Overview of the DESI Milky Way Survey

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, los autores pertenecientes a la UAM y el nombre del grupo de colaboración, si lo hubiereWe describe the Milky Way Survey (MWS) that will be undertaken with the Dark Energy Spectroscopic Instrument (DESI) on the Mayall 4 m telescope at the Kitt Peak National Observatory. Over the next 5 yr DESI MWS will observe approximately seven million stars at Galactic latitudes ∣b∣ > 20°, with an inclusive target selection scheme focused on the thick disk and stellar halo. MWS will also include several high-completeness samples of rare stellar types, including white dwarfs, low-mass stars within 100 pc of the Sun, and horizontal branch stars. We summarize the potential of DESI to advance understanding of the Galactic structure and stellar evolution. We introduce the final definitions of the main MWS target classes and estimate the number of stars in each class that will be observed. We describe our pipelines for deriving radial velocities, atmospheric parameters, and chemical abundances. We use ≃500,000 spectra of unique stellar targets from the DESI Survey Validation program (SV) to demonstrate that our pipelines can measure radial velocities to ≃1 km s−1 and [Fe/H] accurate to ≃0.2 dex for typical stars in our main sample. We find the stellar parameter distributions from ≈100 deg2 of SV observations with ≳90% completeness on our main sample are in good agreement with expectations from mock catalogs and previous surveysThis equipment was funded by MoE, NSTC, and National Tsing Hua University. C.A.P. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) projects AYA2017-86389-P and PID2020-117493GB-I00. C.J.M. acknowledges financial support from Imperial College London through an Imperial College Research Fellowship grant. M.V. and L.B.e.S. acknowledge support from NASA-ATP award 80NSSC20K0509. The work of A.D. and J.N. is supported by NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. T.S.L. acknowledges financial support from the Natural Sciences and Engineering Research Council of Canada (NSERC) through grant RGPIN-2022-04794. B.T. G. was supported by grant ST/T000406/1 from the Science and Technology Facilities Council (STFC). This project has received funding from the European Research Council under the European Unionʼs Horizon 2020 research and innovation program (grant agreement No. 101020057). This research made use of computing time available on the high-performance computing system at the Instituto de Astrofisica de Canaria

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusion

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Hints of the existence of Axion-Like-Particles from the gamma-ray spectra of cosmological sources

Axion Like Particles (ALPs) are predicted to couple with photons in the presence of magnetic fields. This effect may lead to a significant change in the observed spectra of gamma-ray sources such as AGNs. Here we carry out a detailed study that for the first time simultaneously considers in the same framework both the photon/axion mixing that takes place in the gamma-ray source and that one expected to occur in the intergalactic magnetic fields. An efficient photon/axion mixing in the source always means an attenuation in the photon flux, whereas the mixing in the intergalactic medium may result in a decrement and/or enhancement of the photon flux, depending on the distance of the source and the energy considered. Interestingly, we find that decreasing the value of the intergalactic magnetic field strength, which decreases the probability for photon/axion mixing, could result in an increase of the expected photon flux at Earth if the source is far enough. We also find a 30% attenuation in the intensity spectrum of distant sources, which occurs at an energy that only depends on the properties of the ALPs and the intensity of the intergalactic magnetic field, and thus independent of the AGN source being observed. Moreover, we show that this mechanism can easily explain recent puzzles in the spectra of distant gamma-ray sources... [ABRIDGED] The consequences that come from this work are testable with the current generation of gamma-ray instruments, namely Fermi (formerly known as GLAST) and imaging atmospheric Cherenkov telescopes like CANGAROO, HESS, MAGIC and VERITAS.Comment: 16 pages, 7 figures. Replaced to match the published version in Phys. Rev. D. Minor changes with respect to v

Alteraciones en la tasa de respiración de Daphnia magna bajo concentraciones subletales de anatoxina-a

Anatoxina-a es una potente neurotoxina producida por cianobacterias dulceacuícolas que puede representar un riesgo, por sus efectos agudos, para diferentes formas de vida, incluyendo los seres humanos. Aunque se conocen los efectos agudos y crónicos de esta toxina, pocos estudios aportan datos de medidas de efectos subletales sobre la respiración del zooplancton. En este trabajo se cuantifican cambios en la respiración de Daphnia magna bajo una concentración subletal de anatoxina-a, en condiciones experimentales, por medio de un sistema automatizado de medida en continuo de consumo de Oxígeno. Los resultados indican que la presencia de anatoxina-a en dosis subletales reduce significativamente la actividad respiratoria en esta especie, con efectos, dependientes de la edad del organismo.Anatoxin-a is a potent neurotoxin produced by some freshwater cyanobacteria which, because of its acute toxic effects, may represent a hazard to aquatic organisms, and even to human beings. Both the acute and chronic effects of this toxin are rather well known, but few studies provided information about its sublethal effect on the zooplankton respiration. In this paper we have quantified respiration changes in Daphnia magna under sublethal anatoxin-a concentrations in experimental conditions, using an automatic open-flow system of continuous measurement of oxygen consumption. Our results show that the presence of anatoxin-a at sublethal doses reduces significantly the respiratory activity of the animals, being the effects greatly dependent on the individual age

Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET

In this work we present an innovative algorithm for the reconstruction of PET images based on the List-Mode (LM) technique which improves their spatial resolution compared to results obtained with current MLEM algorithms. This study appears as a part of a large project with the aim of improving diagnosis in early Alzheimer disease stages by means of a newly developed hybrid PET-MR insert. At the present, Alzheimer is the most relevant neurodegenerative disease and the best way to apply an effective treatment is its early diagnosis. The PET device will consist of several monolithic LYSO crystals coupled to SiPM detectors. Monolithic crystals can reduce scanner costs with the advantage to enable implementation of very small virtual pixels in their geometry. This is especially useful for LM reconstruction algorithms, since they do not need a pre-calculated system matrix. We have developed an LM algorithm which has been initially tested with a large aperture (186 mm) breast PET system. Such an algorithm instead of using the common lines of response, incorporates a novel calculation of tubes of response. The new approach improves the volumetric spatial resolution about a factor 2 at the border of the field of view when compared with traditionally used MLEM algorithm. Moreover, it has also shown to decrease the image noise, thus increasing the image quality. © 2012 Elsevier B.V. All rights reserved.This work was supported by the Centre for Industrial Technological Development co-funded by FEDER through the Technology Fund (DREAM Project, IDI-20110718), by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant. No. FIS2010-21216-CO2-01TEO 2008/114.Moliner Martínez, L.; Correcher, C.; González Martínez, AJ.; Conde Castellanos, PE.; Hernández Hernández, L.; Orero Palomares, A.; Rodríguez Álvarez, MJ.... (2013). Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 702:129-132. https://doi.org/10.1016/j.nima.2012.08.029S12913270

Monolithic crystals for PET devices: optical coupling optimization

NOTICE: this is the author’s version of a work that was accepted for publication in Nuclear Instruments and Methods in Physics Research Section A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nuclear Instruments and Methods in Physics Research Section A [Volume 731, 11 December 2013, Pages 288–294] DOI 10.1016/j.nima.2013.05.049[EN] In this work we present a method to efficiently collect scintillation light when using monolithic scintillator crystals. The acceptance angle of the scintillation light has been reduced by means of optical devices reducing the border effect which typically affects continuous crystals. We have applied this procedure on gamma detectors for PET systems using both position sensitive PMTs and arrays of SiPMs. In the case of using SiPMs, this approach also helps to reduce the photosensor active area. We evaluated the method using PMTs with a variety of different crystals with thicknesses ranging from 10 to 24 mm. We found that our design allows the use of crystal blocks with a thickness of up to 18 mm without degrading the spatial resolution caused by edge effects and without a significant detriment to the energy resolution. These results were compared with simulated data. The first results of monolithic LYSO crystals coupled to an array of 256 SiPMs by means of individual optical light guides are also presented.This work was supported by the Centre for Industrial Technological Development co-funded by FEDER through the Technology Fund (DREAM Project, IDI-20110718), the Spanish Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D +I) under Grant no. FIS2010-21216-CO2-01 and the Valencian Local Government under Grant PROMETEO 2008/114.González Martínez, AJ.; Peiró, A.; Conde, P.; Hernández Hernández, L.; Moliner Martínez, L.; Orero Palomares, A.; Rodríguez-Álvarez, M.... (2013). Monolithic crystals for PET devices: optical coupling optimization. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 731:288-294. https://doi.org/10.1016/j.nima.2013.05.049S28829473

Design of the PET–MR system for head imaging of the DREAM Project

NOTICE: this is the author’s version of a work that was accepted for publication in Nuclear Instruments and Methods in Physics Research Section A. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nuclear Instruments and Methods in Physics Research Section A, Volume 702, 21 February 2013, Pages 94–97 DOI 10.1016/j.nima.2012.08.028In this paper we describe the overall design of a PET–MR system for head imaging within the framework of the DREAM Project as well as the first detector module tests. The PET system design consists of 4 rings of 16 detector modules each and it is expected to be integrated in a head dedicated radio frequency coil of an MR scanner. The PET modules are based on monolithic LYSO crystals coupled by means of optical devices to an array of 256 Silicon Photomultipliers. These types of crystals allow to preserve the scintillation light distribution and, thus, to recover the exact photon impact position with the proper characterization of such a distribution. Every module contains 4 Application Specific Integrated Circuits (ASICs) which return detailed information of several light statistical momenta. The preliminary tests carried out on this design and controlled by means of ASICs have shown promising results towards the suitability of hybrid PET–MR systems.This work was supported by the Centre for Industrial Technological Development co-funded by FEDER through the Technology Fund (DREAM Project, IDI-20110718), the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I) under Grant no. FIS2010-21216-CO2-01 and the Valencian Local Government under Grant PROMETEO 2008/114.González Martínez, AJ.; Conde, P.; Hernández Hernández, L.; Herrero Bosch, V.; Moliner Martínez, L.; Monzó Ferrer, JM.; Orero Palomares, A.... (2013). Design of the PET–MR system for head imaging of the DREAM Project. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 702:94-97. https://doi.org/10.1016/j.nima.2012.08.028S949770

ALBIRA: A small animal PET/SPECT/CT imaging system

Purpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled to multianode photomultiplier tubes (MA-PMTs), while computed tomography (CT) comprises a commercially available microfocus x-ray tube and a CsI scintillator 2D pixelated flat panel x-ray detector. In this study the authors will report on the design and performance evaluation of the multimodal system. Methods: X-ray transmission measurements are performed based on cone-beam geometry. Individual projections were acquired by rotating the x-ray tube and the 2D flat panel detector, thus making possible a transaxial field of view (FOV) of roughly 80 mm in diameter and an axial FOV of 65 mm for the CT system. The single photon emission computed tomography (SPECT) component has a dual head detector geometry mounted on a rotating gantry. The distance between the SPECT module detectors can be varied in order to optimize specific user requirements, including variable FOV. The positron emission tomography (PET) system is made up of eight compact modules forming an octagon with an axial FOV of 40 mm and a transaxial FOV of 80 mm in diameter. The main CT image quality parameters (spatial resolution and uniformity) have been determined. In the case of the SPECT, the tomographic spatial resolution and system sensitivity have been evaluated with a99mTc solution using single-pinhole and multi-pinhole collimators. PET and SPECT images were reconstructed using three-dimensional (3D) maximum likelihood and ordered subset expectation maximization (MLEM and OSEM) algorithms developed by the authors, whereas the CT images were obtained using a 3D based FBP algorithm. Results: CT spatial resolution was 85μm while a uniformity of 2.7% was obtained for a water filled phantom at 45 kV. The SPECT spatial resolution was better than 0.8 mm measured with a Derenzo-like phantom for a FOV of 20 mm using a 1-mm pinhole aperture collimator. The full width at half-maximum PET radial spatial resolution at the center of the field of view was 1.55 mm. The SPECT system sensitivity for a FOV of 20 mm and 15% energy window was 700 cps/MBq (7.8 × 10−2%) using a multi-pinhole equipped with five apertures 1 mm in diameter, whereas the PET absolute sensitivity was 2% for a 350–650 keV energy window and a 5 ns timing window. Several animal images are also presented. Conclusions: The new small animal PET/SPECT/CT proposed here exhibits high performance, producing high-quality images suitable for studies with small animals. Monolithic design for PET and SPECT scintillator crystals reduces cost and complexity without significant performance degradation.This study was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant No. FIS2010-21216-CO2-01 and Valencian Local Government under Grant PROMETEO 2008/114. The authors also thank Brennan Holt for checking and correcting the text.Sánchez Martínez, F.; Orero Palomares, A.; Soriano Asensi, A.; Correcher Salvador, C.; Conde Castellanos, PE.; González Martínez, AJ.; Hernández Hernández, L.... (2013). ALBIRA: A small animal PET/SPECT/CT imaging system. Medical Physics. 40(5):5190601-5190611. https://doi.org/10.1118/1.4800798S5190601519061140

Calibration and performance tests of detectors for laser-accelerated protons

We present the calibration and performance tests carried out with two detectors for intense proton pulses accelerated by lasers. Most of the procedures were realized with proton beams of 0.46-5.60 MeV from a tandem accelerator. One approach made use of radiochromic films, for which we calibrated the relation between optical density and energy deposition over more than three orders of magnitude. The validity of these results and of our analysis algorithms has been confirmed by controlled irradiation of film stacks and reconstruction of the total beam charge for strongly non-uniform beam profiles. For the spectral analysis of protons from repeated laser shots, we have designed an online monitor based on a plastic scintillator. The resulting signal from a photomultiplier directly measured on a fast oscilloscope is especially useful for time-of-flight applications. Variable optical filters allow for suppression of saturation and an extension of the dynamic range. With pulsed proton beams we have tested the detector response to a wide range of beam intensities from single particles to 3 ×105 protons per 100 ns time interval.Project funded by the Spanish Ministry of Economy and Competitiveness and co-funded with FEDER's funds within the INNPACTO 2011 program under Grant No. IPT-2011-0862-900000. This work was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+i) under Grant No. TEC 2013-48036-C3-1-R and the Valencian Local Government under Grants PROMETEOII/2013/010 and ISIC 2011/013. The work of A. J. Gonzalez is financed by CSIC with a JAE-Doc contract under Junta de Ampliacion de Estudios program, cofinanced by the European Social Fund.Peer Reviewe