Diseño e implementación de un plan de mantenimiento para la empresa Fernandez y Compañia S.A.

En el trabajo se presentara inicialmente algunos conceptos generales que permiten llevar a cabo un diseño del plan de mantenimiento de máquinas industriales para el proceso de manipulación y corte de la madera, con el propósito de lograr la recolección y descentralización de la información de equipos existentes en la organización, que permitan fácil recopilación de datos para el mantenimiento y garantizar la vida útil de la maquinaria entre las diferentes sedes interna y externas de la Empresa Fernández y Compañía S.A. determinando las funciones de producción óptima para la utilización eficiente de los recursos disponibles tecnológicamente para la implementación de un buen servicios al cliente. Lo anotado anteriormente, permite fijar unas pautas para posteriores estudios en nuestro medio, que le garanticen a la empresa optimización del mantenimiento en las diferentes tecnologías en maquinarias que cada día van evolucionando con el fin de mejorar la calidad en la producción, corte y terminado de la madera. Dejando como conclusión y recomendaciones para una buena gestión de mantenimiento que aporten a los planes estratégicos empresariales lo más actualizado posible. Con el fin de que los nuevos proyectos y procesos se puedan incorporar a ellos sin ninguna dificultad.Ingeniero de Telecomunicacionespregrad

Dibenzothiophene adsorption at boron doped carbon nanoribbons studied within density functional theory

"The adsorption of dibenzothiophene (DBT) on bare and boron-doped armchair carbon nanoribbons (ACNRs) is being investigated in the framework of the density functional theory by implementing periodic boundary conditions that include corrections from dispersion interactions. The reactivity of the ACNRs is characterized by using the Fukui functions as well as the electrostatic potential as local descriptors. Non-covalent adsorption mechanism is found when using the local Perdew-Becke-Ernzerhof functional, regardless of the DBT orientation and adsorption location. The dispersion interactions addition is a milestone to describe the adsorption process. The charge defects introduced in small number (i.e., by doping with B atoms), within the ACNRs increases the selectivity towards sulfur mainly due to the charge depletion at B sites. The DBT magnitude in the adsorption energy shows non-covalent interactions. As a consequence, the configurations where the DBT is adsorbed on a BC3 island increase the adsorption energy compared to random B arrangements. The stability of these configurations can be explained satisfactorily in terms of dipole interactions. Nevertheless, from the charge-density difference analysis and the weak Bader charge-distribution interactions cannot be ruled out completely. This is why the electronic properties of the ribbons are analyzed in order to elucidate the key role played by the B and DBT states in the adsorbed configurations.

Development of Taenia pisiformis in golden hamster (Mesocricetus auratus)

The life cycle of Taenia pisiformis includes canines as definitive hosts and rabbits as intermediate hosts. Golden hamster (Mesocricetus auratus) is a rodent that has been successfully used as experimental model of Taenia solium taeniosis. In the present study we describe the course of T. pisiformis infection in experimentally infected golden hamsters. Ten females, treated with methyl-prednisolone acetate were infected with three T. pisiformis cysticerci each one excised from one rabbit. Proglottids released in faeces and adults recovered during necropsy showed that all animals were infected. Eggs obtained from the hamsters' tapeworms, were assessed for viability using trypan blue or propidium iodide stains. Afterwards, some rabbits were inoculated with eggs, necropsy was performed after seven weeks and viable cysticerci were obtained. Our results demonstrate that the experimental model of adult Taenia pisiformis in golden hamster can replace the use of canines in order to study this parasite and to provide eggs and adult tapeworms to be used in different types of experiments

Identifiability of Control-Oriented Glucose-Insulin Linear Models: Review and Analysis

One of the main challenges of glucose control in patients with type 1 diabetes is identifying a control-oriented model that reliably predicts the behavior of glycemia. Here, a review is provided emphasizing the structural identifiability and observability properties, which surprisingly reveals that few of them are globally identifiable and observable at the same time. Thus, a general proposal was developed to encompass four linear models according to suitable assumptions and transformations. After the corresponding structural properties analysis, two minimal model structures are generated, which are globally identifiable and observable. Then, the practical identifiability is analyzed for this application showing that the standard collected data in many cases do not have the necessary quality to ensure a unique solution in the identification process even when a considerable amount of data is collected. The two minimal control-oriented models were identified using a standard identification procedure using data from 30 virtual patients of the UVA/Padova simulator and 77 diabetes care data from adult patients of a diabetes center. The identification was performed in two stages: calibration and validation. In the first stage, the average length was taken as two days (dictated by the practical identifiability). For both structures, the mean absolute error was 16.8 mg/dl and 9.9 mg/dl for virtual patients and 21.6 mg/dl and 21.5 mg/dl for real patients. For the second stage, a one-day validation window was considered long enough for future artificial pancreas applications. The mean absolute error was 23.9 mg/dl and 12.3 mg/dl for virtual patients and 39.2 mg/dl and 36.6 mg/dl for virtual and real patients. These results confirm that linear models can be used as prediction models in model-based control strategies as predictive control.Fil: Hoyos, J. D.. Universidad Nacional de Colombia. Sede Medellín; ColombiaFil: Villa Tamayo, M. F.. Universidad Nacional de Colombia. Sede Medellín; ColombiaFil: Builes Montano, C. E.. Universidad de Antioquia; ColombiaFil: Ramirez Rincon, A.. Universidad Pontificia Bolivariana; ColombiaFil: Godoy, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Garcia Tirado, J.. University of Virginia; Estados UnidosFil: Rivadeneira Paz, Pablo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

An Extracellular Subtilase Switch for Immune Priming in Arabidopsis

In higher eukaryotes, induced resistance associates with acquisition of a priming state of the cells for a more effective activation of innate immunity; however, the nature of the components for mounting this type of immunological memory is not well known. We identified an extracellular subtilase from Arabidopsis, SBT3.3, the overexpression of which enhances innate immune responses while the loss of function compromises them. SBT3.3 expression initiates a durable autoinduction mechanism that promotes chromatin remodeling and activates a salicylic acid(SA)-dependent mechanism of priming of defense genes for amplified response. Moreover, SBT3.3 expression-sensitized plants for enhanced expression of the OXI1 kinase gene and activation of MAP kinases following pathogen attack, providing additional clues for the regulation of immune priming by SBT3.3. Conversely, in sbt3.3 mutant plants pathogen-mediated induction of SA-related defense gene expression is drastically reduced and activation of MAP kinases inhibited. Moreover, chromatin remodeling of defense-related genes normally associated with activation of an immune priming response appear inhibited in sbt3.3 plants, further indicating the importance of the extracellular SBT3.3 subtilase in the establishment of immune priming. Our results also point to an epigenetic control in the regulation of plant immunity, since SBT3.3 is up-regulated and priming activated when epigenetic control is impeded. SBT3.3 represents a new regulator of primed immunity.The Spanish MICINN (BFU2009-09771, EUI2009-04009 to PV) and Generalitat Valenciana (Prometeo2010/020 to PV) provided support for this work. 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The Plant Cell, 18(7), 1750-1765. doi:10.1105/tpc.105.039677Law, J. A., & Jacobsen, S. E. (2009). MOLECULAR BIOLOGY: Dynamic DNA Methylation. Science, 323(5921), 1568-1569. doi:10.1126/science.1172782López, A., Ramírez, V., García-Andrade, J., Flors, V., & Vera, P. (2011). The RNA Silencing Enzyme RNA Polymerase V Is Required for Plant Immunity. PLoS Genetics, 7(12), e1002434. doi:10.1371/journal.pgen.1002434Luna, E., Bruce, T. J. A., Roberts, M. R., Flors, V., & Ton, J. (2011). Next-Generation Systemic Acquired Resistance. Plant Physiology, 158(2), 844-853. doi:10.1104/pp.111.187468Slaughter, A., Daniel, X., Flors, V., Luna, E., Hohn, B., & Mauch-Mani, B. (2011). Descendants of Primed Arabidopsis Plants Exhibit Resistance to Biotic Stress. Plant Physiology, 158(2), 835-843. doi:10.1104/pp.111.191593Gil, M. J., Coego, A., Mauch-Mani, B., Jordá, L., & Vera, P. (2005). The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway. The Plant Journal, 44(1), 155-166. doi:10.1111/j.1365-313x.2005.02517.xJordá, L., & Vera, P. (2000). Local and Systemic Induction of Two Defense-Related Subtilisin-Like Protease Promoters in Transgenic Arabidopsis Plants. Luciferin Induction of PR Gene Expression. Plant Physiology, 124(3), 1049-1058. doi:10.1104/pp.124.3.1049Rautengarten, C., Steinhauser, D., Büssis, D., Stintzi, A., Schaller, A., Kopka, J., & Altmann, T. (2005). Inferring Hypotheses on Functional Relationships of Genes: Analysis of the Arabidopsis thaliana Subtilase Gene Family. PLoS Computational Biology, 1(4), e40. doi:10.1371/journal.pcbi.0010040Jordá, L., Coego, A., Conejero, V., & Vera, P. (1999). A Genomic Cluster Containing Four Differentially Regulated Subtilisin-like Processing Protease Genes Is in Tomato Plants. 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MAP kinase signalling cascade in Arabidopsis innate immunity. Nature, 415(6875), 977-983. doi:10.1038/415977aBethke, G., Unthan, T., Uhrig, J. F., Poschl, Y., Gust, A. A., Scheel, D., & Lee, J. (2009). Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling. Proceedings of the National Academy of Sciences, 106(19), 8067-8072. doi:10.1073/pnas.0810206106Bethke, G., Pecher, P., Eschen-Lippold, L., Tsuda, K., Katagiri, F., Glazebrook, J., … Lee, J. (2012). Activation of the Arabidopsis thaliana Mitogen-Activated Protein Kinase MPK11 by the Flagellin-Derived Elicitor Peptide, flg22. Molecular Plant-Microbe Interactions, 25(4), 471-480. doi:10.1094/mpmi-11-11-0281Rushton, P. J., Somssich, I. E., Ringler, P., & Shen, Q. J. (2010). WRKY transcription factors. Trends in Plant Science, 15(5), 247-258. doi:10.1016/j.tplants.2010.02.006Dong, J., Chen, C., & Chen, Z. (2003). 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A Peroxidase-Dependent Apoplastic Oxidative Burst in Cultured Arabidopsis Cells Functions in MAMP-Elicited Defense. Plant Physiology, 158(4), 2013-2027. doi:10.1104/pp.111.190140OSSOVSKAYA, V. S., & BUNNETT, N. W. (2004). Protease-Activated Receptors: Contribution to Physiology and Disease. Physiological Reviews, 84(2), 579-621. doi:10.1152/physrev.00028.2003Buchon, N., Poidevin, M., Kwon, H.-M., Guillou, A., Sottas, V., Lee, B.-L., & Lemaitre, B. (2009). A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proceedings of the National Academy of Sciences, 106(30), 12442-12447. doi:10.1073/pnas.0901924106Brunn, G. J., Bungum, M. K., Johnson, G. B., & Platt, J. L. (2005). Conditional signaling by Toll-like receptor 4. The FASEB Journal, 19(7), 872-874. doi:10.1096/fj.04-3211fjeDe Zoete, M. R., Bouwman, L. I., Keestra, A. M., & van Putten, J. P. M. (2011). 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Servicio centralizado de proyección de material docente

[ES] En los últimos años las tecnologías TIC se han ido incorporando en los diferentes ámbitos de la enseñanza, desde las pizarras electrónicas para las clases magistrales hasta el uso de tabletas para la visualización de libros docentes en formato electrónico. De hecho, resulta cada vez más frecuente que los docentes empleen sus portátiles para presentar su material en formato de transparencias. No obstante, esto implica que los profesores deben llevar sus portátiles al aula y conectarlos a través de un cable, sea VGA o HDMI, al proyector. Esto resta movilidad al profesor, anclado a través del cable al proyector, además de requerir que disponga de un portátil que ha de llevar al aula. Dado que, en la actualidad, casi la totalidad de la población dispone de móviles inteligentes, este artículo presenta la solución propuesta en un proyecto de innovación docente desarrollado (PID 14-61) en la Universidad de Granada. En éste, se propone una solución en la que el profesor sólo deberá llevar su móvil (o alternativamente una tableta o un portátil) al aula. El material docente será subido a un servidor central desde su despacho, y la visualización en el proyector será controlada a través del móvil usando una interfaz muy amigable y sencillo.El presente trabajo ha sido financiado a traves del Programa de Innovacion y Buenas Prácticas Docentes del Secretariado de Innovacion Docente de la Universidad de Granada, Proyecto de Innovacion Docente 14-61 ”Servicio de Proyeccion de Material Docente”, dentro de la acción 1 (innovacion en la gestión on-line de los procesos de ensenanza-aprendizaje). Parte del presente trabajo ha sido ˜ desarrollado por los alumnos D. Juan Ramon Gutiérrez Martínez, D. Daniel Alvarez González y D. David Gallardo Jimenez, siendo estos dos últimos becarios del citado PID.Navarro Ortiz, J.; Sendra, S.; Ameigeiras, P.; Torre, ADL.; Garcia, L.; Gomez, A.; Lopez-Soler, J.... (2018). Servicio centralizado de proyección de material docente. En XIII Jornadas de Ingeniería telemática (JITEL 2017). Libro de actas. Editorial Universitat Politècnica de València. 330-336. https://doi.org/10.4995/JITEL2017.2017.6508OCS33033

Conference: Reparations in the Inter-American System: A Comparative Approach Conference

This publication will enhance the understanding of what we call the law of reparations, developed in the Inter-American Court and Commission of Human Rights. Reparations have a special meaning for the victims of human rights violations and, in particular, the victims of mass and gross violations that took place in this hemisphere during the twentieth century. For those victims and their family members, reestablishing the rights as if no violation had occurred is not possible. Accordingly, to them, avoiding the repetition of those violations in the future is of paramount importance. In achieving that goal, what the victims want is the investigation and punishment of those who appear guilty as an essential component of the law of compensation. Material and moral damages, symbolic measures of redress, as well as legislative changes when needed are also crucially important. The inter-American system’s supervisory organs, within the limits of their jurisdiction, and in particular through the interpretation of Article 63 of the American Convention, have creatively developed the law of reparations within the Americas. As a result of the decisions from the supervisory organs, what has emerged is perhaps the most comprehensive legal regime on reparations developed in the human rights field in international law. This contains edited versions of speeches delivered at the conference

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

BACKGROUND: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. METHODS AND RESULTS: Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio = 4.60; p-value < 0.001). Besides, the discriminant power of miRNA-MRS was significantly higher than the observed for age and gender (AUROC = 0.970 vs. 0.881; p = 0.042). CONCLUSIONS: SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality

Investigación en matemáticas, economía y ciencias sociales

El resultado de este libro que reune inquietudes académicas en torno a temas tan estudiados como los que están alrededor del maíz, del frijol o del café; y tan contemporáneos como las aplicaciones concretas de las ciencias ya citadas, al estudio de la adopción del comercio electrónico en empresas del sector agroindustrial o, el caso de la generación de biogas o energía eléctrica por medio de biodigestores. Al editar este texto e incorporarlo a la bibliografía de los temas de referencia, se enriquecen opciones de consulta para los estudiosos de esos temas en general; pero también para interesados en aspectos tan específicos como la cadena de suministro del mercado hortofrutícola en Texcoco