Normal or Arthritic: Is 25-hydroxy Vitamin D status significant?

Background: Vitamin D is required for proper skeletal development and function. However, the status of vitamin D in healthy subjects and those suffering from arthritis in Nepal is largely unknown. Objective: This study measured vitamin D level in healthy and arthritic individuals of Western Nepal. Methods: Vitamin D level in healthy and arthritic subjects were measured by using LIASION 25-hydroxy Vitamin D assay, a direct competitive chemiluminescence immunoassay (CLIA). Results: Our result suggested that most of the subjects, irrespective of age and disease condition, have subnormal/normal level of vitamin D (≥16ng/mL). Also, the data suggested that serum vitamin D level is significantly higher in males than in females. Moreover, the vitamin D level is higher in healthy individuals when compared with those suffering from arthritis. However, vitamin D level in normal subjects and arthritic patients could not be correlated. Conclusion: Vitamin D level is higher in normal subjects compared to arthritic individuals. However, the level could not be correlated suggesting need of a pilot study to determine vitamin D level and its association with arthritis in Nepalese. Journal of Gandaki Medical College Vol. 10, No. 1, 2017, Page: 21-2

Measurements of (tt)over-barH Production and the CP Structure of the Yukawa Interaction between the Higgs Boson and Top Quark in the Diphoton Decay Channel

The first observation of the (tt) over barH process in a single Higgs boson decay channel with the full reconstruction of the final state (H -> gamma gamma) is presented, with a significance of 6.6 standard deviations (sigma). The CP structure of Higgs boson couplings to fermions is measured, resulting in an exclusion of the pure CP-odd structure of the top Yukawa coupling at 3.2 sigma. The measurements are based on a sample of protonproton collisions at a center-of-mass energy root s = 13 TeV collected by the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb(-1). The cross section times branching fraction of the (tt) over barH process is measured to be sigma B-(tt) over barH(gamma gamma) = 1.56(-0.32)(+0.34) th, which is compatible with the standard model prediction of 1.13(-0.11)(+0.08) fb. The fractional contribution of the CP-odd component is measured to be f(CP)(Hu) = 0.00 +/- 0.33.Peer reviewe