538 research outputs found
Perfect preferential orientation of nitrogen-vacancy defects in a synthetic diamond sample
We show that the orientation of nitrogen-vacancy (NV) defects in diamond can
be efficiently controlled through chemical vapor deposition (CVD) growth on a
(111)-oriented diamond substrate. More precisely, we demonstrate that
spontaneously generated NV defects are oriented with a ~ 97 % probability along
the [111] axis, corresponding to the most appealing orientation among the four
possible crystallographic axes. Such a nearly perfect preferential orientation
is explained by analyzing the diamond growth mechanism on a (111)-oriented
substrate and could be extended to other types of defects. This work is a
significant step towards the design of optimized diamond samples for quantum
information and sensing applications.Comment: 6 pages, 4 figure
Tolerance and efficacy of preventive gastrostomy feeding in pediatric oncology
BackgroundMalnutrition in pediatric oncology remains underestimated, although having a negative impact on outcome. Enteral nutrition (EN) using percutaneous endoscopic gastrostomy (PEG) may prevent or reverse malnutrition consequences. We aimed to evaluate both efficacy and safety of early EN during tumors treatment in children. Procedures Medical records of pediatric patients having a PEG tube inserted between 1995 and 2009 were retrospectively reviewed. We compared type and incidence of complications in Group 1, including 74 patients suffering from cancer, and control Group 2, including 57 patients with neurological impairment. Efficacy of EN was evaluated through nutritional parameters [Z-scores weight for height (W/H) and height for age (H/A)], post-operative complications and relapse rates. Statistical significance was set for Pâ<â0.05. Results PEG tolerance was similar in both groups, as shown by comparable complication rates (62% vs. 76%, NS). EN allowed improvement or stabilization of Z-score W/H in 76% of oncologic patients. The final height loss was lower (â0.5 vs. â1.2âSD of Z-scores H/A) when EN was started at the beginning of the oncologic treatment. In bone tumors, EN prevented weight loss during chemotherapy, and tended to lessen surgical complications, relapses and deaths. Conclusions Early gastrostomy feeding represents a relatively safe way to prevent malnutrition in children with cancer, and might play a role in bone tumors oncological outcome. Further prospective studies are needed to confirm these results and assess the impact of EN and PEG on quality of life
The Balance of Apoptotic and Necrotic Cell Death in Mycobacterium tuberculosis Infected Macrophages Is Not Dependent on Bacterial Virulence
An important mechanism of Mycobacterium tuberculosis pathogenesis is the ability to control cell death pathways in infected macrophages: apoptotic cell death is bactericidal, whereas necrotic cell death may facilitate bacterial dissemination and transmission
Technologies sĂ©mantiques pour lâapprentissage de la botanique en mobilitĂ©
National audienceLe projet ANR ReVeRIES (Reconnaissance de VĂ©gĂ©taux RĂ©crĂ©ative, Interactive et Educative sur Smartphone), lancĂ© en fĂ©vrier 2016, vise Ă faciliter sur lâaide numĂ©rique Ă lâapprentissage de la botanique en situation rĂ©elle, câest Ă dire dans la nature, ou les utilisateurs ne peuvent utiliser quâun smartphone. Les solutions existantes pour lâassistance Ă lâidentification sont fondĂ©es sur la construction manuelle de clĂ©s dâidentifications. La spĂ©cificitĂ© de notre solution est lâutilisation de technologies sĂ©mantiques pour assister la crĂ©ation et la mise Ă jour automatique dâune clĂ© dâidentification
Using LES to Study Reacting Flows and Instabilities in Annular Combustion Chambers
Great prominence is put on the design of aeronautical gas turbines due to increasingly stringent regulations and the need to tackle rising fuel prices. This drive towards innovation has resulted sometimes in new concepts being prone to combustion instabilities. In the particular field of annular combustion chambers, these instabilities often take the form of azimuthal modes. To predict these modes, one must compute the full combustion chamber, which remained out of reach until very recently and the development of massively parallel computers. Since one of the most limiting factors in performing Large Eddy Simulation (LES) of real combustors is estimating the adequate grid, the effects of mesh resolution are investigated by computing full annular LES of a realistic helicopter combustion chamber on three grids, respectively made of 38, 93 and 336 million elements. Results are compared in terms of mean and fluctuating fields. LES captures self-established azimuthal modes. The presence and structure of the modes is discussed. This study therefore highlights the potential of LES for studying combustion instabilities in annular gas turbine combustors
TNOs are Cool: A survey of the trans-Neptunian region. VIII. Combined Herschel PACS and SPIRE observations of nine bright targets at 70â500 ÎŒm
International audienceAims. Trans-Neptunian objects (TNOs) are bodies populating the Kuiper belt and they are believed to retain the most pristine and least altered material of the solar system. The Herschel open time key programme entitled âTNOs are Cool: A survey of the trans-Neptunian regionâ has been awarded 373 h to investigate the albedo, size distribution and thermal properties of TNOs and Centaurs. Here we focus on the brightest targets observed by both the PACS and SPIRE multiband photometers: the dwarf planet Haumea, six TNOs (Huya, Orcus, Quaoar, Salacia, 2002 UX25, and 2002 TC302), and two Centaurs (Chiron and Chariklo).Methods. Flux densities are derived from PACS and SPIRE instruments using optimised data reduction methods. The spectral energy distribution obtained with the Herschel PACS and SPIRE instruments over 6 bands (centred at 70, 100, 160, 250, 350, and 500 ÎŒm), with Spitzer-MIPS at 23.7 and 71.4 ÎŒm, and with WISE at 11.6 and 22.1 ÎŒm in the case of 10199 Chariklo, has been modelled with the NEATM thermal model in order to derive the albedo, diameter, and beaming factor. For the Centaurs Chiron and Chariklo and for the 1000 km sized Orcus and Quaoar, a thermophysical model was also run to better constrain their thermal properties.Results. We derive the size, albedo, and thermal properties, including thermal inertia and surface emissivity, for the 9 TNOs and Centaurs. Several targets show a significant decrease in their spectral emissivity longwards of ~300 ÎŒm and especially at 500 ÎŒm. Using our size estimations and the mass values available in the literature, we also derive the bulk densities for the binaries Quaoar/Weywot (2.18-0.36+0.43 g/cm3), Orcus/Vanth (1.53-0.13+0.15 g/cm3), and Salacia/Actea (1.29-0.23+0.29 g/cm3). Quaoarâs density is similar to that of the other dwarf planets Pluto and Haumea, and its value implies high contents of refractory materials mixed with ices
Validation and Performance of the LHC Cryogenic System through Commissioning of the First Sector
The cryogenic system [1] for the Large Hadron Collider accelerator is presently in its final phase of commissioning at nominal operating conditions. The refrigeration capacity for the LHC is produced using eight large cryogenic plants and eight 1.8 K refrigeration units installed on five cryogenic islands. Machine cryogenic equipment is installed in a 26.7-km circumference ring deep underground tunnel and are maintained at their nominal operating conditions via a distribution system consisting of transfer lines, cold interconnection boxes at each cryogenic island and a cryogenic distribution line. The functional analysis of the whole system during all operating conditions was established and validated during the first sector commissioning in order to maximize the system availability. Analysis, operating modes, main failure scenarios, results and performance of the cryogenic system are presented
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial immune response and for determining the outcome of infection. However, these interactions are poorly understood, at least at the molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast, complement receptor (CR)3 and mannose receptor (MR), which are the main M. tuberculosis receptors on macrophages (MÏs), appeared to play a minor role, if any, in mycobacterial binding to DCs. The mycobacteria-specific lipoglycan lipoarabinomannan (LAM) was identified as a key ligand of DC-SIGN. Freshly isolated human LDCs were found to express DC-SIGN, and M. tuberculosisâderived material was detected in CD14âHLA-DR+DC-SIGN+ cells in lymph nodes (LNs) from patients with tuberculosis. Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGNâmediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity
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