Entangling voluntarism, leisure time and political work: the governmentalities of neighbourhood planning in England

Neighbourhood planning was the first volunteer-led statutory planning tool to be created in the UK. Whilst it has provoked debate and critique covering numerous practical and theoretical aspects (Wargent and Parker, 2018), little attention has been paid to the actual experience and motives of the volunteers who spend their leisure time by volunteering to prepare a plan. Given the range of leisure activities that have been shaped in the context of a neo-liberalised policy environment we add to longstanding debates concerning the political nature of leisure and how neo-liberal policies require, and exploit, volunteer time and input while claiming to offer forms of empowerment. Qualitative data derived from neighbourhood plan volunteers is presented here to highlight the political work of neighbourhood planning, thus responding to calls to extend the analysis of the political in and through leisure (Rose et al, 2018). It is argued that neighbourhood planning pushes the boundaries of what can be legitimately asked of volunteers and expected in terms of delivering policy outcomes

Anarchism, Utopianism and Hospitality: The Work of René Schérer

René Schérer (born 1922) is lamentably almost unknown to the Anglo-American world as his work has, as yet, not been translated . He is one of the main specialists of the French “utopian socialist”, Charles Fourier (1772-1837), and a major thinker in his own right. He is the author of more than twenty books and co-editor of the journal Chimères. Colleague and friend at Vincennes university (Paris 8) of Michel Foucault, Gilles Deleuze, Félix Guattari, Jacques Derrida, Jacques Rancière, Jean-François Lyotard, François Châletet, Alain Brossat, Georges Navet, Miguel Abensour, Pierre Macherey… he continues to host seminars at Paris 8 (now located at St. Denis). He is a living testimony to a radical past, and a continuing inspiration to a new generation of young thinkers. This article aims to convey the original specificity of his understanding of anarchism. By so doing, it will stress the importance of his work for any thinking concerned with a politicised resistance to social conformity and the supposed “state of things” today

The Parental Non-Equivalence of Imprinting Control Regions during Mammalian Development and Evolution

In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Imprinting is linked to therian reproduction, that is, the placenta and imprinting emerged at roughly the same time and potentially co-evolved. We assessed the transcriptome-wide and ontology effect of maternally versus paternally methylated ICRs at the developmental stage of setting of the chorioallantoic placenta in the mouse (8.5dpc), using two models of imprinting deficiency including completely imprint-free embryos. Paternal and maternal imprints have a similar quantitative impact on the embryonic transcriptome. However, transcriptional effects of maternal ICRs are qualitatively focused on the fetal-maternal interface, while paternal ICRs weakly affect non-convergent biological processes, with little consequence for viability at 8.5dpc. Moreover, genes regulated by maternal ICRs indirectly influence genes regulated by paternal ICRs, while the reverse is not observed. The functional dominance of maternal imprints over early embryonic development is potentially linked to selection pressures favoring methylation-dependent control of maternal over paternal ICRs. We previously hypothesized that the different methylation histories of ICRs in the maternal versus the paternal germlines may have put paternal ICRs under higher mutational pressure to lose CpGs by deamination. Using comparative genomics of 17 extant mammalian species, we show here that, while ICRs in general have been constrained to maintain more CpGs than non-imprinted sequences, the rate of CpG loss at paternal ICRs has indeed been higher than at maternal ICRs during evolution. In fact, maternal ICRs, which have the characteristics of CpG-rich promoters, have gained CpGs compared to non-imprinted CpG-rich promoters. Thus, the numerical and, during early embryonic development, functional dominance of maternal ICRs can be explained as the consequence of two orthogonal evolutionary forces: pressure to tightly regulate genes affecting the fetal-maternal interface and pressure to avoid the mutagenic environment of the paternal germline

Human oocyte-derived methylation differences persist in the placenta revealing widespread transient imprinting

Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. Here we present the data describing the fate of germline-derived methylation in humans. With the exception of a few known paternally methylated germline differentially methylated regions (DMRs) associated with known imprinted domains, we demonstrate that sperm-derived methylation is reprogrammed by the blastocyst stage of development. In contrast a large number of oocyte-derived methylation differences survive to the blastocyst stage and uniquely persist as transiently methylated DMRs only in the placenta. Furthermore, we demonstrate that this phenomenon is exclusive to primates, since no placenta-specific maternal methylation was observed in mouse. Utilizing single cell RNA-seq datasets from human preimplantation embryos we show that following embryonic genome activation the maternally methylated transient DMRs can orchestrate imprinted expression. However despite showing widespread imprinted expression of genes in placenta, allele-specific transcriptional profiling revealed that not all placenta-specific DMRs coordinate imprinted expression and that this maternal methylation may be absent in a minority of samples, suggestive of polymorphic imprinted methylation

The evolution of genomic imprinting:Theories, predictions and empirical tests

The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. In this review, we examine the three theories that have best withstood theoretical and empirical scrutiny. These are: Haig and colleagues’ kinship theory; Day and Bonduriansky’s sexual antagonism theory; and Wolf and Hager’s maternal–offspring coadaptation theory. These theories have fundamentally different perspectives on the adaptive significance of imprinting. The kinship theory views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the differential effect that gene dosage has on the fitness of matrilineal and patrilineal relatives. The sexual antagonism and maternal–offspring coadaptation theories view genomic imprinting as a mechanism to modify the resemblance of an individual to its two parents, with imprinting evolving to increase the probability of expressing the fitter of the two alleles at a locus. In an effort to stimulate further empirical work on the topic, we carefully detail the logic and assumptions of all three theories, clarify the specific predictions of each and suggest tests to discriminate between these alternative theories for why particular genes are imprinted