275 research outputs found
Zinc(II) coordination polymers with pseudopeptidic ligands
Two new phenyl-bridged pseudopeptidic ligands have been prepared and structurally characterised. The nature of the ligands’ substituents play an important role in the nature of the solid state structure yielding either hydrogen bonded linked sheets of molecules or infinite hydrogen bonded networks. Both these ligands were reacted with a range of zinc(II) salts with the aim of synthesising coordination polymers and networks and exploring the role that anions could play in determining the final structure. The crystal structures of four of these systems (with ZnSO4 and ZnBr2) were determined; in one case, a 3D coordination network was obtained where zinc–ligand coordination bonds generated the 3D arrangements. Three other 3D networks were obtained by anion-mediated hydrogen bonding of coordination 1D chains or 2D sheets. These four very different structures highlight the important role played by the ligands’ substituents and the counteranions present in the system
Successful Implementation of a Window for Routine Antimicrobial Prophylaxis Shorter than That of the World Health Organization Standard
Objective. To evaluate the feasibility of implementation of the refined window for routine antimicrobial prophylaxis (RAP) of 30-74 minutes before skin incision compared to the World Health Organization (WHO) standard of 0-60 minutes. Design. Prospective study on timing of routine antimicrobial prophylaxis in 2 different time periods. Setting. Tertiary referral university hospital with 30,000 surgical procedures per year. Methods. In all consecutive vascular, visceral, and trauma procedures, the timing was prospectively recorded during a first time period of 2 years (A; baseline) and a second period of 1 year (B; after intervention). An intensive intervention program was initiated after baseline. The primary outcome parameter was timing; the secondary outcome parameter was surgical site infection (SSI) rate in the subgroup of patients undergoing cholecystectomy/colon resection. Results. During baseline time period A (3,836 procedures), RAP was administered 30-74 minutes before skin incision in 1,750 (41.0%) procedures; during time period B (1,537 procedures), it was administered in 914 (56.0%; P < .001). The subgroup analysis did not reveal a significant difference in SSI rate. Conclusions. This bundle of interventions resulted in a statistically significant improvement of timing of RAP even at a shortened window compared to the WHO standar
Independent indistinguishable quantum light sources on a reconfigurable photonic integrated circuit
We report a compact, scalable, quantum photonic integrated circuit realised
by combining multiple, independent InGaAs/GaAs quantum-light-emitting-diodes
(QLEDs) with a silicon oxynitride waveguide circuit. Each waveguide joining the
circuit can then be excited by a separate, independently electrically contacted
QLED. We show that the emission from neighbouring QLEDs can be independently
tuned to degeneracy using the Stark Effect and that the resulting photon
streams are indistinguishable. This enables on-chip Hong-Ou-Mandel-type
interference, as required for many photonic quantum information processing
schemes.Comment: 15 pages, 5 figure
Electrically driven and electrically tunable quantum light sources
Compact and electrically controllable on-chip sources of indistinguishable photons are desirable for the development of integrated quantum technologies. We demonstrate that two quantum dot light emitting diodes (LEDs) in close proximity on a single chip can function as a tunable, all-electric quantum light source. Light emitted by an electrically excited driving LED is used to excite quantum dots in the neighbouring diode. The wavelength of the quantum dot emission from the neighbouring driven diode is tuned via the quantum confined Stark effect. We also show that we can electrically tune the fine structure splitting.The authors acknowledge funding from the EPSRC for MBE system used for the growth of the QD-LED. E.M. and C.D. acknowledge support by the Marie Curie Actions within the Seventh Framework Programme for Research of the European Commission, under the Ini- tial Training Network PICQUE (Grant No. 608062) J. L. gratefully acknowledges financial support from the EPSRC CDT in Photonic Systems Development and Toshiba Research Europe Ltd
Wafer-scale epitaxial modulation of quantum dot density
Precise control of the properties of semiconductor quantum dots (QDs) is vital for creating novel devices for quantum photonics and advanced opto-electronics. Suitable low QD-densities for single QD devices and experiments are challenging to control during epitaxy and are typically found only in limited regions of the wafer. Here, we demonstrate how conventional molecular beam epitaxy (MBE) can be used to modulate the density of optically active QDs in one- and two- dimensional patterns, while still retaining excellent quality. We find that material thickness gradients during layer-by-layer growth result in surface roughness modulations across the whole wafer. Growth on such templates strongly influences the QD nucleation probability. We obtain density modulations between 1 and 10 QDs/µm2 and periods ranging from several millimeters down to at least a few hundred microns. This method is universal and expected to be applicable to a wide variety of different semiconductor material systems. We apply the method to enable growth of ultra-low noise QDs across an entire 3-inch semiconductor wafer
Wafer-Scale Epitaxial Modulation of Quantum Dot Density
Precise control of the properties of semiconductor quantum dots (QDs) is
vital for creating novel devices for quantum photonics and advanced
opto-electronics. Suitable low QD-density for single QD devices and experiments
are challenging to control during epitaxy and are typically found only in
limited regions of the wafer. Here, we demonstrate how conventional molecular
beam epitaxy (MBE) can be used to modulate the density of optically active QDs
in one- and two- dimensional patterns, while still retaining excellent quality.
We find that material thickness gradients during layer-by-layer growth result
in surface roughness modulations across the whole wafer. Growth on such
templates strongly influences the QD nucleation probability. We obtain density
modulations between 1 and 10 QDs/ and periods ranging from several
millimeters down to at least a few hundred microns. This novel method is
universal and expected to be applicable to a wide variety of different
semiconductor material systems. We apply the method to enable growth of
ultra-low noise QDs across an entire 3-inch semiconductor wafer
Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products.
The use of compendial pH 6.8 phosphate buffer to assess dissolution of enteric coated products gives rise to poor in vitro-in vivo correlations because of the inadequacy of the buffer to resemble small intestinal fluids. A more representative and physiological medium, pH 6.8 bicarbonate buffer, was developed to evaluate the dissolution behaviour of enteric coatings. The bicarbonate system was evolved from pH7.4 Hanks balanced salt solution to produce a pH 6.8 bicarbonate buffer (modified Hanks buffer, mHanks), which resembles the ionic composition and buffer capacity of intestinal milieu. Prednisolone tablets were coated with a range of enteric polymers: hypromellose phthalate (HP-50 and HP-55), cellulose acetate phthalate (CAP), hypromellose acetate succinate (HPMCAS-LF and HPMCAS-MF), methacrylic acid copolymers (EUDRAGIT® L100-55, EUDRAGIT® L30D-55 and EUDRAGIT® L100) and polyvinyl acetate phthalate (PVAP). Dissolution of coated tablets was carried out using USP-II apparatus in 0.1M HCl for 2h followed by pH 6.8 phosphate buffer or pH 6.8 mHanks bicarbonate buffer. In pH 6.8 phosphate buffer, the various enteric polymer coated products displayed rapid and comparable dissolution profiles. In pH 6.8 mHanks buffer, drug release was delayed and marked differences were observed between the various coated tablets, which is comparable to the delayed disintegration times reported in the literature for enteric coated products in the human small intestine. In summary, the use of pH 6.8 physiological bicarbonate buffer (mHanks) provides more realistic and discriminative in vitro release assessment of enteric coated formulations compared to compendial phosphate buffer
Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytoskeleton reversing platelet spreading, and therefore reduce the capability of thrombi to withstand a high shear environment. Our data demonstrates that GSNO, DEANONOate, and a PKG-activating cGMP analogue reversed stress fibre formation and increased actin nodule formation in adherent platelets. This effect is sGC dependent and independent of ADP and thromboxanes. Stress fibre formation is a RhoA dependent process and NO induced RhoA inhibition, however, it did not phosphorylate RhoA at ser188 in spread platelets. Interestingly NO and PGI2 synergise to reverse stress fibre formation at physiologically relevant concentrations. Analysis of high shear conditions indicated that platelets activated on fibrinogen, induced stress fibre formation, which was reversed by GSNO treatment. Furthermore, preformed thrombi on collagen post perfused with GSNO had a 30% reduction in thrombus height in comparison to the control. This study demonstrates that NO can reverse key platelet functions after their initial activation and identifies a novel mechanism for controlling excessive thrombosis
Clinical overview and treatment options for non-skeletal manifestations of mucopolysaccharidosis type IVA
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