Veštački mrest klena (Leuciscus cephalus, linnaeus, 1758)

Chub Leuciscus cephalus (L.) is a rheophilic cyprinid which prefers lotic habitat conditions, shallow water (0.1–0.3 m) and gravel banks with moderate to high water flow (0.15–0.75m s–1) for spawning. The aim of the research was to determine the basic quality parameters water for chub spawning and adequate conditions for eggs and larval growth. Artificial reproduction of chub was studied during one subsequent reproductive season. Chub reproduction was conducted in two different variations. Spawners were caught in June from natural waters (Izgare i Sesalska reka). Fish were transported to the hatchery and kept in tank (1000 l). The second group was spawned on catching location and eggs were putted in aquarium for develop

Mašinskih prstenovi u Srpskoj poljoprivredi – iskustva, izazovi i dalji razvoj

Creation of machinery rings in the Republic of Serbia is a topic that attracts scientists of different profiles. This form of interest association is particularly important for small farmers. Appropriate direct and indirect incentives encourage the creation of stakeholder associations of small farmers. In the most part, after the 2000th year, these incentives are implemented through projects in agriculture financed from international sources. The aim of this paper is to analyze the experiences, challenges and opportunities for further development of machinery rings. Interesting association of small agricultural producers have effects on increasing competitiveness at the micro level which is essential for the growth of export performance of agricultural and food products. The analysis results show that in the Republic of Serbia in the period 2000th-2009th there are some positive experience, but there are significant opportunities for further development of machinery rings.Stvaranje mašinskih prstenova u Republici Srbiji je tema koja zaokuplja naučnike različitih profila. Ovakav oblik interesnog udruživanja je posebno važan za male poljoprivredne proizvođače. Odgovarajućim direktnim i indirektnim podsticajima podstiče se stvaranje interesnih udruženja malih farmera. U najvećoj meri, nakon 2000. godine, ovi podsticaji su realizovani kroz projekte u poljoprivredi finansiranih iz međunarodnih izvora. Cilj ovog rada je da se analiziraju iskustva, izazovi i mogućnosti za dalji razvoj mašinskih prstenova. Interesno udruživanje malih proizvođača ima efekte na povećanje konkurentnosti na mikro nivou što je ključno za rast izvoznih performansi poljoprivredno-prehrambenih proizvoda. Rezultati analize pokazuju da su u Republici Srbiji u periodu 2000.-2009. godine stečena određena iskustva, ali da postoje značajne mogućnosti za dalji razvoj mašinskih prstenova

MOLNUPIRAVIR COMPARED TO NIRMATRELVIR/RITONAVIR FOR COVID-19 IN HIGH-RISK PATIENTS WITH HAEMATOLOGICAL MALIGNANCY IN EUROPE. A MATCHED-PAIRED ANALYSIS FROM THE EPICOVIDEHA REGISTRY

Introduction: Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression to severe SARS-CoV-2 infections, which reduce both hospitalization and mortality rates. Nirmatrelvir/ritonavir was authorised in Europe in December 2021, while molnupiravir is not yet licensed in Europe as of February 2022. Molnupiravir may be an alternative to nirmatrelvir/ritonavir, because it displays less frequent drug-drug interactions and contraindications. A caveat connected to molnupiravir derives from the mode of action inducing viral mutations. In clinical trials on patients without haematological malignancy, mortality rate reduction of molnupiravir appeared less pronounced than that of nirmatrelvir/ritonavir. Little is known about the comparative efficacy of the two drugs in patients with haematological malignancy at high-risk of severe COVID-19. Thus, we here assess the effectiveness of molnupiravir compared to nirmatrelvir/ritonavir in our cohort of patients with haematological malignancies. Methods: Clinical data of patients treated either with molnupiravir or nirmatrelvir/ritonavir monotherapy for COVID-19 were retrieved from the EPICOVIDEHA registry. Patients treated with molnupiravir were matched by sex, age (±10 years), and baseline haematological malignancy severity to controls treated with nirmatrelvir/ritonavir. Results: A total of 116 patients receiving molnupiravir for the clinical management of COVID-19 were matched to an equal number of controls receiving nirmatrelvir/ritonavir. In each of the groups, 68 (59%) patients were male; with a median age of 64 years (IQR 53-74) for molnupiravir recipients and 64 years (IQR 54-73) for nirmatrelvir/ritonavir recipients; 57% (n=66) of the patients had controlled baseline haematological malignancy, 13% (n=15) stable, and 30% (n=35) had active disease at COVID-19 onset in each of the groups. During COVID-19 infection, one third of patients from each group were admitted to hospital. Although a similar proportion of vaccinated patients was observed in both groups (molnupiravir n=77, 66% vs nirmatrelvir/ritonavir n=87, 75%), those treated with nirmatrelvir/ritonavir had more often received four doses (n=27, 23%) as compared to patients treated with molnupiravir (n=5, 4%, p<0.001). No differences were detected in COVID-19 severity (p=0.39) or hospitalization (p=1.0). No statistically significant differences were identified in overall mortality rate (p=0.78) or in survival probability (d30 p=0.19, d60 p=0.67, d90 p=0.68, last day of follow up p=0.68). In all patients, deaths were either attributed to COVID-19 or the infection contributed to death as per treating physician's judgement. Conclusions: In high-risk patients with haematological malignancies and COVID-19, molnupiravir showed rates of hospitalization and mortality comparable to those of nirmatrelvir/ritonavir in this matched-pair analysis. Molnupiravir appears to be a plausible alternative to nirmatrelvir/ritonavir for COVID-19 treatment in patients with haematological malignancy

Subjectively Experienced Time and User Satisfactio : An Experimental Study of Progress Indicator Design in Mobile Application

In the user’s interaction with systems, waiting and interruptions often constitute a source of negative experiences. However, system response time can be difficult or impossible to control, due to for example poor internet connection. This study explores “subjective experienced time”, which refers to the users’ assessment of system response timeliness. The aim of this study is to gain increased knowledge of user satisfaction and subjectively experienced time in interaction with mobile applications. Thirty participants used and evaluated three mobile applications, containing unique stimuli in progress indicators. The results show correlation between progress indicators’ degree of feedback and the subjectively experienced time and user satisfaction. Contributions include increased insight into the somewhat complex connection between the degree of feedback, subjectively experienced time and user satisfaction, as well as design implications for user-centred design

Age from faces in the deep learning revolution

Face analysis includes a variety of specific problems as face detection, person identification, gender and ethnicity recognition; in the last two decades, significant research efforts have been devoted to the challenging task of age estimation from faces, as witnessed by the high number of published papers. The explosion of the deep learning paradigm, that is determining a spectacular increasing of the performance, is in the public eye; consequently, the number of approaches based on deep learning is impressively growing and this also happened for age estimation. The exciting results obtained have been recently surveyed on almost all the specific face analysis problems; the only exception stands for age estimation, whose last survey dates back to 2010 and does not include any deep learning based approach to the problem. This paper provides an analysis of the deep methods; these are analysed from different points of view: the network architecture together with the learning procedure, the used datasets, data preprocessing and augmentation, and the exploitation of additional data coming from gender, race and face expression. The review is completed by discussing the results obtained on public datasets, so as the impact of different aspects on system performance, together with still open issues

Celiac disease and thrombotic events: Systematic review of published cases

Extraintestinal manifestations of celiac disease (CD) should be considered, even in patients without typical intestinal symptoms. The aim of our study is to examine the literature regarding the occurrence of thrombotic events in CD, and to synthesize the data from case reports and case series. A systematic review of the literature was conducted by searching the Pub-Med/MEDLINE database, from the date of database inception to January 2022, to identify published cases and case series on this topic, in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 55 cases were included in the study. The majority of patients were previously healthy individuals, with no comorbidities. In less than one-third of the cases (30.91%), the diagnosis of CD was established before the onset of thrombosis, while in the remaining cases (34.54%), thrombosis preceded the diagnosis or was diagnosed concomitantly with CD. The most common sites for thrombosis occurrence were hepatic veins (30.91%), while thrombosis of cerebral blood vessels, deep venous thrombosis of lower extremities, and pulmonary thromboembolism were less frequent. Thrombosis was most commonly isolated to one site only (78.18%). In 69.09% of cases ( = 38), some form of anticoagulation, along with a gluten-free diet, was initiated

Suppurative Thrombosis of the Portal Vein (Pylephlebits): A Systematic Review of Literature

Suppurative portal vein thrombosis (pylephlebitis) is an uncommon condition usually associated with an intra-abdominal infection or inflammatory process. In this study, we aimed to synthesize data on previously published cases according to the PRISMA guidelines. A total of 103 patients were included. Patients were more commonly male (71.8%) and had a mean age of 49 years. The most common infection associated with pylephlebitis was diverticulitis (n = 29, 28.2%), and Escherichia coli was the most isolated pathogen (n = 21, 20.4%). Blood cultures were positive in 64 cases (62.1%). The most common site of thrombosis was the main portal vein (PV) in 59 patients (57.3%), followed by the superior mesenteric vein (SMV) in 40 patients (38.8%) and the right branch of the PV in 30 patients (29.1%). Sepsis developed in 60 patients (58.3%). The mortality rate in our review was 8.7%, and independent risk factors for mortality were the presence of pertinent comorbidities (OR 5.5, p = 0.02), positive blood cultures (OR 2.2, p = 0.02), and sepsis (OR 17.2, p = 0.049)