28 research outputs found
Synchronization, Diversity, and Topology of Networks of Integrate and Fire Oscillators
We study synchronization dynamics of a population of pulse-coupled
oscillators. In particular, we focus our attention in the interplay between
networks topological disorder and its synchronization features. Firstly, we
analyze synchronization time in random networks, and find a scaling law
which relates to networks connectivity. Then, we carry on comparing
synchronization time for several other topological configurations,
characterized by a different degree of randomness. The analysis shows that
regular lattices perform better than any other disordered network. The fact can
be understood by considering the variability in the number of links between two
adjacent neighbors. This phenomenon is equivalent to have a non-random topology
with a distribution of interactions and it can be removed by an adequate local
normalization of the couplings.Comment: 6 pages, 8 figures, LaTeX 209, uses RevTe
New approaches to model and study social networks
We describe and develop three recent novelties in network research which are
particularly useful for studying social systems. The first one concerns the
discovery of some basic dynamical laws that enable the emergence of the
fundamental features observed in social networks, namely the nontrivial
clustering properties, the existence of positive degree correlations and the
subdivision into communities. To reproduce all these features we describe a
simple model of mobile colliding agents, whose collisions define the
connections between the agents which are the nodes in the underlying network,
and develop some analytical considerations. The second point addresses the
particular feature of clustering and its relationship with global network
measures, namely with the distribution of the size of cycles in the network.
Since in social bipartite networks it is not possible to measure the clustering
from standard procedures, we propose an alternative clustering coefficient that
can be used to extract an improved normalized cycle distribution in any
network. Finally, the third point addresses dynamical processes occurring on
networks, namely when studying the propagation of information in them. In
particular, we focus on the particular features of gossip propagation which
impose some restrictions in the propagation rules. To this end we introduce a
quantity, the spread factor, which measures the average maximal fraction of
nearest neighbors which get in contact with the gossip, and find the striking
result that there is an optimal non-trivial number of friends for which the
spread factor is minimized, decreasing the danger of being gossiped.Comment: 16 Pages, 9 figure
Nonequilibrium phase transition in a model for the propagation of innovations among economic agents
We characterize the different morphological phases that occur in a simple
one-dimensional model of propagation of innovations among economic agents [X.\
Guardiola, {\it et. al.}, Phys. Rev E {\bf 66}, 026121 (2002)]. We show that
the model can be regarded as a nonequilibrium surface growth model. This allows
us to demonstrate the presence of a continuous roughening transition between a
flat (system size independent fluctuations) and a rough phase (system size
dependent fluctuations). Finite-size scaling studies at the transition strongly
suggest that the dynamic critical transition does not belong to directed
percolation and, in fact, critical exponents do not seem to fit in any of the
known universality classes of nonequilibrium phase transitions. Finally, we
present an explanation for the occurrence of the roughening transition and
argue that avalanche driven dynamics is responsible for the novel critical
behavior
Comparing community structure identification
We compare recent approaches to community structure identification in terms
of sensitivity and computational cost. The recently proposed modularity measure
is revisited and the performance of the methods as applied to ad hoc networks
with known community structure, is compared. We find that the most accurate
methods tend to be more computationally expensive, and that both aspects need
to be considered when choosing a method for practical purposes. The work is
intended as an introduction as well as a proposal for a standard benchmark test
of community detection methods.Comment: 10 pages, 3 figures, 1 table. v2: condensed, updated version as
appears in JSTA
Improved community structure detection using a modified fine tuning strategy
The community structure of a complex network can be determined by finding the
partitioning of its nodes that maximizes modularity. Many of the proposed
algorithms for doing this work by recursively bisecting the network. We show
that this unduely constrains their results, leading to a bias in the size of
the communities they find and limiting their effectivness. To solve this
problem, we propose adding a step to the existing algorithms that does not
increase the order of their computational complexity. We show that, if this
step is combined with a commonly used method, the identified constraint and
resulting bias are removed, and its ability to find the optimal partitioning is
improved. The effectiveness of this combined algorithm is also demonstrated by
using it on real-world example networks. For a number of these examples, it
achieves the best results of any known algorithm.Comment: 6 pages, 3 figures, 1 tabl
Retrospective cohort study: Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: Role of faecal immunochemical test
BACKGROUND: Faecal immunochemical test (FIT) has been recommended to assess symptomatic patients for colorectal cancer (CRC) detection. Nevertheless, some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized. A positive FIT result could be related to other gastrointestinal cancers (GIC).
AIM: To assess the risk of GIC detection and related death in FIT-positive symptomatic patients (threshold 10 µg Hb/g faeces) without CRC.
METHODS: Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion detection. Ambulatory patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare, underwent a quantitative FIT before undergoing a complete colonoscopy. Patients without CRC were divided into two groups (positive and negative FIT) using the threshold of 10 µg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the research. We determined the cumulative risk of GIC, CRC and upper GIC. Hazard rate (HR) was calculated adjusted by age, sex and presence of significant colonic lesion.
RESULTS: We included 2709 patients without CRC and a complete baseline colonoscopy, 730 (26.9%) with FIT = 10 µgr Hb/gr. During a mean time of 45.5 ± 20.0 mo, a GIC was detected in 57 (2.1%) patients: An upper GIC in 35 (1.3%) and a CRC in 14 (0.5%). Thirty-six patients (1.3%) died due to GIC: 22 (0.8%) due to an upper GIC and 9 (0.3%) due to CRC. FIT-positive subjects showed a higher CRC risk (HR 3.8, 95%CI: 1.2-11.9) with no differences in GIC (HR 1.5, 95%CI: 0.8-2.7) or upper GIC risk (HR 1.0, 95%CI: 0.5-2.2). Patients with a positive FIT had only an increased risk of CRC-related death (HR 10.8, 95%CI: 2.1-57.1) and GIC-related death (HR 2.2, 95%CI: 1.1-4.3), with no differences in upper GIC-related death (HR 1.4, 95%CI: 0.6-3.3). An upper GIC was detected in 22 (0.8%) patients during the first year. Two variables were independently associated: anaemia (OR 5.6, 95%CI: 2.2-13.9) and age = 70 years (OR 2.7, 95%CI: 1.1-7.0).
CONCLUSION: Symptomatic patients without CRC have a moderate risk increase in upper GIC, regardless of the FIT result. Patients with a positive FIT have an increased risk of post-colonoscopy CRC
Nutrición parenteral domiciliaria en España 2018. Informe del Grupo de Nutrición Artificial Domiciliaria y Ambulatoria NADYA
Objetivo: comunicar los datos de nutrición parenteral domiciliaria (NPD) obtenidos del registro del grupo NADYA-SENPE (www.nadya-senpe.com) del año 2018.
Material y métodos: análisis descriptivo de los datos recogidos de pacientes adultos y pediátricos con NPD en el registro NADYA-SENPE del 1 de enero al 31 de diciembre de 2018.
Resultados: se registraron 278 pacientes (54, 7% mujeres), 23 niños y 255 adultos, procedentes de 45 hospitales españoles, lo que representa una tasa de prevalencia de 5, 95 pacientes/millón de habitantes/año 2018. El diagnóstico más frecuente en adultos fue “oncológico paliativo” (22, 0%), seguido de “otros”. En niños fue la enfermedad de Hirschsprung junto con la enterocolitis necrotizante, con cuatro casos (17, 4%). El primer motivo de indicación fue síndrome de intestino corto tanto en niños (60, 9%) como en adultos (35, 7%). El tipo de catéter más utilizado fue el tunelizado tanto en niños (81, 0%) como en adultos (41, 1%). Finalizaron 75 episodios, la causa más frecuente fue el fallecimiento (52, 0%) y el paso a vía oral (33, 3%).
Conclusiones: el número de centros y profesionales colaboradores en el registro de pacientes que reciben NPD se mantiene estable, así como las principales indicaciones y los motivos de finalización de la NPD.
Aim: To communicate home parenteral nutrition (HPN) data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe. com) for the year 2018.
Material and methods: Descriptive analysis of the data collected from adult and pediatric patients with HPN in the NADYA-SENPE group registry from January 1st, 2018 to December 31st, 2018.
Results: There were 278 patients from 45 Spanish hospitals (54.7% women), 23 children and 255 adults, which represent a prevalence rate of 5.95 patients/million inhabitants/year 2018. The most frequent diagnosis in adults was “palliative cancer” (22.0%), followed by “others”. In children it was Hirschsprung’s disease together with necrotizing enterocolitis, with four cases (17.4%). The first indication was short bowel syndrome in both children (60.9%) and adults (35.7%). The most frequently used type of catheter was tunneled in both children (81.0%) and adults (41.1%). Ending 75 episodes, the most frequent cause was death (52.0%) and change to oral feeding (33.3%).
Conclusions: The number of centers and collaborating professionals in the registry of patients receiving HPN remains stable, as well as the main indications and reasons for termination of HPN
Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Homocistinuria; curso clínico y tratamiento dietético: a propósito de dos casos Clinical management of homocystinuria: case report and review of the literature
La homocistinuria es un error congénito del metabolismo de la metionina que conduce al acúmulo de metionina y de su principal metabolito, homocisteína, en plasma, orina y tejidos. El acúmulo de homocisteína posee toxicidad sobre los sistemas óseo (osteoporosis), ocular (luxación del cristalino), nervioso (convulsiones, alteraciones psiquiátricas) y vascular (accidentes cerebrovasculares, enfermedad cardiovascular). Presentamos 2 casos de homocistinuria en 2 pacientes hermanos y, a continuación, revisamos las estrategias terapéuticas disponibles.Homocystinuria is a congenital disorder of methyonine metabolism that leads to increased plasmatic, urinary and tissue deposits of methyonine and its main metabolite: homocysteine. Homocysteine deposits are toxic for the skeletal system (osteoporosis), the eyes (lens dislocation), central nervous system (seizures, psychiatric disorders) and also induce vascular damage (stroke and other cardiovascular events). This article reports two patients with homocystinuria in two siblings, followed by a concise review on the therapeutic strategies available for this disorder