The Apollo project manager, anomalies and ambiguities

Problems of Apollo project managers in decision making and production engineerin

The Professional and Technical Qualifications of Apollo Project Managers

Qualifications of Apollo project manager personne

Environmental fatigue analysis of nuclear structural components: Assessment procedures, loads, and a case study

ABSTRACT: Nowadays, environmental fatigue assessment is mandatory in many countries, in the design and operational stages of nuclear structural components. The analysis of environmental fatigue can be a complex engineering process that is generally performed following national or international procedures. Such procedures are not always based on the same assumptions, and novel analysts may find a confusing variety of documents. Moreover, once a specific procedure has been chosen for the analysis, it is possible to complete the fatigue assessment by using design transients (and loads) or, alternatively, real loads provided by monitoring systems. In this context, this paper provides a comprehensive review of the different environmental fatigue assessment procedures and a brief description of the different types of load inputs (design vs. real data). The work is completed with a case study, in which the (fatigue) cumulative usage factor is estimated in a particular nuclear component by using one of the abovementioned assessment procedures (NUREG/CR-6909) and two options for the load inputsFunding: This research was funded by EURATOM, grant number 662320

Alternate Routes of Administration and Risk for HIV Among Prescription Opioid Abusers

Route of administration is an important contributor to the adverse health consequences of prescription medication abuse. The current study examines characteristics associated with non-oral routes of administration among a large sample of prescription opioid abusers and explores needle-related human immunodeficiency virus (HIV) risk behaviors as well. In the study, 791 opioid abusers completed a one-time structured interview, including complete histories of illicit and prescription drug abuse and route of drug administration. The most common method of pill use was oral (91%), followed by intranasal (53.1%), injection (23.8%), and smoking (14.5%). The youngest prescription opioid abusers, ages 18-24, displayed significantly higher odds of using alternate routes of administration and of reusing nonsterile needles for injection. HIV prevention programming should be developed for young prescription opioid injectors

Prediction of fracture loads in PMMA specimens using the Equivalent Material Concept and the Theory of Critical Distances combined criterion

This paper provides a methodology for the prediction of fracture loads in notched materials that combines the Equivalent Material Concept with the Theory of Critical Distances. The latter has a linear-elastic nature, and requires material (critical distance) calibration in those cases where the non-linear material behaviour is significant. The calibration may be performed by fracture testing on notched specimens, finite elements modelling or a combination of fracture and simulation. In any case, it may constitute a major issue when applying the Theory of Critical Distances on an industrial level. The proposed methodology sets out to define an equivalent linear-elastic material on which the Theory of Critical Distances may be applied through its basic formulation and without any previous calibration of the corresponding critical distance. It has been applied to PMMA Single Edge Notch Bending specimens, providing accurate predictions of fracture loads.The authors of this work would like to express their gratitude to the Spanish Ministry of Science and Innovation for the financial support of the project MAT2014-58443-P: “Análisis del comportamiento en fractura de componentes estructurales con defectos en condiciones debajo confinamiento tensional”, on the results of which this paper is based

Novel Mutation in the Apob Gene (Apo B-15.56): A Case Report

Novel Mutation in the Apob Gene (Apo B-15.56): A Case ReportFamilial hypobetalipoproteinemia (FHBL) is a rare co-dominant genetic disorder characterized by decrease of plasma low density lipoprotein-cholesterol (LDL-c) or apolipoprotein B (Apo-B) equal to or less than the 5th percentile for the population. We describe a 48-year-old male who presented with fatty liver disease (FLD), insulin resistance (IR), obesity and hypertension. Our patient thus met the latest diagnostic criteria of the metabolic syndrome (MS) proposed by the Adult Treatment Panel and the International Diabetes Federation. However, he had very low plasma concentration of LDL-c and Apo-B. DNA sequencing showed that he and two first-degree relatives affected by obesity and mild IR were heterozygous for a single nucleotide deletion on exon 15 of the APOB gene, which was predicted to form a truncated Apo-B designated Apo B-15.56

The patient-physician relationship in the face of oncological disease: A review of literature on the emotional and psychological reactions of patients and physician

The physician-patient relationship is daily destabilized by emotional reactions and psychic defenses that cancer arises in the two partners. Continued scientific and technological progresses which were reached by medicine in recent years, and particularly oncologic clinical discoveries, increased the chance of not only survival but also healing. Nevertheless, cancer diagnosis is still a hard existential text that destabilizes everyday life, all the psychic and relational balance, inevitably causing a psychological and social change not only in the patient who is affected but also into the wide social network around him (family, friends, doctors, healthcare team). The aim of this review is to understand how problems, feelings, emotions, distresses or defense mechanisms could garble the relation and the communication dynamics between physician and patients and then prejudicing the efficacy of oncologic therapeutic compliance. Pubmed and Scopus were searched, using strings related to "cancer", "physician-patient relations", burn-out", "compliance", and "communication", identifying literature published from 2000 to January 2015. Extracted papers were assessed for their relevance (10 of 412 papers initially reviewed). Results indicate that a good and empathetic relationship between physician and patient were related to good therapeutic adherence. In particular, a good physician-patient relation maximizes the impact of clinical therapies and reduces psychophysical implications

Factors Contributing to the Rise of Buprenorphine Misuse: 2008-2013

OBJECTIVE: The purpose of the present study was to examine the motivations underlying the use of buprenorphine outside of therapeutic channels and the factors that might account for the reported rapid increase in buprenorphine misuse in recent years. METHODS: This study used: (1) a mixed methods approach consisting of a structured, self-administered survey (N=10,568) and reflexive, qualitative interviews (N=208) among patients entering substance abuse treatment programs for opioid dependence across the country, centered on opioid misuse patterns and related behaviors; and (2) interviews with 30 law enforcement agencies nationwide about primary diverted drugs in their jurisdictions. RESULTS: Our results demonstrate that the misuse of buprenorphine has increased substantially in the last 5 years, particularly amongst past month heroin users. Our quantitative and qualitative data suggest that the recent increases in buprenorphine misuse are due primarily to the fact that it serves a variety of functions for the opioid-abusing population: to get high, manage withdrawal sickness, as a substitute for more preferred drugs, to treat pain, manage psychiatric issues and as a self-directed effort to wean themselves off opioids. CONCLUSION: The non-therapeutic use of buprenorphinehas risen dramatically in the past five years, particularly in those who also use heroin. However, it appears that buprenorphine is rarely preferred for its inherent euphorigenic properties, but rather serves as a substitute for other drugs, particularly heroin, or as a drug used, preferable to methadone, to self-medicate withdrawal sickness or wean off opioids

High-speed data transfer with FPGAs and QSFP+ modules

We present test results and characterization of a data transmission system based on a last generation FPGA and a commercial QSFP+ (Quad Small Form Pluggable +) module. QSFP+ standard defines a hot-pluggable transceiver available in copper or optical cable assemblies for an aggregated bandwidth of up to 40 Gbps. We implemented a complete testbench based on a commercial development card mounting an Altera Stratix IV FPGA with 24 serial transceivers at 8.5 Gbps, together with a custom mezzanine hosting three QSFP+ modules. We present test results and signal integrity measurements up to an aggregated bandwidth of 12 Gbps.Comment: 5 pages, 3 figures, Published on JINST Journal of Instrumentation proceedings of Topical Workshop on Electronics for Particle Physics 2010, 20-24 September 2010, Aachen, Germany(R Ammendola et al 2010 JINST 5 C12019

The Changing Face of Heroin Use in the United States: A Retrospective Analysis of the Past 50 Years

IMPORTANCE: Over the past several years, there have been a number of mainstream media reports that the abuse of heroin has migrated from low-income urban areas with large minority populations to more affluent suburban and rural areas with primarily white populations. OBJECTIVE: To examine the veracity of these anecdotal reports and define the relationship between the abuse of prescription opioids and the abuse of heroin. DESIGN, SETTING, AND PARTICIPANTS: Using a mixed-methods approach, we analyzed (1) data from an ongoing study that uses structured, self-administered surveys to gather retrospective data on past drug use patterns among patients entering substance abuse treatment programs across the country who received a primary (DSM-IV) diagnosis of heroin use/dependence (n = 2797) and (2) data from unstructured qualitative interviews with a subset of patients (n = 54) who completed the structured interview. MAIN OUTCOMES AND MEASURES: In addition to data on population demographics and current residential location, we used cross-tabulations to assess prevalence rates as a function of the decade of the initiation of abuse for (1) first opioid used (prescription opioid or heroin), (2) sex, (3) race/ethnicity, and (4) age at first use. Respondents indicated in an open-ended format why they chose heroin as their primary drug and the interrelationship between their use of heroin and their use of prescription opioids. RESULTS: Approximately 85% of treatment-seeking patients approached to complete the Survey of Key Informants\u27 Patients Program did so. Respondents who began using heroin in the 1960s were predominantly young men (82.8%; mean age, 16.5 years) whose first opioid of abuse was heroin (80%). However, more recent users were older (mean age, 22.9 years) men and women living in less urban areas (75.2%) who were introduced to opioids through prescription drugs (75.0%). Whites and nonwhites were equally represented in those initiating use prior to the 1980s, but nearly 90% of respondents who began use in the last decade were white. Although the high produced by heroin was described as a significant factor in its selection, it was often used because it was more readily accessible and much less expensive than prescription opioids. CONCLUSION AND RELEVANCE: Our data show that the demographic composition of heroin users entering treatment has shifted over the last 50 years such that heroin use has changed from an inner-city, minority-centered problem to one that has a more widespread geographical distribution, involving primarily white men and women in their late 20s living outside of large urban areas