1,661 research outputs found
Allergic sensitisation in South Africa: Exploring regional variation in sensitisation
Background. Allergy is a common health problem in South Africa (SA), and a rational approach to allergy testing is essential to ensure cost-effective as well as optimal patient diagnosis and management.Objectives. To review allergy testing data with respect to current national testing recommendations, and to explore the regional variations in sensitisation.Methods. Retrospective data review on allergy testing from a private pathology provider in SA over a 2-year period. Data on skin-prick testing (SPT) and allergen-specific IgE testing originating from all the provinces of SA were collected and analysed with regards to allergen positivity rate and regional sensitisation patterns.Results. Among the patients (N=45 0320) tested for a suspected inhalant allergy, 46% tested positive. Only 45% of these received additional testing for the nine recommended inhalant allergens included in the current national testing protocol. Among the patients (N=6 775) who received SPT for a suspected inhalant allergy, 59% yielded one or more positive results. The most frequent sensitising allergens were house dust mite (Dermatophagoides pteronyssinus) and grass pollen. The house dust mite, Blomia tropicalis, was a significant sensitiser in coastal regions. SPT identified two other important regional allergens which are not included in the current recommendations for inhalant allergen-specific IgE testing.Conclusions. The current diagnostic recommendations include allergens that demonstrate significant sensitisation in all regions of SA. Two additional allergens that show significant regional sensitisation in the South African population were identified. These findings may aid the recommendations for the most appropriate and cost-effective approach to allergy testing of symptomatic patients in SA
Simplifying one-loop amplitudes in superstring theory
We show that 4-point vector boson one-loop amplitudes, computed in ref.[1] in
the RNS formalism, around vacuum configurations with open unoriented strings,
preserving at least N=1 SUSY in D=4, satisfy the correct supersymmetry Ward
identities, in that they vanish for non MHV configurations (++++) and (-+++).
In the MHV case (--++) we drastically simplify their expressions. We then study
factorisation and the limiting IR and UV behaviour and find some unexpected
results. In particular no massless poles are exposed at generic values of the
modular parameter. Relying on the supersymmetric properties of our bosonic
amplitudes, we extend them to manifestly supersymmetric super-amplitudes and
compare our results with those obtained in the D=4 hybrid formalism, pointing
out difficulties in reconciling the two approaches for contributions from N=1,2
sectors.Comment: 38 pages plus appendice
Instanton effects in N=1 brane models and the Kahler metric of twisted matter
We consider locally consistent systems of magnetized D9 branes on an
orbifolded six-torus which support N=1 gauge theories. In such realizations,
the matter multiplets arise from "twisted" strings connecting different stacks
of branes. The introduction of Euclidean 5 branes (E5) wrapped on the
six-dimensional compact space leads to instanton effects. For instance, if the
system is engineered so as to yield SQCD, a single E5 brane may account for the
ADS/TVY superpotential. We discuss the subtle interplay that exists between the
annuli diagrams with an E5 boundary and the holomorphicity properties of the
effective low-energy action of the N=1 theory. The consistency of this picture
allows to obtain information on the Kahler metric of the chiral matter
multiplets arising from twisted strings.Comment: 33 pages, 4 figures. V2: improved discussion, clarifyng comments and
references added. Version to be published in JHE
An Inflaton Mass Problem in String Inflation from Threshold Corrections to Volume Stabilization
Inflationary models whose vacuum energy arises from a D-term are believed not
to suffer from the supergravity eta problem of F-term inflation. That is,
D-term models have the desirable property that the inflaton mass can naturally
remain much smaller than the Hubble scale. We observe that this advantage is
lost in models based on string compactifications whose volume is stabilized by
a nonperturbative superpotential: the F-term energy associated with volume
stabilization causes the eta problem to reappear. Moreover, any shift
symmetries introduced to protect the inflaton mass will typically be lifted by
threshold corrections to the volume-stabilizing superpotential. Using threshold
corrections computed by Berg, Haack, and Kors, we illustrate this point in the
example of the D3-D7 inflationary model, and conclude that inflation is
possible, but only for fine-tuned values of the stabilized moduli. More
generally, we conclude that inflationary models in stable string
compactifications, even D-term models with shift symmetries, will require a
certain amount of fine-tuning to avoid this new contribution to the eta
problem.Comment: 25 page
Combinatorial Markov chains on linear extensions
We consider generalizations of Schuetzenberger's promotion operator on the
set L of linear extensions of a finite poset of size n. This gives rise to a
strongly connected graph on L. By assigning weights to the edges of the graph
in two different ways, we study two Markov chains, both of which are
irreducible. The stationary state of one gives rise to the uniform
distribution, whereas the weights of the stationary state of the other has a
nice product formula. This generalizes results by Hendricks on the Tsetlin
library, which corresponds to the case when the poset is the anti-chain and
hence L=S_n is the full symmetric group. We also provide explicit eigenvalues
of the transition matrix in general when the poset is a rooted forest. This is
shown by proving that the associated monoid is R-trivial and then using
Steinberg's extension of Brown's theory for Markov chains on left regular bands
to R-trivial monoids.Comment: 35 pages, more examples of promotion, rephrased the main theorems in
terms of discrete time Markov chain
Instantons in N=2 magnetized D-brane worlds
In a toroidal orbifold of type IIB string theory we study instanton effects
in N=2 super Yang-Mills theories engineered with systems of wrapped magnetized
D9 branes and Euclidean D5 branes. We analyze the various open string sectors
in this brane system and study the 1-loop amplitudes described by annulus
diagrams with mixed boundary conditions, explaining their role in the stringy
instanton calculus. We show in particular that the non-holomorphic terms in
these annulus amplitudes precisely reconstruct the appropriate Kahler metric
factors that are needed to write the instanton correlators in terms of purely
holomorphic variables. We also explicitly derive the correct holomorphic
structure of the instanton induced low energy effective action in the Coulomb
branch.Comment: 40 pages, 5 figures, JHEP class. Some footnotes added and typos
corrected. Version published in JHE
Chronic fatigue syndrome
Objective. To acknowledge the dinical syndrome chronic fatigue syndrome (CFS) and outline the diagnostic criteria and reasonable management.Outcomes. Attempt at containment of treatment cost and improvement of the quality of care of patients with CFS.Evidence. Delphi-type commentary from 20 expert clinicians and appropriate organisations. Limited literature survey.Values. To clarify the reasonable management of CFS amid conflicting clinical opinion on a condition qf concern to patients, funders and doctors, An adaptation:of an existing guideline was sent to organisations and individuals for comment. Comments received were included in this guideline where possible.Benefits, harms and costs. To acknowledge a clinical syndrome with a reasonable approach to management considering the cost implications. No cost analysis was done.Recommendations. To recommend the following: (I) diagnostic criteria for CFS; (il) potential differential diagnoses and possible investigations; and (iil) management protocol.Validation. The draft guidelines were subjected to external review by individual doctors who are acknowledged CFS treaters, doctor groups and the patient support group. There were major disputes about the content, with the responses falling into two groups: thosewho do not believe CFS is a distinguishable illness, and those who do.Developer and funding. The Committee for Science and Education, Medical Association of South Africa, Endorsements. Medical Association of South Africa and national health care organisations (see list at the end of the document)
Desensitizing Inflation from the Planck Scale
A new mechanism to control Planck-scale corrections to the inflationary eta
parameter is proposed. A common approach to the eta problem is to impose a
shift symmetry on the inflaton field. However, this symmetry has to remain
unbroken by Planck-scale effects, which is a rather strong requirement on
possible ultraviolet completions of the theory. In this paper, we show that the
breaking of the shift symmetry by Planck-scale corrections can be
systematically suppressed if the inflaton field interacts with a conformal
sector. The inflaton then receives an anomalous dimension in the conformal
field theory, which leads to sequestering of all dangerous high-energy
corrections. We analyze a number of models where the mechanism can be seen in
action. In our most detailed example we compute the exact anomalous dimensions
via a-maximization and show that the eta problem can be solved using only
weakly-coupled physics.Comment: 34 pages, 3 figures
Proximity of Iron Pnictide Superconductors to a Quantum Tricritical Point
We determine the nature of the magnetic quantum critical point in the doped
LaFeAsO using a set of constrained density functional calculations that provide
ab initio coefficients for a Landau order parameter analysis. The system turns
out to be remarkably close to a quantum tricritical point, where the nature of
the phase transition changes from first to second order. We compare with the
effective field theory and discuss the experimental consequences.Comment: 4 pages, 4 figure
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