398 research outputs found
Milk Casein Alleles, Haplotypes and QTL Effect on Protein and Fat Content and Milk Yield in Argentinean Criollo and Cross Goats
LHCD during current ramp experiments on Alcator C-Mod
The lower hybrid current drive (LHCD) system on Alcator C-Mod is capable of sustaining fully non-inductive discharges for multiple current relaxation times (Ïcr ⌠200 ms) at line averaged densities in the range of 5x1019 m-3. Some of these non-inductive discharges develop unstable MHD modes that can greatly reduce current drive performance, particularly in discharges with plasma current of 0.5 MA or less [1,2]. Avoiding these unstable MHD modes motivated an experiment to test if the stable current profile shape of a higher current non-inductive discharge could be achieved in a lower current discharge. Starting from a discharge at 0.8 MA, the plasma current was ramped down to 0.5 MA over 200 ms. The surface voltage of the plasma swings negative during the ramp, with the loop voltage reversal impacting the edge fast electron measurements immediately. Little change can be seen during the Ip ramp in the core fast electron measurements, indicating that the loop voltage reversal does not penetrate fully to the magnetic axis on the timescale of the current ramp. The resulting discharge did not exhibit deleterious MHD instabilities, however the existence of this one discharge does not necessarily represent a robust solution to the problem
Cognitive Impairment, Sexual Activity and Physical Tenderness in Community-Dwelling Older Adults: A Cross-Sectional Exploration
Background: The ability to engage in sexual activity and better cognitive functioning are both associated with better health. However, the association between cognitive functioning and sexual activity is understudied. Objective: To examine the association between cognitive functioning with sexual activity and physical tenderness among community-dwelling older adults. Methods: From the Rotterdam Study, cognitive imp
Hydroxychloroquine partially prevents endothelial dysfunction induced by anti-beta-2-GPI antibodies in an in vivo mouse model of antiphospholipid syndrome
Background
Antiphospholipid syndrome is associated with endothelial dysfunction, which leads to thrombosis and early atheroma. Given that hydroxychloroquine has anti-thrombotic properties in lupus, we hypothesized that it could reduce endothelial dysfunction in an animal model of antiphospholipid syndrome. We evaluated the effect of hydroxychloroquine in preventing endothelial dysfunction in a mouse model of antiphospholipid syndrome.
Methods
Antiphospholipid syndrome was induced by an injection of monoclonal anti-beta-2-GPI antibodies. Vascular reactivity was evaluated in mesenteric resistance arteries isolated from mice 3 weeks (APL3W) after receiving a single injection of anti-beta-2-GPI antibodies and after 3 weeks of daily oral hydroxychloroquine treatment (HCQ3W) compared to control mice (CT3W). We evaluated endothelial dysfunction by measuring acetylcholine-mediated vasodilation. A pharmacological approach was used to evaluate NO synthase uncoupling (tetrahydrobiopterin) and the generation of reactive oxygen species (Tempol).
Results
Impaired acetylcholine-mediated dilation was evidenced in mice 3 weeks after anti-beta-2-GPI antibodies injection compared to CT3W, by reduced maximal dilation (p<0.0001) and sensitivity (pKd) (p = 0.01) to acetylcholine. Hydroxychloroquine improved acetylcholine-dependent dilation, on pKd (p = 0.02) but not maximal capacity compared to untreated mice. The addition of tetrahydrobiopterin (p = 0.02) and/or Tempol (p = 0.0008) improved acetylcholine-mediated dilation in APL3W but not in HCQ3W.
Conclusions
We demonstrated that endothelial dysfunction in mouse resistance arteries persisted at 3 weeks after a single injection of monoclonal anti-beta-2-GPI antibodies, and that hydroxychloroquine improved endothelium-dependent dilation at 3 weeks, through improvement of NO synthase coupling and oxidative stress reduction
Produtividade e valor nutritivo de pasto de capim-elefante manejado sob princĂpios agroecolĂłgicos.
Objetivou-se avaliar o valor nutritivo do capim-elefante, quanto aos teores de PB e FDN e a digestibilidade in vitro da MS (DIVMS), submetido a algumas prĂĄticas agroecolĂłgicas. Foram usados dois piquetes (0,15 ha cada), onde foi estabelecido o capim-elefante, em 2001, com espaçamento entrelinhas de trĂȘs metros. Nas entrelinhas, estabeleceram-se aveia (Avena strigosa Schreb.) e azevĂ©m (Lolium multiflorum Lam.) no perĂodo hibernal e, no estival, permitiu-se o desenvolvimento de espĂ©cies de crescimento espontĂąneo. A adubação foi feita com fertilizantes orgĂąnicos (150 kg de N /ha). No perĂodo experimental (24/04/2004 a 05/05/2005), foram conduzidos sete pastejos. Os animais experimentais foram vacas da raça Holandesa que receberam, como complementação alimentar, 3,5 kg/dia de concentrado. Avaliaram-se a massa de forragem inicial, composição botĂąnica do pasto e os componentes estruturais. Para as anĂĄlises de valor nutritivo do pasto, foram feitas amostragens simulando o pastejo. O delineamento experimental foi de blocos ao acaso com duas repetiçÔes (piquetes) e sete tratamentos (pastejos). Os melhores resultados do valor nutritivo foram obtidos no perĂodo hibernal. Foram encontradas correlaçÔes negativas da PB e DIVMS e positivas da FDN com a biomassa de lĂąminas foliares do capim-elefante. O capim-elefante, manejado sob princĂpios agroecolĂłgicos, apresentou alto valor nutritivo e produtividade, tanto no verĂŁo quanto no inverno, possibilitando que a produção animal seja mais sustentĂĄvel no decorrer do ano
Synergy study of the Equatorial and Upper port ITER ECH Launchers for an enhanced Physics Performance
Search for the Flavor-Changing Neutral Current Decay with the HERA-B Detector
We report on a search for the flavor-changing neutral current decay using events recorded with a dimuon trigger in
interactions of 920 GeV protons with nuclei by the HERA-B experiment. We find
no evidence for such decays and set a 90% confidence level upper limit on the
branching fraction .Comment: 17 pages, 4 figures (of which 1 double), paper to be submitted to
Physics Letters
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