that may produce the observed decrease in the fraction of variable sources from z=0.5 out to z=2.Comment: 24 pages, including 15 figures and 1 table. In press on Ap

Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells

Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in metastatic breast cancer (MBC). Experimental Design: We used a CTC molecular characterization approach to investigate heterogeneity of 14 hotspot mutations in ESR1 and their correlation with endocrine resistance. Combining the CellSearch and DEPArray technologies allowed recovery of 71 single CTCs and 12 WBC from 3 ER-positive MBC patients. Forty CTCs and 12 WBC were subjected to whole genome amplification by MALBAC and Sanger sequencing. Results: Among 3 selected patients, 2 had an ESR1 mutation (Y537). One showed two different ESR1 variants in a single CTC and another showed loss of heterozygosity. All mutations were detected in matched cell-free DNA (cfDNA). Furthermore, one had 2 serial blood samples analyzed and showed changes in both cfDNA and CTCs with emergence of mutations in ESR1 (Y537S and T570I), which has not been reported previously. Conclusions: CTCs are easily accessible biomarkers to monitor and better personalize management of patients with previously demonstrated ER-MBC who are progressing on endocrine therapy. We showed that single CTC analysis can yield important information on clonal heterogeneity and can be a source of discovery of novel and potential driver mutations. Finally, we also validate a workflow for liquid biopsy that will facilitate early detection of ESR1 mutations, the emergence of endocrine resistance and the choice of further target therapy. ©2017 AACR

Simulating the WFXT sky

We investigate the scientific impact of the Wide Field X-ray Telescope mission. We present simulated images and spectra of X-ray sources as observed from the three surveys planned for the nominal 5-year WFXT lifetime. The goal of these simulations is to provide WFXT images of the extragalactic sky in different energy bands based on accurate description of AGN populations, normal and star forming galaxies, groups and clusters of galaxies. The images are realized using a detailed PSF model, instrumental and physical backgrounds/foregrounds, accurate model of the effective area and the related vignetting effect. Thanks to this comprehensive modelization of the WFXT properties, the simulated images can be used to evaluate the flux limits for detection of point and extended sources, the effect of source confusion at very faint fluxes, and in general the efficiency of detection algorithms. We also simulate the spectra of the detected sources, in order to address specific science topics which are unique to WFXT. Among them, we focus on the characterization of the Intra Cluster Medium (ICM) of high-z clusters, and in particular on the measurement of the redshift from the ICM spectrum in order to build a cosmological sample of galaxy clusters. The end-to-end simulation procedure presented here, is a valuable tool in optimizing the mission design. Therefore, these simulations can be used to reliably characterize the WFXT discovery space and to verify the connection between mission requirements and scientific goals. Thanks to this effort, we can conclude on firm basis that an X-ray mission optimized for surveys like WFXT is necessary to bring X-ray astronomy at the level of the optical, IR, submm and radio wavebands as foreseen in the coming decade.Comment: "Proceedings of "The Wide Field X-ray Telescope Workshop", held in Bologna, Italy, Nov. 25-26 2009. To appear in Memorie della Societa Astronomica Italiana 2010 (arXiv:1010.5889)