189 research outputs found
High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil
Background: Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV-infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected subjects, especially men who have sex with men (MSM).Methodology/Principal Findings: We assessed the HHV-8 seroprevalence, clinical correlates, and incidence after one year of follow-up in a cohort of 228 recently HIV-1-infected individuals, of whom 83.6% were MSM, using indirect immunofluorescence assay. the prevalence of HHV-8 infection at the time of cohort enrollment was 25.9% (59/228). in the univariate model, there were significant associations with male gender, black ethnicity, MSM practice, and previous hepatitis B virus and syphilis infections. in the multivariate model we could still demonstrate association with MSM, hepatitis B, and black ethnicity. No differences in mean CD4+ cell counts or HIV viral load according to HHV-8 status were found. in terms of incidence, there were 23/127 (18.1%) seroconversions in the cohort after 1 year.Conclusions: HHV-8 is highly prevalent among recently HIV-1-infected subjects. Correlations with other sexually transmitted infections suggest common transmission routes.Universidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilWeb of Scienc
Optical Spectra of SNR Candidates in NGC 300
We present moderate-resolution (<5A) long-slit optical spectra of 51 nebular
objects in the nearby Sculptor Group galaxy NGC 300 obtained with the 2.3 meter
Advanced Technology Telescope at Siding Spring Observatory, Australia. Adopting
the criterion of [SII]/Ha>=0.4 to confirm supernova remnants (SNRs) from
optical spectra, we find that of 28 objects previously proposed as SNRs from
optical observations, 22 meet this criterion with six showing [SII]/Ha of less
than 0.4. Of 27 objects suggested as SNRs from radio data, four are associated
with the 28 previously proposed SNRs. Of these four, three (included in the 22
above) meet the criterion. In all, 22 of the 51 nebular objects meet the
[SII]/Ha criterion as SNRs while the nature of the remaining 29 objects remains
undetermined by these observations.Comment: Accepted for publication in Astrophysics & Space Scienc
Aetiology and Clinical Presentation of Pneumonia in Hospitalized and Outpatient Children in Northeast Brazil and Risk Factors for Severity
Data on presentation, aetiology, and prognostic indicators of childhood
pneumonia, which can help design strategies for controlling the
disease, are generally scarce in developing countries. In this paper,
the distribution of aetiologic agents, clinical presentation, and
evolution of pneumonia cases are described, and the factors associated
with duration of pneumonia episode and of hospital admission examined.
During June 1994-June 1995, 472 children, aged 6-59 months, with
clinical diagnosis of pneumonia, who were admitted to hospital or
treated as outpatients, were investigated in Recife, Northeast Brazil.
Pneumonia, in most cases, was confirmed by radiology. A combination of
methods was used for investigating the aetiology of pneumonia. Data
obtained on a large number of clinical, socioeconomic and biological
variables were analyzed to determine the prognostic factors for the
severity and outcome of pneumonia. Bacteria were identified in 26.7% of
the cases, while viruses and mixed infections accounted for 8.4% and
2.7% respectively. Haemophilus influenzae (18.9%), Streptococcus
pneumoniae (6.4%), and respiratory syncytial virus (5.0%) were most
often identified. The pneumonia case-fatality rate was 0.8%. The best
clinical predictors of severity were: lung complications at baseline,
tachypnoea (for duration of episode), and chest-indrawing (for duration
of hospital admission). Young age, low birth-weight, and prolonged
fever prior to admission to the study also predicted a more prolonged
illness, and under-nutrition was a predictor of longer hospital stay.
While the development of new vaccines is an important measure for
reducing morbidity and mortality due to pneumonia, emphasis on
appropriate case management needs to be maintained, with particular
attention to children who show the identified risk factors for a poor
prognosis
Murchison Widefield Array and XMM-Newton observations of the Galactic supernova remnant G5.9+3.1
In this paper we discuss the radio continuum and X-ray properties of the
so-far poorly studied Galactic supernova remnant (SNR) G5.9+3.1. We present the
radio spectral energy distribution (SED) of the Galactic SNR G5.9+3.1 obtained
with the Murchison Widefield Array (MWA). Combining these new observations with
the surveys at other radio continuum frequencies, we discuss the integrated
radio continuum spectrum of this particular remnant. We have also analyzed an
archival XMM-Newton observation, which represents the first detection of X-ray
emission from this remnant. The SNR SED is very well explained by a simple
power-law relation. The synchrotron radio spectral index of G5.9+3.1, is
estimated to be 0.420.03 and the integrated flux density at 1GHz to be
around 2.7Jy. Furthermore, we propose that the identified point radio source,
located centrally inside the SNR shell, is most probably a compact remnant of
the supernova explosion. The shell-like X-ray morphology of G5.9+3.1 as
revealed by XMM-Newton broadly matches the spatial distribution of the radio
emission, where the radio-bright eastern and western rims are also readily
detected in the X-ray while the radio-weak northern and southern rims are weak
or absent in the X-ray. Extracted MOS1+MOS2+PN spectra from the whole SNR as
well as the north, east, and west rims of the SNR are fit successfully with an
optically thin thermal plasma model in collisional ionization equilibrium with
a column density N_H~0.80x cm and fitted temperatures spanning
the range kT~0.14-0.23keV for all of the regions. The derived electron number
densities n_e for the whole SNR and the rims are also roughly comparable
(ranging from ~ cm to ~ cm, where f
is the volume filling factor). We also estimate the swept-up mass of the X-ray
emitting plasma associated with G5.9+3.1 to be ~.Comment: Accepted for publication in A&
JC virus-associated central nervous system diseases in HIV-infected patients in Brazil: clinical presentations, associated factors with mortality and outcome
The National Tumor Association Foundation (ANT): A 30 year old model of home palliative care
<p>Abstract</p> <p>Background</p> <p>Models of palliative care delivery develop within a social, cultural, and political context. This paper describes the 30-year history of the National Tumor Association (ANT), a palliative care organization founded in the Italian province of Bologna, focusing on this model of home care for palliative cancer patients and on its evaluation.</p> <p>Methods</p> <p>Data were collected from the 1986-2008 ANT archives and documents from the Emilia-Romagna Region Health Department, Italy. Outcomes of interest were changed in: number of patients served, performance status at admission (Karnofsky Performance Status score [KPS]), length of participation in the program (days of care provided), place of death (home vs. hospital/hospice), and satisfaction with care. Statistical methods included linear and quadratic regressions. A linear and a quadratic regressions were generated; the independent variable was the year, while the dependent one was the number of patients from 1986 to 2008. Two linear regressions were generated for patients died at home and in the hospital, respectively. For each regression, the R square, the unstandardized and standardized coefficients and related P-values were estimated.</p> <p>Results</p> <p>The number of patients served by ANT has increased continuously from 131 (1986) to a cumulative total of 69,336 patients (2008), at a steady rate of approximately 121 additional patients per year and with no significant gender difference. The annual number of home visits increased from 6,357 (1985) to 904,782 (2008). More ANT patients died at home than in hospice or hospital; this proportion increased from 60% (1987) to 80% (2007). The rate of growth in the number of patients dying in hospital/hospice was approximately 40 patients/year (p < 0.01), vs. approximately 177 patients/year for patients who died at home. The percentage of patients with KPS < 40 at admission decreased from 70% (2003) to 30% (2008); the percentage of patients with KPS > 40 increased. Mean days of care for patients with KPS > 40 exceeded mean days for patients with KPS < 40 (p < 0.001). Patients and caregivers reported high satisfaction with care in each year of assessment; in 2008, among 187 interviewed caregivers, 95% judged the quality of doctors' assistance, and 91% judged the quality of nurses' assistance, to be "optimal."</p> <p>Conclusions</p> <p>The ANT home care model of palliative care delivery has been well-received, with progressively growing numbers of patients served. It has resulted in a greater proportion of home deaths and in patients' accessing palliative care at an earlier point in the disease trajectory. Changes in ANT chronicle palliative care trends in general.</p
Seroprevalence of Kaposi Sarcoma–associated Herpesvirus and Other Serologic Markers in the Brazilian Amazon
To determine the presence of Kaposi sarcoma–associated herpesvirus (KSHV) and other serologic markers, we tested serum specimens of 339 Amerindians, 181 rural non-Amerindians, and 1,133 urban blood donors (13 Amerindians) in the Brazilian Amazon. High KSHV seroprevalence in children and inverse association with herpes simplex virus type 2 indicates predominant nonsexual transmission among Amerindians
SARS-CoV-2 reinfection caused by the P.1 lineage in Araraquara city, Sao Paulo State, Brazil
Reinfection by the severe acute respiratory syndrome coronavirus type 2 (SARS-COV-2) has been reported in many countries, suggesting that the virus may continue to circulate among humans despite the possibility of local herd immunity due to massive previous infections. The emergence of variants of concern (VOC) that are more transmissible than the previous circulating ones has raised particular concerns on the vaccines effectiveness and reinfection rates. The P.1 lineage was first identified in December 2020 in Manaus city and is now globally spread. We report the first case of reinfection of SARS-CoV-2 caused by the P.1 variant outside of Manaus. The potential of these new variants to escape naturally and vaccine- induced immunity highlights the need for a global vigilance
Galactic and Extragalactic Samples of Supernova Remnants: How They Are Identified and What They Tell Us
Supernova remnants (SNRs) arise from the interaction between the ejecta of a
supernova (SN) explosion and the surrounding circumstellar and interstellar
medium. Some SNRs, mostly nearby SNRs, can be studied in great detail. However,
to understand SNRs as a whole, large samples of SNRs must be assembled and
studied. Here, we describe the radio, optical, and X-ray techniques which have
been used to identify and characterize almost 300 Galactic SNRs and more than
1200 extragalactic SNRs. We then discuss which types of SNRs are being found
and which are not. We examine the degree to which the luminosity functions,
surface-brightness distributions and multi-wavelength comparisons of the
samples can be interpreted to determine the class properties of SNRs and
describe efforts to establish the type of SN explosion associated with a SNR.
We conclude that in order to better understand the class properties of SNRs, it
is more important to study (and obtain additional data on) the SNRs in galaxies
with extant samples at multiple wavelength bands than it is to obtain samples
of SNRs in other galaxiesComment: Final 2016 draft of a chapter in "Handbook of Supernovae" edited by
Athem W. Alsabti and Paul Murdin. Final version available at
https://doi.org/10.1007/978-3-319-20794-0_90-
- …