538 research outputs found
A determination of the molar gas constant R by acoustic thermometry in helium
We have determined the acoustic and microwave frequencies of a misaligned spherical resonator
maintained near the temperature of the triple point of water and filled with helium with carefully
characterized molar mass M = (4.002 6032 ± 0.000 0015) g mol-1, with a relative standard uncertainty
ur(M) = 0.37Ă10-6. From these data and traceable thermometry we estimate the speed of sound in our
sample of helium at TTPW = 273.16 K and zero pressure to be u0
2 = (945 710.45 ± 0.85) m2 s-2 and
correspondingly deduce the value R = (8.314 4743 ± 0.000 0088) J mol-1 K-1 for the molar gas
constant. We estimate the value k = R/NA = (1.380 6508 ± 0.000 0015) à 10-23 J K-1 for the Boltzmann
constant using the currently accepted value of the Avogadro constant NA. These estimates of R and k,
with a relative standard uncertainty of 1.06 Ă 10-6, are 1.47 parts in 106 above the values recommended
by CODATA in 2010
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Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study
BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers. In the present study, we investigated whether deep convolutional neural networks (CNNs) can extract prognosticators directly from these widely available images.
METHODS AND FINDINGS: We hand-delineated single-tissue regions in 86 CRC tissue slides, yielding more than 100,000 HE image patches, and used these to train a CNN by transfer learning, reaching a nine-class accuracy of >94% in an independent data set of 7,180 images from 25 CRC patients. With this tool, we performed automated tissue decomposition of representative multitissue HE images from 862 HE slides in 500 stage I-IV CRC patients in the The Cancer Genome Atlas (TCGA) cohort, a large international multicenter collection of CRC tissue. Based on the output neuron activations in the CNN, we calculated a "deep stroma score," which was an independent prognostic factor for overall survival (OS) in a multivariable Cox proportional hazard model (hazard ratio [HR] with 95% confidence interval [CI]: 1.99 [1.27-3.12], p = 0.0028), while in the same cohort, manual quantification of stromal areas and a gene expression signature of cancer-associated fibroblasts (CAFs) were only prognostic in specific tumor stages. We validated these findings in an independent cohort of 409 stage I-IV CRC patients from the "Darmkrebs: Chancen der VerhĂŒtung durch Screening" (DACHS) study who were recruited between 2003 and 2007 in multiple institutions in Germany. Again, the score was an independent prognostic factor for OS (HR 1.63 [1.14-2.33], p = 0.008), CRC-specific OS (HR 2.29 [1.5-3.48], p = 0.0004), and relapse-free survival (RFS; HR 1.92 [1.34-2.76], p = 0.0004). A prospective validation is required before this biomarker can be implemented in clinical workflows.
CONCLUSIONS: In our retrospective study, we show that a CNN can assess the human tumor microenvironment and predict prognosis directly from histopathological images
The Global Lake Ecological Observatory Network (GLEON): the evolution of grassroots network science
Nine years later, with over 380 members from 40 countries, and 50 publications to its credit, GLEON is growing at a rapid pace and pushing the boundaries of the practice of network science. GLEON is really three networks: a network of lakes, data, and peopl
Episodic disturbances drive nutrient dynamics along freshwaterâtoâestuary gradients in a subtropical wetland
Wetlands are biogeochemically active ecosystems where primary production and respiration interact with physicoâchemical conditions to influence nutrient availability across spatioâtemporal scales. The effect of episodic disturbances on water quality dynamics within wetlands is relatively unknown, especially in large oligotrophic wetlands such as the Everglades. We describe a range of episodic disturbance events and their impacts on the spatioâtemporal dynamics of surface water total N (TN) and total P (TP) concentrations in the Everglades as a means to understand their effect and legacies. Water quality monitoring along the two principal drainagesâTaylor Slough (TS) and Shark River Slough (SRS)âhas been ongoing since 2000, spanning myriad disturbances ranging from highâenergy storms such as Hurricane Wilma in 2005 to a record cold event in 2010 and large fires. Local events include pulsed rainfall, low marsh stage, and stage recession and recovery (i.e., droughts and subsequent dryâtoâwet transitions). The deposition of marineâderived sediment from Hurricane Wilma corresponded with a doubling of TP in SRS mangrove sites (from 0.39 to 0.84 ÎŒmol/L) before recovering to preâdisturbance mean after 5â6 yr. A brief increase in TP within one week of the 2010 cold event was followed by delayed spikes in TN (\u3e1000 ÎŒmol/L) and TN:TP exceeding 5000 after one month. In 2008, a large fire in upper SRS prior to the wet season caused a lagged TP pulse at downstream locations SRS2, SRS3, and possibly SRS4. TP also varied negatively with depth/stage in marsh sites and positively with salinity in estuarine sites, reflecting physical concentration or dilution effects. In upper TS, TP varied according to extremes such as high rainfall and low stage relative to normal conditions. Although excess P in the Everglades is generally derived from anthropogenic upland or natural marine sources, episodic disturbance mobilizes internal sources of nutrients along an Everglades freshwaterâtoâestuary continuum, affecting water quality from days to years depending on disturbance type and intensity. The capacity for resilience is high in coastal wetland ecosystems that are exposed to highâenergy tropical storms and other episodic events, even in the highly managed Florida Everglades
Measurement of J/Psi production in pp collisions at sqrt(s)=2.76 and 7 TeV with ALICE
We present results from the ALICE experiment on the inclusive J/Psi
production in pp collisions at sqrt(s)=2.76 and 7 TeV. The integrated and
differential cross sections are evaluated down to pT=0 in two rapidity ranges,
|y|<0.9 and 2.5<y<4, in the dielectron and dimuon decay channel respectively.
The measurement at sqrt(s)=2.76 TeV, the same energy as Pb-Pb collisions,
provides a crucial reference for the study of hot nuclear matter effects on
J/Psi production. The J/Psi yield in pp collisions at sqrt(s)=7 TeV has also
been studied as a function of the charged particle multiplicity and first
results are presented.Comment: 4 pages, 4 figures, parallel talk at Quark Matter 2011, Annecy,
Franc
A Global lake ecological observatory network (GLEON) for synthesising high-frequency sensor data for validation of deterministic ecological models
A Global Lake Ecological Observatory Network (GLEON; www.gleon.org) has formed to provide a coordinated response to the need for scientific understanding of lake processes, utilising technological advances available from autonomous sensors. The organisation embraces a grassroots approach to engage researchers from varying disciplines, sites spanning geographic and ecological gradients, and novel sensor and cyberinfrastructure to synthesise high-frequency lake data at scales ranging from local to global. The high-frequency data provide a platform to rigorously validate processbased ecological models because model simulation time steps are better aligned with sensor measurements than with lower-frequency, manual samples. Two case studies from Trout Bog, Wisconsin, USA, and Lake Rotoehu, North Island, New Zealand, are presented to demonstrate that in the past, ecological model outputs (e.g., temperature, chlorophyll) have been relatively poorly validated based on a limited number of directly comparable measurements, both in time and space. The case studies demonstrate some of the difficulties of mapping sensor measurements directly to model state variable outputs as well as the opportunities to use deviations between sensor measurements and model simulations to better inform process understanding. Well-validated ecological models provide a mechanism to extrapolate high-frequency sensor data in space and time, thereby potentially creating a fully 3-dimensional simulation of key variables of interest
Progress towards an accurate determination of the Boltzmann constant by Doppler spectroscopy
In this paper, we present significant progress performed on an experiment
dedicated to the determination of the Boltzmann constant, k, by accurately
measuring the Doppler absorption profile of a line in a gas of ammonia at
thermal equilibrium. This optical method based on the first principles of
statistical mechanics is an alternative to the acoustical method which has led
to the unique determination of k published by the CODATA with a relative
accuracy of 1.7 ppm. We report on the first measurement of the Boltzmann
constant by laser spectroscopy with a statistical uncertainty below 10 ppm,
more specifically 6.4 ppm. This progress results from improvements in the
detection method and in the statistical treatment of the data. In addition, we
have recorded the hyperfine structure of the probed saQ(6,3) rovibrational line
of ammonia by saturation spectroscopy and thus determine very precisely the
induced 4.36 (2) ppm broadening of the absorption linewidth. We also show that,
in our well chosen experimental conditions, saturation effects have a
negligible impact on the linewidth. Finally, we draw the route to future
developments for an absolute determination of with an accuracy of a few ppm.Comment: 22 pages, 11 figure
Charmed quark component of the photon wave function
We determine the c-anti-c component of the photon wave function on the basis
of (i) the data on the transitions e+ e- -> J/psi(3096), psi(3686), psi(4040),
psi(4415), (ii) partial widths of the two-photon decays eta_{c0}(2979),
chi_{c0}(3415), chi_{c2}(3556) -> gamma-gamma, and (iii) wave functions of the
charmonium states obtained by solving the Bethe-Salpeter equation for the
c-anti-c system. Using the obtained c-anti-c component of the photon wave
function we calculate the gamma-gamma decay partial widths for radial
excitation 2S state, eta_{c0}(3594) -> gamma-gamma, and 2P states
chi_{c0}(3849), chi_{c2}(3950) -> gamma-gamma.Comment: 20 pages, 8 figure
Air fluorescence measurements in the spectral range 300-420 nm using a 28.5 GeV electron beam
Measurements are reported of the yield and spectrum of fluorescence, excited
by a 28.5 GeV electron beam, in air at a range of pressures of interest to
ultra-high energy cosmic ray detectors. The wavelength range was 300 - 420 nm.
System calibration has been performed using Rayleigh scattering of a nitrogen
laser beam. In atmospheric pressure dry air at 304 K the yield is 20.8 +/- 1.6
photons per MeV.Comment: 29 pages, 10 figures. Submitted to Astroparticle Physic
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