Features of the seasonal dynamics of airborne fungal spore concentrations in Ukraine

Fungi represent a distinct kingdom of ubiquitous living beings. Most other organisms are constantly in contact with elements of the fungal body. In particular, the widespread vegetation of fungi in the environment, their sporulation and the further spread of spores and mycelia by air currents make the contact of fungal particles with human respiratory organs inevitable. This can lead to the development of sensitization and allergies. Therefore, the aim of the presented study was to determine the taxonomy of airborne fungal spores, the qualitative and quantitative changes in this composition at different times of the year compared with previous sporulation seasons, as well as the prevention of allergic diseases. The study of fungal sporulation was carried out from 2011 to 2021 by volumetric method using Burkard trap of a Hirst type in a 24-hour mode (from February to November). The device was installed on the roof of the chemical building of the National Pirogov Memorial Medical University, Vinnytsya. Reading of the microscopic slides obtained from air samples was carried out using light microscopes with a magnification of 400 and 1000 by the method of 12 vertical transects. It was found that spores of various taxonomic groups of fungi, namely, of Asco- and Basidiomycetes were observed throughout the growing season from March to October with the highest concentrations in mid and late summer. Thus, in June, July and August, peak concentrations of spores of the fungi Ganoderma, Coprinus, Cladosporium were observed; in July, September and October – of Ustilaginales; from July to November – of Alternaria, Epicoccum; in October – of different Basidiospores, and also Periconia, Stemphylium and Uredinales; in September – of Agrocybe. Among all studied micromycetes, concentrations of Cladosporium spores were the highest. However, significant sporulation persisted even in the autumn period, which made fungal spores a specific causative agent of airborne respiratory diseases at this time, especially against the background of low pollen concentrations. Climate change can lead to modification in the length of the fungal growing season. This information should be taken into account when predicting the symptoms of seasonal allergies in the population

Dual circuit radio frequency identification system of animals

У роботі проаналізовано вплив технічних і біологічних факторів на ефективність роботи систем радіоідентифікації великої рогатої худоби при використанні рідерів з рамковими антенами. Встановлено, що у таких системах достовірність читання кодів транспондерів у значній мірі залежить від відстані і взаємоорієнтації антен транспондерів і рідерів. Для підвищення достовірності читання кодів транспондерів запропоновано використовувати конструктив проходу тварин у якості двоконтурної просторової антени, що індуктивно пов'язана з антеною рідера.This is analyzed the influence of technical and biological factors on the performance of radioidentification systems of cattle by using readers with loop antennas. It is found that the reliability of of reading transponders codes largely depends on the distance and interaction orientation of antennas and transponder readers. To improve the reliability of reading the transponder codes is suggested to use the constructive passage of animals as a twodimensional antenna which inductively is connected with the antenna reade

Formation of the informational space as an element of Ukraine’s humanitarian policy in the context of European integration

The article examines conceptual features of information space transformations in postclassical era and its implications for Ukraine within the process of European integration of the country. The key concerns of today's information space in Ukraine in its connection with humanitarian policy are considered. The presence of the phenomenon of paradigm shift in the information space caused by war, and the necessity of changing methods of organizing this space as an element of the humanitarian policy of Ukraine, taking into account national realities and the process of European integration, is noted

ВЗАЄМОЗВ’ЯЗОК ПОКАЗНИКІВ КОМПОНЕНТНОГО СКЛАДУ ТІЛА З ФУНКЦІОНАЛЬНИМ СТАНОМ СЕРЦЕВО-СУДИННОЇ СИСТЕМИ У ЖІНОК МОЛОДОГО ВІКУ ЗАЛЕЖНО ВІД ТИПУ ГЕМОДИНАМІКИ

Nowadays, the measurement of body composition gives us ability to assess the physical condition of the human’s body. Thuswise, we could suppose about the functional abilities of the body. The aim – according to the gender difference in body composition, we presume that it should be different connection between indices of body composition and cardio-vascular system. Material and Methods. The subject of this study were 41 young women aged from 18 to 25. The weight, BMI and the indices of body composition were measured by body-analizator Tanita BC-601. The function of cardiovascular system was measured using medical device ‘REOKOM’. The women were divided into groups according to the criteria of type of the hemodynamic. As a result, 24 women had eykinetic type of the hemodynamic (I group) and 17 women had hypokinetic type of the hemodynamic (II group). Results. Firstly, the results show that there was the significant correlation between indices of visceral fat and cardiac output (CO). Secondly, the indices of fat mass (FM) and fat-free mass (FFM) had the significant correlation with the CO in the second group. Conclusions. The findings of this study suggest that in comparison with the man’s body, the increased amount of the fat mass in the woman’s body has a greater influence on its metabolic processes. Moreover, it influences on the functional condition of the cardiovascular system. That is why, the woman’s physical activity should be based on the body composition and functional condition of the cardio-vascular system.На сегодняшний день определение компонентного состава тела позволяет нам оценить физичес­кое состояние человека. Таким образом опосредованно можна определить функциональные возможности организма. Цель – определить возможную разную связь между определенными компонентами состава тела и показателями гемодинамики с учетом гендерных различий между компонетным составом тела. Материал и методы. В статье представлено исследование с определением влияния компонентного состава тела на функциональное состояние сердечно-сосудистой системы женщин. В исследовании приняла участие 41 здоровая студентка в возрасте 18–25 лет. Измерение массы тела, ИМТ, показателей содержания общего жира (СОЖ), висцерального жира (СВЖ), содержания безжировой массы (СБМ) проводилось с использованием анализатора состава тела Таnita ВС-601. Функциональное состояние сердечно-сосудистой системы оценивали при помощи грудной реографии с использованием реографического комплекса «РЕОКОМ». Критерием распределения женщин за показателями компонентного состава и сердечно-сосудистой деятельности был тип гемодинамики: 24 девушки имели эукинетический тип гемодинамики (первая группа), 17 – гипокинетический тип (вторая группа). Результаты. В результате проведенной статистической обработки данных между двумя группами была обнаружена корреляционная связь между минутным объемом крови (МОК) и общим периферическим сопротивлением (ОПС) с СВЖ в первой группе. При анализе корреляционных соотношений у женщин с гипокинетическим типом гемодинамики (вторая группа) было выявлено, что МОК имеет умеренную положительную корелляционную связь с СОЖ и отрицательную связь с СБМ. Выводы. Увеличенное содержание жировой ткани в женском организме, в сравнении с мужским, в значительной степени влияет не только на метаболические процессы, но и на функциональное состояние сердечно-сосудистой системы. Следовательно, формирование физической нагрузки у женщин будет зависеть от компонентного состава тела и функциональных возможностей сердечно-сосудистой системы.На сьогоднішній день визначення компонентного складу тіла дозволяє нам оцінити фізичний стан людини. Таким чином опосередковано можна визначити функціональні можливості організму. Мета – визначити можливий різний зв’язок між певними компонентами складу тіла та показниками гемодинаміки з врахуванням гендерних відмінностей між компонетним складом тіла. Матеріал і методи. В статті представлено дослідження з визначення впливу компонентного складу тіла на функціональний стан серцево-судинної системи у жінок. У дослідженні взяла участь 41 студентка віком від 18 до 25 років. Вимірювання маси тіла, ІМТ та показників вмісту загального жиру (ВЗЖ) та вісцерального жиру (ВВЖ), вмісту безжирової маси (ВБМ) проводили з використанням аналізатора складу тіла Tanita BC-601. Функціональний стан серцево-судинної системи (ССС) оцінювали за допомогою грудної реографії з використанням реографічного комплексу «PЕОКОМ». Критерієм поділу жінок за показниками компонентного складу тіла та серцево-судинної діяльності був тип гемодинаміки: 24 жінки мали еукінетичний тип гемодинаміки (І група), 17 – гіпокінетичний тип (ІІ група). Результати. У результаті проведеної статистичної обробки даних було виявлено кореляційний зв’язок між хвилинним об’ємом крові (ХОК) та загальним периферійним опором (ЗПО) з ВВЖ у І групі. При аналізі кореляційних співвідношень у жінок з гіпокінетичним типом гемодинаміки (ІІ група) було виявлено, що ХОК має помірний позитивний кореляційний зв’язок з ВЗЖ, та негативний зв’язок з ВБМ. Висновки. Збільшений вміст жирової тканини в жіночому організмі, порівняно з чоловічим, більшою мірою впливає не тільки на метаболічні процеси, а й на функціональний стан серцево-судинної системи. Таким чином, формування фізичного навантаження в жінок базуватиметься на показниках компонентного складу тіла та функ­ціо­нальних можливостях ССС

Designing an automatic pollen monitoring network for direct usage of observations to reconstruct the concentration fields

We consider several approaches to a design of a regional-to-continent-scale automatic pollen monitoring network in Europe. Practical challenges related to the arrangement of such a network limit the range of possible solutions. A hierarchical network is discussed, highlighting the necessity of a few reference sites that follow an extended observations protocol and have corresponding capabilities. Several theoretically rigorous approaches to a network design have been developed so far. However, before starting the process, a network purpose, a criterion of its performance, and a concept of the data usage should be formalized. For atmospheric composition monitoring, developments follow one of the two concepts: a network for direct representation of concentration fields and a network for model-based data assimilation, inverse problem solution, and forecasting. The current paper demonstrates the first approach, whereas the inverse problems are considered in a follow-up paper. We discuss the approaches for the network design from theoretical and practical standpoints, formulate criteria for the network optimality, and consider practical constraints for an automatic pollen network. An application of the methodology is demonstrated for a prominent example of Germany's pollen monitoring network. The multi-step method includes (i) the network representativeness and (ii) redundancy evaluation followed by (iii) fidelity evaluation and improvement using synthetic data

Digitally‐Enabled, Patient‐Centred Care in Rhinitis and Asthma Multimorbidity: The ARIA‐MASK‐air ® Approach

MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma.info:eu-repo/semantics/publishedVersio

Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air® approach

MASK-air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)