The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin

The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin

Avaliação das propriedades físico-químicas do solo em sistema de corte e trituração da capoeira na Amazônia Central.

Com o objetivo de testar a tecnologia de corte e trituração em diferentes tipos de capoeiras na Amazônia, no Estado do Amazonas foram implantadas parcelas de 0,5 ha em seis lotes do Projeto de Assentamento do Tarumã-Mirim no município de Manaus. As características químicas e físicas do solo foram avaliadas no decorrer da decomposição dos resíduos de trituração da capoeira pelo período de dois anos

Selectivity of saflufenacil applied alone or mixed to glyphosate in maize.

The use of selective herbicides is important for weed management in agricultural crops. Selectivity studies of new molecules are really important to expand the control options of glyphosate-resistant and -tolerant eudicotyledons in corn. The objective of this work was to evaluate the selectivity of the herbicide saflufenacil applied alone in different doses in post-emergence of corn and in a mixture with glyphosate. The design used was randomized blocks, with four replications, with treatments consisting of five doses of saflufenacil, applied alone and in a mixture with a fixed dose of glyphosate, in addition to the weeded control and only glyphosate. At 7, 14, 21 and 28 days after application (DAT), the phytotoxicity of the herbicides to the crop was evaluated. The physiological variables were measured at 35 DAT. At harvest, yield components were determined, in addition to the mass of 1,000 grains and grain yield. The application of the mixture of glyphosate with saflufenacil increases phytotoxicity symptoms and yield losses. Doses of up to 70 g ha-1, applied alone, caused low phytotoxicity to corn and did not interfere in yield. The use of glyphosate + saflufenacil tank mixtures caused decreases in yield of 43.96 and 40.81% when compared, respectively, with the weeded control and the averages of the applications of the herbicides alone. Saflufenacil has the potential to be used in the management of eudicotyledonous weeds, as long as it is not mixed with glyphosate and the dose limit is respected

Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice

The extracellular matrix (ECM) is an important component of the tumor microenvironment and undergoes extensive remodeling during both initiation and progression of breast cancer (BC). EMILIN1 is an ECM glycoprotein, whose function has been linked to cancer and metastasis. However, EMILIN1 role during mammary gland and BC development has never been investigated. In silico and molecular analyses of human samples from normal mammary gland and BC showed that EMILIN1 expression was lower in tumors than in healthy mammary tissue and it predicted poor prognosis, particularly in HER2-positive BC. HER2+ BC accounts for 15-20% of all invasive BC and is characterized by high aggressiveness and poor prognosis. The Δ16HER2 isoform, a splice variant with very high oncogenic potential, is frequently expressed in HER2+ BC and correlates with metastatic disease. To elucidate the role of EMILIN1 in BC, we analyzed the phenotype of MMTV-Δ16HER2 transgenic mice, developing spontaneous multifocal mammary adenocarcinomas, crossed with EMILIN1 knock-out (KO) animals. We observed that Δ16HER2/EMILIN1 KO female mice exhibited an accelerated normal mammary gland development and a significantly anticipated appearance of palpable tumors (13.32 vs 15.28 weeks). This accelerated tumor initiation was corroborated by an increased number of tumor foci observed in mammary glands from Δ16HER2/EMILIN1 KO mice compared to the wild-type counterpart. Altogether our results underscore the centrality of ECM in the process of BC initiation and point to a role for EMILIN1 during normal mammary gland development and in protecting from HER2-driven breast tumorigenesis

The moral technical imaginaries of internet convergence in an American television network

How emergent technologies are imagined, discussed, and implemented reveals social morality about how society, politics, and economics should be organized. For the television industry in the United States, for instance, the development of internet “convergence” provoked the rise of a new discourse about participatory democracy as well as the hopes for lucrative business opportunities. The simultaneity of technical, moral, and social ordering defines the “moral technical imaginary.” Populating this concept with ethnographic and historical detail, this article expands the theory of the moral technical imaginary with information from six years of participant observation, interviews, and employment with Current TV, an American-based television news network founded by Vice President Al Gore to democratize television production. This chapter explores the limits of political participation and morality when faced with neoliberal capitalism

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Targets for high repetition rate laser facilities: Needs, challenges and perspectives

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10Ã\u82 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: Dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities

Morphophysiological responses of wheat cultivars in competition with diploid and tetraploid ryegrass.

Wheat crop growth and development can be affected by weed infestation, especially ryegrass. Thus, the objective of this study was to evaluate the competitive ability of wheat cultivars wit h the diploid and tetraploid ryegrass biotypes. Greenhouse experiments were conducted in a completely randomized design with four replications. BRS Parrudo and TBIO Sinuelo wheat cultivars and the competitors ryegrass diploid and tetraploid were used. The population of each species was defined and then the replacement series experiments were carried out, containing the following proportions of wheat and ryegrass plants: 100:0, 75:25, 50:50, 25:75; and 0:100%, equivalent to 32:0; 24:8; 16:16; 8:24; and 0:32 plants per pot. Fifty days after species emergence, physiological traits, such as photosynthetic activity ( A ), stomatal conductance ( g S ), transpiration rate E ), internal concentration of mesophyll CO 2 (C i ), water use efficiency (WUE), and carboxylation ef ficiency (CE), were evaluated, along with the morphological traits of leaf area (LA), stem diameter (SD), number of tillers (NT), and shoot dry mass (DM). Competitiveness analysis was performed by means of diagrams applied to substitutive experiments using relative competitiveness indices. The ryegrass, both diploid and tetraploid, had a negative effect on the variables related to A , WUE and also those associated with plant growth. The ryegrass negatively changed the LA, DM, SD, and NT of the cultivars BRS Parrudo and TBIO Sinuelo, which demonstrates competition between the cultivars of wheat and the weed ryegrass with mutual damage to the species involved in th recommended for wheat cultivation