Characterization of H+ Excretion in a Model Renal Epithelium

The cellular regulation of acidification and intracellular ph (pHi) was studied in the integument of Rana pipiens, a model renal epithelium. Acidification was enhanced by : (1) chronic metabolic acidosis, (2) high salinity adaptation, and (3) ibuprofen treatment

Incentives, Information, and Emergent Collective Accuracy

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93557/1/mde2560.pd

Positronium scattering by atoms and molecules at low energies

The recent theoretical and experimental activities in positronium (Ps) scattering by atoms and molecules are reviewed with special emphasis at low energies. We critically compare the results of different groups $-$ theoretical and experimental. The theoretical approaches considered include the $R$-matrix and close-coupling methods applied to Ps-H, Ps-He, and Ps-Li scattering, and a coupled-channel approach with a nonlocal model-potential for Ps scattering by H, He, H$_2$, Ne, Ar, Li, Na, K, Rb, Cs, and Ps and for pickoff quenching in Ps-He scattering. Results for scattering lengths, partial, total and differential cross sections as well as resonance and binding energies in different systems are discussed.Comment: 6 revtex pages, 3 postscript figure

Web-Based Simulation: Evolution or Revolution?

ACM Transactions on Modeling and Computer Simulation, Vol. 10, No. 1, January 2000, Pages 3–17

Floundering or Flourishing? Early Insights from the Inception of Integrated Care Systems in England

Background: In 2022, England embarked on an ambitious and innovative re-organisation to produce an integrated health and care system with a greater focus on improving population health. This study aimed to understand how nascent ICSs are developing and to identify the key challenges and enablers to integration. Methods: Four ICSs participated in the study between November 2021 and May 2022. Semi-structured interviews with system leaders (n = 67) from health, social and voluntary care as well as representatives of local communities were held. A thematic framework approach supported by Leutz’s five laws of integration framework was used to analyse the data. Results: The benefits of ICSs include enhancing the delivery of good quality care, improving population health and providing more person-centred care in the community. However, differences between health and social care such as accountability, organisational/professional cultures, risks of duplicating efforts, tensions over funding allocation, issues of data integration and struggles in engaging local communities threaten to hamper integration. Conclusions: Despite ICS’s investing in the structural and relational components of integrated care, the unprecedented pressures on systems to reduce demand on primary and emergency care tackling elective backlogs may detract from a key goal of ICSs, improving population health and prevention

Pulsar timing irregularities and the imprint of magnetic field evolution

(Abridged) The rotational evolution of isolated neutron stars is dominated by the magnetic field anchored to the solid crust of the star. Assuming that the core field evolves on much longer timescales, the crustal field evolves mainly though Ohmic dissipation and the Hall drift, and it may be subject to relatively rapid changes with remarkable effects on the observed timing properties. We investigate whether changes of the magnetic field structure and strength during the star evolution may have observable consequences in the braking index, which is the most sensitive quantity to reflect small variations of the timing properties that are caused by magnetic field rearrangements. By performing axisymmetric, long-term simulations of the magneto-thermal evolution of neutron stars with state-of-the-art microphysical inputs, we find that the effect of the magnetic field evolution on the braking index can be divided into three qualitatively different stages depending on the age and the internal temperature: a first stage that may be different for standard pulsars (with n~3) or low field neutron stars that accreted fallback matter during the supernova explosion (systematically n<3); in a second stage, the evolution is governed by almost pure Ohmic field decay, and a braking index n>3 is expected; in the third stage, at late times, when the interior temperature has dropped to very low values, Hall oscillatory modes in the neutron star crust result in braking indices of high absolute value and both positive and negative signs. Models with strong (1e14 G) multipolar or toroidal components, even with a weak (~1e12 G) dipolar field are consistent with the observed trend of the timing properties.Comment: 7 pages, 5 figures, accepted for publication in Astronomy & Astrophysics (submitted July 24, 2012

A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods

Motivation: The rapid expansion of whole-genome copy number (CN) studies brings a demand for increased precision and resolution of CN estimates. Recent studies have obtained CN estimates from more than one platform for the same set of samples, and it is natural to want to combine the different estimates in order to meet this demand. Estimates from different platforms show different degrees of attenuation of the true CN changes. Similar differences can be observed in CNs from the same platform run in different labs, or in the same lab, with different analytical methods. This is the reason why it is not straightforward to combine CN estimates from different sources (platforms, labs and analysis methods)

The Pine Needle, Fall 1948

Libraries and archives collect materials from different cultures and time periods to preserve and make available the historical record. As a result, materials such as those presented here may reflect sexist, misogynistic, abusive, racist, or discriminatory attitudes or actions that some may find disturbing, harmful, or difficult to view. Both a humor and literary magazine, The Pine Needle was a University of Maine student-produced periodical that began publication in the fall of 1946, the first post-World War II semester that saw GIs returning to campus. The Needle reflected an edginess and rebellion not found in previous UMaine student publications. While past student publications relied on euphemisms for alcohol and dating on campus, The Needle openly promoted the sexualization of co-eds and the use of drugs, tobacco, and alcohol by students who experienced war. Cover art for this issue is by Donald T. Caswell and depicts a man wearing a letterman\u27s sweater chatting up a smiling co-ed wearing a ball cap. In the background, two largely faceless men wearing suits and exhibit hostile posture that communicates jealousy. Don Caswell (1923-2014), was a native of Limestone, Maine and grew up in Brownsville. He joined the U.S. Navy following high school graduation in 1942. He served as a radio operator aboard ships patrolling the Gulf of Alaska throughout the war. Caswell attended the University of Maine on the G.I. Bill, majoring in Art and History. On campus, he was active in the Officer Training Program and was stationed in Tripoli, North Africa as a U.S. Air Force officer during the Korean War. Caswell served as a Lieutenant Colonel in the Air National Guard