Understanding the shared meaning of recovery from Substance Use Disorders.:New findings from the What is Recovery? Study.

Background:Substance use disorder (SUD) resolution typically involves a long-term, comprehensive process of change now widely referred to as “recovery.” Yet, definitions of recovery vary substantially, producing significant confusion. To support formal recovery definitions, we aimed to systematically identify recovery elements that are central to those in recovery and shared regardless of subgroup/pathway.Methods:Data were from the What is Recovery? Study, involving a diverse, national, online survey of people in recovery (N = 9341). Surveys included a 35-item recovery measure reflecting 4 domains; participants reported whether or not each element definitely belonged in their recovery definitions. Analyses examined item endorsements overall and among 30 subgroups defined a priori (by sociodemographics, substance use characteristics, and help-seeking history) to determine where items met study-specific centrality thresholds (ie, endorsement by ⩾80% and top-10 ranking, by endorsement level). We then classified items as “core” if meeting centrality thresholds both overall and for all 30 subgroups, and “prevalent” if meeting centrality thresholds overall and for 26 to 29 subgroups.Results:Four “core” recovery elements emerged, including a process of growth or development; being honest with oneself; taking responsibility for the things one can change; and reacting in a more balanced way. Four “prevalent” recovery elements also emerged, referencing the ability to enjoy life and handle negative feelings without substance use; abstinence and/or nonproblematic substance use; and living a life that contributes. Subgroups differing most in their endorsements included those reporting mild/moderate SUD severity; non-abstinent recovery; and no specialty treatment or mutual-help group attendance.Conclusions:Recovery elements identified here partially reflect some stakeholder definitions, but offer greater specificity and include novel elements (eg, personal integrity). Elements may point to areas of functioning that are damaged in the addiction process and can support an addiction-free life. Findings should inform institutional recovery definitions; SUD services and research; and communications about recovery

Pattern matching and pattern discovery algorithms for protein topologies

We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgraph isomorphism and finding maximal common subgraphs in a restricted class of ordered graphs. We have developed a subgraph isomorphism algorithm for ordered graphs, which performs well on the given set of data. The maximal common subgraph problem then is solved by repeated subgraph extension and checking for isomorphisms. Despite the apparent inefficiency such approach gives an algorithm with time complexity proportional to the number of graphs in the input set and is still practical on the given set of data. As a result we obtain fast methods which can be used for building a database of protein topological motifs, and for the comparison of a given protein of known secondary structure against a motif database

VNbCrMo refractory high-entropy alloy for nuclear applications

Refractory high-entropy alloys (RHEAs) with high melting points and low neutron absorption cross-section are sought for generation-IV fission and fusion reactors. A high throughput computational screening tool, Alloy Search and Predict (ASAP), was used to identify promising RHEA candidates from over 1 million four-element equimolar combinations. The selected VNbCrMo RHEA was further studied by CALPHAD to predict phase formation, which was compared to an experimentally produced ingot aged at 1200 °C. The VNbCrMo RHEA was found to constitute a majority bcc phase, with a 6% area fraction of C15-Laves formed at interdendritic regions, in contrast to the predictions of single-phase. The prediction of the yield strength by a model based upon edge dislocation mechanisms indicated 2.1 GPa at room temperature and 850 MPa at 1000 °C for the equimolar single bcc phase. The hardness of the alloy with C15-Laves was 748 HV (yield strength ∼2.4 GPa). Finally, the macroscopic neutron absorption cross-section was modelled for a wide range of energies. Displacements per atom per year and activation calculations, up to 1000 years after 2 years of continuous operation, in typical fusion and fission reactor scenarios were also performed using the inventory code FISPACT-II. This work gives new insight into the phase stability and performance of the VNbCrMo RHEA, which is compared with a similar design concept alloy, to assess the potential of novel RHEAs for use in advanced nuclear applications.Fil: Ferreirós, Pedro Antonio. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: von Tiedemann, S. O.. The University Of Birmingham (tub);Fil: Parkes, N.. The University Of Birmingham (tub);Fil: Gurah, D.. The University Of Birmingham (tub);Fil: King, D. J. M.. Imperial College London; Reino UnidoFil: Norman, P.. The University Of Birmingham (tub);Fil: Gilbert, M. R.. The University Of Birmingham (tub);Fil: Knowles, A. J.. Imperial College London; Reino Unid

Effect of photoperiod and host distribution on the horizontal transmission of Isaria fumosorosea (Hypocreales: Cordycipitaceae) in greenhouse whitefly assessed using a novel model bioassay

A model bioassay was used to evaluate the epizootic potential and determine the horizontal transmission efficiency of Isaria fumosorosea Trinidadian strains against Trialeurodes vaporariorum pharate adults under optimum conditions (25±0.5°C, ~100% RH) at two different photoperiods. Untreated pharate adults were arranged on laminated graph paper at different distributions to simulate varying infestation levels on a leaf surface. Four potential hosts were located 7, 14 and 21 mm away from a central sporulating cadaver simulating high, medium and low infestation levels, respectively. Percent hosts colonized were recorded 7, 12, 14 and 21 days post-treatment during a 16- and 24-h photophase. After 21 days, mean percent hosts colonized at the highest, middle and lowest infestation levels were 93 and 100%, 22 and 58%, 25 and 39% under a 16- and 24-h photophase, respectively. From the results, it was concluded that the longer the photophase, the greater the percentage of hosts colonized, and as host distance increased from the central sporulating cadaver, colonization decreased. The use of this novel model bioassay technique is the first attempt to evaluate the epizootic potential and determine the horizontal transmission efficiency of I. fumosorosea Trinidadian strains under optimal environmental conditions at different photoperiods. This bioassay can be used to assess horizontal transmission efficiency for the selection of fungi being considered for commercial biopesticide development

Trajectory versus probability density entropy

We study the problem of entropy increase of the Bernoulli-shift map without recourse to the concept of trajectory and we discuss whether, and under which conditions if it does, the distribution density entropy coincides with the Kolmogorov-Sinai entropy, namely, with the trajectory entropy.Comment: 24 page

Nonlinear interference in a mean-field quantum model

Using similar nonlinear stationary mean-field models for Bose-Einstein Condensation of cold atoms and interacting electrons in a Quantum Dot, we propose to describe the original many-particle ground state as a one-particle statistical mixed state of the nonlinear eigenstates whose weights are provided by the eigenstate non-orthogonality. We search for physical grounds in the interpretation of our two main results, namely, quantum-classical nonlinear transition and interference between nonlinear eigenstates.Comment: RevTeX (pdfLaTeX), 7 pages with 5 png-figures include

Local rewiring of genome-nuclear lamina interactions by transcription

Transcriptionally inactive genes are often positioned at the nuclear lamina (NL), as part of large lamina-associated domains (LADs). Activation of such genes is often accompanied by repositioning toward the nuclear interior. How this process works and how it impacts flanking chromosomal regions are poorly understood. We addressed these questions by systematic activation or inactivation of individual genes, followed by detailed genome-wide analysis of NL interactions, replication timing, and transcription patterns. Gene activation inside LADs typically causes NL detachment of the entire transcription unit, but rarely more than 50-100 kb of flanking DNA, even when multiple neighboring genes are activated. The degree of detachment depends on the expression level and the length of the activated gene. Loss of NL interactions coincides with a switch from late to early replication timing, but the latter can involve longer stretches of DNA. Inactivation of active genes can lead to increased NL contacts. These extensive datasets are a resource for the analysis of LAD rewiring by transcription and reveal a remarkable flexibility of interphase chromosomes

Emerging Artificial Societies Through Learning

The NewTies project is implementing a simulation in which societies of agents are expected to de-velop autonomously as a result of individual, population and social learning. These societies are expected to be able to solve environmental challenges by acting collectively. The challenges are in-tended to be analogous to those faced by early, simple, small-scale human societies. This report on work in progress outlines the major features of the system as it is currently conceived within the project, including the design of the agents, the environment, the mechanism for the evolution of language and the peer-to-peer infrastructure on which the simulation runs

The anapole moment and nucleon weak interactions

From the recent measurement of parity nonconservation (PNC) in the Cs atom we have extracted the constant of the nuclear spin dependent electron-nucleon PNC interaction, $\kappa = 0.442 (63)$; the anapole moment constant, $\kappa_a = 0.364 (62)$; the strength of the PNC proton-nucleus potential, $g_p = 7.3 \pm 1.2 (exp.) \pm 1.5 (theor.)$; the $\pi$-meson-nucleon interaction constant, $f_\pi \equiv h_\pi^{1} = [9.5 \pm 2.1 (exp.) \pm 3.5 (theor.)] \times 10^{-7}$; and the strength of the neutron-nucleus potential, $g_n = -1.7 \pm 0.8 (exp.) \pm 1.3 (theor.)$.Comment: Uses RevTex, 12 pages. We have added an explanation of the effect of finite nuclear siz