54 research outputs found
ΠΠΏΠ»ΠΈΠ² ΡΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ ΡΠ΄Π½ΠΈΡ Π½Π° ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎ-Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΡ Π² ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΡΠΉ Π·Π°Π»ΠΎΠ·Ρ ΡΠ° ΠΏΠ΅ΡΡΠ½ΡΡ ΡΡΡΡΠ²
Topicality. The succinate derivatives are widely used as a basis for the metabolite type drugs development whichΒ possess various pharmacological effects. The start of drugs production and their medical use depends directly on theirΒ safety for health. The xenobiotic safety assessment involves the identification of such changes that may be associatedΒ with mechanisms of adaptation or damage in organs and systems of the organism.Aim. To determine the nature of succinate derivativesβ impact on the indices of the lipid peroxidation and antioxidantΒ system in pancreas and liver of rats.Materials and methods. The succinate derivatives were administered to rats orally 30-fold. The biological materialΒ studied were the homogenate of pancreas and liver. We determined the content of the dienic conjugates, lipid hydroperoxidesΒ and thiobarbituric acid reactive substances. We also verified the activeness of catalase, superoxide dismutase,Β glutathione peroxidase and glutathione S-transferasees.Results and discussion. We found the influence of succinate derivatives in sub-toxic doses characterized by increasedΒ intensity of the lipid peroxidation in the pancreas interconnected with the changes in the activity of these reactions in the liver.Β These effects were determined due to the antioxidant enzymes activity decrease. The compoundsβ impact differed in the degreeof disorders in the oxidative-antioxidant organs homeostasis . We have registered that the influence of relatively lowΒ doses of the succinate derivatives caused less severe and multidirectional changes in the lipid peroxidation indices andΒ signs of the enhanced the antioxidant protection in the studied organs.Conclusions. The succinate derivatives course changes in the activity of the free radical oxidation and antioxidantsystem in pancreas and liver thus can affect the state of the metabolic processes in organism.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ ΡΠΈΡΠΎΠΊΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΡΡ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½Π° ΠΈΡ
ΠΎΡΠ½ΠΎΠ²Π΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΡΡΠ΅ΠΊΡΠ°ΠΌΠΈ. ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅Β Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ Π½Π°ΠΏΡΡΠΌΡΡ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΈΡ
Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π΄Π»ΡΒ Π·Π΄ΠΎΡΠΎΠ²ΡΡ. ΠΡΠ΅Π½ΠΊΠ° Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² ΠΏΡΠ΅Π΄ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡΒ Π²Π»ΠΈΡΡΡ Π½Π° ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΈΠ»ΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β Π²ΡΡΡΠ½ΠΈΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΠΊΡΠΈΠ½Π°Ρ- ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π»ΠΈΠΏΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠΈ ΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Π΅ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΊΡΡΡΠ°ΠΌ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ 30-ΠΊΡΠ°ΡΠ½ΠΎ. ΠΠΈΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌΒ ΡΠ»ΡΠΆΠΈΠ»ΠΈ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π°Ρ ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π΄ΠΈΠ΅Π½ΠΎΠ²ΡΡ
ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ², Π³ΠΈΠ΄ΡΠΎΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ΅ΠΉ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠ΅Π°Π³ΠΈΡΡΡΡΠΈΡ
Ρ ΡΠΈΠΎΠ±Π°ΡΠ±ΠΈΡΡΡΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ°ΡΠ°Π»Π°Π·Ρ,Β ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ, Π³Π»ΡΡΠ°ΡΠΈΠΎΠ½ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·Ρ ΠΈ Π³Π»ΡΡΠ°ΡΠΈΠΎΠ½-S-ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π² ΡΡΠ±ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄ΠΎΠ·Π°Ρ
Β Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π² ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Π΅, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ. Π’Π°ΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΡ
ΡΠ½Π·ΠΈΠΌΠΎΠ². ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ ΠΏΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° ΠΎΡΠ³Π°Π½ΠΎΠ². Π ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΌΠ°Π»ΡΡ
Π΄ΠΎΠ·Π°Ρ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ΡΠΌΠ΅Π½Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅, ΡΠ°Π·Π½ΠΎΠ½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈΒ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ ΠΎΡΠ³Π°Π½ΠΎΠ².ΠΡΠ²ΠΎΠ΄Ρ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠ΅ Π²ΡΠ·ΡΠ²Π°ΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡΒ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Π΅ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ, ΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΠΌΠΎΠ³ΡΡ Π²Π»ΠΈΡΡΡ Π½Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅.ΠΠΊΡΡΠ°Π»ΡΠ½ΡΡΡΡ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ
ΡΠ΄Π½Ρ ΡΠΈΡΠΎΠΊΠΎ Π·Π°ΡΡΠΎΡΠΎΠ²ΡΡΡΡΡΡ Π΄Π»Ρ ΡΠΎΠ·ΡΠΎΠ±ΠΊΠΈ Π½Π° ΡΡ
ΠΎΡΠ½ΠΎΠ²Ρ Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΡ Π΄ΡΡ Π· ΡΡΠ·Π½ΠΎΠΌΠ°Π½ΡΡΠ½ΠΈΠΌΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΠΌΠΈ Π΅ΡΠ΅ΠΊΡΠ°ΠΌΠΈ. ΠΠΏΡΠΎΠ²Π°Π΄ΠΆΠ΅Π½Π½Ρ Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ² Ρ Π²ΠΈΡΠΎΠ±Π½ΠΈΡΡΠ²ΠΎ ΡΠ° ΠΌΠ΅Π΄ΠΈΡΠ½Ρ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ Π½Π°ΠΏΡΡΠΌΡ Π·Π°Π»Π΅ΠΆΠΈΡΡ Π²ΡΠ΄ ΡΡ
Π±Π΅Π·ΠΏΠ΅ΡΠ½ΠΎΡΡΡ Π΄Π»Ρ Π·Π΄ΠΎΡΠΎΠ²βΡ. ΠΡΡΠ½ΠΊΠ° Π±Π΅Π·ΠΏΠ΅ΡΠ½ΠΎΡΡΡ ΠΊΡΠ΅Π½ΠΎΠ±ΡΠΎΡΠΈΠΊΡΠ² ΠΏΠ΅ΡΠ΅Π΄Π±Π°ΡΠ°Ρ Π²ΠΈΡΠ²Π»Π΅Π½Π½Ρ ΡΠ°ΠΊΠΈΡ
Π·ΠΌΡΠ½, ΡΠΊΡ ΠΌΠΎΠΆΡΡΡ Π²ΠΏΠ»ΠΈΠ²Π°ΡΠΈ Π½Π° ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΈ Π°Π΄Π°ΠΏΡΠ°ΡΡΡ Π°Π±ΠΎ ΠΏΠΎΡΠΊΠΎΠ΄ΠΆΠ΅Π½Π½Ρ ΠΎΡΠ³Π°Π½ΡΠ²Β ΡΠ° ΡΠΈΡΡΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΡΠ·ΠΌΡ.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ β Π·βΡΡΡΠ²Π°ΡΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
Π½Π° ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠΈ Π»ΡΠΏΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΡΡ ΡΠ° Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ Ρ ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΡΠΉ Π·Π°Π»ΠΎΠ·Ρ ΡΠ° ΠΏΠ΅ΡΡΠ½ΡΡ ΡΡΡΡΠ².ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ
ΡΠ΄Π½Ρ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΡΡΠ°ΠΌ ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎ 30-ΡΠ°Π·ΠΎΠ²ΠΎ. ΠΡΠΎΠΌΠ°ΡΠ΅ΡΡΠ°Π»ΠΎΠΌ ΡΠ»ΡΠΆΠΈΠ»ΠΈΒ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π°Ρ ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΠΎΡ Π·Π°Π»ΠΎΠ·ΠΈ ΡΠ° ΠΏΠ΅ΡΡΠ½ΠΊΠΈ. ΠΠΈΠ·Π½Π°ΡΠ°Π»ΠΈ Π²ΠΌΡΡΡ Π΄ΡΡΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΎΠ½βΡΠ³Π°ΡΡΠ², Π³ΡΠ΄ΡΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄ΡΠ² Π»ΡΠΏΡΠ΄ΡΠ², Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ, ΡΠΊΡ ΡΠ΅Π°Π³ΡΡΡΡ Π· ΡΡΠΎΠ±Π°ΡΠ±ΡΡΡΡΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ, Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·ΠΈ, ΠΊΠ°ΡΠ°Π»Π°Π·ΠΈ, Π³Π»ΡΡΠ°ΡΡΠΎΠ½-Β ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·ΠΈ ΡΠ° Π³Π»ΡΡΠ°ΡΡΠΎΠ½-S-ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ Π²ΠΏΠ»ΠΈΠ² ΡΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
Π² ΡΡΠ±ΡΠΎΠΊΡΠΈΡΠ½ΠΈΡ
Π΄ΠΎΠ·Π°Ρ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡΡ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½ΡΠΌ ΡΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π»ΡΠΏΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΡΡ Ρ ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΡΠΉ Π·Π°Π»ΠΎΠ·Ρ, ΡΠΎ Π²Π·Π°ΡΠΌΠΎΠΏΠΎΠ²βΡΠ·Π°Π½ΠΎ Π·Ρ Π·ΠΌΡΠ½Π°ΠΌΠΈΒ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΡ
ΡΠ΅Π°ΠΊΡΡΠΉ Ρ ΠΏΠ΅ΡΡΠ½ΡΡ ΡΡΡΡΠ². Π’Π°ΠΊΡ Π΅ΡΠ΅ΠΊΡΠΈ ΠΎΠ±ΡΠΌΠΎΠ²Π»Π΅Π½Ρ Π·Π½ΠΈΠΆΠ΅Π½Π½ΡΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΡ
Π΅Π½Π·ΠΈΠΌΡΠ². ΠΡΡ ΡΠΏΠΎΠ»ΡΠΊ Π²ΡΠ΄ΡΡΠ·Π½ΡΡΡΡΡΡ Π·Π° ΡΡΡΠΏΠ΅Π½Π΅ΠΌ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ ΠΎΠΊΠΈΡΠ½ΠΎ-Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Ρ ΠΎΡΠ³Π°Π½ΡΠ². Π£ Π²ΡΠ΄Π½ΠΎΡΠ½ΠΎΠΌΠ°Π»ΠΈΡ
Π΄ΠΎΠ·Π°Ρ
ΡΠΏΠΎΠ»ΡΠΊ Π·Π°ΡΠ΅ΡΡΡΡΠΎΠ²Π°Π½Ρ ΠΌΠ΅Π½Ρ Π²ΠΈΡΠ°ΠΆΠ΅Π½Ρ, ΡΡΠ·Π½ΠΎΡΠΏΡΡΠΌΠΎΠ²Π°Π½Ρ Π·ΠΌΡΠ½ΠΈ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΡΠ² Π»ΡΠΏΠΎΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°ΡΡΡ ΡΠ° ΠΎΠ·Π½Π°ΠΊΠΈ ΠΏΠΎΠΊΡΠ°ΡΠ΅Π½Π½Ρ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
ΠΈΡΡΡ ΠΎΡΠ³Π°Π½ΡΠ².ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π‘ΡΠΊΡΠΈΠ½Π°Ρ-ΠΏΠΎΡ
ΡΠ΄Π½Ρ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΡΡ Π·ΠΌΡΠ½ΠΈ ΡΡΠ°Π½Ρ Π²ΡΠ»ΡΠ½ΠΎ-ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ ΡΠ° Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΡΡΠΈΡΡΠ΅ΠΌΠΈ Ρ ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΡΠΉ Π·Π°Π»ΠΎΠ·Ρ ΡΠ° ΠΏΠ΅ΡΡΠ½ΡΡ, ΡΠΎ ΠΌΠΎΠΆΠ΅ Π²ΠΏΠ»ΠΈΠ²Π°ΡΠΈ Π½Π° ΠΏΠ΅ΡΠ΅Π±ΡΠ³ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΡΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² Π² ΠΎΡΠ³Π°Π½ΡΠ·ΠΌΡ
Experimental research of cerebroprotective activity of the new 4-aminobutatanoic acid derivative
The aim. To study the cerebroprotective activity of a new derivative of 4-aminobutanoic acid the compound KGM-5 on the effect on survival and behavioural responses, cognitive impairment and neurological deficits in rats with acute cerebrovascular accident.
Materials and methods. Acute cerebrovascular accident (ACVA) was simulated in rats by irreversible unilateral carotid occlusion (UCO) under anesthesia with sodium thiopental (35 mg/kg, intraperitoneally, IP). Five groups of animals were used: intact control (IC, n=6), a group of animals with ACVA, which were not treated (control pathology, CP, n=13); group of animals with ACVA, which were treated for 5 days after surgery (first injection 30 min before surgery) with the compound KGM-5 (ACVA+KGM-5, n=14) at a conditionally effective dose of 30 mg/kg body weight of animals, a group of animals with ACVA (ACVA+CD βPicamilonβ, n=13), who received IP for 5 days, the comparison drug (CD) βPicamilonβ at a dose of 17 mg/kg and pseudo-operated animals (POA), n=8), which were operated without ligation of the carotid artery, which allows to level the effect of anesthesia and surgery on the studied indicators. The cerebroprotective effect of the studied agents was assessed by an integral criterion β survival of animals (throughout the experiment), indicators of neurological deficit (24, 48, 72, 94 hours after ACVA modelling), the state of cognitive functions in the test of extrapolation escape test (EET) (72 hours after ACVA modelling)
Results. The KGM-5 compound contributed to a significant reduction in the severity of neurological deficit, as evidenced by significant differences in this indicator compared with CP, respectively, the first (0.5 points vs. 1.25 points, p<0.05), the third (0.0 points against 1.0 point, p<0.05) and the fourth day (0.0 points vs. 0.5 points, p<0.05) after OCO. Under the influence of CD βPicamilonβ reduction of neurological deficit compared with CP was observed on the first, third and fourth days, but these differences were insignificant (p>0.05). Both studied agents - the compound KGM-5 and CD βPicamilonβ contributed to the improvement of cognitive functions of rats with ACVA, as evidenced by a significant reduction (p<0.05) of the latent period of diving in the EET, respectively, 1.8 and 1.7 times compared with CP and did not show a significant effect on animal survival.
Conclusion. The cerebroprotective activity of a new 4-aminobutanoic acid derivative in the conditions of acute cerebrovascular accident in rats was established in terms of the ability to reduce the severity of neurological deficits and improve cognitive functions in the extrapolation escape test. The severity of cerebroprotective activity of the new compound is not inferior to GABA-ergic drug βPicamilonβ
Π‘ΠΎΡ ΡΠ°Π½Π΅Π½ΠΈΠ΅ Π½Π°ΡΠ»Π΅Π΄ΠΈΡ Π°ΡΡ ΠΈΡΠ΅ΠΊΡΡΡΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π―ΠΏΠΎΠ½ΠΈΠΈ
The main focus of the article is on the problem of the modern attitude to the remaining legacy of Metabolism in Japan. In the course of the research rare cases of renovation of architecture in Japan were revealed. In order to determine the historical value of modern architecture in Japan, a system βlanguage-tradition-spaceβ which links with the Japanese culture, was used. The full-scale survey of one of the Tokyo districts was also carried out to prove the certain connection between the value of space and time in modern Japanese culture.ΠΠ²ΡΠΎΡ ΡΠΎΡΡΠ΅Π΄ΠΎΡΠ°ΡΠΈΠ²Π°Π΅Ρ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΡΠΎΡ
ΡΠ°Π½ΠΈΠ²ΡΠ΅ΠΌΡΡΡ Π½Π°ΡΠ»Π΅Π΄ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π² Π―ΠΏΠΎΠ½ΠΈΠΈ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π΄ΠΊΠΈΠ΅ ΡΠ»ΡΡΠ°ΠΈ ΡΠ΅Π½ΠΎΠ²Π°ΡΠΈΠΈ Π°ΡΡ
ΠΈΡΠ΅ΠΊΡΡΡΡ ΡΡΠΎΠ³ΠΎ ΡΠ²ΠΎΡΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ. ΠΠ»Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π½Π½ΠΎΡΡΠΈ Π°ΡΡ
ΠΈΡΠ΅ΠΊΡΡΡΠ½ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² Π² Π―ΠΏΠΎΠ½ΠΈΠΈ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏ Β«ΡΠ·ΡΠΊ β ΡΡΠ°Π΄ΠΈΡΠΈΡ β ΠΌΠ΅ΡΡΠΎΒ». ΠΠ»Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΈ Π½Π΅ΡΠ°Π·ΡΡΠ²Π½ΠΎΡΡΠΈ ΡΠ²ΡΠ·ΠΈ ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΡΠ° ΠΈ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠΏΠΎΠ½ΡΠΊΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π½Π°ΡΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π°Π²ΡΠΎΡΠΎΠΌ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΡΠ°ΠΉΠΎΠ½ΠΎΠ² Π’ΠΎΠΊΠΈΠΎ β ΠΠΈΠ½Π΄Π·Π°
The rationale for the development of new drinking yoghurt based on the technology of fermented milk drink functional purpose
The aim of this work is to study and develop new varieties of drinking yogurt based on the technology of fermented milk drinks with added wild plant ingredients. In this case the wild plant βactinidia kolomiktaβ (A. kolomikta) which grows in the southern Far East of Russia was used. Research on the product range and consumer preferences in retail networks was conducted in the cities of Khabarovsk and Vladivostok allowing to justify the introduction of the new yogurts. The study shows that among the available yogurts only one fifth is produced in the far East and more than half of the yogurts are produced in the Central part of Russia. Although, yogurt from local raw materials was found in isolated cases, there was no yogurt preparation that uses wild plants. A vast majority of the respondents were interested in and were willing to buy enriched yogurt with functional food ingredients such as those present in fermented milk products prepared with traditional technologies which are used for the preparation of the yogurt of our study. The paper also presents the formulation and technological scheme of the new drink, their physicochemical and organoleptic characteris-tics, and safety performance. The new drinkable yogurt that contains the βactinidia kolomik-taβ fruit complies with the properties of functional food. This type of yogurts are eligible as functional food because they meet the requirements of the operating normative documenta-tion (GOST R 52409-2005) and are probiotic. The functional ingredients providing these properties to the yogurt are the vitamin and mineral components. The study concludes that is viable to obtain high-quality drinking yogurt with functional purposes using the Far Eastern herbal raw ingredient βactinidia kolomiktaβ
Nasal Chemosensory-Stimulation Evoked Activity Patterns in the Rat Trigeminal Ganglion Visualized by In Vivo Voltage-Sensitive Dye Imaging
Mammalian nasal chemosensation is predominantly mediated by two independent neuronal pathways, the olfactory and the trigeminal system. Within the early olfactory system, spatiotemporal responses of the olfactory bulb to various odorants have been mapped in great detail. In contrast, far less is known about the representation of volatile chemical stimuli at an early stage in the trigeminal system, the trigeminal ganglion (TG), which contains neurons directly projecting to the nasal cavity. We have established an in vivo preparation that allows high-resolution imaging of neuronal population activity from a large region of the rat TG using voltage-sensitive dyes (VSDs). Application of different chemical stimuli to the nasal cavity elicited distinct, stimulus-category specific, spatiotemporal activation patterns that comprised activated as well as suppressed areas. Thus, our results provide the first direct insights into the spatial representation of nasal chemosensory information within the trigeminal ganglion imaged at high temporal resolution
St.Petersburg Escape Experience Tour
The growing popularity of Russia as a tourist destination and the high interest towards escape rooms and quests opens new business opportunities and market niches. The aim of this thesis is to develop a tourist product based on the new escape room tourism concept combining the historical, cultural and game experiences. The choice of the theme and destination was determined by the authorsβ personal backgrounds and the destination proximity to Finland.
The theoretical research was implemented with the use of several tools, such as Porterβs Five Forces Model, SWOT-analysis, User Persona, BonBus analysis, Product Design Canvas, Value Proposition Design, Customer Journey Map, online survey and 5-step marketing strategy. The practical part provides the authors finding and application of the chosen methods to St. Petersburg Escape Experience Tour development. The selection of these particular theories results in understanding of the current market situation, defining the main target customer groups and sets a framework for the product development. The project plan chapter presents the timeline for the development process and describes the steps the authors took and will take from ideation to the product launch.
The details of the developed product are presented in Appendix 1 and include environmental analysis, customer target group defining, itinerary choices and combination and market entry strategies. The product development was supported by the authors experience gained from testing the itinerary elements during the self-performed study trip to the selected destination.
The actual work is aimed at providing a sustainable basis for the possible future launch of a new authentic and multidimensional tourism experience product, based on the existing demand and satisfying the customersβ need for a new type of adventure tour to St. Petersburg
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