524 research outputs found
The HIFI spectral survey of AFGL 2591 (CHESS). II. Summary of the survey
This paper presents the richness of submillimeter spectral features in the
high-mass star forming region AFGL 2591. As part of the CHESS (Chemical
Herschel Survey of Star Forming Regions) Key Programme, AFGL 2591 was observed
by the Herschel/HIFI instrument. The spectral survey covered a frequency range
from 480 up to 1240 GHz as well as single lines from 1267 to 1901 GHz (i.e. CO,
HCl, NH3, OH and [CII]). Rotational and population diagram methods were used to
calculate column densities, excitation temperatures and the emission extents of
the observed molecules associated with AFGL 2591. The analysis was supplemented
with several lines from ground-based JCMT spectra. From the HIFI spectral
survey analysis a total of 32 species were identified (including
isotopologues). In spite of the fact that lines are mostly quite week, 268
emission and 16 absorption lines were found (excluding blends). Molecular
column densities range from 6e11 to 1e19 cm-2 and excitation temperatures range
from 19 to 175 K. One can distinguish cold (e.g. HCN, H2S, NH3 with
temperatures below 70 K) and warm species (e.g. CH3OH, SO2) in the protostellar
envelope.Comment: Accepted to A&
Insights into mitochondrial dysfunction: aging, amyloid-ÎČ, and tau-A deleterious trio
Significance: Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder mainly affecting elderly individuals. The pathology of AD is characterized by amyloid plaques (aggregates of amyloid-ÎČ [AÎČ]) and neurofibrillary tangles (aggregates of tau), but the mechanisms underlying this dysfunction are still partially unclear. Recent Advances: A growing body of evidence supports mitochondrial dysfunction as a prominent and early, chronic oxidative stress-associated event that contributes to synaptic abnormalities and, ultimately, selective neuronal degeneration in AD. Critical Issues: In this review, we discuss on the one hand whether mitochondrial decline observed in brain aging is a determinant event in the onset of AD and on the other hand the close interrelationship of this organelle with AÎČ and tau in the pathogenic process underlying AD. Moreover, we summarize evidence from aging and Alzheimer models showing that the harmful trio "aging, AÎČ, and tau protein" triggers mitochondrial dysfunction through a number of pathways, such as impairment of oxidative phosphorylation (OXPHOS), elevation of reactive oxygen species production, and interaction with mitochondrial proteins, contributing to the development and progression of the disease. Future Directions: The aging process may weaken the mitochondrial OXPHOS system in a more general way over many years providing a basis for the specific and destructive effects of AÎČ and tau. Establishing strategies involving efforts to protect cells at the mitochondrial level by stabilizing or restoring mitochondrial function and energy homeostasis appears to be challenging, but very promising route on the horizon
Molecular Mechanisms Leading from Periodontal Disease to Cancer
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKLâRANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome
Strong absorption by interstellar hydrogen fluoride: Herschel/HIFI observations of the sight-line to G10.6-0.4 (W31C)
We report the detection of strong absorption by interstellar hydrogen
fluoride along the sight-line to the submillimeter continuum source G10.6-0.4
(W31C). We have used Herschel's HIFI instrument, in dual beam switch mode, to
observe the 1232.4763 GHz J=1-0 HF transition in the upper sideband of the Band
5a receiver. The resultant spectrum shows weak HF emission from G10.6-0.4 at
LSR velocities in the range -10 to -3 km/s, accompanied by strong absorption by
foreground material at LSR velocities in the range 15 to 50 km/s. The spectrum
is similar to that of the 1113.3430 GHz 1(11)-0(00) transition of para-water,
although at some frequencies the HF (hydrogen fluoride) optical depth clearly
exceeds that of para-H2O. The optically-thick HF absorption that we have
observed places a conservative lower limit of 1.6E+14 cm-2 on the HF column
density along the sight-line to G10.6-0.4. Our lower limit on the HF abundance,
6E-9 relative to hydrogen nuclei, implies that hydrogen fluoride accounts for
between ~ 30 and 100% of the fluorine nuclei in the gas phase along this
sight-line. This observation corroborates theoretical predictions that -
because the unique thermochemistry of fluorine permits the exothermic reaction
of F atoms with molecular hydrogen - HF will be the dominant reservoir of
interstellar fluorine under a wide range of conditions.Comment: Accepted for publication in Astronomy and Astrophysics (Herschel
special issue). This revised version corrects a typographic error in the HTML
abstract, in which the lower limit on the HF abundance (should be 6E-9) was
previously misstated. The abstract in the PDF version is correct and the
latter has not been modifie
Phytoplankton calcification as an effective mechanism to prevent cellular calcium poisoning
Marine phytoplankton have developed the remarkable ability to tightly regulate the concentration of free calcium ions in the intracellular cytosol at a level of ~ 0.1 ÎŒmol Lâ1 in the presence of seawater Ca2+ concentrations of 10 mmol Lâ1. The low cytosolic calcium ion concentration is of utmost importance for proper cell signalling function. While the regulatory mechanisms responsible for the tight control of intracellular Ca2+ concentration are not completely understood, phytoplankton taxonomic groups appear to have evolved different strategies, which may affect their ability to cope with changes in seawater Ca2+ concentrations in their environment on geological timescales. For example, the Cretaceous (145 to 66 Ma), an era known for the high abundance of coccolithophores and the production of enormous calcium carbonate deposits, exhibited seawater calcium concentrations up to 4 times present-day levels. We show that calcifying coccolithophore species (Emiliania huxleyi, Gephyrocapsa oceanica and Coccolithus braarudii) are able to maintain their relative fitness (in terms of growth rate and photosynthesis) at simulated Cretaceous seawater calcium concentrations, whereas these rates are severely reduced under these conditions in some non-calcareous phytoplankton species (Chaetoceros sp., Ceratoneis closterium and Heterosigma akashiwo). Most notably, this also applies to a non-calcifying strain of E. huxleyi which displays a calcium sensitivity similar to the non-calcareous species. We hypothesize that the process of calcification in coccolithophores provides an efficient mechanism to alleviate cellular calcium poisoning and thereby offered a potential key evolutionary advantage, responsible for the proliferation of coccolithophores during times of high seawater calcium concentrations. The exact function of calcification and the reason behind the highly ornate physical structures of coccoliths remain elusive
Incremental Value of Computed Tomography Perfusion for Final Infarct Prediction in Acute Ischemic Cerebellar Stroke
Background
The diagnosis of ischemic cerebellar stroke is challenging because of nonspecific symptoms and very limited accuracy of commonly applied computed tomography (CT) imaging. Advances in CT perfusion imaging provide increasing value in the detection of posterior circulation stroke, but the prognostic value remains unclear. We aimed to identify imaging parameters that predict morphologic outcome in cerebellar stroke patients using advanced CT including wholeâbrain CT perfusion (WBâCTP).
Methods and Results
We selected all subjects with cerebellar WBâCTP perfusion deficits and followâupâconfirmed cerebellar infarction from a consecutive cohort with suspected stroke who underwent WBâCTP. PosteriorâcirculationâAcuteâStrokeâPrognosisâEarlyâCTâScore (pcâASPECTS) was determined on noncontrast CT, CT angiography source images, and on parametric WBâCTP maps. Cerebellar perfusion deficit volumes on all maps and the final infarction volume on followâup imaging were quantified. Uniâ and multivariate regression analyses were performed. Sixty patients fulfilled the inclusion criteria. pcâASPECTS on CT angiography source images (Ă, â9.239; 95% CI, â14.220 to â4.259; P0.05).
Conclusions
In contrast to noncontrast CT and CT angiography, WBâCTP imaging contains prognostic information for morphologic outcome in patients with acute cerebellar stroke
Interstellar OH+, H2O+ and H3O+ along the sight-line to G10.6-0.4
We report the detection of absorption lines by the reactive ions OH+, H2O+
and H3O+ along the line of sight to the submillimeter continuum source
G10.60.4 (W31C). We used the Herschel HIFI instrument in dual beam switch
mode to observe the ground state rotational transitions of OH+ at 971 GHz, H2O+
at 1115 and 607 GHz, and H3O+ at 984 GHz. The resultant spectra show deep
absorption over a broad velocity range that originates in the interstellar
matter along the line of sight to G10.60.4 as well as in the molecular gas
directly associated with that source. The OH+ spectrum reaches saturation over
most velocities corresponding to the foreground gas, while the opacity of the
H2O+ lines remains lower than 1 in the same velocity range, and the H3O+ line
shows only weak absorption. For LSR velocities between 7 and 50 kms we
estimate total column densities of (OH+) cm,
(H2O+) cm and (H3O+) cm. These detections confirm the role of O and OH in
initiating the oxygen chemistry in diffuse molecular gas and strengthen our
understanding of the gas phase production of water. The high ratio of the OH+
by the H2O+ column density implies that these species predominantly trace
low-density gas with a small fraction of hydrogen in molecular form
Herschel/HIFI observations of interstellar OH+ and H2O+ towards W49N: a probe of diffuse clouds with a small molecular fraction
We report the detection of absorption by interstellar hydroxyl cations and
water cations, along the sight-line to the bright continuum source W49N. We
have used Herschel's HIFI instrument, in dual beam switch mode, to observe the
972 GHz N = 1 - 0 transition of OH+ and the 1115 GHz 1(11) - 0(00) transition
of ortho-H2O+. The resultant spectra show absorption by ortho-H2O+, and strong
absorption by OH+, in foreground material at velocities in the range 0 to 70
km/s with respect to the local standard of rest. The inferred OH+/H2O+
abundance ratio ranges from ~ 3 to ~ 15, implying that the observed OH+ arises
in clouds of small molecular fraction, in the 2 - 8% range. This conclusion is
confirmed by the distribution of OH+ and H2O+ in Doppler velocity space, which
is similar to that of atomic hydrogen, as observed by means of 21 cm absorption
measurements, and dissimilar from that typical of other molecular tracers. The
observed OH+/H abundance ratio of a few E-8 suggests a cosmic ray ionization
rate for atomic hydrogen of (0.6 - 2.4) E-16 s-1, in good agreement with
estimates inferred previously for diffuse clouds in the Galactic disk from
observations of interstellar H3+ and other species.Comment: Accepted for publication in A&A Letter
Cost-effectiveness of short-protocol emergency brain MRI after negative non-contrast CT for minor stroke detection
OBJECTIVES To investigate the cost-effectiveness of supplemental short-protocol brain MRI after negative non-contrast CT for the detection of minor strokes in emergency patients with mild and unspecific neurological symptoms. METHODS The economic evaluation was centered around a prospective single-center diagnostic accuracy study validating the use of short-protocol brain MRI in the emergency setting. A decision-analytic Markov model distinguished the strategies \textquotedblno additional imaging\textquotedbl and \textquotedbladditional short-protocol MRI\textquotedbl for evaluation. Minor stroke was assumed to be missed in the initial evaluation in 40% of patients without short-protocol MRI. Specialized post-stroke care with immediate secondary prophylaxis was assumed for patients with detected minor stroke. Utilities and quality-of-life measures were estimated as quality-adjusted life years (QALYs). Input parameters were obtained from the literature. The Markov model simulated a follow-up period of up to 30 years. Willingness to pay was set to 26,304 (CT only: $27,109). Cumulative calculated effectiveness in the CT-only group was 14.25 QALYs (short-protocol MRI group: 14.31 QALYs). In the deterministic sensitivity analysis, additional short-protocol MRI remained the dominant strategy in all investigated ranges. Probabilistic sensitivity analysis results from the base case analysis were confirmed, and additional short-protocol MRI resulted in lower costs and higher effectiveness. CONCLUSION Additional short-protocol MRI in emergency patients with mild and unspecific neurological symptoms enables timely secondary prophylaxis through detection of minor strokes, resulting in lower costs and higher cumulative QALYs. KEY POINTS âą Short-protocol brain MRI after negative head CT in selected emergency patients with mild and unspecific neurological symptoms allows for timely detection of minor strokes. âą This strategy supports clinical decision-making with regard to immediate initiation of secondary prophylactic treatment, potentially preventing subsequent major strokes with associated high costs and reduced QALY. âą According to the Markov model, additional short-protocol MRI remained the dominant strategy over wide variations of input parameters, even when assuming disproportionally high costs of the supplemental MRI scan
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