461 research outputs found
The everyday states of austerity: Politics and livelihoods in Europe
This special issue addresses how working people in Southern Europe engage with austerity state formations. We argue that in order to look at people’s responses to austerity, one cannot avoid delving into the ways people engage with state formations and the co-production of state functions, material relations and ideological configurations. Whether imposed by supranation-al institutions or voluntarily endorsed by a national elite, austerity politics were concretely implemented and legitimated by state institutions, making the austerity–state nexus a “critical junction” of social reproduction (Kalb and Tak 2006).info:eu-repo/semantics/publishedVersio
Soft x-rays absorption and high-resolution powder x-ray diffraction study of superconducting CaxLa(1-x)Ba(1.75-x)La(0.25+x)Cu3Oy system
We have studied the electronic structure of unoccupied states measured by O
K-edge and Cu L-edge x-ray absorption spectroscopy (XAS), combined with crystal
structure studied by high resolution powder x-ray diffraction (HRPXRD), of
charge-compensated layered superconducting CaxLa(1-x)Ba(1.75-x)La(0.25+x)Cu3Oy
(0<x<0.4, 6.4<y<7.3) cuprate. A detailed analysis shows that, apart from hole
doping, chemical pressure on the electronically active CuO2 plane due to the
lattice mismatch with the spacer layers greatly influences the superconducting
properties of this system. The results suggest chemical pressure to be the most
plausible parameter to control the maximum critical temperatures (Tcmax) in
different cuprate families at optimum hole density.Comment: 14 pages, 11 figures, accepted for publication in Journal of Physics
and Chemistry of Solid
N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota
Supporting Information
S1 File. Microbiota Data Set. NS.S, NS.LD, NS.HD stand for non-separated Saline, non-separated
Low Dose, non-separated High Dose, respectively. MS.S, MS.LD, MS.HD stand for
maternally separated Saline, maternally separated Low Dose, maternally separated High Dose,
respectively.
(ZIP)peer-reviewedBackground
Early life stress is a risk factor for many psychiatric disorders ranging from depression to anxiety. Stress, especially during early life, can induce dysbiosis in the gut microbiota, the key modulators of the bidirectional signalling pathways in the gut-brain axis that underline several neurodevelopmental and psychiatric disorders. Despite their critical role in the development and function of the central nervous system, the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the regulation of gut-microbiota in early-life stress has not been explored.
Methods and Results
Here, we show that long-term supplementation of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) (80% EPA, 20% DHA) n-3 PUFAs mixture could restore the disturbed gut-microbiota composition of maternally separated (MS) female rats. Sprague-Dawley female rats were subjected to an early-life stress, maternal separation procedure from postnatal days 2 to 12. Non-separated (NS) and MS rats were administered saline, EPA/DHA 0.4 g/kg/day or EPA/DHA 1 g/kg/day, respectively. Analysis of the gut microbiota in adult rats revealed that EPA/DHA changes composition in the MS, and to a lesser extent the NS rats, and was associated with attenuation of the corticosterone response to acute stress.
Conclusions
In conclusion, EPA/DHA intervention alters the gut microbiota composition of both neurodevelopmentally normal and early-life stressed animals. This study offers insights into the interaction between n-3 PUFAs and gut microbes, which may play an important role in advancing our understanding of disorders of mood and cognitive functioning, such as anxiety and depression.Research was funded by Food Institutional Research Measure (FIRM) under Grant No. 10/RD/TMFRC/709, the APC Microbiome Institute under Grant No. 07/CE/B1368 and 12/RC/2273, Science Foundation Ireland (SFI) under Grant No. 12/IA/1537
CIRSE Standards of Practice on Thermal Ablation of Bone Tumours.
Percutaneous thermal ablation is an effective, minimally invasive means of treating a variety of focal benign and malignant osseous lesions. To determine the role of ablation in individual cases, multidisciplinary team (MDT) discussion is required to assess the suitability and feasibility of a thermal ablative approach, to select the most appropriate technique and to set the goals of treatment i.e. curative or palliative.
This document will presume the indication for treatment is clear and approved by the MDT and will define the standards required for the performance of each modality. CIRSE Standards of Practice documents are not intended to impose a standard of clinical patient care, but recommend a reasonable approach to, and best practices for, the performance of thermal ablation of bone tumours.
The writing group was established by the CIRSE Standards of Practice Committee and consisted of five clinicians with internationally recognised expertise in thermal ablation of bone tumours. The writing group reviewed the existing literature on thermal ablation of bone tumours, performing a pragmatic evidence search using PubMed to search for publications in English and relating to human subjects from 2009 to 2019. Selected studies published in 2020 and 2021 during the course of writing these standards were subsequently included. The final recommendations were formulated through consensus.
Recommendations were produced for the performance of thermal ablation of bone tumours taking into account the biologic behaviour of the tumour and the therapeutic intent of the procedure. Recommendations are provided based on lesion characteristics and thermal modality, for the use of tissue monitoring and protection, and for the appropriately timed application of adjunctive procedures such as osseus consolidation and transarterial embolisation.
Percutaneous thermal ablation has an established role in the successful management of bone lesions, with both curative and palliative intent. This Standards of Practice document provides up-to-date recommendations for the safe performance of thermal ablation of bone tumours
Regional climate models' performance in representing precipitation and temperature over selected Mediterranean areas
This paper discusses the relative performance of several climate models in providing reliable forcing for hydrological modeling in six representative catchments in the Mediterranean region. We consider 14 Regional Climate Models (RCMs), from the EU-FP6 ENSEMBLES project, run for the A1B emission scenario on a common 0.22° (about 24 km) rotated grid over Europe and the Mediterranean region. In the validation period (1951 to 2010) we consider daily precipitation and surface temperatures from the observed data fields (E-OBS) data set, available from the ENSEMBLES project and the data providers in the ECA&D project. Our primary objective is to rank the 14 RCMs for each catchment and select the four best-performing ones to use as common forcing for hydrological models in the six Mediterranean basins considered in the EU-FP7 CLIMB project. Using a common suite of four RCMs for all studied catchments reduces the (epistemic) uncertainty when evaluating trends and climate change impacts in the 21st century. We present and discuss the validation setting, as well as the obtained results and, in some detail, the difficulties we experienced when processing the data. In doing so we also provide useful information and advice for researchers not directly involved in climate modeling, but interested in the use of climate model outputs for hydrological modeling and, more generally, climate change impact studies in the Mediterranean region
Effects of Field Simulated Marine Heatwaves on Sedimentary Organic Matter Quantity, Biochemical Composition, and Degradation Rates
Since rising temperature (T) will enhance biochemical reactions and coastal marine sediments are hotspots of carbon cycling, marine heatwaves’ (MHWs’) intensification caused by climate change will affect coastal biogeochemistry. We investigated the effects of MHWs on sediment organic matter (OM) in a nearshore locality (NW Sardinia, Mediterranean Sea) receiving an artificial warm water plume generating T anomalies of 1.5–5.0 °C. Sediments were collected before and after 3 and 11 weeks from the initial plume release. Both MHWs influenced sedimentary OM quantity, composition, and degradation rates, with major effects associated with the highest T anomaly after 3 weeks. Both MHWs enhanced sedimentary OM contents, with larger effects associated with the highest T anomaly. Phytopigment contents increased in the short term but dropped to initial levels after 11 weeks, suggesting the occurrence of thermal adaptation or stress of microphytobenthos. In the longer term we observed a decrease in the nutritional quality of OM and a slowdown of its turnover mediated by extracellular enzymes, suggestive of a decreased ecosystem functioning. We anticipate that intensification of MHWs will affect benthic communities not only through direct effects on species tolerance but also by altering benthic biogeochemistry and the efficiency of energy transfer towards higher trophic levels
Effects of Current and Future Summer Marine Heat Waves on Posidonia oceanica: Plant Origin Matters?
Marine heat waves (MHWs), prolonged discrete anomalously warm water events, have
been increasing significantly in duration, intensity and frequency all over the world,
and have been associated with a variety of impacts including alteration of ecosystem
structure and function. This study assessed the effects of current and futureMHWs on the
Mediterranean seagrass Posidonia oceanica performance, also testing the importance
of the thermal environment where the plant lives. The effects of current MHWs were
studied through a mensurative experiment in a cold and in a warm site (West and
North-West Sardinia, Italy, respectively). Future MHWs effects were tested through a
manipulative experiment using P. oceanica shoots collected fromthe cold and warmsites
and transplanted in a common garden in front of a power plant (North-West Sardinia):
here plants were exposed to heat longer in duration and stronger in intensity than
the natural MHWs of the last 20 years, resembling the future scenario. Morphological
(total # of leaves, maximum leaf length, and percentage of total necrotic leaf length
per shoot) and biochemical variables (leaf proteins, carbohydrates, and lipids) were
considered. Plants had similar sublethal responses in both the experiments for most
of the variables, revealing that current and future MHWs had similar effect types, but
different in magnitude depending on the intensity of the waves: in general, the number
of leaves, the maximum leaf length and lipid content decreased, while the leaf necrosis
and carbohydrates increased. However, also the origin of the plants affected the results,
corroborating the hypothesis that the thermal context the plants live affects their tolerance
to the heat. Overall, this study provided evidence about the importance of biochemical
variations, such as carbohydrate and lipid levels, as potentially good indicators of
seagrass heat stress
The use of Building Technology to support Disaster Resilience: The case study of Air Shelter House
This paper reports on a study to investigate the feasibility of Thermal Reflective Multi-layer System (TRMS) as support for Disaster Resilience. It is an innovative insulation system, developed from space engineering studies, lightweight and is characterized by a thermal conductivity of 0.038 W/mK, making it a strong candidate for inexpensive shelter after disaster design. One of the results of this study is a proposal for the Air Shelter House (ASH), a new concept design of a shelter based on TRMS. The combined use of TRMS with low cost building materials and a 3D printer system for the construction joints provides a good comprise of building cost and energy efficiency performance. Such an innovative design supports disaster resilience during response, reconstruction and mitigation phases and is suitable for a wide variety of cultural and environmental situations where energy efficiency is important
What if a Social Robot Excluded You? Using a Conversational Game to Study Social Exclusion in Teen-robot Mixed Groups
Effects of Current and Future Summer Marine Heat Waves on Posidonia oceanica: Plant Origin Matters?
Marine heat waves (MHWs), prolonged discrete anomalously warm water events, have been increasing significantly in duration, intensity and frequency all over the world, and have been associated with a variety of impacts including alteration of ecosystem structure and function. This study assessed the effects of current and future MHWs on the Mediterranean seagrass Posidonia oceanica performance, also testing the importance of the thermal environment where the plant lives. The effects of current MHWs were studied through a mensurative experiment in a cold and in a warm site (West and North-West Sardinia, Italy, respectively). Future MHWs effects were tested through a manipulative experiment using P. oceanica shoots collected from the cold and warm sites and transplanted in a common garden in front of a power plant (North-West Sardinia): here plants were exposed to heat longer in duration and stronger in intensity than the natural MHWs of the last 20 years, resembling the future scenario. Morphological (total # of leaves, maximum leaf length, and percentage of total necrotic leaf length per shoot) and biochemical variables (leaf proteins, carbohydrates, and lipids) were considered. Plants had similar sublethal responses in both the experiments for most of the variables, revealing that current and future MHWs had similar effect types, but different in magnitude depending on the intensity of the waves: in general, the number of leaves, the maximum leaf length and lipid content decreased, while the leaf necrosis and carbohydrates increased. However, also the origin of the plants affected the results, corroborating the hypothesis that the thermal context the plants live affects their tolerance to the heat. Overall, this study provided evidence about the importance of biochemical variations, such as carbohydrate and lipid levels, as potentially good indicators of seagrass heat stress.En prens
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