Are all adverse effects undesirable? a case of chemotherapy induced adverse effect- an exception!?

Targeted cancer therapies, a recent development in cancer chemotherapy are drugs that block the growth and spread of cancer by interfering with specific molecules which are responsible for the progression of cancer, among which tyrosine kinase inhibitors play an important role. Erlotinib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor and is a promising drug for the treatment of non-small cell lung cancers and unresectable metastatic pancreatic cancers. Adverse drug reactions are noxious and unintended responses to drugs that occur at doses normally used in man. Cancer chemotherapeutics are well known to cause a wide range of adverse effects from mild to serious ones. All anticancer drugs cause alopecia, gastrointestinal disturbances, skin and hair changes as they affect all the rapidly proliferating cells in addition to cancer cells. Erlotinib causes some less serious adverse effects, one of which is trichomegaly which is presented here in this case report. Though adverse reactions are generally undesirable, trichomegaly induced by erlotinib could be considered as a marker of good tumor response to treatment and a positive outcome. Moreover, this adverse effect could be exploited in the treatment of madarosis for which currently, treatment options are very few

Greatness of leader in Thirukural

International audienc

Greatness of leader in Thirukural

International audienc

Mycosynthesis of Zinc Oxide Nanoparticles Coated with Silver using Ganoderma lucidum (Curtis) P. Karst and Its Evaluation of In Vitro Antidiabetic and Anticancer Potential

Nanotechnology is an evolving interdisciplinary field of research interspersing material science and nanobiotechnology. Nanoparticles are studied extensively for their specific catalytic, magnetic, electronic, optical, antimicrobial, theranostic, diagnosis, wound healing, and anti-inflammatory properties. ZnO nanoparticles (NPs) have many applications owing to their unique characteristics, which include low cost, nontoxicity, abundance in nature, and the ability to prepare compounds with varying morphologies having different properties. The main aim of the study is to biosynthesis of ZnO nanoparticles coated with silver from the aqueous extract of Ganoderma lucidum (Curtis) P. Karst and to evaluate its antidiabetic potential by performing alpha-glucosidase inhibition and alpha-amylase inhibition assays and to evaluate the anticancer potential by cytotoxicity (MTT) assay against human breast cancer MDA-MB 231 cell lines. The biosynthesis of ZnO nanoparticles coated with Ag was characterized by UV–vis spectroscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray analysis, scanning electron microscope, and transmission electron microscopy. An increasing concentration in the biosynthesized ZnO nanoparticles coated with Ag produces strong antidiabetic activity through enzyme inhibition effect and anticancer activity through the reduction of cell viability. The present study recommended that the “Biological” method of biological nanoparticle production is a promising approach that allows synthesis in aqueous conditions, with low energy requirements and low costs. In the future, the mycosynthesized nanoparticles might be used in the medical arena to treat and prevent diseases