Boundaries in the Moyal plane

We study the oscillations of a scalar field on a noncommutative disc implementing the boundary as the limit case of an interaction with an appropriately chosen confining background. The space of quantum fluctuations of the field is finite dimensional and displays the rotational and parity symmetry of the disc. We perform a numerical evaluation of the (finite) Casimir energy and obtain similar results as for the fuzzy sphere and torus.Instituto de Física La Plat

Early Cambrian U-Pb zircon age and Hf-isotope data from the Guasayán pluton, Sierras Pampeanas, Argentina: implications for the northwestern boundary of the Pampean arc

An Early Cambrian pluton, known as the Guasayán pluton, has been identified in the central area of Sierra de Guasayán, northwestern Argentina. A U?Pb zircon Concordia age of 533 ± 4 Ma was obtained by LA-MC-ICP-MS and represents the first report of robustly dated Early Cambrian magmatism for the northwestern Sierras Pampeanas. The pluton was emplaced in low-grade metasedimentary rocks and its magmatic assemblage consists of K-feldspar (phenocrysts) + plagioclase + quartz + biotite, with zircon, apatite, ilmenite, magnetite and monazite as accessory minerals. Geochemically, the granitic rock is a metaluminous subalkaline felsic granodiorite with SiO2 = 69.24%, Na2O+ K2O = 7.08%, CaO = 2.45%, Na2O/ K2O = 0.71 and FeO/MgO = 3.58%. Rare earth element patterns show moderate slope (LaN/YbN = 8.05) with a slightly negative Eu anomalies (Eu/Eu* = 0.76). We report the first in situ Hf isotopes data (εHft = -0.12 to -4.76) from crystallized zircons in the Early Cambrian granites of the Sierras Pampeanas, helping to constrain the magma source and enabling comparison with other Pampean granites. The Guasayán pluton might provide a link between Early Cambrian magmatism of the central Sierras Pampeanas and that of the Eastern Cordillera, contributing to define the western boundary of the Pampean paleo-arc.Fil: Dahlquist, Juan Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Verdecchia, Sebastián Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Baldo, Edgardo Gaspar Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; ArgentinaFil: Basei, Miguel A. S.. Universidade Do Brasilia. Instituto de Geociencias; BrasilFil: Alasino, Pablo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; ArgentinaFil: Uran, Gimena Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; ArgentinaFil: Rapela, Carlos Washington. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: da Costa Campos Neto, Mario. Universidade de Sao Paulo; BrasilFil: Zandomeni, Priscila Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Ciencias de la Tierra. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones en Ciencias de la Tierra; Argentin

Impaired Motion Processing in Schizophrenia and the Attenuated Psychosis Syndrome : Etiological and Clinical Implications

The authors thank Gail Silipo, M.A. for assistance in subject recruitment, Raj Sangoi (RT)(R)(MR) and Caxia Hu, M.S., for assistance in MRI scanning and Isabel and Herb Stusser for their generous support. This research was supported by NIMH grant MH084031 (MJH) DA03383 (DCJ).Peer reviewedPostprin

Optical Photometry of the Type Ia SN 1999ee and the Type Ib/c SN 1999ex in IC 5179

We present UBVRIz lightcurves of the Type Ia SN 1999ee and the Type Ib/c SN 1999ex, both located in the galaxy IC 5179. SN 1999ee has an extremely well sampled lightcurve spanning from 10 days before Bmax through 53 days after peak. Near maximum we find systematic differences ~0.05 mag in photometry measured with two different telescopes, even though the photometry is reduced to the same local standards around the supernova using the specific color terms for each instrumental system. We use models for our bandpasses and spectrophotometry of SN 1999ee to derive magnitude corrections (S-corrections) and remedy this problem. This exercise demonstrates the need of accurately characterizing the instrumental system before great photometric accuracies of Type Ia supernovae can be claimed. It also shows that this effect can have important astrophysical consequences since a small systematic shift of 0.02 mag in the B-V color can introduce a 0.08 mag error in the extinction corrected peak B magnitudes of a supernova and thus lead to biased cosmological parameters. The data for the Type Ib/c SN 1999ex present us with the first ever observed shock breakout of a supernova of this class. These observations show that shock breakout occurred 18 days before Bmax and support the idea that Type Ib/c supernovae are due to core collapse of massive stars rather than thermonuclear disruption of white dwarfs.Comment: 55 pages, 15 figures, accepted by the Astronomical Journa

VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

Background -- The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Results -- Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org. Conclusions -- Because it uses novel mapping algorithms VISMapper is remarkably faster than previous available programs. It also provides a useful graphical interface to analyze the integration sites found in the genomic context

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder

P300 amplitude is insensitive to working memory load in schizophrenia

<p>Abstract</p> <p>Background</p> <p>Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to have an aberrant brain connectivity and impairments in WM capacity. The aim of this study was to determine the dependency of the P300 component on WM load in a sample of SZ subjects.</p> <p>Methods</p> <p>We recorded 26 subjects (13 SZ patients and their matched controls) with an 80-channel electroencephalogram. Subjects performed an N-back task, a WM paradigm that manipulates the number of items to be stored in memory.</p> <p>Results</p> <p>In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the attentional control condition and the high WM load condition. In contrast, SZs evidenced low P300 amplitude in all conditions. A significant between group difference in P300 amplitude was evidenced only at the low WM load condition (1 -back), being smaller in SZs.</p> <p>Conclusions</p> <p>SZ subjects display a lower than normal P300 amplitude, which does not vary as a function of memory load. These results are consistent with a general impairment in WM capacity in these patients.</p

Characterization of the humoral and cellular immunity induced by a recombinant BCG vaccine for the respiratory syncytial virus in healthy adults

IntroductionThe human respiratory syncytial virus (hRSV) is responsible for most respiratory tract infections in infants. Even though currently there are no approved hRSV vaccines for newborns or infants, several candidates are being developed. rBCG-N-hRSV is a vaccine candidate previously shown to be safe in a phase I clinical trial in adults (clinicaltrials.gov identifier #NCT03213405). Here, secondary immunogenicity analyses were performed on these samples.MethodsPBMCs isolated from immunized volunteers were stimulated with hRSV or mycobacterial antigens to evaluate cytokines and cytotoxic T cell-derived molecules and the expansion of memory T cell subsets. Complement C1q binding and IgG subclass composition of serum antibodies were assessed.ResultsCompared to levels detected prior to vaccination, perforin-, granzyme B-, and IFN-γ-producing PBMCs responding to stimulus increased after immunization, along with their effector memory response. N-hRSV- and mycobacterial-specific antibodies from rBCG-N-hRSV-immunized subjects bound C1q.ConclusionImmunization with rBCG-N-hRSV induces cellular and humoral immune responses, supporting that rBCG-N-hRSV is immunogenic and safe in healthy individuals.Clinical trial registrationhttps://classic.clinicaltrials.gov/ct2/show/, identifier NCT03213405

Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

BACKGROUND: The development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVac® is an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. METHODS: This study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged ≥18 years. Volunteers received two doses of CoronaVac® separated by two (0-14 schedule) or four weeks (0-28 schedule). 2,302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. RESULTS: Both schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern between schedules. Stimulation of PBMCs with MPs induced the secretion of IFN-g and the expression of activation induced markers for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-g secretion. CONCLUSIONS: Immunization with CoronaVac® in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule. FUNDING: Ministry of Health, Government of Chile, Confederation of Production and Commerce & Millennium Institute on Immunology and Immunotherapy, Chile. CLINICAL TRIAL NUMBER: NCT04651790

Recensiones [Revista de Historia Económica Año VIII Otoño 1990 n. 3 pp. 679-732]

J. I. Fortea Pérez. Monarquía y Cortes en la Corona de Castilla. Las ciudades ante la política fiscal de Felipe V (Por Francisco Comín Comín).-- Guy Bois. La mutation de l'an mil. Lournand, village maconnais de l'Antiquité' au féodalisme (Por Gaspar Feliú).-- Andrés Barrera González. Casa, herencia y familia en la Cataluña rural (Por Carmen Sarasúa García).-- A. Kondo. La agricultura española del siglo XIX (Por James Simpson).-- Miguel Ángel Melón. Extremadura en el Antiguo Régimen, economía y sociedad en tierras de Cáceres, 1100-1814 (Por Enrique Llopis).-- Carlos Rodríguez Braun. La cuestión colonial y la economía clásica. De Adam Smith y Jeremy Bentham a Karl Marx (Por Salvador Almenar).-- Roberto Cortes Conde. Dinero, deuda y crisis. Evolución fiscal y monetaria en la Argentina (Por Pablo Martín Aceña).-- Mercedes Cabrera Calvo-Sotelo, Francisco Comín Comín y José Luis García Delgado (Director). Santiago Alba. Un programa de reforma económica en la España del primer tercio del siglo XX (Por Juan Pro Ruiz).-- Bill Albert y Adrian Graves (eds.). The World Sugar Economy in War and Depression, 1914-40 (Por Manuel Martín Rodríguez).-- Roque Moreno Fonseret. La crisis económica en la provincia de Alicante, 1973-1983 (Por José A. Miranda Encarnación).-- Alvaro Cuervo. La crisis bancaria en España 1977-1985. Causas, sistemas de tratamiento y coste (Por Gabriel Tortella).-- VV. AA.. L’espai viscut. Col loqui Internacional d'Historia Local (Por Salvador Calatayud Giner).-- Massimo M. Augello, Marco Bianchini, Gabriela Gioli y Piero Roggi (eds.). Le cattedre di economia politica in Italia. La diffusione di una disciplina «sospetta» (Por Carlos Rodríguez Braun)Publicad