1,091 research outputs found
A LEKID-based CMB instrument design for large-scale observations in Greenland
We present the results of a feasibility study, which examined deployment of a
ground-based millimeter-wave polarimeter, tailored for observing the cosmic
microwave background (CMB), to Isi Station in Greenland. The instrument for
this study is based on lumped-element kinetic inductance detectors (LEKIDs) and
an F/2.4 catoptric, crossed-Dragone telescope with a 500 mm aperture. The
telescope is mounted inside the receiver and cooled to K by a
closed-cycle He refrigerator to reduce background loading on the detectors.
Linearly polarized signals from the sky are modulated with a metal-mesh
half-wave plate that is rotated at the aperture stop of the telescope with a
hollow-shaft motor based on a superconducting magnetic bearing. The modular
detector array design includes at least 2300 LEKIDs, and it can be configured
for spectral bands centered on 150~GHz or greater. Our study considered
configurations for observing in spectral bands centered on 150, 210 and
267~GHz. The entire polarimeter is mounted on a commercial precision rotary air
bearing, which allows fast azimuth scan speeds with negligible vibration and
mechanical wear over time. A slip ring provides power to the instrument,
enabling circular scans (360 degrees of continuous rotation). This mount, when
combined with sky rotation and the latitude of the observation site, produces a
hypotrochoid scan pattern, which yields excellent cross-linking and enables
34\% of the sky to be observed using a range of constant elevation scans. This
scan pattern and sky coverage combined with the beam size (15~arcmin at
150~GHz) makes the instrument sensitive to in the angular
power spectra
The Detector System for the Stratospheric Kinetic Inductance Polarimeter (SKIP)
The Stratospheric Kinetic Inductance Polarimeter (SKIP) is a proposed
balloon-borne experiment designed to study the cosmic microwave background, the
cosmic infrared background and Galactic dust emission by observing 1133 square
degrees of sky in the Northern Hemisphere with launches from Kiruna, Sweden.
The instrument contains 2317 single-polarization, horn-coupled, aluminum
lumped-element kinetic inductance detectors (LEKID). The LEKIDs will be
maintained at 100 mK with an adiabatic demagnetization refrigerator. The
polarimeter operates in two configurations, one sensitive to a spectral band
centered on 150 GHz and the other sensitive to 260 and 350 GHz bands. The
detector readout system is based on the ROACH-1 board, and the detectors will
be biased below 300 MHz. The detector array is fed by an F/2.4 crossed-Dragone
telescope with a 500 mm aperture yielding a 15 arcmin FWHM beam at 150 GHz. To
minimize detector loading and maximize sensitivity, the entire optical system
will be cooled to 1 K. Linearly polarized sky signals will be modulated with a
metal-mesh half-wave plate that is mounted at the telescope aperture and
rotated by a superconducting magnetic bearing. The observation program consists
of at least two, five-day flights beginning with the 150 GHz observations.Comment: J Low Temp Phys DOI 10.1007/s10909-013-1014-3 The final publication
is available at link.springer.co
The prevalence and incidence of mental ill-health in adults with autism and intellectual disabilities
The prevalence, and incidence, of mental ill-health in adults with intellectual disabilities and autism were compared with the whole population with intellectual disabilities, and with controls, matched individually for age, gender, ability-level, and Down syndrome. Although the adults with autism had a higher point prevalence of problem behaviours compared with the whole adult population with intellectual disabilities, compared with individually matched controls there was no difference in prevalence, or incidence of either problem behaviours or other mental ill-health. Adults with autism who had problem behaviours were less likely to recover over a two-year period than were their matched controls. Apparent differences in rates of mental ill-health are accounted for by factors other than autism, including Down syndrome and ability level
Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery)
Motor Skill Learning, Retention, and Control Deficits in Parkinson's Disease
Parkinson's disease, which affects the basal ganglia, is known to lead to various impairments of motor control. Since the basal ganglia have also been shown to be involved in learning processes, motor learning has frequently been investigated in this group of patients. However, results are still inconsistent, mainly due to skill levels and time scales of testing. To bridge across the time scale problem, the present study examined de novo skill learning over a long series of practice sessions that comprised early and late learning stages as well as retention. 19 non-demented, medicated, mild to moderate patients with Parkinson's disease and 19 healthy age and gender matched participants practiced a novel throwing task over five days in a virtual environment where timing of release was a critical element. Six patients and seven control participants came to an additional long-term retention testing after seven to nine months. Changes in task performance were analyzed by a method that differentiates between three components of motor learning prominent in different stages of learning: Tolerance, Noise and Covariation. In addition, kinematic analysis related the influence of skill levels as affected by the specific motor control deficits in Parkinson patients to the process of learning. As a result, patients showed similar learning in early and late stages compared to the control subjects. Differences occurred in short-term retention tests; patients' performance constantly decreased after breaks arising from poorer release timing. However, patients were able to overcome the initial timing problems within the course of each practice session and could further improve their throwing performance. Thus, results demonstrate the intact ability to learn a novel motor skill in non-demented, medicated patients with Parkinson's disease and indicate confounding effects of motor control deficits on retention performance
Instances and connectors : issues for a second generation process language
This work is supported by UK EPSRC grants GR/L34433 and GR/L32699Over the past decade a variety of process languages have been defined, used and evaluated. It is now possible to consider second generation languages based on this experience. Rather than develop a second generation wish list this position paper explores two issues: instances and connectors. Instances relate to the relationship between a process model as a description and the, possibly multiple, enacting instances which are created from it. Connectors refers to the issue of concurrency control and achieving a higher level of abstraction in how parts of a model interact. We believe that these issues are key to developing systems which can effectively support business processes, and that they have not received sufficient attention within the process modelling community. Through exploring these issues we also illustrate our approach to designing a second generation process language.Postprin
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Carbon storage in Ghanaian cocoa ecosystems
Background: The recent inclusion of the cocoa sector as an option for carbon storage necessitates the need to
quantify the C stocks in cocoa systems of Ghana.
Results: Using farmers’ fields, the carbon (C) stocks in shaded and unshaded cocoa systems selected from the Eastern (ER) and Western (WR) regions of Ghana were measured. Total ecosystem C (biomass C + soil C to 60 cm depth) ranged from 81.8 to 153.9 Mg C/ha. The bulk (~89 %) of the systems’ C stock was stored in the soils. The total C stocks were higher in the WR (137.8 ± 8.6 Mg C/ha) than ER (95.7 ± 8.6 Mg C/ha).
Conclusion: Based on the cocoa cultivation area of 1.45 million hectares, the cocoa sector in Ghana potentially
could store 118.6–223.2 Gg C in cocoa systems with cocoa systems aged within 30 years regardless of shade management. Thus, the decision to include the cocoa sector in the national carbon accounting emissions budget of Ghana is warranted
Insulin Analogs Versus Human Insulin in the Treatment of Patients With Diabetic Ketoacidosis: A randomized controlled trial
Reconstruction of ancient microbial genomes from the human gut
Loss of gut microbial diversity1–6 in industrial populations is associated with chronic diseases7, underscoring the importance of studying our ancestral gut microbiome. However, relatively little is known about the composition of pre-industrial gut microbiomes. Here we performed a large-scale de novo assembly of microbial genomes from palaeofaeces. From eight authenticated human palaeofaeces samples (1,000–2,000 years old) with well-preserved DNA from southwestern USA and Mexico, we reconstructed 498 medium- and high-quality microbial genomes. Among the 181 genomes with the strongest evidence of being ancient and of human gut origin, 39% represent previously undescribed species-level genome bins. Tip dating suggests an approximate diversification timeline for the key human symbiont Methanobrevibacter smithii. In comparison to 789 present-day human gut microbiome samples from eight countries, the palaeofaeces samples are more similar to non-industrialized than industrialized human gut microbiomes. Functional profiling of the palaeofaeces samples reveals a markedly lower abundance of antibiotic-resistance and mucin-degrading genes, as well as enrichment of mobile genetic elements relative to industrial gut microbiomes. This study facilitates the discovery and characterization of previously undescribed gut microorganisms from ancient microbiomes and the investigation of the evolutionary history of the human gut microbiota through genome reconstruction from palaeofaeces.Ethics Overview of samples Reference-based taxonomic composition De novo genome reconstruction Methanobrevibacter smithii tip dating Functional genomic analysis Discussion Online content Method
Empirical or microbiologically guided systemic antimicrobials as adjuncts to non-surgical periodontal therapy? A systematic review
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