Seroepidemiology of <i>Trichomonas vaginalis</i> in rural women in Zimbabwe and patterns of association with HIV infection

Serological assays using dried blood spots from 5221 women in rural areas of eastern Zimbabwe were used to assess the epidemiology of Trichomonas vaginalis infection, and its association with HIV. Antibodies to T. vaginalis and to HIV were detected by enzyme immunoassays. Behavioural and demographic data were collected by confidential questionnaires. In total, 516 (9.9%) women were seropositive for T. vaginalis and seroprevalence increased with age among younger women. Divorced, widowed and single women were more likely to be seropositive. After controlling for age, seropositivity was significantly associated with being sexually active, having multiple sex partners, having a partner who had multiple sex partners, and having a new sex partner in the past year. Seropositivity was associated with a recent history of genital discharge. Overall, 208 (40.3%) T. vaginalis-positive samples were also positive for HIV, compared with 1106 (23.5%) T. vaginalis-negative samples (age and sex adjusted OR 2.11, 95% CI 1.74–2.55, P&lt;0.001). There was increased risk for being HIV-positive amongst T. vaginalis-seropositive women regardless of residence, employment or education. In a logistic regression controlling for common risk factors, the association remained significant. T. vaginalis-seropositive young women with a history of genital discharge were much more likely to be HIV-positive than women who were T. vaginalis-seronegative and had no history of discharge (OR 6.08, 95% CI 2.95–12.53). Although a causal relationship cannot be assumed, detection and treatment of trichomoniasis may be important in strategies to reduce HIV transmission through sexually transmitted infection control

Spectroscopy of very hot plasma in non-flaring parts of a solar limb active region: spatial and temporal properties

In this work we investigate the thermal structure of an off-limb active region in various non-flaring areas, as it provides key information on the way these structures are heated. In particular, we concentrate in the very hot component (>3 MK) as it is a crucial element to discriminate between different heating mechanisms. We present an analysis using Fe and Ca emission lines from both SOHO/SUMER and HINODE/EIS. A dataset covering all ionization stages from Fe X to Fe XIX has been used for the thermal analysis (both DEM and EM). Ca XIV is used for the SUMER-EIS radiometric cross-calibration. We show how the very hot plasma is present and persistent almost everywhere in the core of the limb AR. The off-limb AR is clearly structured in Fe XVIII. Almost everywhere, the EM analysis reveals plasma at 10 MK (visible in Fe XIX emission) which is down to 0.1% of EM of the main 3 MK plasma. We estimate the power law index of the hot tail of the EM to be between -8.5 and -4.4. However, we leave an open question on the possible existence of a small minor peak at around 10 MK. The absence in some part of the AR of Fe XIX and Fe XXIII lines (which fall into our spectral range) enables us to determine an upper limit on the EM at such temperatures. Our results include a new Ca XIV 943.59 \AA~ atomic model

Making the ‘Evolutionary Leap’: Using Open Knowledge Approaches to Improve Development Outcomes

The starting point of the Open Knowledge Hub project was our belief that the adoption of so-called ‘Open Knowledge’ approaches had the potential to improve the impact of research evidence on development outcomes and address inequalities in the visibility, accessibility and uptake of diverse knowledge about development. This paper describes what we learned about the drivers and motivations for knowledge organisations to engage with Open Knowledge approaches. It also addresses the issues and barriers to engagement that, we have argued, threaten to undermine these potential benefits. The paper looks at both direct learning from the project and external research evidence accumulated during our work

Searching for black holes in subways.

Abstract Current mobile agent algorithms for mapping faults in computer networks assume that the network is static. However, for large classes of highly dynamic networks (e.g., wireless mobile ad hoc networks, sensor networks, vehicular networks), the topology changes as a function of time. These networks, called delay-tolerant, challenged, opportunistic, etc., have never been investigated with regard to locating faults. We consider a subclass of these networks modelled on an urban subway system. We examine the problem of creating a map of such a subway. More precisely, we study the problem of a team of asynchronous computational entities (the mapping agents) determining the location of black holes in a highly dynamic graph, whose edges are defined by the asynchronous movements of mobile entities (the subway carriers). We determine necessary conditions for the problem to be solvable. We then present and analyze a solution protocol; we show that our algorithm solves the fault mapping problem in subway networks with the minimum number of agents possible, k = γ + 1, where γ is the number of carrier stops at black holes. The number of carrier moves between stations required by the algorithm in the worst case is , where n C is the number of subway trains, and l R is the length of the subway route with the most stops. We establish lower bounds showing that this bound is tight. Thus, our protocol is both agent-optimal and move-optimal

The clock gene period in the medfly Ceratitis capitata.

We have isolated the clock gene period (per) from the medfly Ceratitis capitata, one of the most economically important insect pest species. The overall pattern of conserved, non-conserved and functional domains that are observed within dipteran and lepidopteran per orthologues is preserved within the coding sequence. Expression analysis from fly heads revealed a daily oscillation in per mRNA in both light[ratio ]dark cycles and in constant darkness. However PER protein levels from head extracts did not show any significant evidence for cycling in either of these two conditions. When the Ceratitis per transgene under the control of the Drosophila per promoter and 3′UTR was introduced into Drosophila per-null mutant hosts, the transformants revealed a low level of rescue of behavioural rhythmicity. Nevertheless, the behaviour of the rhythmic transformants showed some similarities to that of Ceratitis, suggesting that Ceratitis per carries species-specific information that can evidently affect the Drosophila host's downstream rhythmic behaviour

Contribution of host factors and workplace exposure to the outcome of occupational asthma

The outcome of occupational asthma after diagnosis is often poor. The identification of factors associated with a worse outcome may help in the management of the disease, determining its prognosis and assessing the permanent impairment attributable to occupational exposure. The aim of this systematic review was to provide the available evidence from the medical literature to answer the question: "What is the contribution of host factors and workplace exposure to the risk of a bad outcome of occupational asthma?" A systematic literature search was conducted in March 2010. We retrieved 177 abstracts. Of these, 67 were assessed as potentially relevant. After full text evaluation, 35 articles that were actually relevant for the question were included in the analysis. The information obtained was sufficient to establish that older age, high-molecular-weight agents, impaired lung function and longer duration of exposure to the offending agent at the time of diagnosis had a negative role on the outcome of occupational asthma. Atopy and smoking at diagnosis did not seem to influence the outcome of occupational asthma. A limited number of studies considered sex and the pattern of asthmatic reaction on specific inhalation challenge and their findings were contradictory

Pellets recovered from stick nests and new diet items of Furnariidae (Aves: Passeriformes)

This is the first record showing eleven species in seven genera of Furnariidae (Aves: Passeriformes) from Argentina that regurgitate pellets. A total of 627 nests of Furnariidae was examined, and from 84 nests (13.3%), 1,329 pellets were recovered. These pellets were found in the closed, domed nests of many Furnariidae, because in comparison to other passerine birds, their nests were used for roosting, especially in the subfamily Synallaxinae. Anumbius annumbi had the highest percentage of nests containing pellets. Food items identified from the pellets provided important new data on the diets of several species of Furnariidae.Fil: Turienzo, Paola Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Iorio, Osvaldo Rubén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentin

Nature and Nurture? Comparing Lyα Detections in UV-bright and Fainter [O iii]+Hβ Emitters at z ∼ 8 with Keck/MOSFIRE

The 100% detection rate of Lyα emission in a sample of four luminous z ∼ 8 galaxies with red Spitzer/IRAC colors suggests objects with unusual ionizing capabilities that created early ionized bubbles in a neutral era. Whether such bubbles reflect enhanced ionizing properties (nature) or an overdense environment (nurture), however, remains unclear. Here we aim to distinguish between these hypotheses via a search for Lyα emission in five fainter galaxies drawn from the CANDELS-GOODS fields using a similar IRAC excess and UV magnitudes that should reflect reduced clustering effects. Using Keck/MOSFIRE we tentatively detect >4σ line emission in only two targets at redshifts z_{Lyα} = 7.1081 and 7.9622 with rest-frame EWs of 16–17 Å, ∼1.5× weaker compared to their brighter counterparts. Thus, we find a reduced rate for Lyα emission of 0.40_{-0.25}^{+0.30} compared to 1.00_{-0.44}^{+0.00} for more luminous examples. The lower rate agrees with predictions from simulations of a mostly neutral intergalactic medium and an intrinsic EW0,Lyα distribution for z ∼ 6 galaxies. However, even with an extreme EW_{0,Lyα} model, it is challenging to match the detection rate for the luminous objects. Spectral energy distribution fitting of our fainter sample indicates young and star-forming systems, albeit with less extreme star formation rates and ionization parameters compared to their luminous counterparts. The enhanced Lyα rate in luminous galaxies is thus likely a byproduct of both extreme ionizing properties as well as environmental effects. Further studies with JWST may be required to resolve the physical nature of this puzzling population