24 research outputs found
Impact of opportunistic Mycobacterium tuberculosis infection on the phenotype of peripheral blood T cells of AIDS patients
While the detrimental consequences of opportunistic tuberculosis (TB) in the course and outcome of HIV-1 infection are well studied, little information about the impact of the mycobacterial infection on the phenotype of T lymphocytes is available. In this study we analyzed by cytofluorimetry the peripheral blood T cell phenotype of 13 patients with AIDS, 23 HIV-1 negative patients with active pulmonary TB, nine HIV-1/Mycobacterium tuberculosis coinfected individuals, and 21 age- and sex-matched healthy controls. CD4+ T cells were equally depleted in AIDS and coinfection (P<0.001). The findings suggest a rescuing effect of the added mycobacterial infection. CD3 T cell loss was not observed in coinfection, whereas it was severe in AIDS (P<0.001). Similar (albeit less striking) effects were observed with other markers (CD45RA, CD45RO, and CD27) that were diminished in CD4+ T cells of AIDS patients. Apparent detrimental effects of the added mycobacterial infection were the increased expression of the proapoptotic molecule CD95 on CD4+ T cells, and decreased expression of the major costimulatory molecule CD28 on CD8+ T cells. In this work we show that M. tuberculosis infection modifies the T cell phenotype of the HIV-1 infected individual
Sex differences in human mate preferences vary across sex ratios
This material is based on work supported by the National Science Foundation under grant no. 1845586. The work of T.T.K.H. was supported by grant no. 501.01-2016.02 from the Vietnam National Foundation for Science and Technology Development (NAFOSTED). A.O. was supported by the Ministry of Science and Higher Education (grant no. 626/STYP/12/2017). A.S. and P.S. were supported by National Science Center-Poland (grant no. 2014/13/B/HS6/02644). Marina Butovskaya and D.D. were supported by State assignment project No. 01201370995 of the Institute of Ethnology and Anthropology, Moscow, Russia. P.G., A.L. and N.M. were supported by the Hungarian Scientific Research Fund-(OTKA; grant no. K125437). F.J. was supported by the National Nature Science Foundation of China (grant no. 71971225). G.A. was supported by UKRI/GCRF Gender, Justice, Security Grant (grant no. AH/S004025/1).A wide range of literature connects sex ratio and mating
behaviours in non-human animals. However, research
examining sex ratio and human mating is limited in
scope. Prior work has examined the relationship between
sex ratio and desire for short-term, uncommitted mating
as well as outcomes such as marriage and divorce rates.
Less empirical attention has been directed towards the
relationship between sex ratio and mate preferences,
despite the importance of mate preferences in the human
mating literature. To address this gap, we examined sex
ratio’s relationship to the variation in preferences for attractiveness,
resources, kindness, intelligence and health in a
long-term mate across 45 countries (n = 14 487). We predicted
that mate preferences would vary according to
relative power of choice on the mating market, with
increased power derived from having relatively few competitors
and numerous potential mates. We found that
each sex tended to report more demanding preferences
for attractiveness and resources where the opposite sex
was abundant, compared to where the opposite sex was scarce. This pattern dovetails with those found for mating
strategies in humans and mate preferences across species,
highlighting the importance of sex ratio for understanding
variation in human mate preferences.National Science Foundation (NSF) 1845586National Foundation for Science & Technology Development (NAFOSTED) 501.01-2016.02Ministry of Science and Higher Education, PolandEuropean Commission 626/STYP/12/2017National Science Centre, Poland 2014/13/B/HS6/02644Institute of Ethnology and Anthropology, Moscow, Russia 01201370995Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) K125437National Natural Science Foundation of China (NSFC) 71971225UKRI/GCRF Gender, Justice, Security Grant AH/S004025/
Antigen-loaded dendritic cells triggers a specific cytotoxic T lymphocytes immune response against hepatocellular carcinoma: in vitro study
Logit Model Use to Assess Credit Risk Levels on Service Sector Companies in Emerging Markets:Venezuela� Case
Sex Differences in Mate Preferences Across 45 Countries: A Large-Scale Replication.
Considerable research has examined human mate preferences across cultures, finding universal sex differences in preferences for attractiveness and resources as well as sources of systematic cultural variation. Two competing perspectives-an evolutionary psychological perspective and a biosocial role perspective-offer alternative explanations for these findings. However, the original data on which each perspective relies are decades old, and the literature is fraught with conflicting methods, analyses, results, and conclusions. Using a new 45-country sample (N = 14,399), we attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives. Support for universal sex differences in preferences remains robust: Men, more than women, prefer attractive, young mates, and women, more than men, prefer older mates with financial prospects. Cross-culturally, both sexes have mates closer to their own ages as gender equality increases. Beyond age of partner, neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries
Sex differences in human mate preferences vary across sex ratios
A wide range of literature connects sex ratio and mating behaviours in non-human animals. However, research examining sex ratio and human mating is limited in scope. Prior work has examined the relationship between sex ratio and desire for short-term, uncommitted mating as well as outcomes such as marriage and divorce rates. Less empirical attention has been directed towards the relationship between sex ratio and mate preferences, despite the importance of mate preferences in the human mating literature. To address this gap, we examined sex ratio's relationship to the variation in preferences for attractiveness, resources, kindness, intelligence and health in a long-term mate across 45 countries (n = 14 487). We predicted that mate preferences would vary according to relative power of choice on the mating market, with increased power derived from having relatively few competitors and numerous potential mates. We found that each sex tended to report more demanding preferences for attractiveness and resources where the opposite sex was abundant, compared to where the opposite sex was scarce. This pattern dovetails with those found for mating strategies in humans and mate preferences across species, highlighting the importance of sex ratio for understanding variation in human mate preferences.info:eu-repo/semantics/publishedVersio