Swift observations of GRB 060614: an anomalous burst with a well behaved afterglow

GRB 060614 is a remarkable GRB observed by Swift with puzzling properties, which challenge current progenitor models. The lack of any bright SN down to very strict limits and the vanishing spectral lags are typical of short GRBs, strikingly at odds with the long (102s) duration of this event. Here we present spectral and temporal analysis of the Swift observations. We show that the burst presents standard optical, UV and X-ray afterglows. An achromatic break is observed simultaneously in optical and X-rays, at a time consistent with the break in the R-band light curve measured by the VLT. The achromatic behaviour and the consistent post-break decay slopes make GRB 060614 one of the best examples of a jet break for a Swift burst. The optical, UV and X-rays afterglow light curves have also an earlier break at ~30 ks. In the optical, there is strong spectral evolution around this break, suggesting the passage of a break frequency through the optical/UV band. The very blue spectrum at early times and the trend in the light curves (rising at low frequencies, and decaying at higher energies) suggest this may be the injection frequency. The early X-ray light curve is well interpreted as the X-ray counterpart of the burst extended emission. Spectral analysis of BAT/XRT data in the 80s overlap time show that the Ep of the burst has decreased to as low as 8keV at the beginning of the XRT observation. The Ep continues to decrease through the XRT energy band and exits it at about 500s after the trigger. The average Ep of the burst is likely < 24 keV but larger than 8 keV. The initial peak observed by BAT is however distinctly harder than the rest with Ep ~300 keV as measured by Konus Wind. Considering the time-averaged spectral properties, GRB 060614 is consistent with the Eiso-Ep_rest, Egamma-Ep_rest, and Liso-Ep correlations.Comment: 20 pages, 9 figures, 8 tables. Abstract shortened for posting on astro-ph. Accepted for publication by A&

Application of biotic and taxonomic distinctness indices in assessing the Ecological Quality Status of two coastal lakes: Caprolace and Fogliano lakes (Central Italy)

Marine biotic indices (AMBI, BENTIX) and the statistical tool M-AMBI (Multivariate AMBI) were applied as a comparative approach in assessing the Ecological Quality Status (EcoQS) of two Mediterranean coastal lakes (Caprolace and Fogliano lakes) situated in the Circeo National Park (Central Italy). The macrobenthic community was analysed using univariate indices (community structure), correspondence analysis (CA) and taxonomic distinctness indices (Delta(+) and Lambda(+)). The community composition showed a dominance of lagoonal species in both coastal lakes, while in Caprolace lake marine taxa were also found. Diversity index (H') complies to ranges found in Mediterranean lagoons and taxonomic distinctness indices demonstrated that taxonomy structure is in accordance with natural variability ranges. Principal component analysis (PCA) on chemical parameters of water and sediment showed that both coastal lakes differ mainly in their organic matter composition. In fact, the protein fraction of bio-polymeric carbon prevails in Fogliano lake, while the 'refractory' component represented by carbohydrate fraction is predominant in Caprolace lake. The difference between the two coastal lakes was also demonstrated by co-inertia analysis (COIA) performed using abundance of species and concentrations of chemical parameters. The results from the application of the three biotic indices do not highlight a clear distinction between the two lagoons. However, the AMBI index provided a more suitable evaluation of EcoQS corresponding to 'slightly polluted' lagoons while M-AMBI and moreover BENTIX indices indicated a worsening situation. The biotic indices are widely used in assessing the EcoQS in marine environments, but their proper application in transitional waters would depend on a resettlement; thresholds established in the biotic index scale values need to be modified according to natural variability of transitional waters referring to abiotic conditions and abundance of tolerant species. (C) 2008 Elsevier Ltd. All rights reserved

Assessing pollen extreme events over a Mediterranean site: Role of local surface meteorology

The presence of very high pollen levels in the atmosphere is associated with a strong impact on health and a worsening of symptoms in people who already have a respiratory disease. However, there is no specification on the aerobiological, environmental and meteorological factors that allow for characterizing a pollen event as of great magnitude due to the significant impact it can cause on the population and the environment. This work proposes criteria to typify the levels of atmospheric pollen as an extreme pollen event (EPE), and aims to determine the meteorological variables that can affect the presence and permanence of high pollen concentrations over a period of time. To address this goal, the quasi-climatological pollen dataset recorded in Granada (Southeastern Spain) during the period 1992-2019, has been used. On the daily accumulated pollen concentrations, the 95th, 97th and 99th percentiles were calculated. Spearman's correlation between the pollen concentration exceeding the proposed thresholds (C>P95, C>P97, C>P99) and surface meteorological variables recorded during up to five days before the event were established in order to identify the meteorological conditions that might affect the EPEs. As for the number of days with values higher than the established percentiles, it has been seen that in the case of total pollen and Olea, Cupressaceae and Pinus, there is a robust monotonically ascending trend throughout the study period. Regarding meteorological variables, relative humidity and 24-h accumulated precipitation are shown as the two most influential variables up to three days before the event, although temperatures, visibility and wind direction also show a correlation with some pollen types. The criteria proposed in this work allow us for classifying high levels of pollen as an EPE, and lay the foundations of these extreme events in a context of climate change in which they will become more frequent.the Spanish Ministry of Economy and Competitiveness (MINECO) for support through project BIOCLOUD (RTI2018-101154-A-100) and INTEGRATYON3 (PID2020.117825GB.C21)Regional Government of Andalusia through project AEROPRE (P18-RT-3820) and ADAPNE (P20-00136)INPARK (B-RNM-474-UGR18)DEM3TRIOS (A-RNM-430-UGR20)Earth System Excellence Units Progra

Structure and Stability of an Amorphous Metal

Using molecular dynamics simulations, with a realistic many-body embedded-atom potential, and a novel method to characterize local order, we study the structure of pure nickel during the rapid quench of the liquid and in the resulting glass. In contrast with previous simulations with pair potentials, we find more crystalline order and fewer icosahedra for slower quenching rates, resulting in a glass less stable against crystallization. It is shown that there is not a specific amorphous structure, only the arrest of the transition from liquid to crystal, resulting in small crystalline clusters immersed in an amorphous matrix with the same structure of the liquid.Comment: 4 pages, 4 ps figs., to appear in Phys. Rev. Let

The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study.

INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic ('COVID' cohort, 16/03/2020-10/05/2020), with 12-month follow-up. RESULTS: Among 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8-4.1) vs. 4.4 (IQR 3.6-5.2) months, p = 0.093). CONCLUSION: Pathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned

Identification and characterization of Rhipicephalus (Boophilus) microplus candidate protective antigens for the control of cattle tick infestations

The cattle ticks, Rhipicephalus (Boophilus) spp., affect cattle production in tropical and subtropical regions of the world. Tick vaccines constitute a cost-effective and environmentally friendly alternative to tick control. The recombinant Rhipicephalus microplus Bm86 antigen has been shown to protect cattle against tick infestations. However, variable efficacy of Bm86-based vaccines against geographic tick strains has encouraged the research for additional tick-protective antigens. Herein, we describe the analysis of R. microplus glutathione-S transferase, ubiquitin (UBQ), selenoprotein W, elongation factor-1 alpha, and subolesin (SUB) complementary DNAs (cDNAs) by RNA interference (RNAi) in R. microplus and Rhipicephalus annulatus. Candidate protective antigens were selected for vaccination experiments based on the effect of gene knockdown on tick mortality, feeding, and fertility. Two cDNA clones encoding for UBQ and SUB were used for cattle vaccination and infestation with R. microplus and R. annulatus. Control groups were immunized with recombinant Bm86 or adjuvant/saline. The highest vaccine efficacy for the control of tick infestations was obtained for Bm86. Although with low immunogenic response, the results with the SUB vaccine encourage further investigations on the use of recombinant subolesin alone or in combination with other antigens for the control of cattle tick infestations. The UBQ peptide showed low immunogenicity, and the results of the vaccination trial were inconclusive to assess the protective efficacy of this antigen. These experiments showed that RNAi could be used for the selection of candidate tick-protective antigens. However, vaccination trials are necessary to evaluate the effect of recombinant antigens in the control of tick infestations, a process that requires efficient recombinant protein production and formulation systems

Discovery of a Supernova Explosion at Half the Age of the Universe and its Cosmological Implications

The ultimate fate of the universe, infinite expansion or a big crunch, can be determined by measuring the redshifts, apparent brightnesses, and intrinsic luminosities of very distant supernovae. Recent developments have provided tools that make such a program practicable: (1) Studies of relatively nearby Type Ia supernovae (SNe Ia) have shown that their intrinsic luminosities can be accurately determined; (2) New research techniques have made it possible to schedule the discovery and follow-up observations of distant supernovae, producing well over 50 very distant (z = 0.3 -- 0.7) SNe Ia to date. These distant supernovae provide a record of changes in the expansion rate over the past several billion years. By making precise measurements of supernovae at still greater distances, and thus extending this expansion history back far enough in time, we can distinguish the slowing caused by the gravitational attraction of the universe's mass density Omega_M from the effect of a possibly inflationary pressure caused by a cosmological constant Lambda. We report here the first such measurements, with our discovery of a Type Ia supernova (SN 1997ap) at z = 0.83. Measurements at the Keck II 10-m telescope make this the most distant spectroscopically confirmed supernova. Over two months of photometry of SN 1997ap with the Hubble Space Telescope and ground-based telescopes, when combined with previous measurements of nearer SNe Ia, suggests that we may live in a low mass-density universe. Further supernovae at comparable distances are currently scheduled for ground and space-based observations.Comment: 12 pages and 4 figures (figure 4 is repeated in color and black and white) Nature, scheduled for publication in the 1 January, 1998 issue. Also available at http://www-supernova.lbl.go

The potential of marginal coastal nursery habitats for the conservation of a culturally important Caribbean marine species

Aim: Identifying the potential of marginal habitats for species conservation is of key importance when their core high-quality habitats are under substantial disturbances and threats. However, there is currently a knowledge gap on how useful marine marginal habitats may be for conserving endangered marine species. Here, we investigate the potential of groundwater-fed coastal areas for the conservation of the queen conch, an economically and culturally important marine gastropod. Location: The inlet of Xel-Ha, typical of groundwater-fed coastal areas widely distributed along the Yucatan Peninsula coast in Mexico and partially protected by a network of marine protected areas. Methods: We tracked 66 queen conchs (Lobatus gigas) using acoustic telemetry over a period of 3.5 years. We investigated for ontogenetic niche shift using a network analysis and by modelling their growth. Results: The queen conchs exhibited the same ontogenetic niche shift required to complete their life cycle in this marginal habitat as they do in offshore core habitats. A total of 33 individuals departed the inlet and migrated from shallow groundwater-affected nursery grounds to deeper marine habitats more suitable for breeding aggregation. Main conclusions: As the broad-scale movement behaviour of queen conch in this inlet is similar to that observed on the overfished core habitats, our findings suggest that groundwater-fed coastal areas should be included in conservation planning for an effective management of this species within a network of marine protected areas