10 research outputs found
Analysis of the steel braced frames equipped with ADAS devices under the far field records
A diverse view of science to catalyse change:Valuing diversity leads to scientific excellence, the progress of science and, most importantly, it is simply the right thing to do. we must value diversity not only in words, but also in actions
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Damping characteristics of friction damped braced frame and its effectiveness in the mega-sub controlled structure system
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A Diverse View of Science to Catalyse Change
Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions. From the structure of DNA,1 to computer science,2 and space-station batteries,3 several key scientific discoveries that enhance our lives today, were made by marginalized scientists. These three scientists, Rosalind E. Franklin, Alan M. Turing and Olga D. González-Sanabria, did not conform to the cultural expectations of how scientists should look and behave. Unfortunately, marginalized scientists are often viewed as just a resource rather than the lifeblood that constitutes science itself. We need to embrace scientists from all walks of life and corners of the globe; this will also mean that nobody is excluded from tackling the life-threatening societal challenges that lie ahead. An awareness of science policy is essential to safeguarding our future. Science policy deals with creating the framework and codes of conduct that determine how science can best serve society.4-6 Discussions around science policy are often accompanied by anecdotes of “good” and “bad” practices regarding the merits of diversity and inclusion. Excellence and truth, which flow inexorably from diversity and inclusion, are the bedrocks upon which science should influence political and economic outcomes. A vital area of science policy is to support the professional development of marginalized scientists, an objective that must be acted upon by scientific leaders and communicators..
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Psychiatric Genomics Consortium Autism Group, Astrid M. VicenteFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552240/Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.E. Robinson and D. Weiner were funded by National Institute of
Mental Health grant 1K01MH099286-01A1 and Brain Behavior Research Foundation (NARSAD) Young
Investigator grant 22379. E. Wigdor was funded by the Stanley Center for Psychiatric Research at the Broad
Institute. A. Okbay was funded by ERC Consolidator Grant (647648 EdGe). We thank the families who took part in
the Simons Simplex Collection study and the clinicians who collected data at each of the study sites. The iPSYCH
project is funded by the Lundbeck Foundation and the universities and university hospitals of Aarhus and
Copenhagen. Genotyping of iPSYCH and PGC samples was supported by grants from the Stanley Foundation, the
Simons Foundation (SFARI 311789 to M. Daly) and the National Institute of Mental Health (5U01MH094432-02
to M. Daly). This work was also supported by a grant from the Simons Foundation (SFARI 402281 to S. Sanders).info:eu-repo/semantics/publishedVersio