648 research outputs found
Study of a high spatial resolution 10B-based thermal neutron detector for application in neutron reflectometry: the Multi-Blade prototype
Although for large area detectors it is crucial to find an alternative to
detect thermal neutrons because of the 3He shortage, this is not the case for
small area detectors. Neutron scattering science is still growing its
instruments' power and the neutron flux a detector must tolerate is increasing.
For small area detectors the main effort is to expand the detectors'
performances. At Institut Laue-Langevin (ILL) we developed the Multi-Blade
detector which wants to increase the spatial resolution of 3He-based detectors
for high flux applications. We developed a high spatial resolution prototype
suitable for neutron reflectometry instruments. It exploits solid 10B-films
employed in a proportional gas chamber. Two prototypes have been constructed at
ILL and the results obtained on our monochromatic test beam line are presented
here
Possible Superconductivity at 37 K in Graphite-Sulfur Composite
Sulfur intercalated graphite composites with diamagnetic transitions at 6.7 K
and 37 K are prepared. The magnetization hysteresis loops (MHL), Xray
diffraction patterns, and resistance were measured. From the MHL, a slight
superconducting like penetration process is observed at 15 K in low field
region. The XRD shows no big difference from the mixture of graphite and sulfur
indicating that the volume of the superconducting phase (if any) is very small.
The temperature dependence of resistance shows a typical semiconducting
behavior with a saturation in low temperature region. This saturation is either
induced by the de-localization of conducting electrons or by possible
superconductivity in this system.Comment: CHIN. PHYS.LETT v18 1648 (2001
Some Restrictions Abroad Affecting Corporations
A neutron detector concept based on solid layers of boron carbide enriched in 1 B has been in development for the last few years as an alternative for He-3 by collaboration between the ILL, ESS and Linkoping University. This Multi-Grid detector uses layers of aluminum substrates coated with (B4C)-B-10 on both sides that are traversed by the incoming neutrons. Detection is achieved using a gas counter readout principle. By segmenting the substrate and using multiple anode wires, the detector is made inherently position sensitive. This development is aimed primarily at neutron scattering instruments with large detector areas, such as time-of-flight chopper spectrometers. The most recent prototype has been built to be interchangeable with the He-3 detectors of IN6 at ILL. The 1 B detector has an active area of 32 x 48 cm(2). It was installed at the IN6 instrument and operated for several weeks, collecting data in parallel with the regularly scheduled experiments, thus providing the first side-by-side comparison with the conventional He-3 detectors. Results include an efficiency comparison, assessment of the in-detector scattering contribution, sensitivity to gamma-rays and the signal-to-noise ratio in time-of-flight spectra. The good expected performance has been confirmed with the exception of an unexpected background count rate. This has been identified as natural alpha activity in aluminum. New convertor substrates are under study to eliminate this source of background
Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals A beta Aggregation Dependent Anionic Lipid Accumulations and Metabolism
Amyloid plaque formation constitutes one of the main pathological hallmarks of Alzheimer’s disease (AD) and is suggested to be a critical factor driving disease pathogenesis. Interestingly, in patients that display amyloid pathology but remain cognitively normal, Aβ deposits are predominantly of diffuse morphology suggesting that cored plaque formation is primarily associated with cognitive deterioration and AD pathogenesis. Little is known about the molecular mechanism responsible for conversion of monomeric Aβ into neurotoxic aggregates and the predominantly cored deposits observed in AD. The structural diversity among Aβ plaques, including cored/compact- and diffuse, may be linked to their distinct Aβ profile and other chemical species including neuronal lipids. We developed a novel, chemical imaging paradigm combining matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) and fluorescent amyloid staining. This multimodal imaging approach was used to probe the lipid chemistry associated with structural plaque heterogeneity in transgenic AD mice (tgAPPSwe) and was correlated to Aβ profiles determined by subsequent laser microdissection and immunoprecipitation-mass spectrometry. Multivariate image analysis revealed an inverse localization of ceramides and their matching metabolites to diffuse and cored structures within single plaques, respectively. Moreover, phosphatidylinositols implicated in AD pathogenesis, were found to localize to the diffuse Aβ structures and correlate with Aβ1–42. Further, lysophospholipids implicated in neuroinflammation were increased in all Aβ deposits. The results support previous clinical findings on the importance of lipid disturbances in AD pathophysiology and associated sphingolipid processing. These data highlight the potential of multimodal imaging as a powerful technology to probe neuropathological mechanisms
Determination of absolute neutrino masses from Z-bursts
Ultrahigh energy neutrinos (UHE\nu) scatter on relic neutrinos (R\nu)
producing Z bosons, which can decay hadronically producing protons (Z-burst).
We compare the predicted proton spectrum with the observed ultrahigh energy
cosmic ray (UHECR) spectrum and determine the mass of the heaviest R\nu via a
maximum likelihood analysis. Our prediction depends on the origin of the
power-like part of the UHECR spectrum: m_\nu=2.75^{+1.28}_{-0.97} eV for
Galactic halo and 0.26^{+0.20}_{-0.14} eV for extragalactic (EG) origin. The
necessary UHE\nu flux should be detected in the near future.Comment: slight rewording, revised neutrino fluxes, conclusions unchanged,
version to appear in Phys. Rev. Let
Grand Unification Signal from Ultra High Energy Cosmic Rays?
The spectrum of ultrahigh energy (above \approx 10^{9} GeV) cosmic rays is
consistent with the decay of GUT scale particles. The predicted mass is
m_X=10^b GeV, where b=14.6_{-1.7}^{+1.6}.Comment: 4 pages, 3 figures one figure removed, one table added, conclusions
essentially remained the same within errorbar
Relic neutrino masses and the highest energy cosmic rays
We consider the possibility that a large fraction of the ultrahigh energy
cosmic rays are decay products of Z bosons which were produced in the
scattering of ultrahigh energy cosmic neutrinos on cosmological relic
neutrinos. We compare the observed ultrahigh energy cosmic ray spectrum with
the one predicted in the above Z-burst scenario and determine the required mass
of the heaviest relic neutrino as well as the necessary ultrahigh energy cosmic
neutrino flux via a maximum likelihood analysis. We show that the value of the
neutrino mass obtained in this way is fairly robust against variations in
presently unknown quantities, like the amount of neutrino clustering, the
universal radio background, and the extragalactic magnetic field, within their
anticipated uncertainties. Much stronger systematics arises from different
possible assumptions about the diffuse background of ordinary cosmic rays from
unresolved astrophysical sources. In the most plausible case that these
ordinary cosmic rays are protons of extragalactic origin, one is lead to a
required neutrino mass in the range 0.08 eV - 1.3 eV at the 68 % confidence
level. This range narrows down considerably if a particular universal radio
background is assumed, e.g. to 0.08 eV - 0.40 eV for a large one. The required
flux of ultrahigh energy cosmic neutrinos near the resonant energy should be
detected in the near future by AMANDA, RICE, and the Pierre Auger Observatory,
otherwise the Z-burst scenario will be ruled out.Comment: 19 pages, 22 figures, REVTeX
Tibio-femoral joint constraints for bone pose estimation during movement using multi-body optimization
The financial support of the Universita'Italo-Francese (Call Vinci) and of the Department of Human Movement and Sport Sciences of the University of Rome ''Foro Italico'' is gratefully acknowledged. The authors wish to acknowledge Dr. Sophie Lacoste for her technical support and John McCamley for his contribution to the refinement of the manuscriptWhen using skin markers and stereophotogrammetry for movement analysis, bone pose estimation may be performed using multi-body optimization with the intent of reducing the effect of soft tissue artefacts. When the joint of interest is the knee, improvement of this approach requires defining subject-specific relevant kinematic constraints. The aim of this work was to provide these constraints in the form of plausible values for the distances between origin and insertion of the main ligaments (ligament lengths), during loaded healthy knee flexion, taking into account the indeterminacies associated with landmark identification during anatomical calibration. Ligament attachment sites were identified through virtual palpation on digital bone templates. Attachments sites were estimated for six knee specimens by matching the femur and tibia templates to low-dose stereoradiography images. Movement data were obtained using stereophotogrammetry and pin markers. Relevant ligament lengths for the anterior and posterior cruciate, lateral collateral, and deep and superficial bundles of the medial collateral ligaments (ACL, PCL, LCL, MCLdeep, MCLsup) were calculated. The effect of landmark identification variability was evaluated performing a Monte Carlo simulation on the coordinates of the origin-insertion centroids. The ACL and LCL lengths were found to decrease, and the MCLdeep length to increase significantly during flexion, while variations in PCL and MCLsup length was concealed by the experimental indeterminacy. An analytical model is given that provides subject-specific plausible ligament length variations as functions of the knee flexion angle and that can be incorporated in a multi-body optimization procedure
- …