A dynamic programming approach for evaluating a portfolio of R&D projects with a budget

The Real Options approach has proved to be a suitable methodology for capturing the flexibility in the investment decision process. This is very useful for the financial evaluation of R&D projects where there are several possible decisions concerning to the investment – delaying, improving or abandoning. Since the risk of an R&D project is usually due to singular characteristics of the project and is uncorrelated with the financial markets, the contingent claims analysis may be not adequate to value R&D projects. Based on a dynamic programming evaluation model, presented in Huchzermeier and Loch [1], we propose an approach to valuing a portfolio of R&D projects with a budget. Specifically, considering a budget constraint, we make an extension of the model mentioned above for assessing the projects in the portfolio simultaneously. To test the proposed evaluation procedure, we generated several R&D portfolios with different dimensions and characteristics. According to our computational experience, the main conclusions are presented

Molecular structure and charge density analysis of p-methoxybenzoic acid (anisic acid)

A concerted X-ray and ab initio SCF-MO study of the structure and charge density of p-methoxybenzoic acid (anisic acid) is reported. An extensive X-ray data set (7401 reflections) was measured on a single crystal using Mo Kα radiation and the structure refined with 2121 unique reflections, leading to a final R(F)-factor of 0.047 calculated for reflections with I>2σ. The molecular geometry of crystalline anisic acid, where the molecules dimerize via a moderately strong CO–H⋯O hydrogen bond, is compared with that of the isolated molecule, resulting from SCF-MO ab initio calculations. A topological analysis of the molecular charge density was performed using Bader's method to gain insight into the dominant intra- and intermolecular interactions in this compound. In particular, the effects of the substituents on the observed distortions of the benzene ring were investigated as well as the internal rotation of the methyl group

Magnetostructural correlations in BiFeO3-based multiferroics

This work was supported by funds from FEDER (Programa Operacional Factores de Competitividade COMPETE) and from FCT-Fundaça˜o para a Cieˆncia e a Tecnologia under the project UID/FIS/04564/2016. V. A. K. is grateful to Fundaça˜o para a Cieˆncia e a Tecnologia for financial support through the FCT Investigator Programme (project IF/00819/2014). D. V. K. is grateful to BRFFR (grant F16R-066). Access to the TAIL-UC facility funded under QREN-Mais Centro project ICT_2009_02_012_1890 is gratefully acknowledged

3β-Acet­oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri­azole-1-carboxyl­ate

The title triterpene, C35H53N3O4, is a C-28 carbamate derivative of 3β-acet­oxy­betulin prepared in a one-step reaction from the commercially available 1,1′-carbonyl-di(1,2,4-triazole) (CDT), crystallized from acetone/n-hexane. All rings are trans fused. The carbamate and acetate substituents are in axial and equatorial positions, respectively. A quantum chemical ab initio Roothaan Hartree–Fock calculation of the equilibrium geometry of the isolated mol­ecule gives values for bond lengths and valency angles in close agreement with experimental values. The calculation also reproduces the observed mol­ecular conformation, with puckering parameters that agree well with those determined from the crystallographic study

Spin exchange in elastic e-O_2 collisions

Recent experiments using polarized electron beams have shown that spin exchange effects for elastic collisions with O_2 and NO are much smaller than for Na atoms. We report calculated spin-flip differential cross sections for elastic collisions of polarized electrons with O_2 in agreement with experiment. In general, we can attribute the large variation of the spin-flip differential cross sections to resonances and interference effects. Such features arising from interference, however, may be washed out in the molecular case due to the average over orientations. Calculations with oriented O_2 molecules show strong exchange effects as for Na

Investigar e inovar na educação em ciências para um futuro sustentável

No pico de uma real situação de emergência planetária, a educação torna-se a melhor aliada de uma luta global com vista a um desenvolvimento sustentável. Para concretizar a Década da Educação para um Futuro Sustentável, a investigação em educação em ciências e a correspondente inovação na formação de professores e no ensino, apresentam-se entre os contributos mais fortes, amplos e eficazes. Parte do nosso contributo, que se apresenta neste artigo, tem passado pelo desenvolvimento de alguns estudos situados no quadro teórico que sustenta a educação CTS e assentes em temáticas centrais para a educação para a sustentabilidade ambiental: os transportes e a mobilidade, o uso da água, a fome no mundo, a preservação da biodiversidade. A aposta tem-se dirigido para o ensino nos primeiros anos através do desenho de propostas didácticas validadas por especialistas e em sala de aula e utilizadas quer no ensino quer como ferramentas de formação inicial e contínua de professores

Probing the interference between non-linear, axionic and space-time-anisotropy effects in the QED vacuum

We pursue the investigation of a generic non-linear extension of axionic electrodynamics (ED) in a Carroll-Field-Jackiw (CFJ) scenario that implements Lorentz-symmetry violation (LSV). The model consists of an arbitrary non-linear ED action coupled to the axion field in presence of an anisotropy four-vector that realizes the breaking of Lorentz symmetry under the particle point of view. The non-linear electromagnetic field is expanded around a constant and uniform magnetic background up to second order in the propagating photon field. Our attention is the study of the material properties of the vacuum in the particular case of a space-like CFJ $4$-vector. The dispersion relations associated to the plane wave solutions are explicitly worked out in two situations: the magnetic background perpendicular and parallel to the wave direction. We extend these results to consider the analysis of the birefringence phenomenon in presence of non-linearity, the axion and the LSV manifested through the spatial anisotropy. Three specific proposals of non-linear ED are contemplated: Euler-Heisenberg, Born-Infeld and the Modified Maxwell ED. Throughout the paper, we shall justify why we follow the unusual path of connecting, in a single Lagrangian density, three pieces of physics beyond the Standard Model, namely, non-linearity, axions and LSV. We anticipate that we shall not be claiming that the simultaneous introduction of these three topics beyond the Standard Model will bring new insights or clues for the efforts to detect axions or to constrain parameters associate to both non-linear ED and LSV physics . Our true goal is to actually inspect and describe how axionic, non-linear and LSV effects interfere with one another whenever physical entities like refraction indices and birefringence are computed in presence of an external constant and homogeneous magnetic background.Comment: 27 pages, no figure

The axion-photon mixing in non-linear electrodynamic scenarios

In this contribution, we re-assess some aspects of axionic electrodynamics by coupling non-linear electromagnetic effects to axion physics. We present a number of motivations to justify the coupling of the axion to the photon in terms of a general non-linear extension of the electromagnetic sector. Our emphasis in the paper relies on the investigation of the constitutive permittivity and permeability tensors, for which the axion contributes by introducing dependence on the frequency and wave vector of the propagating radiation. Also, we point out how the axion mass and the axion-photon-photon coupling constant contribute to a dispersive behavior of the electromagnetic waves, in contrast to what happens in the case of non-linear extensions, when effective refractive indices appear which depend only on the direction of the propagation with respect to the external fields. The axion changes this picture by yielding refractive indices with dependence on the wavelength. We apply our results to the special case of the Born-Infeld Electrodynamics and we show that it becomes birefringent whenever the axion is coupled. The paper is supplemented by an Appendix, where we approach the recent discussion on the controversy in defining the Poynting vector of axionic electrodynamics. We present our path to tackle the question and give the expressions we work out for both the Poynting vector and the momentum density transported by the waves.Comment: 30 pages, no figure

Influence of temperature and fat content on ideal sucrose concentration, sweetening power, and sweetness equivalence of different sweeteners in chocolate milk beverage

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOThe introduction of new products catering to specific dietary needs and the corresponding changes in the consumer profile reflect a growing demand for diet and "light" products. However, little information is available regarding the sensory effects of different sweeteners in products consumed at different temperatures and with varying fat contents. In this regard, this study aimed to determine the influence of temperature and fat content on the ideal sucrose concentration and the sweetness equivalence and sweetening power of different sweeteners: Neotame (NutraSweet Corp., Chicago, IL), aspartame, neosucralose, sucralose, and stevia (95% rebaudioside A), with sucrose as reference, in a chocolate milk beverage using a just-about-right (JAR) scale and magnitude estimation. Increasing temperature of consumption had an inverse effect on the ideal sucrose concentration in whole milk beverages, whereas no difference was noted in beverages made skim milk. In addition, a decrease in sweetening power was observed for all of the sweeteners analyzed considering the same conditions. The findings suggest that different optimal conditions exist for consumption of chocolate milk beverage related to sweetness perception, which depends on the fat level of milk used in the formulation. This information can be used by researchers and dairy processors when developing chocolate milk beverage formulations.New products catering to specific dietary needs and the corresponding changes in the consumer profile reflect a growing demand for diet and “light” products. However, little information is available regarding the sensory effects of different sweeteners in products consumed at different temperatures and with varying fat contents. In this regard, this study aimed to determine the influence of temperature and fat content on the ideal sucrose concentration and the sweetness equivalence and sweetening power of different sweeteners: Neotame (NutraSweet Corp., Chicago,IL), aspartame, neosucralose, sucralose, and stevia (95% rebaudioside A), with sucrose as reference, in a chocolate milk beverage using a just-about-right (JAR) scale and magnitude estimation. Increasing temperature of consumption had an inverse effect on the ideal sucrose concentration in whole milk beverages, whereas no difference was noted in beverages made skim milk. In addition, a decrease in sweetening power was observed for all of the sweeteners analyzed considering the same conditions. The findings suggest that different optimal conditions exist for consumption of chocolate milk beverage related to sweetness perception, which depends on the fat level of milk used in the formulation. This information can be used by researchers and dairy processors when developing chocolate milk beverage formulations971273447353CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGIC

Pharmacogenetic: screening relevant polymorphisms on antiretroviral therapy in a HIV Portuguese population

Poster presented at the 15th European AIDS Conference. Barcelona, 21-24 October 2015"Several factors cause heterogeneity of response to antiretroviral therapy. Genetic polymorphisms, particularly in metabolizing enzyme, cytochrome P450 isoenzymes and transport proteins MDR, MRP and SLC, may cause pharmacokinetic variability in some ARVs, leading to viral failure, drug toxicity and may explain the interpatient variability for drug absorption pathways.