Integrated study of factors affecting fetal weight in singleton pregnancies. Nomogram and development of basic and advanced fetal growth customized models

We have performed a multivariate analysis to explore the influence on birth and ultrasound fetal weight estimation of traditional factors as biochemical data and maternal characteristics in combination with non- traditionally explored predictors as paternal height, Pregnancy-associated plasma protein A (PAPP-A), single umbilical artery or Free-beta Human Chorionic Gonadotropin (fß- HCG). The study was performed for a Spanish population (region of Aragon) in singleton pregnancies at term (37-42 weeks). Also, we have created a nomogram and in order to predict the occurrence of SGA (small for gestational age) and LGA (large for gestational age) cases we provide a multivariate predictive model of fetal weight that have been compared with other models in the prediction of ultrasound and birth weights. After study we have created a software application for automated calculation of percentile fetal weight, adjusting the variables when they were significant

Social Avoidance in Depression:A Study Using a Social Decision-Making Task

Depression significantly affects interpersonal functioning. Social avoidance may play an important role in depression, limiting opportunities and social skills acquisition, contributing to the maintenance of social difficulties. In the last few years, the need for studying social interactions using interactive tasks has been highlighted. This study investigated social avoidance in unmedicated depressed (n = 26) and matched healthy control (n = 26) participants, using a novel computerized social decision-making task (the TEAM task). In this task, participants choose between a social option (playing in a team with a coplayer) and an individual option (playing alone). Although the social option is more profitable from a material point of view, it can also be challenging because of social comparison and guilt feelings for failing the team. It was found that the higher the rank of the coplayer, the stronger the negative emotions (shame, guilt) reported by participants and the more they opted for the individual option. Depressed participants reported significantly less positive (happiness) and more negative (shame, guilt, disappointment) feelings regarding the task. Importantly, depressed participants chose the individual option significantly more often than controls, which led to lower gains in this group. Furthermore, as the task progressed, controls selected the individual option less often, whereas depressed participants selected the individual option more often. Our findings illustrate the importance of social avoidance in depression and how this behavior can lead to negative consequences. They also highlight the role of social comparison and guilt-related processes in underlying social avoidance in depression. (PsycINFO Database Record (c) 2019 APA, all rights reserved

2-Hydroxychalcone−β-cyclodextrin conjugate with pH-modulated photoresponsive binding properties

Stimuli-responsive supramolecular receptors are important building blocks for the construction of self-assembled functional materials. We report the design and synthesis of a pH- and light-responsive 2-hydroxychalcone−β-cyclodextrin conjugate (1-Ct) and its characterization by spectroscopic and computational methods. 1-Ct follows the typical reaction network of trans-chalcone-flavylium photoswitches. Upon light irradiation, 1-Ct can be photochemically converted into the cis-chalcone/hemiketal forms (1-Cc/1-B) under neutral pH conditions or to the flavylium cation (1-AH+) at acidic pH values. This stimuli-responsive β-cyclodextrin host, 1-Ct, was found to form stronger intramolecular self-inclusion complexes (Kintra = 14) than 1-AH+ (Kintra = 3) and weaker than 1-Cc/1-B (overall Kintra = 179), allowing control over their stability and binding properties by combinations of pH and light stimuli.Fundação para a Ciência e a Tecnologia | Ref. UIDB/50006/2020Fundação para a Ciência e a Tecnologia| Ref. UIDP/50006/2020Fundação para a Ciência e a Tecnologia | Ref. UIDB/04326/202

Aportación al conocimiento del género Cheilanthes en la Península Ibérica

Cheilanthes pulchella and Cheilanthes x insularis are mentionedas new from the Iberian Peninsula and distribution of Cheilanthes guanchica and Cheilanthes x iberica is amplied. The Cheilanthes taxa from the Iberian Peninsuli are listed. Key of determination is proposed.En esta nota se citan por primera vez en la Península Ibérica Cheilanthes pulcheIla y Cheilanthes x insularis y se amplia la distribución de Cheilanthes guanchica y Cheilanthes x iberica. Se completa el catálogo de los táxones de este género en la Península Ibérica, añadiéndose una clave de determinación para los mismos

Relationship between the cathodoluminescence emission and resistivity in In doped CdZnTe crystals

Cadmium zinc telluride, CdZnTe, bulk single crystals doped with 1019 at./cm3 of indium in the initial melt were grown by vertical Bridgman technique. The samples were investigated by energy dispersive spectroscopy, cathodoluminiscence (CL), and current-voltage behavior at room temperature. The results shows that Cd and Te vacancy concentration depend on the indium and zinc concentrations. CL measurements indicate a relationship between radiative centers associated to Cd and Te vacancies and resistivity values

High conductance values in p -folded molecular junctions

Folding processes play a crucial role in the development of function in biomacromolecules. Recreating this feature on synthetic systems would not only allow understanding and reproducing biological functions but also developing new functions. This has inspired the development of conformationally ordered synthetic oligomers known as foldamers. Herein, a new family of foldamers, consisting of an increasing number of anthracene units that adopt a folded sigmoidal conformation by a combination of intramolecular hydrogen bonds and aromatic interactions, is reported. Such folding process opens up an efficient through-space charge transport channel across the interacting anthracene moieties. In fact, single-molecule conductance measurements carried out on this series of foldamers, using the scanning tunnelling microscopy-based break-junction technique, reveal exceptionally high conductance values in the order of 10(-1) G(0) and a low length decay constant of 0.02 angstrom(-1) that exceed the values observed in molecular junctions that make use of through-space charge transport pathways.We thank Dr J.I. Miranda (University of the Basque Country) for assistance on NMR characterization. We are grateful to the Basque Science Foundation for Science (Ikerbasque), POLYMAT, the University of the Basque Country (SGIker and UFI11/23), the Deutsche Forschungsgemeinschaft (AU 373/3-1 and MA 5215/4-1), Gobierno de Espana (Ministerio de Economia y Competitividad CTQ2016-77970-R, CTQ2015-71936-REDT, CTQ2015-71406-ERC, CTQ2015-64579-C3-3P, CTQ-2014-54464-R and CTQ-2015-68148), Gobierno Vasco (BERC programme, Consolidated Groups IT520-10 and PC2015-1-01(06-37)), Diputacion Foral de Guipuzcoa (OF215/2016(ES)), CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT ref. UID/CTM/50011/2013), ON2 (NORTE-07-0162-FEDER-000086) and the European Union (ERA Chemistry, Marie Curie Career Integration Grant No. 618247, and FET-Open (2D-INK) Grant No. 664878)

Hospital Virtual: Sistema de información clínica y telecuidado de pacientes VIH/SIDA basado en tecnologías Web 2.0

Este artículo describe el desarrollo de un nuevo sistema de información clínica y telecuidado de pacientes VIH/SIDA que se encuentra implantado en rutina clínica dentro del Servicio de Enfermedades Infecciosas del Hospital Clínic de Barcelona. El proyecto surge ante la necesidad de unificar el sistema de información departamental del servicio y un sistema de telemedicina instalado en el hospital en 2004. Para ello se han diseñado e implementado nuevas bases de datos y dos sistemas específicos para uso de profesionales y pacientes. Además, se ha realizado una integración con el Sistema de Información del Hospital (HIS) permitiendo el acceso a todos los datos requeridos de los pacientes desde una única aplicación. Este nuevo sistema está al servicio de más de 70 profesionales sanitarios que realizan una media de 150 consultas al día disponiendo de información clínica de más de 8000 pacientes

A new European coastal flood database for low–medium intensity events

Coastal flooding is recognized as one of the most devastating natural disasters, resulting in significant economic losses. Therefore, hazard assessment is crucial to support preparedness and response to such disasters. Toward this, flood map databases and catalogues are essential for the analysis of flood scenarios, and furthermore they can be integrated into disaster risk reduction studies. In this study and in the context of the European Coastal Flood Awareness System (ECFAS) project (GA 101004211), which aimed to propose the European Copernicus Coastal Flood Awareness System, a catalogue of flood maps was produced. The flood maps were generated from flood models developed with LISFLOOD-FP for defined coastal sectors along the entire European coastline. For each coastal sector, 15 synthetic scenarios were defined focusing on high-frequency events specific to the local area. These scenarios were constructed based on three distinct storm durations and five different total-water-level (TWL) peaks incorporating tide, mean sea level, surge and wave setup components. The flood model method was extensively validated against 12 test cases for which observed data were collated using satellite-derived flood maps and in situ flood markers. Half of the test cases represented well the flooding with hit scores higher than 80 %. The synthetic-scenario approach was assessed by comparing flood maps from real events and their closest identified scenarios, producing a good agreement and global skill scores higher than 70 %. Using the catalogue, flood scenarios across Europe were assessed, and the biggest flooding occurred in well-known low-lying areas. In addition, different sensitivities to the increase in the duration and TWL peak were noted. The storm duration impacts a few limited flood-prone areas such as the Dutch coast, for which the flooded area increases more than twice between 12 and 36 h storm scenarios. The influence of the TWL peak is more global, especially along the Mediterranean coast, for which the relative difference between a 2- and 20-year return period storm is around 80 %. Finally, at a European scale, the expansion of flood areas in relation to increases in TWL peaks demonstrated both positive and negative correlations with the presence of urban and wetland areas, respectively. This observation supports the concept of storm flood mitigation by wetlands.</p

Studi Implementasi Pendidikan Karakter Pada Pembelajaran Matematika Pada Kelas Cerdas Istimewa Bakat Istimewa (Cibi) SMP Negeri 2 Surakarta

The objective of research was to describe the implementation of character education to mathematics learning, the constraints the teacher faced and the solution the teachers took to the constraints with the implementation of character education in mathematics learning in the gifted and talented class of SMP Negeri 2 Surakarta. This study was a descriptive qualitative research; the subject of researcher was one mathematics teacher and six students in the grade VII gifted and talented class. Techniques of validating data used were researcher persistence and time triangulation. Techniques of analyzing data used were (1) data reduction, (2) data display, and (3) conclusion drawing and verification. The results of research are as follows. 1) The process of character education implementation to learning was below. (a) The development of logical, critical, creative and innovative thinking character was conducted by means of assignment, directing the students to the correct answer and to make decision with debriefing. (b) The development of hard work character was conducted by means of group assignment. (c) The development of curiosity character was conducted by providing the example of material existing in real life. (d) The development of independency character was conducted by assigning the material reading to be discussed in the next meeting. (e) The development of self-confidence character was conducted by means of facilitating the students writing the result on the blackboard. 2) The constraints the teacher faced and the solutions the teacher took were as follows. (a) In the implementation of logical, critical, creative and innovative thinking character, the students monopolized actively the debriefing process so that the teacher should limit and provide other students the opportunity of asking question. (b) In the implementation of hard work character, not all students in the classroom had equal hard work ethos. The solutions taken were to play motivation video and to convince them about the ability they had, to display the students\u27 work, and to reward the students with the best performance. (c) In the implementation of curiosity character, the students who did not want to think too hard responded poorly to the stimulus given. In this case, the teacher could give reward in the form of mark (grade). (d) In the implementation of self-confidence character, the students with less self-confidence would select the easy assignment in presenting the group assignment, and they explained in very soft voice. The solutions taken were to give more mark to the students explaining group assignment, and to direct the students in the presentation. For teacher independency character, the teacher did not face a significant constraint

Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocytedeficient mice reconstituted with human NK cells

Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival