564 research outputs found
Psychiatric Emergency in Children and Adolescents: A Retrospective Study in Parma Local Health Unit
The mental health care system in Italy is based on Law 180/70 which leaves great regional autonomy about the management of adolescent patients suffering from psychiatric diseases. The aim of this study is the evaluation of demographic, social, and clinical features of minors admitted to psychiatric wards, as starting point to improve individualized services for them. Data about all under 18s consecutively admitted to Parmaâs psychiatric wards from 2013 to 2015 were retrospectively collected from medical records. Diagnoses were classified according to ICD-10 criteria, and statistical analysis was performed using SPSS statistical software (IBM SPSS Statistics 22.0) for Windows. Clinical samples include 51 cases, 30 males (mean age: 15.5 years, ranging from 12 to 17 years) and 21 females (mean age: 15.9, ranging from 14 to 17 years). The most frequent diagnosis is conduct disorder (39.2%), with higher prevalence among males. Following this, 23.5% of the patients present comorbidity issues and 9.8% suffer from personality disorders, which is more frequent among females. High percentages of foreigners (31.4%), adopted minors (15.7%), and drug users (40%) are reported. Furthermore, data reveal that unprotective family environment, registered in 80.4% of cases, plays an important role as risk factor for the development of mental disease, readmissions in psychiatric wards, and discharge to residential facilities. Readmissions, as well as compulsory treatments (11 cases), are mainly required in case of conduct disorders and comorbidity diagnosis. Lastly, in contrast with the situation before hospital admission, most patients (63.3%) are discharged and sent to community residential facilities. Findings can be useful to improve the management of psychiatric emergencies in minors, focusing on their specific needs, such as conduct disorders and substance abuse, and to face emerging challenges, for example, mental health disease associated with the growing phenomenon of immigration
Synchrotron characterization of hexagonal and cubic lipidic phases loaded with azolate/phosphane gold(I) compounds: a new approach to the uploading of gold(I)-based drugs
none9Gold(I) phosphane compounds have recently attracted a renewed interest as potential new
protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has
been successfully tested against several cancer cell lines and, in particular, against basal-like breast (BLB)
cancer, a form characterized by strongly severe diagnosis and short life lapse after classic chemotherapy.
Even though the anticancer activity of gold(I) phosphane compounds is thoroughly ascertained, no study
has been devoted to the possibility of their delivery in nanovectors. Herein, nonlamellar lyotropic liquid
crystalline lipid nanosystems, a promising class of smart materials, have been used to encapsulate gold(I)
azolate/phosphane complexes. In particular, ((triphenylphosphine)-gold(I)-(4,5-dichloroimidazolyl-1H-1yl)) (C-I)
and ((triphenylphosphine)-gold(I)-(4,5-dicyanoimidazolyl-1H-1yl)) (C-II) have been encapsulated in three
different lipid matrices: monoolein (GMO), phytantriol (PHYT) and dioleoyl-phosphatidylethanolamine
(DOPE). An integrated experimental approach involving X-ray diffraction and UV resonant Raman (UVRR)
spectroscopy, based on synchrotron light and attenuated total reflectance Fourier transform infrared (ATR-FTIR)
spectroscopy, has been employed to establish the effects of drug encapsulation on the structure and phase
behavior of the host mesophases. The results indicate that gold(I) complexes C-I and C-II are successfully
encapsulated in the three lipid matrices as evidenced by the drug-induced phase transitions or by the changes
in the mesophase lattice parameters observed in X-ray diffraction experiments and by the spectral changes
occurring in UV resonant Raman spectra upon loading the lipid matrices with C-I and C-II.openPaola Astolfi, Michela Pisani, Elisabetta Giorgini, Barbara Rossi, Alessandro Damin, Francesco Vita, Oriano Francescangeli, Lorenzo Luciani, Rossana GalassiAstolfi, Paola; Pisani, Michela; Giorgini, Elisabetta; Rossi, Barbara; Damin, Alessandro; Vita, Francesco; Francescangeli, Oriano; Luciani, Lorenzo; Galassi, Rossan
Cubic and Hexagonal Mesophases for Protein Encapsulation: Structural Effects of Insulin Confinement
Monoolein-based cubic and hexagonal mesophases were investigated as matrices for insulin loading, at low pH, as a function of temperature and in the presence of increasing amounts of oleic acid, as a structural stabilizer for the hexagonal phase. Synchrotron small angle X-ray diffraction, rheological measurements, and attenuated total reflection-Fourier transform infrared spectroscopy were used to study the effects of insulin loading on the lipid mesophases and of the effect of protein confinement in the 2D-and 3D-lipid matrix water channels on its stability and unfolding behavior. We found that insulin encapsulation has only little effects both on the mesophase structures and on the viscoelastic properties of lipid systems, whereas protein confinement affects the response of the secondary structure of insulin to thermal changes in a different manner according to the specific mesophase: in the cubic structure, the unfolding toward an unordered structure is favored, while the prevalence of parallel ÎČ-sheets, and nuclei for fibril formation, is observed in hexagonal structures
Abordagens pedagógicas e sua relação com as teorias de aprendizagem
The teaching practice requires the knowledge of how individuals learn, how the learning originates and develops and becomes as meaningful learning experience. The objective of this paper is to present the theoretical conceptions of the learning process of individuals and their relationship to pedagogical approaches adopted in the models of undergraduate courses. In this sense, the pedagogical models were grouped in a synthesized form, in models that are distinguished by being centered on the teacher; on the student; in the know; on medium of communication or technique; the social context and interaction. Were presented some of the principal aspects discussed in the Psychology Human Development, influencing teaching trends, as Innate, the Environmentalist / Behaviorist, and Interactionist. Discusses the need of educational practices be substantiate conceptually.A prĂĄtica docente demanda o conhecimento de como o indivĂduo aprende, como se origina e se desenvolve o aprendizado e como se transforma em experiĂȘncia significativa de aprendizagem. O objetivo deste artigo Ă© apresentar as concepçÔes teĂłricas sobre o processo de aprendizagem dos indivĂduos e sua relação com as abordagens pedagĂłgicas adotadas nos modelos de cursos de graduação. Nesse sentido, os modelos pedagĂłgicos foram agrupados de forma sintetizada, em modelos que se distinguem por estarem centrados no professor; no estudante; no saber; no meio de comunicação ou na tĂ©cnica; no contexto social e na interação. Foram apresentadas algumas das principais vertentes discutidas na ĂĄrea da Psicologia do Desenvolvimento Humano, que influenciaram as tendĂȘncias pedagĂłgicas, como a Inatista, a Ambientalista/Behaviorista, e as Interacionistas. Discute a necessidade das prĂĄticas educativas serem conceitualmente fundamentadas
Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy
IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical
attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced
colorectal cancers at diagnosis.
OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced
oncologic stage and change in clinical presentation for patients with colorectal cancer.
DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all
17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December
31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period),
in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was
30 days from surgery.
EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery,
palliative procedures, and atypical or segmental resections.
MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer
at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as
cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding,
lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery,
and palliative surgery. The independent association between the pandemic period and the outcomes
was assessed using multivariate random-effects logistic regression, with hospital as the cluster
variable.
RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years)
underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142
(56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was
significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR],
1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic
lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03).
CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the
SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients
undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for
these patients
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
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