23 research outputs found
Economic feasibility of hay enriched extruded production as a complete diet for equine
The present study aimed to evaluate the economic feasibility of production and commercialization project of Hay Enriched Extruded (HEE) as a complete diet for horses. The study was based on survey data and quotation activities involving price from the land preparation (repair, planting and fertilization) to the processing of the product at the factory (extrusion) and marketing. Transportation costs and taxes were also considered. Discounted Cash Flow (30 years) was used to calculate the profitability indicator and the Profit and Loss Statement (PLS). Calculations were developed using Microsoft Office ExcelÂź spreadsheets. Three production scenarios were simulated with different consumer prices: Scenario 1 - equivalent to the complete diet, where the ingredients are supplied together, but purchased separately; Scenario 2 - Considering a value 10% higher than the complete diet; Scenario 3 - Considering a value 20% higher than the complete diet. We observed that the project was economically viable in the three suggested scenarios with positive Net Present Value, Internal Rate of Return greater than 9.4% and payback of 11 to 2 years. The results enable us to conclude that the product may be a promising investment for both product quality and ease of use as the rapid return on invested capital.O presente estudo objetivou avaliar a viabilidade econĂŽmica de um projeto de produção e comercialização do Feno Enriquecido Extrusado (FEE) como dieta completa para equinos. O estudo baseou-se em levantamento de dados e cotação de preços de atividades que envolvem desde o preparo da terra (correção, plantio e adubação) atĂ© o beneficiamento do produto na fĂĄbrica (extrusĂŁo) e comercialização. Foram considerados tambĂ©m os custos com transporte e tributaçÔes. Para o cĂĄlculo dos indicadores de rentabilidade utilizou-se o mĂ©todo do Fluxo de Caixa Descontado (perĂodo de 30 anos) e da Demonstração de Resultados do ExercĂcio (DRE). Os cĂĄlculos foram desenvolvidos utilizando planilhas eletrĂŽnicas do pacote Microsoft Office ExcelÂź. Foram simulados trĂȘs cenĂĄrios de produção com diferentes preços ao consumidor: CenĂĄrio 1) equivalente Ă dieta completa, onde os ingredientes sĂŁo fornecidos em conjunto, mas adquiridos separadamente; CenĂĄrio 2) considerando um valor 10% maior que o da dieta completa; CenĂĄrio 3) considerando um valor 20% maior que o da dieta completa. PĂŽde-se observar que o projeto foi viĂĄvel economicamente nos trĂȘs cenĂĄrios sugeridos com Valor Presente LĂquido (VPL) positivo, Taxa Interna de Retorno (TIR) maior que 9,4% aa e payback de 11 a 2 anos. A produção de FEE pode ser um investimento promissor tanto pela qualidade do produto e facilidade de uso quanto pelo rĂĄpido retorno do capital investido
Economic feasibility of hay enriched extruded production as a complete diet for equine
The present study aimed to evaluate the economic feasibility of production and commercialization project of Hay Enriched Extruded (HEE) as a complete diet for horses. The study was based on survey data and quotation activities involving price from the land preparation (repair, planting and fertilization) to the processing of the product at the factory (extrusion) and marketing. Transportation costs and taxes were also considered. Discounted Cash Flow (30 years) was used to calculate the profitability indicator and the Profit and Loss Statement (PLS). Calculations were developed using Microsoft Office ExcelÂź spreadsheets. Three production scenarios were simulated with different consumer prices: Scenario 1 - equivalent to the complete diet, where the ingredients are supplied together, but purchased separately; Scenario 2 - Considering a value 10% higher than the complete diet; Scenario 3 - Considering a value 20% higher than the complete diet. We observed that the project was economically viable in the three suggested scenarios with positive Net Present Value, Internal Rate of Return greater than 9.4% and payback of 11 to 2 years. The results enable us to conclude that the product may be a promising investment for both product quality and ease of use as the rapid return on invested capital
PrevalĂȘncia de Candida spp. em biofilme dentĂĄrio de usuĂĄrios de aparelhos ortodĂŽnticos fixos
OBJECTIVES: This study aims to evaluate the prevalence of Candida spp. in dental plaque of users of fixed orthodontic appliances (FOA) and relate to their habits and characteristics. MATERIALS AND METHODS: We isolated and identified strains of Candida in saliva samples from individuals using FOA with the presence of microbial biofilm and individuals without the presence of biofilm (control group) in the laboratory cultivation. RESULTS: We analyzed 108 samples from individuals with biofilm and 51 individuals in the control group. Of the 108 samples analyzed, 52 (48.1%) were negative for Candida and 56 (55.2%) were positive, with eight patients were isolated two species of Candida, four patients with C. albicans and C. krusei, with one C. albicans and C. tropicalis, with one C. albicans and C. glabrata, with one C. tropicalis and C. glabrata and with one C. tropicalis and C. krusei. In the control group 33.3% had isolated Candida, even showing no biofilm. CONCLUSION: Were detected and pathogenic Candida species intrinsically resistant to conventional antifungal agents, emphasizing the importance of mycological diagnosis for appropriate treatment of infections caused by this group of fungi present in the oral cavity of individuals.OBJETIVOS: O presente estudo tem como objetivo avaliar a prevalĂȘncia de Candida spp. em biofilme dentĂĄrio de usuĂĄrios de aparelhos ortodĂŽnticos fixos (AOF) e relacionar com seus hĂĄbitos e caracterĂsticas. MATERIAIS E MĂTODOS: Foram isolados e identificados cepas de Candida em amostras de saliva em indivĂduos usuĂĄrios de AOF com presença de biofilme microbiano e indivĂduos usuĂĄrios de AOF mas sem presença de biofilme (grupo controle), a partir do cultivo em laboratĂłrio. RESULTADOS: Neste estudo foram analisadas 108 amostras de indivĂduos com biofilme, e 51 indivĂduos no grupo controle. Das 108 amostras analisadas, 52 (48,1%) foram negativas para o gĂȘnero Candida e 56 (55,2%) foram positivas, sendo que em oito pacientes foram isolados duas espĂ©cies de Candida, quatro pacientes com C. albicans e C. krusei, um com C. albicans e C. tropicalis, um com C. albicans e C. glabrata, um com C. tropicalis e C. glabrata e um com C. tropicalis e C. krusei. No grupo controle 33,3% apresentaram isolamento de Candida, mesmo nĂŁo apresentando biofilme. CONCLUSĂO: Foram detectadas espĂ©cies de Candida patogĂȘnicas e intrinsicamente resistentes aos convencionais antifĂșngicos, ressaltando a importĂąncia do diagnĂłstico micolĂłgico para um tratamento adequado das infecçÔes causadas por este grupo de fungos presentes na cavidade oral dos indivĂduos.
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Prevalence of candida spp. in the dental biofilm of fixed orthodontic appliances users
Objetivos: O presente estudo tem como objetivo avaliar a prevalĂȘncia de Candida spp. em biofilme dentĂĄrio de usuĂĄrios de aparelhos ortodĂŽnticos fixos (AOF) e relacionar com seus hĂĄbitos e caracterĂsticas. Materiais e mĂ©todos: Foram isolados e identificados cepas de Candida em amostras de saliva em indivĂduos usuĂĄrios de AOF com presença de biofilme microbiano e indivĂduos usuĂĄrios de AOF mas sem presença de biofilme (grupo controle), a partir do cultivo em laboratĂłrio. Resultados: Neste estudo foram analisadas 108 amostras de indivĂduos com biofilme, e 51 indivĂduos no grupo controle. Das 108 amostras analisadas, 52 (48,1%) foram negativas para o gĂȘnero Candida e 56 (55,2%) foram positivas, sendo que em oito pacientes foram isolados duas espĂ©cies de Candida, quatro pacientes com C. albicans e C. krusei, um com C. albicans e C. tropicalis, um com C. albicans e C. glabrata, um com C. tropicalis e C. glabrata e um com C. tropicalis e C. krusei. No grupo controle 33,3% apresentaram isolamento de Candida, mesmo nĂŁo apresentando biofilme. ConclusĂŁo: Foram detectadas espĂ©cies de Candida patogĂȘnicas e intrinsicamente resistentes aos convencionais antifĂșngicos, ressaltando a importĂąncia do diagnĂłstico micolĂłgico para um tratamento adequado das infecçÔes causadas por este grupo de fungos presentes na cavidade oral dos indivĂduos.Objectives: This study aims to evaluate the prevalence of Candida spp. in dental plaque of users of fixed orthodontic appliances (FOA) and relate to their habits and characteristics. Materials and methods: We isolated and identified strains of Candida in saliva samples from individuals using FOA with the presence of microbial biofilm and individuals without the presence of biofilm (control group) in the laboratory cultivation. Results: We analyzed 108 samples from individuals with biofilm and 51 individuals in the control group. Of the 108 samples analyzed, 52 (48.1%) were negative for Candida and 56 (55.2%) were positive, with eight patients were isolated two species of Candida, four patients with C. albicans and C. krusei, with one C. albicans and C. tropicalis, with one C. albicans and C. glabrata, with one C. tropicalis and C. glabrata and with one C. tropicalis and C. krusei. In the control group 33.3% had isolated Candida, even showing no biofilm. Conclusion: Were detected and pathogenic Candida species intrinsically resistant to conventional antifungal agents, emphasizing the importance of mycological diagnosis for appropriate treatment of infections caused by this group of fungi present in the oral cavity of individuals
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Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos
Transcriptional enhancers are a primary mechanism by which tissue-specific gene expression is achieved. Despite the importance of these regulatory elements in development, responses to environmental stresses, and disease, testing enhancer activity in animals remains tedious, with a minority of enhancers having been characterized. Here, we have developed âenhancer-FACS-Seqâ (eFS) technology for highly parallel identification of active, tissue-specific enhancers in Drosophila embryos. Analysis of enhancers identified by eFS to be active in mesodermal tissues revealed enriched DNA binding site motifs of known and putative, novel mesodermal transcription factors (TFs). NaĂŻve Bayes classifiers using TF binding site motifs accurately predicted mesodermal enhancer activity. Application of eFS to other cell types and organisms should accelerate the cataloging of enhancers and understanding how transcriptional regulation is encoded within them
PARĂMETROS BIOQUĂMICOS E DESEMPENHO DE EQUINOS SUPLEMENTADOS COM COENZIMA Q10
O objetivo foi avaliar os padrĂ”es fisiolĂłgicos e metabĂłlicos de equinos submetidos ao exercĂcio aerĂłbio e suplementados com CoQ10. Foram utilizados dez equinos machos, castrados, da raça Puro Sangue Ărabe, divididos em grupo controle (GC, sem suplementação) e grupo suplementado (GS). Os cavalos foram submetidos a um programa de exercĂcio aerĂłbio por 90 dias. O GS recebeu 10 mL de um produto comercial contendo 8% de CoQ10. Todos os animais foram exercitados cinco dias por semana durante 60 minutos (30 minutos no sentido horĂĄrio, inversĂŁo do sentido, 30 minutos no sentido anti-horĂĄrio) nas velocidades 8, 12 e 15 km/h em exercitador circular mecĂąnico. Foram avaliadas as frequĂȘncias cardĂacas (FC) basal, mĂĄxima, de repouso e mĂ©dia e as atividades das enzimas sĂ©ricas creatina quinase (CK), aspartato aminotransferase (AST), lactato desidrogenase (LDH). As concentraçÔes sanguĂneas de glicose e lactato foram avaliadas de 0 a 15 minutos apĂłs o tĂ©rmino do exercĂcio. As avaliaçÔes foram realizadas nos dias D0 (inĂcio da suplementação e treinamento), D30, D60 e D90. Foi utilizado o delineamento inteiramente casualizado, considerando p < 0,05. NĂŁo foi observado efeito da suplementação nos parĂąmetros FC basal, mĂĄxima e de repouso. A anĂĄlise estatĂstica da FC mĂ©dia acusou menor valor em D30 e D60 para o GS. A suplementação com CoQ10 nĂŁo influenciou na atividade das enzimas AST e LDH e na concentração sanguĂnea de glicose e lactato apĂłs o exercĂcio. PorĂ©m, o GS apresentou menor atividade da enzima CK e, com o passar dos dias, foi observada maior atividade da enzima. Os resultados sugerem um efeito positivo da suplementação com CoQ10 na atividade da enzima CK e na FC mĂ©dia de equinos submetidos a exercĂcio aerĂłbio, o qual pode tornar-se uma estratĂ©gia para o melhorar o desempenho atlĂ©tico de cavalos em provas de resistĂȘncia
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article
DĂ©couverte et analyse dâinactivateurs de transcription chez la Drosophile agissant comme amplificateurs dans diffĂ©rents contextes cellulaires
A major challenge in biology is to understand how complex gene expression patterns in organismal development are encoded in the genome. While transcriptional enhancers have been studied extensively, few transcriptional silencers have been identified and they remain poorly understood. Here we used a novel strategy to screen hundreds of sequences for tissue-specific silencer activity in whole Drosophila embryos. Strikingly, 100% of the tested elements that we found to act as transcriptional silencers were also active enhancers in other cellular contexts. These elements were enriched in highly occupied target (HOT) region overlap (Roy et al., 2010) and specific transcription factor (TF) motif combinations. CRM bifunctionality complicates the understanding of how gene regulation is specified in the genome and how it is read out differently in different cell types. Our results challenge the common practice of treating elements with enhancer activity identified in one cell type as serving exclusively activating roles in the organism and suggest that thousands or more bifunctional CRMs remain to be discovered in Drosophila and perhaps 104-105 in human (Heintzman et al., 2009). Characterization of bifunctional elements should aid in investigations of how precise gene expression patterns are encoded in the genome.Un des enjeux majeurs de la biologie moderne est de comprendre les mĂ©canismes complexes rĂ©gissant lâexpression de gĂšnes dâun organisme en dĂ©veloppement. Alors que les activateurs (enhancers) ont Ă©tĂ© abondamment Ă©tudiĂ©s et analysĂ©s, seul un relatif petit nombre de rĂ©presseurs (silencers) a Ă©tĂ© identifiĂ© Ă ce jour et restent jusquâĂ prĂ©sent assez mal compris. Un nombre non nĂ©gligeable de CRMs jouent par ailleurs un double rĂŽle Ă la fois dâamplificateurs et dâinactivateurs de transcription en fonction de lâĂ©tat ou du type cellulaire dans lequel ils se trouvent, rajoutant un niveau supplĂ©mentaire de Ă la rĂ©gulation gĂ©nique dans diffĂ©rents types cellulaires et tissus. De façon surprenante, nous avons dĂ©couvert que tous les Ă©lĂ©ments ayant une activitĂ© de rĂ©pression transcriptionnelle que nous avons identifiĂ©s, sâavĂšrent aussi avoir une activitĂ© dâactivation transcriptionnelle dans dâautres contextes cellulaires. Nos rĂ©sultats remettent donc en question le paradigme de deux catĂ©gories distinctes de CRMs et suggĂšrent que des milliers, ou plus, dâĂ©lĂ©ments bifonctionnels restent Ă ĂȘtre dĂ©couverts chez la Drosophile et potentiellement 104-105 chez lâhumain. Le rĂ©fĂ©rencement et la caractĂ©risation de ces Ă©lĂ©ments devraient sâavĂ©rer utiles, si ce nâest cruciaux, afin de comprendre la façon par laquelle ces motifs dâexpression sont encodĂ©s au sein des gĂ©nomes d'organismes mĂ©tazoaires et donc Ă©ventuellement chez lâHomme
Discovery and analysis of silencers in Drosophila acting as enhancers in other cellular contexts
Un des enjeux majeurs de la biologie moderne est de comprendre les mĂ©canismes complexes rĂ©gissant lâexpression de gĂšnes dâun organisme en dĂ©veloppement. Alors que les activateurs (enhancers) ont Ă©tĂ© abondamment Ă©tudiĂ©s et analysĂ©s, seul un relatif petit nombre de rĂ©presseurs (silencers) a Ă©tĂ© identifiĂ© Ă ce jour et restent jusquâĂ prĂ©sent assez mal compris. Un nombre non nĂ©gligeable de CRMs jouent par ailleurs un double rĂŽle Ă la fois dâamplificateurs et dâinactivateurs de transcription en fonction de lâĂ©tat ou du type cellulaire dans lequel ils se trouvent, rajoutant un niveau supplĂ©mentaire de Ă la rĂ©gulation gĂ©nique dans diffĂ©rents types cellulaires et tissus. De façon surprenante, nous avons dĂ©couvert que tous les Ă©lĂ©ments ayant une activitĂ© de rĂ©pression transcriptionnelle que nous avons identifiĂ©s, sâavĂšrent aussi avoir une activitĂ© dâactivation transcriptionnelle dans dâautres contextes cellulaires. Nos rĂ©sultats remettent donc en question le paradigme de deux catĂ©gories distinctes de CRMs et suggĂšrent que des milliers, ou plus, dâĂ©lĂ©ments bifonctionnels restent Ă ĂȘtre dĂ©couverts chez la Drosophile et potentiellement 104-105 chez lâhumain. Le rĂ©fĂ©rencement et la caractĂ©risation de ces Ă©lĂ©ments devraient sâavĂ©rer utiles, si ce nâest cruciaux, afin de comprendre la façon par laquelle ces motifs dâexpression sont encodĂ©s au sein des gĂ©nomes d'organismes mĂ©tazoaires et donc Ă©ventuellement chez lâHomme.A major challenge in biology is to understand how complex gene expression patterns in organismal development are encoded in the genome. While transcriptional enhancers have been studied extensively, few transcriptional silencers have been identified and they remain poorly understood. Here we used a novel strategy to screen hundreds of sequences for tissue-specific silencer activity in whole Drosophila embryos. Strikingly, 100% of the tested elements that we found to act as transcriptional silencers were also active enhancers in other cellular contexts. These elements were enriched in highly occupied target (HOT) region overlap (Roy et al., 2010) and specific transcription factor (TF) motif combinations. CRM bifunctionality complicates the understanding of how gene regulation is specified in the genome and how it is read out differently in different cell types. Our results challenge the common practice of treating elements with enhancer activity identified in one cell type as serving exclusively activating roles in the organism and suggest that thousands or more bifunctional CRMs remain to be discovered in Drosophila and perhaps 104-105 in human (Heintzman et al., 2009). Characterization of bifunctional elements should aid in investigations of how precise gene expression patterns are encoded in the genome