Study of instabilities and transition to turbulence in a linear hall accelerator

Magnetospheric instabilities and transition to plasma turbulence in Hall current accelerator

PHOTOCHEMICAL RING-OPENING IN meso-CHLORINATED CHLOROPHYLLS

Irradiation of 20-chloro-chlorophylls of the a-type with visible light produces long-wavelength shifted photoproducts, which transform in the dark to linear tetrapyrroles (bile pigments). The possible significance for chlorophyll degradation is discussed

Beacon Virtua: A Virtual Reality Simulation Detailing the Recent and Shipwreck History of Beacon Island, Western Australia

Beacon Virtua is a project to document and virtually preserve a historically significant offshore island as a virtual reality experience. In 1629, survivors of the wreck of VOC ship Batavia took refuge on Beacon Island, Western Australia, followed by a mutiny and massacre. In the 1950s the island became the base of a successful fishing industry, and in 1963 human remains from Batavia were located. The fishing community has recently been moved off the island to protect and preserve the site and allow a thorough archaeological investigation of the island. Beacon Virtua exposes users to the history of both the shipwreck survivors and the fishing community. The project uses the virtual environment development software Unity to present a simulation of the island, with 3D models of buildings and jetties, photogrammetric 3D reconstructions of graves and other features, 360° photographic panoramas, and information on the history of the island. The experience has been made available on a wide range of different platforms including via a web-page, as part of an exhibition, and on head mounted displays (VR headsets). This chapter discusses the features included in Beacon Virtua, the storytelling techniques used in the simulation, the challenges encountered and solutions used during the project

Collective neutrino flavor transitions in supernovae and the role of trajectory averaging

Non-linear effects on supernova neutrino oscillations, associated with neutrino self-interactions, are known to induce collective flavor transitions near the supernova core for theta_13 \neq 0. In scenarios with very shallow electron density profiles, these transformations have been shown to couple with ordinary matter effects, jointly producing spectral distortions both in normal and inverted hierarchy. In this work we consider a complementary scenario, characterized by higher electron density, as indicated by post-bounce shock-wave simulations. In this case, early collective flavor transitions are decoupled from later, ordinary matter effects. Moreover, such transitions become more amenable to both numerical computations and analytical interpretations in inverted hierarchy, while they basically vanish in normal hierarchy. We numerically evolve the neutrino density matrix in the region relevant for self-interaction effects. In the approximation of averaged intersection angle between neutrino trajectories, our simulations neatly show the collective phenomena of synchronization, bipolar oscillations, and spectral split, recently discussed in the literature. In the more realistic (but computationally demanding) case of non-averaged neutrino trajectories, our simulations do not show new significant features, apart from the smearing of ``fine structures'' such as bipolar nutations. Our results seem to suggest that, at least for non-shallow matter density profiles, averaging over neutrino trajectories plays a minor role in the final outcome. In this case, the swap of nu_e and nu_{\mu,\tau} spectra above a critical energy may represent an unmistakable signature of the inverted hierarchy, especially for theta_{13} small enough to render further matter effects irrelevant.Comment: v2 (27 pages, including 9 eps figures). Typos removed, references updated. Minor comments added. Corrected numerical errors in Eq.(6). Matches the published versio

A Guide for the Design of Benchmark Environments for Building Energy Optimization

The need for algorithms that optimize building energy consumption is usually motivated with the high energy consumption of buildings on a global scale. However, the current practice for evaluating the performance of such algorithms does not reflect this goal, as in most cases the performance is reported for one specific simulated building only, which provides no indication about the generalization of the score on other buildings. One approach to overcome this severe issue is to establish a shared collection of environments, each representing one simulated building setup, that would enable researchers to systematically compare and contrast the efficacy of their building optimization algorithms at scale. However, this requires that the individual environments are well designed for this goal. This paper is thus targeting the design of suitable environments for such a collection based on a detailed analysis of related publications that allows the identification of relevant characteristics for suitable environments. Based on this analysis a guide is developed that distills these characteristics into questions, intended to support a discussion of relevant topics during the design of such environments. Additional explanations and examples are provided for each question to make the guide more comprehensible. Finally, it is demonstrated how the guide can be applied, by utilizing it for the design of a novel environment, which represents an office building in tropical climate. This environment is released open source alongside this publication. We also indicate how test scenarios from existing publications could be enhanced to comply with the required characteristics according to our guide, underlining its importance for the future development and evaluation of building energy optimization algorithms, and thus for the sustainability of buildings in general

Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs

<p>Abstract</p> <p>Background</p> <p>The susceptibility of microbes such as <it>Plasmodium falciparum </it>to drugs is measured in vitro as the concentration of the drug achieving 50% of maximum effect (IC₅₀); values from a population are summarized as geometric means. For antimalarial drugs, as well as for antibiotics, assessing changes in microbe susceptibility over time under drug pressure would help inform treatment policy decisions, but no standard statistical method exists as yet.</p> <p>Methods</p> <p>A mixed model was generated on log_e-transformed IC₅₀values and calculated geometric least squares means (GLSM) with 90% confidence intervals (CIs). In order to compare IC₅₀s between years, GLSM ratios (GLSMR) with 90%CIs were calculated and, when both limits of the 90%CIs were below or above 100%, the difference was considered statistically significant. Results were compared to those obtained from ANOVA and a generalized linear model (GLM).</p> <p>Results</p> <p>GLSMRs were more conservative than ANOVA and resulted in lower levels of statistical significance. The GLSMRs approach allowed for random effect and adjustment for multiple comparisons. GLM was limited in the number of year-to-year comparisons by the need for a single reference year. The three analyses yielded generally consistent results.</p> <p>Conclusion</p> <p>A robust analytical method can palliate inherent limitations of in vitro sensitivity testing. The random effects GLSMRs with adjustment for multiple comparisons and 90%CIs require only assumptions on the mixed model to be applied. Results are easy to display graphically and to interpret. The GLMSRs should be considered as an option for monitoring changes in drug susceptibility of <it>P. falciparum </it>malaria and other microbes.</p

The kinetics and feedback inhibition of cytidine 5′-triphosphate synthetase in wild-type and mutant Chinese hamster cells

The kinetics and cytidine 5′-triphosphate (CTP) feedback inhibition of CTP synthetase in wild-type and four mutants of Chinese hamster V79 cells have been studied. The enzymes of the wild type and three of the four mutants exhibited positive cooperativity with the substrate uridine 5′-triphosphate (UTP). Three of the mutants had K m app and S 50 valuves distinctly greater than those of the wild type, while the fourth mutant had values similar to those of the wild type. all four mutants exhibited resistance to CTP feedback inhibition, while the wild type was sensitive to such inhibition. It is postulated that a single mutational event in each mutant had caused a concomitant change of the enzyme in its binding both to the substrate UTP and to the end-product CTP.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44151/1/10528_2004_Article_BF00485855.pd

Children's active play: self-reported motivators, barriers and facilitators

Physical activity has important benefits for children's physical health and mental wellbeing, but many children do not meet recommended levels. Research suggests that active play has the potential to make a valuable contribution to children's overall physical activity, whilst providing additional cognitive, social and emotional benefits. However, relatively little is known about the determinants of UK children's active play. Understanding these factors provides the critical first step in developing interventions to increase children's active play, and therefore overall physical activity. Eleven focus groups were conducted with 77, 10-11 year old children from four primary schools in Bristol, UK. Focus groups examined: (i) factors which motivate children to take part in active play; (ii) factors which limit children's active play and (iii) factors which facilitate children's active play. All focus groups were audio-taped and transcribed verbatim. Data were analysed using a thematic approach. Children were motivated to engage in active play because they perceived it to be enjoyable, to prevent boredom, to have physical and mental health benefits and to provide freedom from adult control, rules and structure. However, children's active play was constrained by a number of factors, including rainy weather and fear of groups of teenagers in their play spaces. Some features of the physical environment facilitated children's active play, including the presence of green spaces and cul-de-sacs in the neighbourhood. Additionally, children's use of mobile phones when playing away from home was reported to help to alleviate parents' safety fears, and therefore assist children's active play. Children express a range of motivational and environmental factors that constrain and facilitate their active play. Consideration of these factors should improve effectiveness of interventions designed to increase active play

Paediatric non-progression following grandmother-to-child HIV transmission

Background In contrast to adult HIV infection, where slow disease progression is strongly linked to immune control of HIV mediated by protective HLA class I molecules such as HLA-B*81:01, the mechanisms by which a minority of HIV-infected children maintain normal-for-age CD4 counts and remain clinically healthy appear to be HLA class I-independent and are largely unknown. To better understand these mechanisms, we here studied a HIV-infected South African female, who remained a non-progressor throughout childhood. Results Phylogenetic analysis of viral sequences in the HIV-infected family members, together with the history of grand-maternal breast-feeding, indicated that, unusually, the non-progressor child had been infected via grandmother-to-child transmission. Although HLA-B*81:01 was expressed by both grandmother and grand-daughter, autologous virus in each subject encoded an escape mutation L188F within the immunodominant HLA-B*81:01-restricted Gag-specific epitope TL9 (TPQDLNTML, Gag 180–188). Since the transmitted virus can influence paediatric and adult HIV disease progression, we investigated the impact of the L188F mutant on replicative capacity. When this variant was introduced into three distinct HIV clones in vitro, viral replicative capacity was abrogated altogether. However, a virus constructed using the gag sequence of the non-progressor child replicated as efficiently as wildtype virus. Conclusion These findings suggest alternative sequences of events: the transmission of the uncompensated low fitness L188F to both children, potentially contributing to slow progression in both, consistent with previous studies indicating that disease progression in children can be influenced by the replicative capacity of the transmitted virus; or the transmission of fully compensated virus, and slow progression here principally the result of HLA-independent host-specific factors, yet to be defined

Omnibus Sequences, Coupon Collection, and Missing Word Counts

An {\it Omnibus Sequence} of length $n$ is one that has each possible "message" of length $k$ embedded in it as a subsequence. We study various properties of Omnibus Sequences in this paper, making connections, whenever possible, to the classical coupon collector problem.Comment: 26 page