Response to ‘Protected areas and climate change Reflections from a practitioner's perspective

Cliquet et al. 1 provide a thought-provoking analysis of the challenges posed to the EU's protected areas by climate change. This paper seeks to build on some of the perspectives they brought to what is a highly challenging area of nature conservation law, policy and practice. While there is much to support in their analysis of the relationships between protected areas and climate change, there are two key strands we seek to develop further, based on the RSPB's experience of this area of nature conservation policy and practice: first, is the ecological model for adapting to climate change and second, the legal framework provided by the Birds2 and Habitats3 Directives (the Nature Directives) as it relates to the delivery of such adaptive actions

Simultaneous calculation of the helical pitch and the twist elastic constant in chiral liquid crystals from intermolecular torques

We present a molecular simulation method that yields simultaneously the equilibrium pitch wave number q and the twist elastic constant K2 of a chiral nematic liquid crystal by sampling the torque density. A simulation of an untwisted system in periodic boundary conditions gives the product K2q; a further simulation with a uniform twist applied provides enough information to separately determine the two factors. We test our new method for a model potential, comparing the results with K2q from a thermodynamic integration route, and with K2 from an order fluctuation analysis. We also present a thermodynamic perturbation theory analysis valid in the limit of weak chirality

Explicit representation and parametrised impacts of under ice shelf seas in the z∗ coordinate ocean model NEMO 3.6

Ice-shelf-ocean interactions are a major source of freshwater on the Antarctic continental shelf and have a strong impact on ocean properties, ocean circulation and sea ice. However, climate models based on the ocean-sea ice model NEMO (Nucleus for European Modelling of the Ocean) currently do not include these interactions in any detail. The capability of explicitly simulating the circulation beneath ice shelves is introduced in the non-linear free surface model NEMO. Its implementation into the NEMO framework and its assessment in an idealised and realistic circum-Antarctic configuration is described in this study. Compared with the current prescription of ice shelf melting (i.e. at the surface), inclusion of open sub-ice-shelf cavities leads to a decrease in sea ice thickness along the coast, a weakening of the ocean stratification on the shelf, a decrease in salinity of high-salinity shelf water on the Ross and Weddell sea shelves and an increase in the strength of the gyres that circulate within the over-deepened basins on the West Antarctic continental shelf. Mimicking the overturning circulation under the ice shelves by introducing a prescribed meltwater flux over the depth range of the ice shelf base, rather than at the surface, is also assessed. It yields similar improvements in the simulated ocean properties and circulation over the Antarctic continental shelf to those from the explicit ice shelf cavity representation. With the ice shelf cavities opened, the widely used "three equation" ice shelf melting formulation, which enables an interactive computation of melting, is tested. Comparison with observational estimates of ice shelf melting indicates realistic results for most ice shelves. However, melting rates for the Amery, Getz and George VI ice shelves are considerably overestimated

Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation

Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we showed that pramanicin induced apoptosis in Jurkat T leukemia cells in a dose- and time-dependent manner. Our data reveal that pramanicin induced the release of cytochrome c and caspase-9 and caspase-3 activation, as evidenced by detection of active caspase fragments and fluorometric caspase assays. Pramanicin also activated c-jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinases (ERK 1/2) with different time and dose kinetics. Treatment of cells with specific MAP kinase and caspase inhibitors further confirmed the mechanistic involvement of these signalling cascades in pramanicin-induced apoptosis. JNK and p38 pathways acted as pro-apoptotic signalling pathways in pramanicin-induced apoptosis, in which they regulated release of cytochrome c and caspase activation. In contrast the ERK 1/2 pathway exerted a protective effect through inhibition of cytochrome c leakage from mitochondria and caspase activation, which were only observed when lower concentrations of pramanicin were used as apoptosis-inducing agent and which were masked by the intense apoptosis induction by higher concentrations of pramanicin. These results suggest pramanicin as a potential apoptosis-inducing small molecule, which acts through a well-defined JNK- and p38-dependent apoptosis signalling pathway in Jurkat T leukemia cells

Discrete Group Actions on Spacetimes: Causality Conditions and the Causal Boundary

Suppose a spacetime $M$ is a quotient of a spacetime $V$ by a discrete group of isometries. It is shown how causality conditions in the two spacetimes are related, and how can one learn about the future causal boundary on $M$ by studying structures in $V$. The relations between the two are particularly simple (the boundary of the quotient is the quotient of the boundary) if both $V$ and $M$ have spacelike future boundaries and if it is known that the quotient of the future completion of $V$ is past-distinguishing. (That last assumption is automatic in the case of $M$ being multi-warped.)Comment: 32 page

Treatment Outcomes for At-Risk Young Children With Behavior Problems: Toward a New Definition of Success

This study examined the outcomes of Early Pathways (EP), an in-home parent–child therapy program with 447 at-risk children younger than 5 years of age who were referred for severe behavior and emotional problems, such as aggression, oppositional behavior, and separation anxiety. EP emphasized parent-directed training of child behavior strategies including psychoeducation regarding child development, child-led play, and cognitive-behavioral techniques. Outcomes were assessed using a unique 2-dimensional definition of treatment completion, which consisted of treatment duration and an assessment of reliable change for the primary outcome measure of child behavior problems. Results showed that the majority of children (63.4%) met or exceeded treatment completion. In addition, repeated-measures multivariate analyses of variance at pretest, posttest, and follow-up revealed increased child prosocial behaviors, reduced child behavior problems, improved caregiver nurturing, an increase in parents’ developmentally appropriate expectations of children, improved parent–child relationships, and a decrease in clinical diagnoses following treatment. This study offers guidance for developing effective early-intervention services for families in poverty to enhance outcomes for their young children. Along with its existing large-scale, community-based effectiveness studies, future research should establish additional statistical support including a randomized, waitlist control design of EP

Structural parameters for globular clusters in M31 and generalizations for the fundamental plane

The structures of globular clusters (GCs) reflect their dynamical states and past histories. High-resolution imaging allows the exploration of morphologies of clusters in other galaxies. Surface brightness profiles from new Hubble Space Telescope observations of 34 globular clusters in M31 are presented, together with fits of several different structural models to each cluster. M31 clusters appear to be adequately fit by standard King models, and do not obviously require alternate descriptions with relatively stronger halos, such as are needed to fit many GCs in other nearby galaxies. The derived structural parameters are combined with corrected versions of those measured in an earlier survey to construct a comprehensive catalog of structural and dynamical parameters for M31 GCs with a sample size similar to that for the Milky Way. Clusters in M31, the Milky Way, Magellanic Clouds, Fornax dwarf spheroidal and NGC 5128 define a very tight fundamental plane with identical slopes. The combined evidence for these widely different galaxies strongly reinforces the view that old globular clusters have near-universal structural properties regardless of host environment.Comment: AJ in press; 59 pages including 16 figure

Primer for the Transportable Applications Executive

The Transportable Applications Executive (TAE), an interactive multipurpose executive that provides commonly required functions for scientific analysis systems, is discussed. The concept of an executive is discussed and the various components of TAE are presented. These include on-line help information, the use of menus or commands to access analysis programs, and TAE command procedures

Barriers to women in the UK construction industry

Purpose – This paper aims to identify the main barriers that lead to the under-representation of women in the UK construction industry. The study, funded by ConstructionSkills, seeks to explore the issues that women face and investigate the potential positive impact that continuous professional development (CPD) may have upon improving the retention and career progression of women. Design/methodology/approach – The study uses an open-ended grounded theory (GT) approach, including 231 semi-structured questionnaires and nine focus groups with women from a range of professional occupations. All the findings were analysed using keyword analysis to identify the top two barriers that women face, alongside a series of cross-cutting key themes and issues. Findings – The findings reveal that male-dominated organisational cultures and inflexible working practices are the main barriers to women in the UK construction industry, irrespective of job role or profession. This paper concludes by arguing for a sea-change in the expansion of CPD opportunities for women in managerial, confidence and communication based skills, with accompanying networking and support systems to facilitate the retention and advancement of women in the industry sector. Research limitations/implications – Due to the research approach, the data are not generalisable. Therefore, researchers are advised to research and test the findings with a larger group. Researchers are also recommended to investigate the impact of expanded CPD opportunities for both men and women. Originality/value – The paper puts forward a business case for the advancement of specific CPD training for women, to facilitate the expansion of equality and diversity in the workforce in the UK construction industry

Geologic considerations in underground coal mining system design

Geologic characteristics of coal resources which may impact new extraction technologies are identified and described to aid system designers and planners in their task of designing advanced coal extraction systems for the central Appalachian region. These geologic conditions are then organized into a matrix identified as the baseline mine concept. A sample region, eastern Kentucy is analyzed using both the developed baseline mine concept and the traditional geologic investigative approach