A re-interpretation of the "Bateman Brook Metamorphic Suite", Cape Breton Highlands, Nova Scotia, as sheared, fault-bounded blocks of other units

The Bateman Brook Metamorphic Suite, as previously defined, is the westernmost unit of the Bras d'Or terrene in the central Cape Breton Highlands. It outcrops along the Eastern Highlands Shear Zone, the contact between the Bras d'Or terrane and the Aspy terrane to the northwest. The Bateman Brook unit has been reported to contain a wide range of lithologies, and contacts with adjacent units are mainly faulted. Re-examination of rocks from the Bateman Brook Metamorphic Suite shows it to consist of semipelitic to psammitic schist, banded mafic gneiss, and foliated, dioritic, mafic gneiss. Rocks exhibit two major shear fabrics, an early intensely foliated and lineated fabric indicative of shear at high metamorphic grade, and a later mylonitic fabric indicative of shear at lower grade. As a result of this study, it is recommended that the name Bateman Brook Metamorphic Suite be abandoned. The southern part of the suite is re-assigned to the McMillan Flowage Formation of the Bras d'Or terrane. The central part is interpreted to include rocks of both the Kathy Road Dioritic Suite and the McMillan Flowage Formation. Most of the northern part is re-assigned to the Jumping Brook Metamorphic Suite of the Aspy terrane. RÉSUMÉ La suite métamorphique de Bateman Brook, telle que définie ameiieurement, est l'unité la plus occidentale du terrain de Bras d'Or dans le centre des hautes-terres du Cap-Breton. Elle affleure le long de la zone de cisaillement de Eastern Highlands, le contact entre le terrain de Bras d'Or et le terrain d'Aspy au nord-ouest. L'unité de Bateman Brook à été décrite comme comprenant une grande variété de lithologies et les contacts avec les unités adjacentes sont principalement faillés. Un réexamen de roches provenant de la suite métamorphique de Bateman Brook montre qu'elle consiste en schiste semi-politique à psammitique, en gneiss mafique rubané et en gneiss mafique dioritique et folié. Les roches montrent deux fabriques de cisaillement majeures, une fabriques de foliation et de linéation précoce fortement développée indiquant un cisaillement à haut grade métamorphique et une fabrique mylonitique plus tardive indicative d'un cisaillement à plus faible grade. Comme résultat de cette étude, il est recommandé que le terme de suite métamorphique de Bateman Brook soit abandonné La partie sud de la suite est réassignéle à la Formation de McMillan Flowage du terrain de Bras d'Or. La partie cent rale est interprétée comme incluant des roches appartenant à la suite dioritique de Kathy Road et à la Formation de McMillan Flowage. La plupart de la partie du nord est réassignée à la suite métamorphique de Jumping Brook du terrain d'Avalon. [Traduit par la rédaction

Proton therapy for atypical meningiomas

We report clinical outcomes of proton therapy in patients with World Health Organization grade 2 (atypical) meningiomas. Between 2005 and 2013, 22 patients with atypical meningiomas were treated to a median dose of 63 Gy (RBE) using proton therapy, as an adjuvant therapy after surgery (n = 12) or for recurrence or progression of residual tumor (n = 10). Six patients had presumed radiation-induced meningiomas, but none had received prior radiotherapy for their meningioma. The median follow-up time after radiation was 39 months (range 7–104) and all patients remain alive at last follow-up. The 5-year estimate of local control was 71.1 % (95 % CI 49.3–92.9 %). The 5-year estimate of local control was 87.5 % following a radiation dose >60 Gy (RBE), compared to 50.0 % for ≤60 Gy (RBE) (p = 0.038). The 5-year estimate of neuraxis dissemination was 5 % (95 % CI 0–14.6 %) and 6.2 % (95 % CI 0–18.2 %) for metastases outside of the central nervous system. Radiation necrosis was observed in one patient with a history of prior cranial irradiation. Fractionated proton therapy was associated with favorable tumor control rates for grade 2 meningiomas. Prospective studies are needed to define the optimal radiation dose for high-grade meningiomas

The Grizzly, January 31, 1986

Nursing Homes: A Solution for the Elderly? Investigation 1 • Fetterolf Nears Completion • Smokers and Non-Smokers Must Meet Half Way • Horrible Hunger Continues • A Look at a Better Ursinus • Can a Dream Become a Reality? • The Limelight Shines on Lynne Edwards • Profile: John French Adds a Musical Twist • Pain Brings Gain for the Swimmin\u27 Women • Gymnasts Vaulting Into a New Season • Track Season Starts at the Gun • Basketball Hall of Fame Cites Women\u27s Team as Second in All-Time Victories • Wellness Bear Spotted! • Applications Being Taken for St. Andrew\u27s Scholarship • Women\u27s Studies Program Seeks Campus Wide Interest • Profile: Mr. Rue Keeps Records Straight • Ursinus Professor Publishes Books on Pennsylvania Dutch • Ursinus Professor\u27s Philosophy Text Publishedhttps://digitalcommons.ursinus.edu/grizzlynews/1155/thumbnail.jp

Bounds on the Complexity of Halfspace Intersections when the Bounded Faces have Small Dimension

We study the combinatorial complexity of D-dimensional polyhedra defined as the intersection of n halfspaces, with the property that the highest dimension of any bounded face is much smaller than D. We show that, if d is the maximum dimension of a bounded face, then the number of vertices of the polyhedron is O(n^d) and the total number of bounded faces of the polyhedron is O(n^d^2). For inputs in general position the number of bounded faces is O(n^d). For any fixed d, we show how to compute the set of all vertices, how to determine the maximum dimension of a bounded face of the polyhedron, and how to compute the set of bounded faces in polynomial time, by solving a polynomial number of linear programs

The Grizzly, January 31, 1986

Nursing Homes: A Solution for the Elderly? Investigation 1 • Fetterolf Nears Completion • Smokers and Non-Smokers Must Meet Half Way • Horrible Hunger Continues • A Look at a Better Ursinus • Can a Dream Become a Reality? • The Limelight Shines on Lynne Edwards • Profile: John French Adds a Musical Twist • Pain Brings Gain for the Swimmin\u27 Women • Gymnasts Vaulting Into a New Season • Track Season Starts at the Gun • Basketball Hall of Fame Cites Women\u27s Team as Second in All-Time Victories • Wellness Bear Spotted! • Applications Being Taken for St. Andrew\u27s Scholarship • Women\u27s Studies Program Seeks Campus Wide Interest • Profile: Mr. Rue Keeps Records Straight • Ursinus Professor Publishes Books on Pennsylvania Dutch • Ursinus Professor\u27s Philosophy Text Publishedhttps://digitalcommons.ursinus.edu/grizzlynews/1155/thumbnail.jp

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.

MotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy. Modeling the chronology of these adaptations during full-term pregnancy provides the frameworks for future studies examining deviations implicated in pregnancy-related pathologies including preterm birth and preeclampsia.ResultsWe performed a multiomics analysis of 51 samples from 17 pregnant women, delivering at term. The datasets included measurements from the immunome, transcriptome, microbiome, proteome and metabolome of samples obtained simultaneously from the same patients. Multivariate predictive modeling using the Elastic Net (EN) algorithm was used to measure the ability of each dataset to predict gestational age. Using stacked generalization, these datasets were combined into a single model. This model not only significantly increased predictive power by combining all datasets, but also revealed novel interactions between different biological modalities. Future work includes expansion of the cohort to preterm-enriched populations and in vivo analysis of immune-modulating interventions based on the mechanisms identified.Availability and implementationDatasets and scripts for reproduction of results are available through: https://nalab.stanford.edu/multiomics-pregnancy/.Supplementary informationSupplementary data are available at Bioinformatics online

A microplate technique to simultaneously assay calcium accumulation in endoplasmic reticulum and SERCA release of inorganic phosphate

Traditional analyses of calcium homeostasis have separately quantified either calcium accumulation or release mechanisms. To define the system as a whole, however, requires multiple experimental techniques to examine both accumulation and release. Here we describe a technique that couples the simultaneous quantification of radio-labeled calcium accumulation in endoplasmic reticulum (ER) microsomes with the release of inorganic phosphate (Pi) by the hydrolytic activity of sarco-endoplasmic reticulum calcium ATPase (SERCA) all in the convenience of a 96-well format

Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT

PURPOSE:We aimed to prospectively evaluate anatomic chest computed tomography (CT) with tissue characterization late gadolinium-enhanced magnetic resonance imaging (MRI) in the evaluation of pulmonary fibrosis (PF).METHODS:Twenty patients with idiopathic pulmonary fibrosis (IPF) and twelve control patients underwent late-enhanced MRI and high-resolution CT. Tissue characterization of PF was depicted using a segmented inversion-recovery turbo low-angle shot MRI sequence. Pulmonary arterial blood pool nulling was achieved by nulling main pulmonary artery signal. Images were read in random order by a blinded reader for presence and extent of overall PF (reticulation and honeycombing) at five anatomic levels. Overall extent of IPF was estimated to the nearest 5% as well as an evaluation of the ratios of IPF made up of reticulation and honeycombing. Overall grade of severity was dependent on the extent of reticulation and honeycombing.RESULTS:No control patient exhibited contrast enhancement on lung late-enhanced MRI. All IPF patients were identified with late-enhanced MRI. Mean signal intensity of the late-enhanced fibrotic lung was 31.8±10.6 vs. 10.5±1.6 for normal lung regions, P < 0.001, resulting in a percent elevation in signal intensity from PF of 204.8%±90.6 compared with the signal intensity of normal lung. The mean contrast-to-noise ratio was 22.8±10.7. Late-enhanced MRI correlated significantly with chest CT for the extent of PF (R=0.78, P = 0.001) but not for reticulation, honeycombing, or coarseness of reticulation or honeycombing.CONCLUSION:Tissue characterization of IPF is possible using inversion recovery sequence thoracic MRI

Development and validation of a Surgical Prioritization and Ranking Tool and Navigation Aid for Head and Neck Cancer (SPARTAN‐HN) in a scarce resource setting: Response to the COVID‐19 pandemic

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163412/2/cncr33114_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163412/1/cncr33114.pd

Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens

NetB is a pore-forming toxin produced by Clostridium perfringens and has been reported to play a major role in the pathogenesis of avian necrotic enteritis, a disease that has emerged due to the removal of antibiotics in animal feedstuffs. Here we present the crystal structure of the pore-form of NetB solved to 3.9Å. The heptameric assembly shares structural homology to the Staphylococcal α-hemolysin. However, the rim domain, a region that is thought to interact with the target cell membrane shows sequence and structural divergence leading to the alteration of a phosphocholine binding pocket found in the staphylococcal toxins. Consistent with the structure we show that NetB does not bind phosphocholine efficiently but instead interacts directly with cholesterol leading to enhanced oligomerisation and pore formation. Finally we have identified conserved and non-conserved amino acid positions within the rim loops that significantly affect binding and toxicity of NetB. These findings present new insights into the mode of action of these pore-forming toxins enabling the design of more effective control measures against necrotic enteritis and providing potential new tools to the field of bionanotechnology