Affective temperaments and personality traits in couple well-being

Background. The objective of this study is to establish the link between affective temperament traits and maladaptive personality traits, to verify whether the potential presence of elements related to emotional, affective and dysfunctional relational functioning can affect the couple satisfaction, modifying the well-being or discomfort condition. Materials and Methods. A data collection questionnaire was developed to investigate the factors associated with dysfunctional emotional, affective, and relational modes of functioning. The sample consisted of 473 subjects. Data were collected including the TEMPS-A questionnaire, The Dirty Dozen Italian Assessment and the Relationship Assessment Scale (RAS). Results. The findings of this study showed that the subscales of affective temperament were predictors of dark triad traits. The expressive, irritable and hyperthymic temperamental traits were found to be predictors of trait psychopathy; hyperthymic temperament is also a predictor of narcissistic traits and cyclothymic temperament is a predictor of lower couple satisfaction; men show higher scores than women in Dark triad. Conclusions. This study confirmed that temperamental traits can predict maladaptive personality traits belonging to the dark triad and confirms the importance of evaluating maladaptive personality traits to prevent forms of psychological violence in couple

Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review

Autophagy is a complex process involved in several cell activities, including tissue growth, differentiation, metabolic modulation, and cancer development. In prostate cancer, autophagy has a pivotal role in the regulation of apoptosis and disease progression. Several molecular pathways are involved, including PI3K/AKT/mTOR. However, depending on the cellular context, autophagy may play either a detrimental or a protective role in prostate cancer. For this purpose, current evidence has investigated how autophagy interacts within these complex interactions. In this article, we discuss novel findings about autophagic machinery in order to better understand the therapeutic response and the chemotherapy resistance of prostate cancer. Autophagic-modulation drugs have been employed in clinical trials to regulate autophagy, aiming to improve the response to chemotherapy or to anti-cancer treatments. Furthermore, the genetic signature of autophagy has been found to have a potential means to stratify prostate cancer aggressiveness. Unfortunately, stronger evidence is needed to better understand this field, and the application of these findings in clinical practice still remains poorly feasible

Estratégias em saúde para lidar com a pandemia de covid-19: proposta de um e-book / Health strategies to deal with pandemic covid-19: proposal for an e-book

O objetivo do trabalho é apresentar um e-book elaborado pelo Grupo de Pesquisa em Estilo de Vida e Saúde com o objetivo de reunir informações relevantes para promover ações benéficas à saúde física e mental e maior qualidade de vida neste período com foco em estilo de vida saudável. O material produzido foi intitulado “Estilo de vida: estratégias interprofissionais em saúde para lidar com o período da quarentena” e é composto de 10 capítulos divididos em 42 páginas. Participaram da análise crítica deste produto 10 juízes que avaliaram o conteúdo quanto à organização, estilo da escrita, aparência, e apelo do material, conforme instruções de avaliação da adequação dos materiais do livro Teaching Patients with Low Literacy Skills recomendado pela Harvard T.H. Chan School of Public Health. O e-book proposto neste estudo foi baseado em evidências científicas apresentando imagens ilustrativas e links úteis para o leitor com o objetivo de possibilitar interação em uma linguagem acessível. A produção do e-book poderá servir como ferramenta de promoção de saúde e qualidade de vida para ser utilizada pelo público geral bem como para apoiar ações dos profissionais da área da saúde

The Role of CyaY in Iron Sulfur Cluster Assembly on the E. coli IscU Scaffold Protein

Progress in understanding the mechanism underlying the enzymatic formation of iron-sulfur clusters is difficult since it involves a complex reaction and a multi-component system. By exploiting different spectroscopies, we characterize the effect on the enzymatic kinetics of cluster formation of CyaY, the bacterial ortholog of frataxin, on cluster formation on the scaffold protein IscU. Frataxin/CyaY is a highly conserved protein implicated in an incurable ataxia in humans. Previous studies had suggested a role of CyaY as an inhibitor of iron sulfur cluster formation. Similar studies on the eukaryotic proteins have however suggested for frataxin a role as an activator. Our studies independently confirm that CyaY slows down the reaction and shed new light onto the mechanism by which CyaY works. We observe that the presence of CyaY does not alter the relative ratio between [2Fe2S]2+ and [4Fe4S]2+ but directly affects enzymatic activity

Indicators for sustainable urban mobility: 2030 agenda and the SDGS in evidence

The aim of this study was to identify, through the bibliometric research method, the sustainability indicators built and/or applied in several parts of the world, as a way to monitor and evaluate public policies in the area of Urban Mobility and Transportation and be able to outline future researches establishing comparisons between the researched countries. For selection of the analyzed papers, the parameters established by the 2030 Agenda were used, by means of its 17 SDGs and the indicators constructed by IPEA for Brazil. As a result of the search, 15 papers were identified, written by 58 authors, linked to 53 institutions from 14 different countries. When analyzing the 7 countries with the highest number of citations in the area, it can be noticed that Germany stands out with 38% ofthe total citations, followed by Spain with 30%. It was concluded that the indicators used in the analysed studies indicate that good urban mobility is important not only to improve people's life quality, but also to increase the economic and environmental efficiency of cities. In addition, it helps to promote social equality by allowing people to easily commute to their daily needs, be they work, school, health or leisure

INDICADORES PARA MOBILIDADE URBANA SUSTENTÁVEL: A AGENDA 2030 E OS ODS EM EVIDÊNCIA

The aim of this study was to identify, through the bibliometric research method, the sustainability indicators built and/or applied in several parts of the world, as a way to monitor and evaluate public policies in the area of Urban Mobility and Transportation and be able to outline future researches establishing comparisons between the researched countries. For selection of the analyzed papers, the parameters established by the 2030 Agenda were used, by means of its 17 SDGs and the indicators constructed by IPEA for Brazil. As a result of the search, 15 papers were identified, written by 58 authors, linked to 53 institutions from 14 different countries. When analyzing the 7 countries with the highest number of citations in the area, it can be noticed that Germany stands out with 38% of the total citations, followed by Spain with 30%. It was concluded that the indicators used in the analysed studies indicate that good urban mobility is important not only to improve people's life quality, but also to increase the economic and environmental efficiency of cities. In addition, it helps to promote social equality by allowing people to easily commute to their daily needs, be they work, school, health or leisure.El objetivo de este estudio fue identificar, a través del método de investigación bibliométrica, los Indicadores de Sostenibilidad construidos y/o aplicados en varias partes del mundo, como forma de monitorear y evaluar las políticas públicas en el área de Movilidad y Transporte Urbano y poder delinear futuras investigaciones estableciendo comparaciones entre los países investigados. Para la selección de los trabajos analizados, se utilizaron los parámetros establecidos por la Agenda 2030, a través de sus 17 ODS y los indicadores construidos por el IPEA para Brasil. Como resultado de la recolección, se identificó que los 15 trabajos seleccionados en la búsqueda fueron escritos por 58 autores, vinculados a 53 instituciones de 14 países diferentes. Al analizar los 7 países con mayor número de citaciones en el área, se observa que Alemania se destaca con 38% del total de citaciones, seguida por España con 30%. Se concluye que los indicadores utilizados en los estudios analizados señalan que una buena movilidad urbana es importante no sólo para mejorar la calidad de vida de las personas, sino también para aumentar la eficiencia económica y medioambiental de las ciudades. Además, contribuye a promover la igualdad social, permitiendo a las personas desplazarse fácilmente a sus necesidades diarias, ya sean laborales, escolares, sanitarias o de ocioO objetivo deste estudo foi identificar, através do método bibliométrico de pesquisa, os Indicadores de Sustentabilidade construídos e/ou aplicados em diversas partes do mundo, como forma de acompanhar e avaliar as políticas públicas na área de Mobilidade Urbana e Transportes e poder traçar futuras pesquisas estabelecendo comparações entre os países pesquisados. Para a seleção dos trabalhos analisados, utilizou-se os parâmetros estabelecidos pela Agenda 2030, através dos seus 17 ODS e os indicadores construídos pelo IPEA para o Brasil. Como resultado da coleta identificou-se que os 15 trabalhos selecionados na busca foram escritos por 58 autores, vinculados a 53 instituições provenientes de 14 países distintos. Ao se analisar os 7 países com maior número de citações na área pode-se perceber que a Alemanha se destaca com 38% das citações totais, seguido pela a Espanha com 30%. Concluiu-se que os indicadores utilizados nos estudos analisados apontam que a boa mobilidade urbana é importante não apenas para melhorar a qualidade de vida das pessoas, mas também para aumentar a eficiência econômica e ambiental das cidades. Além disso, ajuda a promover a igualdade social, permitindo que as pessoas se desloquem facilmente às suas necessidades diárias, sejam elas trabalho, escola, saúde ou lazer

Gender-specific counselling of patients with upper tract urothelial carcinoma and Lynch syndrome

Purpose: Lynch syndrome (LS) is an autosomal dominant genetic syndrome resulting in a wide spectrum of malignancies caused by germline mutations in mismatch repair genes (MMR). Gene mutations have different effects and penetrance between the two genders. The aim of this review is to offer a gender-specific evidence-based clinical guide on diagnosis, screening, surveillance, and counselling of UTUC patients with LS.MethodsUsing MEDLINE, a non-systematic review was performed including articles between 2004 and 2022. English language original articles, reviews, and editorials were selected based on their clinical relevance.ResultsUpper tract urothelial carcinoma (UTUC) is the third most common malignancy in Lynch syndrome. Up to 21% of new UTUC cases may have unrecognized LS as the underlying cause. LS-UTUC does not have a clear gender prevalence, even if it seems to slightly prefer the male gender. The MSH6 variant is significantly associated with female gender (p < 0.001) and with gynecological malignancies. Female MSH2 and MLH1 carriers have higher rates for endometrial and ovarian cancer with respect to the general population, while male MSH2 and MLH1 carriers have, respectively, higher rate of prostate cancer and upper GI tract, or biliary or pancreatic cancers. Conflicting evidence remains on the association of testicular cancer with LS.ConclusionLS is a polyhedric disease, having a great impact on patients and their families that requires a multidisciplinary approach. UTUC patients should be systematically screened for LS, and urologists have to be aware that the same MMR mutation may lead to different malignancies according to the patient's gender

A systematic review of robot-assisted partial nephrectomy outcomes for advanced indications: Large tumors (cT2-T3), solitary kidney, completely endophytic, hilar, recurrent, and multiple renal tumors

Objective: Robot-assisted partial nephrectomy (RAPN) has become widely used for treatment of renal cell carcinoma and it is expanding in the field of complex renal masses. The aim of this systematic review was to analyze outcomes of RAPN for completely endophytic renal masses, large tumors (cT2-T3), renal cell carcinoma in solitary kidney, recurrent tumors, completely endophytic and hilar masses, and simultaneous and multiple tumors. Methods: A comprehensive search in the PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials databases was performed in December 2022 for English language papers. The primary endpoint was to evaluate the role of RAPN in the setting of each category of complex renal masses considered. The secondary endpoint was to evaluate the surgical and functional outcomes. Results: After screening 1250 records, 43 full-text manuscripts were selected, comprising over 8500 patients. Twelve and thirteen studies reported data for endophytic and hilar renal masses, respectively. Five and three studies reported outcomes for cT2-T3 and solitary kidney patients, respectively. Four studies focused on redo-RAPN for recurrent tumors. Two studies investigated simultaneous bilateral renal masses and five reports focused on multiple tumor excision in ipsilateral kidney. Conclusion: Over the past decade, evidence supporting the use of RAPN for the most challenging nephron-sparing surgery indications has continuously grown. Although limitations remain including study design and lack of detailed long-term functional and oncological outcomes, the adoption of RAPN for the included advanced indications is associated with favorable surgical outcomes with good preservation of renal function without compromising the oncological result. Certainly, a higher likelihood of complication might be expected when facing extremely challenging cases. However, none of these indications should be considered per se an exclusion criterion for performing RAPN. Ultimately, a risk-adapted approach should be employed