Searching for Authenticity in Disability Identity Development

This article explores the nuances and pathways of disability identity development as well as what may constitute authentic disability identity in various theories and models. Authentic disability identity is influenced by how individuals interact with different power structures and systems and ultimately how they are related to normativity produced by ableism. Because each individual will have unique interactions with these systems, identity development and thus authenticity varies. Practitioners in higher education, with an understanding of how systems influence such nuanced identity, can create more open and flexible pathways to accommodations, improve outreach, and expand support outside of academic contexts

Community Colleges Meeting Students’ Basic Needs

https://sites.google.com/view/dsp-community-college/home Of the students currently enrolled in post-secondary education institutions, more than 50% of college students are attending community colleges. Of these students, 36% are nontraditional students who are between the ages of 22 and 39, 29% first-generation students, and 20% are disabled students. Community colleges and their students are transforming what it means to participate in higher education by providing resources for students with diverse identities, overcoming exclusionary practices that sacrifice students’ physical, mental, and financial wellbeing. As part of a digital storytelling project, we aimed to think critically about injustice in higher education by focusing on a special population or concept, explore these topics through critical theoretical lenses, analyze existing research and best-practices, and present our work in a creative, digital medium. We decided to focus on how community colleges serve low-income students by supporting some of their basic needs: food, housing, healthcare, and technology. Drawing on our research and examples of community colleges who have led the way, particularly during the COVID-19 pandemic, we developed a website as an attempt to demonstrate some of the ideal ways that community colleges could support some of students’ basic needs, thus constructing our ideal community college. Resisting the long history of elitism, exclusion, and sacrifice in higher education is difficult but community co leges are leading the way. Dismantling these oppressive structures by elevating community colleges and their practices that support the basic needs of students is a first step in a revolutionary reimagining of student success

Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases Mediate the Inhibitory Effects of All-Trans Retinoic Acid on the Hypertrophic Growth of Cardiomyocytes

All-trans retinoic acid (RA) has been implicated in mediation of cardiac growth inhibition in neonatal cardiomyocytes. However, the associated signaling mechanisms remain unclear. Utilizing neonatal cardiomyocytes, we demonstrated that RA suppressed the hypertrophic features induced by cyclic stretch or angiotensin II (Ang II). Cyclic stretch- or Ang II-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2), C-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAP kinase) was dose- and time-dependently inhibited by RA. Significant inhibition was observed by 5 μM RA, from 8 to 24 h of pretreatment. This inhibitory effect was not mediated at the level of mitogen-activated protein kinase kinases (MKKs), because RA had no effect on stretch- or Ang II-induced phosphorylation of MEK1/2, MKK4, and MKK3/6. However, the phosphatase inhibitor vanadate reversed the inhibitory effect of RA on MAP kinases and protein synthesis. RA up-regulated the expression level of MAP kinase phosphatase-1 (MKP-1) and MKP-2, and the time course was correlated with the inhibitory effect of RA on activation of MAP kinases. Overexpression of wild-type MKP-1 inhibited the phosphorylation of JNK and p38 in cardiomyocytes. These data indicated that MKPs were involved in the inhibitory effect of RA on MAP kinases. Using specific RAR and RXR antagonists, we demonstrated that both RARs and RXRs were involved in regulating stretch- or Ang II-induced activation of MAP kinases. Our findings provide the first evidence that the anti-hypertrophic effect of RA is mediated by up-regulation of MKPs and inhibition of MAP kinase signaling pathways

Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling

Diabetic cardiomyopathy (DCM), a significant contributor to morbidity and mortality in diabetic patients, is characterized by ventricular dysfunction, in the absence of coronary atherosclerosis and hypertension. There is no specific therapeutic strategy to effectively treat patients with DCM, due to a lack of a mechanistic understanding of the disease process. Retinoic acid, the active metabolite of vitamin A, is involved in a wide range of biological processes, through binding and activation of nuclear receptors: retinoic acid receptors (RAR) and retinoid X receptors (RXR). RAR/RXR-mediated signaling has been implicated in the regulation of glucose and lipid metabolism. Recently, it has been reported that activation of RAR/RXR has an important role in preventing the development of diabetic cardiomyopathy, through improving cardiac insulin resistance, inhibition of intracellular oxidative stress, NF-κB-mediated inflammatory responses and the renin-angiotensin system. Moreover, downregulated RAR/RXR signaling has been demonstrated in diabetic myocardium, suggesting that impaired RAR/RXR signaling may be a trigger to accelerate diabetes-induced development of DCM. Understanding the molecular mechanisms of retinoid receptors in the regulation of cardiac metabolism and remodeling under diabetic conditions is important in providing the impetus for generating novel therapeutic approaches for the prevention and treatment of diabetes-induced cardiac complications and heart failure

Ionic liquids at electrified interfaces

Until recently, “room-temperature” (<100–150 °C) liquid-state electrochemistry was mostly electrochemistry of diluted electrolytes(1)–(4) where dissolved salt ions were surrounded by a considerable amount of solvent molecules. Highly concentrated liquid electrolytes were mostly considered in the narrow (albeit important) niche of high-temperature electrochemistry of molten inorganic salts(5-9) and in the even narrower niche of “first-generation” room temperature ionic liquids, RTILs (such as chloro-aluminates and alkylammonium nitrates).(10-14) The situation has changed dramatically in the 2000s after the discovery of new moisture- and temperature-stable RTILs.(15, 16) These days, the “later generation” RTILs attracted wide attention within the electrochemical community.(17-31) Indeed, RTILs, as a class of compounds, possess a unique combination of properties (high charge density, electrochemical stability, low/negligible volatility, tunable polarity, etc.) that make them very attractive substances from fundamental and application points of view.(32-38) Most importantly, they can mix with each other in “cocktails” of one’s choice to acquire the desired properties (e.g., wider temperature range of the liquid phase(39, 40)) and can serve as almost “universal” solvents.(37, 41, 42) It is worth noting here one of the advantages of RTILs as compared to their high-temperature molten salt (HTMS)(43) “sister-systems”.(44) In RTILs the dissolved molecules are not imbedded in a harsh high temperature environment which could be destructive for many classes of fragile (organic) molecules

Brazilian Consensus on Photoprotection

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of nonmelanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection

Transient Behavior of Free Flames in Laminar and Turbulent Media

160 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1966.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Urban Development, Housing and Student Enclaves in University Towns: Luxury Living in Madison, WI

Includes Maps, Photographs, Graphs, Figures, Screenshots, Appendices and Bibliography.Our research is concerned with recent additions of high-end, high-rise apartment buildings to the State Street area in Madison, WI, taking the Hub at Madison and its follow-up project the James as particular cases. We address the economic and social consequences of these processes specifically for students, and how these buildings might serve to segregate and stratify the student population. We situate these developments in the context of the greater Madison housing market and recent trends in student housing and consider how these developments articulate with and diverge from previous conceptualization of gentrification and studentification. Through a survey and interviews with four students and two community members we are able to better understand the processes of urban change occurring in Madison. We argue that development in downtown Madison has prompted the creation of exclusionary spaces, specifically in connection to students and student housing