Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis

Stefania Paladini - ORCID: 0000-0002-1526-3589 https://orcid.org/0000-0002-1526-3589Evidence This study investigated the relationship between periodontal disease (PD) and Alzheimer’s Disease (AD) through a Systematic Literature Network Analysis (SLNA), combining bibliometric analysis with a Systematic Literature Review (SLR). Analyzing 328 documents from 2000 to 2023, we utilized the Bibliometrix R-package for multiple bibliometric analysis. The SLR primarily centered on the 47 most globally cited papers, highlighting influential research. Our study reveals a positive correlation between Periodontal Disease (PD) and Alzheimer’s Disease (AD), grounded in both biological plausibility and a comprehensive review of the literature, yet the exact causal relationship remains a subject of ongoing scientific investigation. We conducted a detailed analysis of the two main pathways by which PD could contribute to brain inflammation: (a) the Inflammatory Cascade, and (b) Microbial Involvement. The results of our SLNA emphasize the importance of oral health in reducing Alzheimer’s risk, suggesting that managing periodontal health could be an integral part of Alzheimer’s prevention and treatment strategies. The insights from this SLNA pave the way for future research and clinical practices, underscoring the necessity of interdisciplinary methods in both the investigation and treatment of neurodegenerative diseases like Alzheimer’s. Furthermore, our study presents a prospective research roadmap to support ongoing advancement in this field.https://doi.org/10.14283/jpad.2024.79aheadofprintaheadofprin

Towards Supply Chain 5.0: Redesigning Supply Chains as Resilient, Sustainable, and Human-Centric Systems in a Post-pandemic World

From Springer Nature via Jisc Publications RouterHistory: received 2023-03-19, registration 2023-06-08, accepted 2023-06-08, epub 2023-07-29, online 2023-07-29, collection 2023-09Publication status: PublishedStefania Paladini - ORCID: 0000-0002-1526-3589 https://orcid.org/0000-0002-1526-3589The purpose was to investigate the impact of the Industry 5.0 paradigm on the supply chain research field. Our study contributes to the conceptualization of supply chain 5.0, a term that has been receiving increased attention as supply chains adapt to the fifth industrial revolution. We conducted a systematic literature network analysis (SLNA) to examine the research landscape of Industry 5.0 supply chains. We used VOSViewer software and Bibliometrix R-package for multiple bibliometric analyses using 682 documents published between 2016 and 2022. We present a comprehensive framework of supply chain 5.0, including its key concepts, technologies, and trends. Additionally, this research offers a future research agenda to inspire and support further development in this field. We utilized three academic databases for bibliometric analyses: Dimension, Scopus and Lens. Additional databases could provide a wider research landscape and better field representation. We demonstrate how Industry 5.0 enables supply chain evaluation and optimization to assist companies in navigating disruptions without compromising competitiveness and profitability and provide a unique contribution to the field of supply chain 5.0 by exploring promising research areas and guiding the transition to this new paradigm for practitioners and scholars.pubpu

The relationship between periodontal disease and cancer: Insights from a Systematic Literature Network Analysis

Stefania Paladini - ORCID: 0000-0002-1526-3589 https://orcid.org/0000-0002-1526-3589Item is not available in this repository.This paper investigates the relationship between periodontal disease and various cancer types. It provides a comprehensive overview of the existing knowledge about the interaction between periodontal disease and carcinogenesis, explores the underlying biological mechanisms of this connection, and consider the impact of these findings on healthcare practices and future research directions. Utilizing Systematic Literature Network Analysis, which combines bibliometric analysis with Systematic Literature Review, this study analyzes 164 documents from 2000 to 2023. Focus is placed on the 38 most globally cited papers, enabling a targeted and comprehensive analysis of the predominant research within this scope. This review highlights that colorectal, oral, pancreatic, lung, and gastrointestinal cancers have consistent associations with periodontal disease. On the other hand, hematological, breast and prostate cancers show associations with periodontal disease, but these links are less pronounced and more variable, indicating the need for targeted research in these domains. These insights emphasize the necessity for a multidisciplinary healthcare approach, recognizing the systemic implications of periodontal disease. © 2024 Elsevier Ltdhttps://doi.org/10.1016/j.canep.2024.10259591pubpu

Correspondence on "Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase"

Soellner published on the interplay between allosteric and adenosine triphosphate (ATP)-competitive inhibitors of ABL kinase, showing that the latter preferably binds to different conformational states of ABL compared to allosteric agents that specifically target the ABL myristate pocket (STAMP) and deducing that asciminib cannot bind to ABL simultaneously with ATP-competitive drugs. These results are to some extent in line with ours, although our analyses of dose-response matrices from combinations of asciminib with imatinib, nilotinib or dasatinib, show neither synergy nor antagonism, but suggest additive antiproliferative effects on BCR-ABL-dependent KCL22 cells. Furthermore, our X-ray crystallographic, solution nuclear magnetic resonance (NMR), and isothermal titration calorimetry studies show that asciminib can bind ABL concomitantly with type-1 or -2 ATP-competitive inhibitors to form ternary complexes. Concomitant binding of asciminib with imatinib, nilotinib, or dasatinib might translate to benefit some chronic myeloid leukaemia patients

HEALTH INVESTIGATION AND MILK QUALITY EVALUATION IN NATIVE AMIATA DONKEYS (EQUUS ASINUS)

The growing interest toward donkey’s milk as food for children with cow’s milk protein intolerance and for the prevention of obesity and dyslipidemia implies strong hygiene, health and nutritional requirements. Aim of this study was to collect data about donkey health and nutritional, nutraceutical, hygienic and health characteristics of donkey milk. Thirtyone Amiata jennies, a local breed from Tuscany (Central Italy), were examined for body condition score, temperature, heart and respiratory rate. Animals health status was monitored by collecting: milk samples for mastitis agents, faecal samples for parasites, cervical swabs for the detection of reproductive disorders’ bacteria; sera in order to estimate the prevalence of the following infectious agents: Brucella spp., Leptospira spp., Salmonella abortus equi, Equine Arteritis Virus, Equine Herpesvirus I and Toxoplasma gondii; serum and blood samples for biochemical, haematological and immunological analysis. From each jenny were collected milk samples for hygienical and nutritional analysis. Somatic cell count, lysozyme content and activity were investigated. The nutritional milk analysis concerned dry matter, fat, lactose, proteins, caseins, ashes, morphometric analysis of milk fat globules (MFG) and fatty acid profile. Coprological analysis showed prevalence of 96.77% strongyles, 19.35% Dyctiocaulus arnfieldi, 3.22% Oxiuris equi. Staphylococcus aureus was detected in 1 milk sample. The serological investigation showed no significant risks for animal health. Amiata donkey milk showed the following average composition (g/100 mL): 9.38 dry matter, 1.57 protein, 0.40 fat, 7.21 lactose, and 0.36 ash. The unsaturated:saturated fatty acids ratio in milk was close to 1. The donkey MFGs showed an average diameter of 2.05 μm

Impact of Virtual Reality Experience on Accessibility of Cultural Heritage

Accessibility plays a main role among the aspects that contribute to the conservation of Cultural Heritage sites. Seismic stability, fragility of the artefacts, conflicts, deterioration, natural disasters, climate change and visitors’ impact are only some of the possible causes that might lead to the inaccessibility of a heritage site for both researchers and visitors. The increasing potential of Information and Communication Technologies (ICT) in the conservation field has resulted in the development of Augmented and Virtual reality (AR and VR) experiences. These ones can be very effective for what concerns the description of the visual experience, but also improve the understanding of a site and even became analytic research tools. This paper presents an inaccessible Buddhist temple in the Myanmar city of Bagan as a case study for the realization of a VR experience that aims at providing accessibility to knowledge and therefore a better understanding of the cultural value. In order to evaluate the effectiveness of the VR for this purpose, a user study has been conducted and its results are reported.status: Published onlin

Early Respiratory Physiotherapy versus an Individualized Postural Care Program for Reducing Mechanical Ventilation in Preterm Infants: A Randomised Controlled Trial

Background: Tactile stimulation manoeuvres stimulate spontaneous breathing in preterm newborns. The aim of this study is to evaluate the effect of early respiratory physiotherapy on the need for mechanical ventilation during the first week of life in preterm infants with respiratory failure. Methods: This is a monocentric, randomised controlled trial. Preterm infants (gestational age ≤ 30 weeks) not intubated in the delivery room and requiring non-invasive respiratory support at birth were eligible for the study. The intervention group received early respiratory physiotherapy, while the control group received only a daily physiotherapy program (i.e., modifying the infant’s posture in accordance with the patient’s needs). Results: between October 2019 and March 2021, 133 preterm infants were studied, 68 infants in the study group and 65 in routine care. The study group showed a reduction in the need for mechanical ventilation (not statistically significant) and a statistically significant reduction in hemodynamically significant patent ductus arteriosus with respect to the control group (19/68 (28%) vs. 35/65 (54%), respectively, p = 0.03). Conclusions: early respiratory physiotherapy in preterm infants requiring non-invasive respiratory support at birth is safe and has proven to be protective against haemodynamically significant PDA

The B-Star Exoplanet Abundance Study: a co-moving 16–25 M Jup companion to the young binary system HIP 79098

9 pages, 6 figures, accepted for publication in A&AInternational audienceWide low-mass substellar companions are known to be very rare among low-mass stars, but appear to become increasingly common with increasing stellar mass. However, B-type stars, which are the most massive stars within ~150 pc of the Sun, have not yet been examined to the same extent as AFGKM-type stars in that regard. In order to address this issue, we launched the ongoing B-star Exoplanet Abundance Study (BEAST) to examine the frequency and properties of planets, brown dwarfs, and disks around B-type stars in the Scorpius-Centaurus (Sco-Cen) association; we also analyzed archival data of B-type stars in Sco-Cen. During this process, we identified a candidate substellar companion to the B9-type spectroscopic binary HIP 79098 AB, which we refer to as HIP 79098 (AB)b. The candidate had been previously reported in the literature, but was classified as a background contaminant on the basis of its peculiar colors. Here we demonstrate that the colors of HIP 79098 (AB)b are consistent with several recently discovered young and low-mass brown dwarfs, including other companions to stars in Sco-Cen. Furthermore, we show unambiguous common proper motion over a 15-year baseline, robustly identifying HIP 79098 (AB)b as a bona fide substellar circumbinary companion at a 345+/-6 AU projected separation to the B9-type stellar pair. With a model-dependent mass of 16-25 Mjup yielding a mass ratio of <1%, HIP 79098 (AB)b joins a growing number of substellar companions with planet-like mass ratios around massive stars. Our observations underline the importance of common proper motion analysis in the identification of physical companionship, and imply that additional companions could potentially remain hidden in the archives of purely photometric surveys