Anarchism, Utopianism and Hospitality: The Work of René Schérer

René Schérer (born 1922) is lamentably almost unknown to the Anglo-American world as his work has, as yet, not been translated . He is one of the main specialists of the French “utopian socialist”, Charles Fourier (1772-1837), and a major thinker in his own right. He is the author of more than twenty books and co-editor of the journal Chimères. Colleague and friend at Vincennes university (Paris 8) of Michel Foucault, Gilles Deleuze, Félix Guattari, Jacques Derrida, Jacques Rancière, Jean-François Lyotard, François Châletet, Alain Brossat, Georges Navet, Miguel Abensour, Pierre Macherey… he continues to host seminars at Paris 8 (now located at St. Denis). He is a living testimony to a radical past, and a continuing inspiration to a new generation of young thinkers. This article aims to convey the original specificity of his understanding of anarchism. By so doing, it will stress the importance of his work for any thinking concerned with a politicised resistance to social conformity and the supposed “state of things” today

Human oocyte-derived methylation differences persist in the placenta revealing widespread transient imprinting

Thousands of regions in gametes have opposing methylation profiles that are largely resolved during the post-fertilization epigenetic reprogramming. However some specific sequences associated with imprinted loci survive this demethylation process. Here we present the data describing the fate of germline-derived methylation in humans. With the exception of a few known paternally methylated germline differentially methylated regions (DMRs) associated with known imprinted domains, we demonstrate that sperm-derived methylation is reprogrammed by the blastocyst stage of development. In contrast a large number of oocyte-derived methylation differences survive to the blastocyst stage and uniquely persist as transiently methylated DMRs only in the placenta. Furthermore, we demonstrate that this phenomenon is exclusive to primates, since no placenta-specific maternal methylation was observed in mouse. Utilizing single cell RNA-seq datasets from human preimplantation embryos we show that following embryonic genome activation the maternally methylated transient DMRs can orchestrate imprinted expression. However despite showing widespread imprinted expression of genes in placenta, allele-specific transcriptional profiling revealed that not all placenta-specific DMRs coordinate imprinted expression and that this maternal methylation may be absent in a minority of samples, suggestive of polymorphic imprinted methylation

The evolution of genomic imprinting:Theories, predictions and empirical tests

The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. In this review, we examine the three theories that have best withstood theoretical and empirical scrutiny. These are: Haig and colleagues’ kinship theory; Day and Bonduriansky’s sexual antagonism theory; and Wolf and Hager’s maternal–offspring coadaptation theory. These theories have fundamentally different perspectives on the adaptive significance of imprinting. The kinship theory views imprinting as a mechanism to change gene dosage, with imprinting evolving because of the differential effect that gene dosage has on the fitness of matrilineal and patrilineal relatives. The sexual antagonism and maternal–offspring coadaptation theories view genomic imprinting as a mechanism to modify the resemblance of an individual to its two parents, with imprinting evolving to increase the probability of expressing the fitter of the two alleles at a locus. In an effort to stimulate further empirical work on the topic, we carefully detail the logic and assumptions of all three theories, clarify the specific predictions of each and suggest tests to discriminate between these alternative theories for why particular genes are imprinted

The Malthusians.

Mode of access: Internet.Labadie Pamphlet Collection