410 research outputs found
Variance component models for survival data
Extensions of the Cox proportional hazards model for survival data are studied where allowance is made for unobserved heterogeneity and for correlation between the life times of several individuals The extended models are frailtymodels inspired by Yashin et al Estimation is carried out using the EM algorithm Inference is discussed and potential applications are outlined in particular to statistical research in human genetics using twin data or adoption data aimed at separating the eects of genetic and environmental factors on mortalit
Linear nonparametric tests for comparison of counting processes, with applications to censored survival data : (preprint)
An efficient direct solver for a class of mixed finite element problems
In this paper we present an efficient, accurate and parallelizable direct method for the solution of the (indefinite) linear algebraic systems that arise in the solution of fourth-order partial differential equations (PDEs) using mixed finite element approximations. The method is intended particularly for use when multiple right-hand sides occur, and when high accuracy is required in these solutions.
The algorithm is described in some detail and its performance is illustrated through the numerical solution of a biharmonic eigenvalue problem where the smallest eigenpair is approximated using inverse iteration after discretization via the Ciarlet–Raviart mixed finite element method
Photoionisation loading of large Sr+ ion clouds with ultrafast pulses
This paper reports on photoionisation loading based on ultrafast pulses of
singly-ionised strontium ions in a linear Paul trap. We take advantage of an
autoionising resonance of Sr neutral atoms to form Sr+ by two-photon absorption
of femtosecond pulses at a wavelength of 431nm. We compare this technique to
electron-bombardment ionisation and observe several advantages of
photoionisation. It actually allows the loading of a pure Sr+ ion cloud in a
low radio-frequency voltage amplitude regime. In these conditions up to 4x10^4
laser-cooled Sr+ ions were trapped
Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.
Microglia interact with neurons to facilitate synapse plasticity; however, signal(s) contributing to microglia activation for synapse elimination in pathology are not fully understood. Here, using in vitro organotypic hippocampal slice cultures and transient middle cerebral artery occlusion (MCAO) in genetically engineered mice in vivo, we report that at 24 hours after ischemia, microglia release brain-derived neurotrophic factor (BDNF) to downregulate glutamatergic and GABAergic synapses within the peri-infarct area. Analysis of the cornu ammonis 1 (CA1) in vitro shows that proBDNF and mBDNF downregulate glutamatergic dendritic spines and gephyrin scaffold stability through p75 neurotrophin receptor (p75 <sup>NTR</sup> ) and tropomyosin receptor kinase B (TrkB) receptors, respectively. After MCAO, we report that in the peri-infarct area and in the corresponding contralateral hemisphere, similar neuroplasticity occurs through microglia activation and gephyrin phosphorylation at serine-268 and serine-270 in vivo. Targeted deletion of the Bdnf gene in microglia or GphnS268A/S270A (phospho-null) point mutations protects against ischemic brain damage, neuroinflammation, and synapse downregulation after MCAO
Tactile Elevation Perception in Blind and Sighted Participants and Its Implications for Tactile Map Creation
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